Click here to switch to the map view.

The map label for this gene is mutY [H]

Identifier: 213692907

GI number: 213692907

Start: 2261904

End: 2262860

Strand: Reverse

Name: mutY [H]

Synonym: Blon_2051

Alternate gene names: 213692907

Gene position: 2262860-2261904 (Counterclockwise)

Preceding gene: 213692909

Following gene: 213692906

Centisome position: 79.88

GC content: 63.32

Gene sequence:

>957_bases
ATGAACGACACAGCAATTTCTTTACGGCTCGGCGCATGGTGGGAGGCCAATGCGCGTGACTTGCCATGGCGCTTCGGACG
GGCCACGCCGTGGGGCGTGCTGGTCAGTGAGGTGATGAGCCAGCAGACGCAGATGAGTCGTGTGGTGCCGTATTGGAACG
ATTGGATGGCACGCTGGCCTGACGCCCGTGCTCTTGCCGCAGCACCTAAAGCCGATGTGATCACCGCATGGGGCCGGCTT
GGCTATCCTCGCCGTGCGCTGCGATTGCGGGAATGCGCCCGCGTGGTGGCGGAAGAATATGGCGATGAGCTGCCTCGCAC
CTACGACGAGCTCGTCGCTCTGCCCGGTATCGGCGACTACACCGCCTCCGCCGTGCTGAGCTTTGCATTCGGTGAGCGCA
TTGCGGTGATCGATACGAATATTCGCCGCGTGCTGAGCCGCGTATTCCTCGGCACCGAATCTCGCGGGGGAGCGGCGAGC
CCGGCCGAACGCGCGCTCGCCAACCGCATGTTGCCCCAAGACAGGGTTTGTGGGGACGGTGCCGATTGCACGGACCATGC
ATATCGATCCGGCGAACACACTTTCCTGCAGCGCAGCGAACCTCCATCGGTCACGTGGAATCAGTCGGTGATGGAATTGG
GCGCGGTGGTTTGCACAGCCAAGACGCCGTTATGCGAGATTTGCCCGATTGCGGATGATTGTGCATTTCTCAAAGCCGGC
CGCCCCGGACTGGGGGAGCGCCGCACCCGCCCGCGGCAGCGATTCCAAGGCACTGATCGTCAGGTGCGCGGTCTGGTGCT
CGCCGCGCTGCGCGAGCTTCCCGCTGGAGTCACGTTGCCCAGGGAAGATGCCGACAAGCTTTGGAAGGACCAGATTCAGC
TTGCCGCCTGCATCGCCAGCCTTGACGATGACGGCCTGATCGAGATTCTGGACGGCGGCCTGCGACTACCCAACTGA

Upstream 100 bases:

>100_bases
TACCCGTACTCGAACATCGTCTCGACTTTTGTTTCGGGATTCTGCGCGTTCTGCGAATTCTGTTCTGCCTCGTTCGTCAT
AGCTGCTAAGAATAAGAACG

Downstream 100 bases:

>100_bases
CATTGTGAAAAATGGCGGGCTCCCCAAGCGTGTATGGGTGTGGTGACCGTAGACTGGAAGGGTTATGGCAGTGCAGAGGA
ACACATCAGGCGCGAGAACG

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNDTAISLRLGAWWEANARDLPWRFGRATPWGVLVSEVMSQQTQMSRVVPYWNDWMARWPDARALAAAPKADVITAWGRL
GYPRRALRLRECARVVAEEYGDELPRTYDELVALPGIGDYTASAVLSFAFGERIAVIDTNIRRVLSRVFLGTESRGGAAS
PAERALANRMLPQDRVCGDGADCTDHAYRSGEHTFLQRSEPPSVTWNQSVMELGAVVCTAKTPLCEICPIADDCAFLKAG
RPGLGERRTRPRQRFQGTDRQVRGLVLAALRELPAGVTLPREDADKLWKDQIQLAACIASLDDDGLIEILDGGLRLPN

Sequences:

>Translated_318_residues
MNDTAISLRLGAWWEANARDLPWRFGRATPWGVLVSEVMSQQTQMSRVVPYWNDWMARWPDARALAAAPKADVITAWGRL
GYPRRALRLRECARVVAEEYGDELPRTYDELVALPGIGDYTASAVLSFAFGERIAVIDTNIRRVLSRVFLGTESRGGAAS
PAERALANRMLPQDRVCGDGADCTDHAYRSGEHTFLQRSEPPSVTWNQSVMELGAVVCTAKTPLCEICPIADDCAFLKAG
RPGLGERRTRPRQRFQGTDRQVRGLVLAALRELPAGVTLPREDADKLWKDQIQLAACIASLDDDGLIEILDGGLRLPN
>Mature_318_residues
MNDTAISLRLGAWWEANARDLPWRFGRATPWGVLVSEVMSQQTQMSRVVPYWNDWMARWPDARALAAAPKADVITAWGRL
GYPRRALRLRECARVVAEEYGDELPRTYDELVALPGIGDYTASAVLSFAFGERIAVIDTNIRRVLSRVFLGTESRGGAAS
PAERALANRMLPQDRVCGDGADCTDHAYRSGEHTFLQRSEPPSVTWNQSVMELGAVVCTAKTPLCEICPIADDCAFLKAG
RPGLGERRTRPRQRFQGTDRQVRGLVLAALRELPAGVTLPREDADKLWKDQIQLAACIASLDDDGLIEILDGGLRLPN

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=240, Percent_Identity=39.1666666666667, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI115298652, Length=240, Percent_Identity=39.1666666666667, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI115298648, Length=240, Percent_Identity=39.1666666666667, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI115298650, Length=240, Percent_Identity=39.1666666666667, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI6912520, Length=240, Percent_Identity=39.1666666666667, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI190358497, Length=240, Percent_Identity=39.1666666666667, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1789331, Length=312, Percent_Identity=31.4102564102564, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 35188; Mature: 35188

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTAISLRLGAWWEANARDLPWRFGRATPWGVLVSEVMSQQTQMSRVVPYWNDWMARWP
CCCCEEEEEECCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
DARALAAAPKADVITAWGRLGYPRRALRLRECARVVAEEYGDELPRTYDELVALPGIGDY
CCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
TASAVLSFAFGERIAVIDTNIRRVLSRVFLGTESRGGAASPAERALANRMLPQDRVCGDG
HHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHCCCCC
ADCTDHAYRSGEHTFLQRSEPPSVTWNQSVMELGAVVCTAKTPLCEICPIADDCAFLKAG
CCCHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHCC
RPGLGERRTRPRQRFQGTDRQVRGLVLAALRELPAGVTLPREDADKLWKDQIQLAACIAS
CCCCCCHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDDDGLIEILDGGLRLPN
CCCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MNDTAISLRLGAWWEANARDLPWRFGRATPWGVLVSEVMSQQTQMSRVVPYWNDWMARWP
CCCCEEEEEECCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
DARALAAAPKADVITAWGRLGYPRRALRLRECARVVAEEYGDELPRTYDELVALPGIGDY
CCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
TASAVLSFAFGERIAVIDTNIRRVLSRVFLGTESRGGAASPAERALANRMLPQDRVCGDG
HHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHCCCCC
ADCTDHAYRSGEHTFLQRSEPPSVTWNQSVMELGAVVCTAKTPLCEICPIADDCAFLKAG
CCCHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHCC
RPGLGERRTRPRQRFQGTDRQVRGLVLAALRELPAGVTLPREDADKLWKDQIQLAACIAS
CCCCCCHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDDDGLIEILDGGLRLPN
CCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]