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The map label for this gene is aroP [H]

Identifier: 213693285

GI number: 213693285

Start: 2739471

End: 2741021

Strand: Direct

Name: aroP [H]

Synonym: Blon_2439

Alternate gene names: 213693285

Gene position: 2739471-2741021 (Clockwise)

Preceding gene: 213693278

Following gene: 213693289

Centisome position: 96.71

GC content: 60.61

Gene sequence:

>1551_bases
ATGGCGGGCATCGTGCATGGCGGGGTCGCCATCCATGCCGATAGTCAGAGGAACCTGGGGAAGGGCATCATGAGCACCAA
CGATACGTCCGAACAGCCGCGCGAAACCGACGATGTGCCGGTGCCGGCCACGCTGCGCAAGTCACTGAAGAACCGTCATA
TCCAGCTGATTGCACTGGGCGGCGCCATCGGAACCGGCCTGTTCTATGGTTCCAGCGAAGCCATCGCGCTGGCCGGCCCC
TCGATTCTGCTCGCCTACTTGGTCGGCGGCTTCGCAATCTTCATGATCGTGCGCGCGCTGAGCGAAATGTCCGTTGAGGA
TCCGGAGGCGGGCGCGTTCAGCTACTACGCCACTCGCTACTGGTCCAAGCGCGCCGGCTTCATCTCCGGTTGGAACTACT
GGTTCAATTACATCCTCGTCTCGATGGTGGAGCTGTCAGTGGTGGGTTCGTTTGTGAACTACTGGTTCCCGGCGATTCCG
ACATGGGTGTCGGCGGCCGTGTTCTTGGTGATTATCTGCGCCGCCAACCTGCTGGGCGTCTCCAAGTTCGGCGAGTTCGA
GTTCTGGTTCGCCATTATCAAGATTGTGGCCGTGATCGCCATGATTATCGGCGGCCTGGCCGTCATCATCTTCGCTCTGC
CCACCACATCCGGTATCAAAGCGAGCTTTGCCAACTGGTTCACCTTGGAAGGGGGCTTCTTCCCGAACGGTCTCATGGAG
CAGACTAAGGACGGCACCTGGACCGGTCTGTTGATGGCGCTTGTCGTGGTGATGTTCAGCTTCGGCGGCACCGAGCTCAT
CGGCATCACTGCCGGCGAAACCGAGGACCCTCGTCGTACGATTCCCCGCGCCACCAATGACATTATCTGGCGAATTCTCG
TGTTCTACATTGGCGCGCTCGGCGTAATCATGGCCGTAATACCGTGGAACACCATCGGCGGAGACGATGCTCCCAGCCCG
TTCGTGCAAATCTTCGATTCCGTGGGCATCCACGCGGCCGCCGGCATCCTCAACTTCGTGTGCCTGACCGCCGTGATGAG
CGTCTACAACTCCGGCCTGTACGCCAACTCCCGCATGCTGTATTCGCTGGCCAAGCAAGGCAATGCGCCCGCGTATCTGG
GCAAGCTCAACGCTAAGGGCGTGCCGGTGGCCGGCGTGCTGACGTCCGCCGTGATCACCGCCATCGCCGTGGTCGTGGTG
TTCGTGTGGCCCGAGTTCGCGTTCAACTATCTGATGTCGATTGCCACCATCGCCGGCATCATCAACTGGACGATGATCAT
GTTCACCGAGATGAAGTTCCGTAAGGTGGTCGCCGCGGGCGGCGCTCCCGAGGATTCCGAGCTGGCCGGCAAGTCCGGCA
AGGAAGCGCTCGACGCGATTCACTTCAAGCTGCCGTTCGCTAAGGTGACCCCGTGGGTGGTGTTGGCGTTCTTGGCACTG
GTGGTGGTGCTCATGTGCTTCTCCGCCAGCTACCGTGTCGCCGTCATCGCCGGCGTGATTTGGCTCGCCATTCTCTTTGC
GGCCTACCAGCTCACTCAGGCGAAGAAGTAG

Upstream 100 bases:

>100_bases
AACAACACCATGACGGTTGCGCAACCAGCATACGGATCGTGAGTCGCCGGTCTCGCCCAGTGGCGGTGGGCGTTGCCATC
ACGCCATACGGCGTTTTACA

Downstream 100 bases:

>100_bases
AGTCTCATCTGCGAATAGCTCTCAGAATACGCCGCTTGACATTTGCATCTATGGTCTCATTTGGGTCAAATTCCTCTAGG
TAACGCGGGATACCGCCCAG

Product: amino acid permease-associated region

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MAGIVHGGVAIHADSQRNLGKGIMSTNDTSEQPRETDDVPVPATLRKSLKNRHIQLIALGGAIGTGLFYGSSEAIALAGP
SILLAYLVGGFAIFMIVRALSEMSVEDPEAGAFSYYATRYWSKRAGFISGWNYWFNYILVSMVELSVVGSFVNYWFPAIP
TWVSAAVFLVIICAANLLGVSKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTTSGIKASFANWFTLEGGFFPNGLME
QTKDGTWTGLLMALVVVMFSFGGTELIGITAGETEDPRRTIPRATNDIIWRILVFYIGALGVIMAVIPWNTIGGDDAPSP
FVQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRMLYSLAKQGNAPAYLGKLNAKGVPVAGVLTSAVITAIAVVVV
FVWPEFAFNYLMSIATIAGIINWTMIMFTEMKFRKVVAAGGAPEDSELAGKSGKEALDAIHFKLPFAKVTPWVVLAFLAL
VVVLMCFSASYRVAVIAGVIWLAILFAAYQLTQAKK

Sequences:

>Translated_516_residues
MAGIVHGGVAIHADSQRNLGKGIMSTNDTSEQPRETDDVPVPATLRKSLKNRHIQLIALGGAIGTGLFYGSSEAIALAGP
SILLAYLVGGFAIFMIVRALSEMSVEDPEAGAFSYYATRYWSKRAGFISGWNYWFNYILVSMVELSVVGSFVNYWFPAIP
TWVSAAVFLVIICAANLLGVSKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTTSGIKASFANWFTLEGGFFPNGLME
QTKDGTWTGLLMALVVVMFSFGGTELIGITAGETEDPRRTIPRATNDIIWRILVFYIGALGVIMAVIPWNTIGGDDAPSP
FVQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRMLYSLAKQGNAPAYLGKLNAKGVPVAGVLTSAVITAIAVVVV
FVWPEFAFNYLMSIATIAGIINWTMIMFTEMKFRKVVAAGGAPEDSELAGKSGKEALDAIHFKLPFAKVTPWVVLAFLAL
VVVLMCFSASYRVAVIAGVIWLAILFAAYQLTQAKK
>Mature_515_residues
AGIVHGGVAIHADSQRNLGKGIMSTNDTSEQPRETDDVPVPATLRKSLKNRHIQLIALGGAIGTGLFYGSSEAIALAGPS
ILLAYLVGGFAIFMIVRALSEMSVEDPEAGAFSYYATRYWSKRAGFISGWNYWFNYILVSMVELSVVGSFVNYWFPAIPT
WVSAAVFLVIICAANLLGVSKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTTSGIKASFANWFTLEGGFFPNGLMEQ
TKDGTWTGLLMALVVVMFSFGGTELIGITAGETEDPRRTIPRATNDIIWRILVFYIGALGVIMAVIPWNTIGGDDAPSPF
VQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRMLYSLAKQGNAPAYLGKLNAKGVPVAGVLTSAVITAIAVVVVF
VWPEFAFNYLMSIATIAGIINWTMIMFTEMKFRKVVAAGGAPEDSELAGKSGKEALDAIHFKLPFAKVTPWVVLAFLALV
VVLMCFSASYRVAVIAGVIWLAILFAAYQLTQAKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=380, Percent_Identity=23.9473684210526, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI258645169, Length=416, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI258614003, Length=417, Percent_Identity=22.7817745803357, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI258614005, Length=417, Percent_Identity=22.7817745803357, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786302, Length=469, Percent_Identity=46.6950959488273, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1786789, Length=492, Percent_Identity=42.479674796748, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1790653, Length=467, Percent_Identity=38.3297644539615, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI48994972, Length=481, Percent_Identity=39.7089397089397, Blast_Score=326, Evalue=3e-90,
Organism=Escherichia coli, GI1786602, Length=472, Percent_Identity=40.2542372881356, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87081708, Length=475, Percent_Identity=36.2105263157895, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87081915, Length=456, Percent_Identity=34.8684210526316, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1789017, Length=470, Percent_Identity=35.3191489361702, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1788480, Length=426, Percent_Identity=36.3849765258216, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI87081869, Length=265, Percent_Identity=22.2641509433962, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=403, Percent_Identity=24.0694789081886, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=451, Percent_Identity=35.0332594235033, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6320772, Length=459, Percent_Identity=32.4618736383442, Blast_Score=237, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6324059, Length=487, Percent_Identity=32.6488706365503, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=460, Percent_Identity=33.0434782608696, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324924, Length=445, Percent_Identity=31.4606741573034, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6324553, Length=409, Percent_Identity=33.7408312958435, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=432, Percent_Identity=31.4814814814815, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319542, Length=509, Percent_Identity=28.6836935166994, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320251, Length=454, Percent_Identity=30.3964757709251, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=436, Percent_Identity=27.9816513761468, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=433, Percent_Identity=27.9445727482679, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=426, Percent_Identity=28.6384976525822, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322967, Length=447, Percent_Identity=28.8590604026846, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=424, Percent_Identity=28.0660377358491, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319608, Length=436, Percent_Identity=26.1467889908257, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=416, Percent_Identity=30.0480769230769, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=407, Percent_Identity=28.2555282555283, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=454, Percent_Identity=24.8898678414097, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24667468, Length=432, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24666159, Length=432, Percent_Identity=20.8333333333333, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221512776, Length=432, Percent_Identity=20.8333333333333, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55485; Mature: 55354

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIVHGGVAIHADSQRNLGKGIMSTNDTSEQPRETDDVPVPATLRKSLKNRHIQLIALG
CCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEC
GAIGTGLFYGSSEAIALAGPSILLAYLVGGFAIFMIVRALSEMSVEDPEAGAFSYYATRY
CHHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
WSKRAGFISGWNYWFNYILVSMVELSVVGSFVNYWFPAIPTWVSAAVFLVIICAANLLGV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTTSGIKASFANWFTLEGGFFPNGLME
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEECCCCCCCCHHH
QTKDGTWTGLLMALVVVMFSFGGTELIGITAGETEDPRRTIPRATNDIIWRILVFYIGAL
HCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHH
GVIMAVIPWNTIGGDDAPSPFVQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRML
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YSLAKQGNAPAYLGKLNAKGVPVAGVLTSAVITAIAVVVVFVWPEFAFNYLMSIATIAGI
HHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INWTMIMFTEMKFRKVVAAGGAPEDSELAGKSGKEALDAIHFKLPFAKVTPWVVLAFLAL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHH
VVVLMCFSASYRVAVIAGVIWLAILFAAYQLTQAKK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGIVHGGVAIHADSQRNLGKGIMSTNDTSEQPRETDDVPVPATLRKSLKNRHIQLIALG
CCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEC
GAIGTGLFYGSSEAIALAGPSILLAYLVGGFAIFMIVRALSEMSVEDPEAGAFSYYATRY
CHHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
WSKRAGFISGWNYWFNYILVSMVELSVVGSFVNYWFPAIPTWVSAAVFLVIICAANLLGV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTTSGIKASFANWFTLEGGFFPNGLME
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEECCCCCCCCHHH
QTKDGTWTGLLMALVVVMFSFGGTELIGITAGETEDPRRTIPRATNDIIWRILVFYIGAL
HCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHH
GVIMAVIPWNTIGGDDAPSPFVQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRML
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YSLAKQGNAPAYLGKLNAKGVPVAGVLTSAVITAIAVVVVFVWPEFAFNYLMSIATIAGI
HHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INWTMIMFTEMKFRKVVAAGGAPEDSELAGKSGKEALDAIHFKLPFAKVTPWVVLAFLAL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHH
VVVLMCFSASYRVAVIAGVIWLAILFAAYQLTQAKK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]