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The map label for this gene is rmlB [H]

Identifier: 213693237

GI number: 213693237

Start: 2670760

End: 2671785

Strand: Direct

Name: rmlB [H]

Synonym: Blon_2390

Alternate gene names: 213693237

Gene position: 2670760-2671785 (Clockwise)

Preceding gene: 213693235

Following gene: 213693240

Centisome position: 94.28

GC content: 63.94

Gene sequence:

>1026_bases
ATGGCGTGCGGCGGCGTATTCGAGCCGCGTAATATTCTGGTGACTGGCGGATGCGGCTTCATTGGCGCGAACTTCGTGCG
ATACGTGGCGCGGAACCATCCGCACGTGCACATCACCGTGCTCGACAAGCTGACGTACGCCGGCAATCCGGAGAACATCG
CCGGCCTGCCGCCGTCGCAGGTCGATCTTGTCGTCGGAGACATCTGCGACGTCGCGCTGTTGGAGCGTATCGTGCCCGGT
CATGACGCCATCGTCCACTTCGCCGCGGAATCGCACAACGACAACTCCATCGCCAATCCGGAACCGTTCATCCGCACGAA
CGTGGAAGGCACGATGCGGCTGTTGGAGGCCGCCCGGAAACACGACGTGCGCTTCCACCACATCAGCACCGACGAGGTAT
ACGGCGATCTGGCGTTGGATGATCCGGCGCGTTTCACGGAAGACACGCCGTACCACCCTTCAAGCCCGTACAGTGCCTCG
AAGGCGTCGTCCGACCATCTGGTGCGCGCATGGGTGCGTACATACGGCCTGCGCGCCACCATCTCCAACTGCTCCAACAA
CTACGGCCCATACCAGCATGTGGAGAAGTTCATCCCACGGCAGATCACCTCCATCATGGAGGGCGCGCGGCCGAAACTGT
ACGGCACCGGCGAGAACGTGCGCGACTGGATACATACTGAAGACCACTCCCGCGCGGTGTGGGCGATCCTCACCCGCGGG
CGCATCGGCGAAACGTATCTGATCGGAGCTGATGGCGAGATGAGCAACATCGCCGTGCTGCGCATGATCCTGCGGCTGAT
GGGCCAGCCGGAGGATGCGTTCGACTGGGTGCGGGACAGGCCCGGGCACGACAGGCGATACGCGATCGACGCATCCAAAC
TGCGCGCCGAACTGGGCTGGTCGCCGATGCACACCGACTTCGCCGGCGGACTGCGCAACGTCATCGATTGGTATGCGGAA
CACCGCGACTGGTGGGCGCCGGCCAAGGAGGCCACCGAGGCCCGCTACCGCGCGCAAGGGCAGTGA

Upstream 100 bases:

>100_bases
AGAGGCACGAAAAGCTCGCACGGACGCAAGATGGCGTCCGCACCCGGACCCGAACCCCGCAGCAGTTGGCATGCGACGGT
ATGCTGGAATGGTGAACAGC

Downstream 100 bases:

>100_bases
AACGACGGCTGCTACAGGCGGCCCTTCCGCGGCAGAGCGACGTTGCGCAGCAGACGCTGCACAGGCTTAAGCACCACGGT
ATCGGCAATCACCGCAAATA

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MACGGVFEPRNILVTGGCGFIGANFVRYVARNHPHVHITVLDKLTYAGNPENIAGLPPSQVDLVVGDICDVALLERIVPG
HDAIVHFAAESHNDNSIANPEPFIRTNVEGTMRLLEAARKHDVRFHHISTDEVYGDLALDDPARFTEDTPYHPSSPYSAS
KASSDHLVRAWVRTYGLRATISNCSNNYGPYQHVEKFIPRQITSIMEGARPKLYGTGENVRDWIHTEDHSRAVWAILTRG
RIGETYLIGADGEMSNIAVLRMILRLMGQPEDAFDWVRDRPGHDRRYAIDASKLRAELGWSPMHTDFAGGLRNVIDWYAE
HRDWWAPAKEATEARYRAQGQ

Sequences:

>Translated_341_residues
MACGGVFEPRNILVTGGCGFIGANFVRYVARNHPHVHITVLDKLTYAGNPENIAGLPPSQVDLVVGDICDVALLERIVPG
HDAIVHFAAESHNDNSIANPEPFIRTNVEGTMRLLEAARKHDVRFHHISTDEVYGDLALDDPARFTEDTPYHPSSPYSAS
KASSDHLVRAWVRTYGLRATISNCSNNYGPYQHVEKFIPRQITSIMEGARPKLYGTGENVRDWIHTEDHSRAVWAILTRG
RIGETYLIGADGEMSNIAVLRMILRLMGQPEDAFDWVRDRPGHDRRYAIDASKLRAELGWSPMHTDFAGGLRNVIDWYAE
HRDWWAPAKEATEARYRAQGQ
>Mature_340_residues
ACGGVFEPRNILVTGGCGFIGANFVRYVARNHPHVHITVLDKLTYAGNPENIAGLPPSQVDLVVGDICDVALLERIVPGH
DAIVHFAAESHNDNSIANPEPFIRTNVEGTMRLLEAARKHDVRFHHISTDEVYGDLALDDPARFTEDTPYHPSSPYSASK
ASSDHLVRAWVRTYGLRATISNCSNNYGPYQHVEKFIPRQITSIMEGARPKLYGTGENVRDWIHTEDHSRAVWAILTRGR
IGETYLIGADGEMSNIAVLRMILRLMGQPEDAFDWVRDRPGHDRRYAIDASKLRAELGWSPMHTDFAGGLRNVIDWYAEH
RDWWAPAKEATEARYRAQGQ

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=334, Percent_Identity=32.9341317365269, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI42516563, Length=326, Percent_Identity=22.3926380368098, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4504031, Length=334, Percent_Identity=25.1497005988024, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI48994969, Length=354, Percent_Identity=48.8700564971751, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=49.7058823529412, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788366, Length=237, Percent_Identity=30.8016877637131, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786974, Length=322, Percent_Identity=27.9503105590062, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17568069, Length=327, Percent_Identity=33.9449541284404, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115532424, Length=324, Percent_Identity=31.1728395061728, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17507723, Length=337, Percent_Identity=25.8160237388724, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=190, Percent_Identity=30.5263157894737, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17539422, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI133901788, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI133901790, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17539424, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24158427, Length=330, Percent_Identity=26.969696969697, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356223, Length=317, Percent_Identity=24.2902208201893, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38275; Mature: 38144

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACGGVFEPRNILVTGGCGFIGANFVRYVARNHPHVHITVLDKLTYAGNPENIAGLPPSQ
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCH
VDLVVGDICDVALLERIVPGHDAIVHFAAESHNDNSIANPEPFIRTNVEGTMRLLEAARK
HHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHH
HDVRFHHISTDEVYGDLALDDPARFTEDTPYHPSSPYSASKASSDHLVRAWVRTYGLRAT
CCCEEEEECHHHHCCCEECCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHH
ISNCSNNYGPYQHVEKFIPRQITSIMEGARPKLYGTGENVRDWIHTEDHSRAVWAILTRG
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHCCCCCCCEEEEEEECC
RIGETYLIGADGEMSNIAVLRMILRLMGQPEDAFDWVRDRPGHDRRYAIDASKLRAELGW
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECHHHHHHHHCC
SPMHTDFAGGLRNVIDWYAEHRDWWAPAKEATEARYRAQGQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ACGGVFEPRNILVTGGCGFIGANFVRYVARNHPHVHITVLDKLTYAGNPENIAGLPPSQ
CCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCH
VDLVVGDICDVALLERIVPGHDAIVHFAAESHNDNSIANPEPFIRTNVEGTMRLLEAARK
HHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHH
HDVRFHHISTDEVYGDLALDDPARFTEDTPYHPSSPYSASKASSDHLVRAWVRTYGLRAT
CCCEEEEECHHHHCCCEECCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHH
ISNCSNNYGPYQHVEKFIPRQITSIMEGARPKLYGTGENVRDWIHTEDHSRAVWAILTRG
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHCCCCCCCEEEEEEECC
RIGETYLIGADGEMSNIAVLRMILRLMGQPEDAFDWVRDRPGHDRRYAIDASKLRAELGW
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECHHHHHHHHCC
SPMHTDFAGGLRNVIDWYAEHRDWWAPAKEATEARYRAQGQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 11796113 [H]