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The map label for this gene is csgA [H]

Identifier: 218230775

GI number: 218230775

Start: 3301222

End: 3301926

Strand: Reverse

Name: csgA [H]

Synonym: BCB4264_A3423

Alternate gene names: 218230775

Gene position: 3301926-3301222 (Counterclockwise)

Preceding gene: 218231213

Following gene: 218232773

Centisome position: 60.93

GC content: 36.17

Gene sequence:

>705_bases
ATGAGGGTTCTAATTACAGGTGGAAATCGAGGGTTAGGGTTACAGTTAGTAAAAGTATTTCATGAAAATGGGCATATTGT
TTATCCGTTAGTTAGAACTAAGATTGCGGTAACGCAATTGAAGCAAATGTTTAGTTGTAGATGTTTTCCTATATTGGCAG
ACTTATCGGCTGATGAGAGTACGGAGCAAATTAAGAAACAGCTTGAGGAATATACAGAGTATATTGATCTAGTTATAAAT
AACGCTGGCATTACTGGAAAGGAAACTGAGATTTTACATACAAATTCAGAAGAGTTAACGGACTTATTTAATATTCATTG
CTTAGGTGTCATTCGAGTTGTAAAAGGTACATATGTGTCTTTAGCTAAATCGAATCATCCGAGAATCATAAATGTGTCTT
CTCGATTAGGTTCATTGCATAAAATGGCGAACAAAGAGTTTCCACAAGGTCAGTTCTCATATTCATATCGAATTGCTAAA
GCTGCACAAAATATGTTAACACTCTGCTTACAACAAGAGTTTGAGAATAAAGGAATTCGTGTAACTGCCATTCACCCTGG
AAAATTAAAGACTGACATTGGTGCTTTTGATGCGAATATGACTCCGGCAGAAGGAGCAAAAAATATATATGATTGGGTAA
GAGGTTCAAACGAGGATGTTTCAGGGAAGTTTATTGAGCCAGGTGTAGGTGAATTAAAGTGGTGA

Upstream 100 bases:

>100_bases
GAGCAGGTTTTTCTTTTGAATGCAAGAGAGAGGCGTTTTCTTTAGAGAATGGTGAGTGGATGGATTTTCTTATTTATTTT
AAAAATAAGGAGATGGATAT

Downstream 100 bases:

>100_bases
TATACGATCTTGCAATCATTCAGAATCTATTTGGGCCCTCTAAAAAAGTGTTAAATGGCTTACCAAAGGCAGTAACGATT
GAAGAAATAGAAGAAGATGT

Product: oxidoreductase, short chain dehydrogenase/reductase family

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTKIAVTQLKQMFSCRCFPILADLSADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEILHTNSEELTDLFNIHCLGVIRVVKGTYVSLAKSNHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAK
AAQNMLTLCLQQEFENKGIRVTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVRGSNEDVSGKFIEPGVGELKW

Sequences:

>Translated_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTKIAVTQLKQMFSCRCFPILADLSADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEILHTNSEELTDLFNIHCLGVIRVVKGTYVSLAKSNHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAK
AAQNMLTLCLQQEFENKGIRVTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVRGSNEDVSGKFIEPGVGELKW
>Mature_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTKIAVTQLKQMFSCRCFPILADLSADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEILHTNSEELTDLFNIHCLGVIRVVKGTYVSLAKSNHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAK
AAQNMLTLCLQQEFENKGIRVTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVRGSNEDVSGKFIEPGVGELKW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=214, Percent_Identity=27.1028037383178, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115534660, Length=198, Percent_Identity=30.8080808080808, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558994, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322779, Length=243, Percent_Identity=25.5144032921811, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=26.8, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26153; Mature: 26153

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTKIAVTQLKQMFSCRCFPILADLSADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCH
TEQIKKQLEEYTEYIDLVINNAGITGKETEILHTNSEELTDLFNIHCLGVIRVVKGTYVS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCHHEE
LAKSNHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAKAAQNMLTLCLQQEFENKGIR
EECCCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVRGSNEDVSGKFIEPGVGELKW
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTKIAVTQLKQMFSCRCFPILADLSADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCH
TEQIKKQLEEYTEYIDLVINNAGITGKETEILHTNSEELTDLFNIHCLGVIRVVKGTYVS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCHHEE
LAKSNHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAKAAQNMLTLCLQQEFENKGIR
EECCCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVRGSNEDVSGKFIEPGVGELKW
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]