Click here to switch to the map view.

The map label for this gene is polC [H]

Identifier: 218231342

GI number: 218231342

Start: 3637618

End: 3638565

Strand: Reverse

Name: polC [H]

Synonym: BCB4264_A3719

Alternate gene names: 218231342

Gene position: 3638565-3637618 (Counterclockwise)

Preceding gene: 218231635

Following gene: 218232850

Centisome position: 67.14

GC content: 32.49

Gene sequence:

>948_bases
GTGGGGAATGTATCCTTACCGTTAGATTATGTTGTAATTGATTTTGAAACAACAGGATTTAACCCTTATAATGATAAAAT
TATTCAAGTTGCAGCAGTGAAATATCGTAATCATGAATTAGTAGATCAATTTGTTTCATACGTGAATCCAGAGCGGCCAA
TTCCGGACCGAATAACGAGTTTAACAGGTATTACTAATTATCGCGTTTCAGATGCTCCGACGATTGAAGAAGTGTTACCT
TTATTTTTAGCATTTTTACATACAAATGTTATTGTGGCCCATAATGCTTCTTTTGATATGCGCTTTTTGAAAAGTAATGT
AAATATGCTTGGGTTGCCTGAACCTAAAAATAAAGTAATTGATACTGTATTTTTAGCGAAGAAATACATGAAGCATGCGC
CTAATCATAAACTTGAAACGTTAAAACGAATGCTTGGAATTCGTTTAAGCTCTCATAATGCATTTGACGATTGCATTACG
TGTGCTGCTGTTTATCAAAAGTGTGTAGCTATTGAAGAAGAAGGGAAACGAAAAGTAAATAAGGCTATGCTTGATGAAAC
TGCGGTATATGAAGCGGTGAAAGAAATACTTGCATGTAATAAACGGAATGTAGAATGGCTACGTTGTATGAACGTAGGAA
GTTATTTAGATATAAAAGCTTTTTATCCAGTTATGAGAGTAAAGGTAAAAGGGCGAAAGAAATATGTATTAACAGAGATA
TTAGAAGAAGATGTGAAAGAAATATGTACAAGCTTAAAATGTGAACCAGCGTTAAAAAGTGAAGTTGGTAATACGAGAAT
TATGCTTAATAGCTTAGAGGATGTTATGAGATTAGAAAGTTATATTTTAGAACAGTATGATTTTGTATTACAGGCGCTTC
ATGATTATAAAGAAAATGAAATGAATGCAGATGAAAAGTTGAAAGAGTATTTAAATATTATGGTATGA

Upstream 100 bases:

>100_bases
GGTGGAGAGTTCCCATTTCTGTCTTTTCTTTTTCAAGTAGTAATCACTTCATGATATGATGTAAGAAATATAACCGTTTA
GAGATAAAGGAGTGTATGGA

Downstream 100 bases:

>100_bases
AAAACTCCGTGTGCAATATATTGTACACGGAGTTTTTTTAGGAGTACTAAAACATAAAATTTTCTTGCAAATCTGATTAA
AGAGTTTTTTGTTTGCTCAT

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MGNVSLPLDYVVIDFETTGFNPYNDKIIQVAAVKYRNHELVDQFVSYVNPERPIPDRITSLTGITNYRVSDAPTIEEVLP
LFLAFLHTNVIVAHNASFDMRFLKSNVNMLGLPEPKNKVIDTVFLAKKYMKHAPNHKLETLKRMLGIRLSSHNAFDDCIT
CAAVYQKCVAIEEEGKRKVNKAMLDETAVYEAVKEILACNKRNVEWLRCMNVGSYLDIKAFYPVMRVKVKGRKKYVLTEI
LEEDVKEICTSLKCEPALKSEVGNTRIMLNSLEDVMRLESYILEQYDFVLQALHDYKENEMNADEKLKEYLNIMV

Sequences:

>Translated_315_residues
MGNVSLPLDYVVIDFETTGFNPYNDKIIQVAAVKYRNHELVDQFVSYVNPERPIPDRITSLTGITNYRVSDAPTIEEVLP
LFLAFLHTNVIVAHNASFDMRFLKSNVNMLGLPEPKNKVIDTVFLAKKYMKHAPNHKLETLKRMLGIRLSSHNAFDDCIT
CAAVYQKCVAIEEEGKRKVNKAMLDETAVYEAVKEILACNKRNVEWLRCMNVGSYLDIKAFYPVMRVKVKGRKKYVLTEI
LEEDVKEICTSLKCEPALKSEVGNTRIMLNSLEDVMRLESYILEQYDFVLQALHDYKENEMNADEKLKEYLNIMV
>Mature_314_residues
GNVSLPLDYVVIDFETTGFNPYNDKIIQVAAVKYRNHELVDQFVSYVNPERPIPDRITSLTGITNYRVSDAPTIEEVLPL
FLAFLHTNVIVAHNASFDMRFLKSNVNMLGLPEPKNKVIDTVFLAKKYMKHAPNHKLETLKRMLGIRLSSHNAFDDCITC
AAVYQKCVAIEEEGKRKVNKAMLDETAVYEAVKEILACNKRNVEWLRCMNVGSYLDIKAFYPVMRVKVKGRKKYVLTEIL
EEDVKEICTSLKCEPALKSEVGNTRIMLNSLEDVMRLESYILEQYDFVLQALHDYKENEMNADEKLKEYLNIMV

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1786409, Length=196, Percent_Identity=28.0612244897959, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36261; Mature: 36129

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNVSLPLDYVVIDFETTGFNPYNDKIIQVAAVKYRNHELVDQFVSYVNPERPIPDRITS
CCCCCCCEEEEEEEEEECCCCCCCCCEEEEEHHHHCCHHHHHHHHHHCCCCCCCHHHHHH
LTGITNYRVSDAPTIEEVLPLFLAFLHTNVIVAHNASFDMRFLKSNVNMLGLPEPKNKVI
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCEECCCCCHHHHH
DTVFLAKKYMKHAPNHKLETLKRMLGIRLSSHNAFDDCITCAAVYQKCVAIEEEGKRKVN
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMLDETAVYEAVKEILACNKRNVEWLRCMNVGSYLDIKAFYPVMRVKVKGRKKYVLTEI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEHHHHHHHHHEEECCCHHHHHHHH
LEEDVKEICTSLKCEPALKSEVGNTRIMLNSLEDVMRLESYILEQYDFVLQALHDYKENE
HHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MNADEKLKEYLNIMV
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
GNVSLPLDYVVIDFETTGFNPYNDKIIQVAAVKYRNHELVDQFVSYVNPERPIPDRITS
CCCCCCEEEEEEEEEECCCCCCCCCEEEEEHHHHCCHHHHHHHHHHCCCCCCCHHHHHH
LTGITNYRVSDAPTIEEVLPLFLAFLHTNVIVAHNASFDMRFLKSNVNMLGLPEPKNKVI
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCEECCCCCHHHHH
DTVFLAKKYMKHAPNHKLETLKRMLGIRLSSHNAFDDCITCAAVYQKCVAIEEEGKRKVN
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMLDETAVYEAVKEILACNKRNVEWLRCMNVGSYLDIKAFYPVMRVKVKGRKKYVLTEI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEHHHHHHHHHEEECCCHHHHHHHH
LEEDVKEICTSLKCEPALKSEVGNTRIMLNSLEDVMRLESYILEQYDFVLQALHDYKENE
HHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MNADEKLKEYLNIMV
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]