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The map label for this gene is purM [H]

Identifier: 218231041

GI number: 218231041

Start: 317364

End: 318404

Strand: Direct

Name: purM [H]

Synonym: BCB4264_A0342

Alternate gene names: 218231041

Gene position: 317364-318404 (Clockwise)

Preceding gene: 218231603

Following gene: 218232251

Centisome position: 5.86

GC content: 38.81

Gene sequence:

>1041_bases
ATGGCGAATGCATATAAGCAAGCAGGAGTAGATATTGAAGCTGGATATGAAGCGGTATCTCGCATGAAAAAACACGTACA
AACAACTATGAGAAAAGAAGTACTAGGCGGTTTAGGCGGTTTTGGAGGTATGTTTGATCTATCAAAATTTGCATTAGAAG
AACCTGTATTAGTATCTGGAACAGATGGCGTGGGAACGAAATTGATGCTCGCTTTTATGGCAGATAAACATGACACAATT
GGTATTGATGCAGTAGCAATGTGTGTAAATGATATTGTTGTCCAAGGAGCAGAGCCGCTTTTCTTCCTTGATTATATTGC
TTGTGGTAAAGCTGAACCTAGTAAAATTGAAAACATCGTCAAAGGTATATCAGAGGGCTGTCGCCAAGCTGGTTGTGCAT
TAATCGGTGGAGAAACAGCTGAAATGCCAGGAATGTATTCTACGGAAGAATATGATTTAGCTGGTTTTACAGTTGGGATT
GTTGATAAAAAGAAAATTGTAACAGGTGAAAAGATTGAAGCTGGTCACGTGCTAATTGGCTTAGCATCTAGCGGTATTCA
TAGCAATGGTTACTCTTTAGTACGAAAAGTGTTATTAGAAGATGGGGAACTATCTTTAGAGCGTATTTATGGCCGCTTAG
AACTACCTCTTGGTGAAGAATTATTAAAACCAACGAAAATTTATGTCAAACCTATTTTAGAACTATTGAAGAAACATGAA
GTATACGGTATGGCGCATATTACAGGTGGTGGATTTATTGAAAATATTCCACGCATGTTGCCAGAAGGAATCGGTGCTGA
GATTGAACTAGGATCTTGGGAAATTCAGCCGATCTTTAGTTTGCTTCAAGAGGTTGGAAAACTGGAAGAGAAAGAAATGT
TCAATATTTTTAACATGGGTATTGGTATGGTAGTAGCAGTGAAGGAAGAAGATGCAAAAGATGTTGTTCGTCTTCTTGAA
GAGCAAGGAGAAATGGCTCGTATTATTGGACGTACTATACAAGGAGCTGGCGTTACTTTTAATGGGGGCACAGCACTATG
A

Upstream 100 bases:

>100_bases
GTGAGAAAAGCTTCTATTTCTTTTGATGTAGGAGCTAGATCCTTTCTTAAAATAGCCCGCCCTGGATGGGGAGAAATTAA
AAGACGAGGTGTAAATAACG

Downstream 100 bases:

>100_bases
GTAGATTAGCAGTTTTTGCTTCTGGAAGTGGATCTAACTTTCAATCTCTCGTTAATGCGGTAGAAGAAAAAAGATTGGAT
GCAGAAATTAGTTTATTAGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTI
GIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGI
VDKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLERIYGRLELPLGEELLKPTKIYVKPILELLKKHE
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDVVRLLE
EQGEMARIIGRTIQGAGVTFNGGTAL

Sequences:

>Translated_346_residues
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTI
GIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGI
VDKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLERIYGRLELPLGEELLKPTKIYVKPILELLKKHE
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDVVRLLE
EQGEMARIIGRTIQGAGVTFNGGTAL
>Mature_345_residues
ANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTIG
IDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIV
DKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLERIYGRLELPLGEELLKPTKIYVKPILELLKKHEV
YGMAHITGGGFIENIPRMLPEGIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDVVRLLEE
QGEMARIIGRTIQGAGVTFNGGTAL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=48.8023952095808, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=48.8023952095808, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=48.8023952095808, Blast_Score=323, Evalue=1e-88,
Organism=Escherichia coli, GI1788845, Length=328, Percent_Identity=54.5731707317073, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17567511, Length=326, Percent_Identity=40.7975460122699, Blast_Score=235, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=359, Percent_Identity=43.4540389972145, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24582400, Length=284, Percent_Identity=41.9014084507042, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37289; Mature: 37158

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEC
TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHH
KGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGEKIEAGHVLIG
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCEEEEE
LASSGIHSNGYSLVRKVLLEDGELSLERIYGRLELPLGEELLKPTKIYVKPILELLKKHE
EECCCCCCCHHHHHHHHHHCCCCHHHHHHHCHHCCCCCHHHHCHHHHHHHHHHHHHHHHH
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMG
HHEEEEECCCHHHHHHHHHHHCCCCCEEEECCEEHHHHHHHHHHHHCCHHHHHHHHHHCC
IGMVVAVKEEDAKDVVRLLEEQGEMARIIGRTIQGAGVTFNGGTAL
CCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure 
ANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEC
TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHH
KGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGEKIEAGHVLIG
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCEEEEE
LASSGIHSNGYSLVRKVLLEDGELSLERIYGRLELPLGEELLKPTKIYVKPILELLKKHE
EECCCCCCCHHHHHHHHHHCCCCHHHHHHHCHHCCCCCHHHHCHHHHHHHHHHHHHHHHH
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMG
HHEEEEECCCHHHHHHHHHHHCCCCCEEEECCEEHHHHHHHHHHHHCCHHHHHHHHHHCC
IGMVVAVKEEDAKDVVRLLEEQGEMARIIGRTIQGAGVTFNGGTAL
CCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA