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The map label for this gene is prs [H]

Identifier: 213692593

GI number: 213692593

Start: 1893755

End: 1894774

Strand: Direct

Name: prs [H]

Synonym: Blon_1726

Alternate gene names: 213692593

Gene position: 1893755-1894774 (Clockwise)

Preceding gene: 213692592

Following gene: 213692594

Centisome position: 66.85

GC content: 64.02

Gene sequence:

>1020_bases
GTGAGCGCAATCCTTGAAGGGAAGCCCGATAAGAATCTTATTCTCGTTACGGGAAGGATTCATCCGAAGTTGGCTGAGGA
TGTCGCCGAGCAGCTCGGCATCGACGTCCTTGAAACCACCGCATACGATTTCGCCAACGGCGAGATGTACGTGCGCTACA
CCGAATCGGTGCGTGGCGCCGATGTGTTCGTGCTGCAAAGCCATTACAAGCCCATCAACAAGGCGATCATGGAGCAGCTC
ATCATGATCGACGCGCTGAAGCGCGCCTCGGCCCGTTCCATTACTGCGGTCTGCCCGTTGCTCGGCTACTCCCGTCAGGA
CAAGAAGCACCGCGGCCGCGAGCCCATCTCCTGCCGTCTGGTGTTCGACCTGCTGAAGACCGCCGGTGCCGACCGCATCA
TGTCGGTCGATCTGCATGCCGCGCAGTCCCAAGGCTTCTTCGACGGCCCGGTCGATCATCTGGTGGCCATGCCGGTGCTG
GTCGACTACATCCGTGATCGTTTCCAGGACCATCTCGACAACGTCGCCGTCGTCTCCCCCGACGCCGGCCGCATTCGCGT
AGCCGAGCAGTGGGCGCAGCGTCTCGGCGGCGGTCCTCTCGCTTTCGTGCACAAGACGCGCGACATCACCCGCCCGAACC
AGGCGGTCGCCAACCGTGTGGTCGGCGACGTCGCCGGCAAGGACTGCGTGCTTGTCGATGACCTGATCGACACCGCGGGT
ACCATCGCGGGCGCATGCCACGTGCTGCAGGACGCGGGAGCCAAGTCGGTGACCGTGGTCGCCACGCATGGCGTGCTCTC
CGGCCCGGCCATCGAGCGACTCAAGAACTGCGGTGCGCGCGAGGTCGTGCTGACCGACACCGTGCCGATTCCCGAGGAAA
AGCGCTGGGATGGCTTGACCGTCCTGTCGATCGCCCCGCTGCTGGCCAGCGCCATCCGCGCCGTATTCGAGGACGGCTCG
GTCGCCGAACTGTTCGACACCTACCCCGAGCACCACGGTCAAGGCTTCCTGTTCGCCTGA

Upstream 100 bases:

>100_bases
AGCGGCAGGTGAACGGCAGGCAACGCTGAGTTGTCCAACCGGTCGTGAAGAACGGCTATGCTGAAGACTGCATCAACGAG
ACCACACGTTGGGAGACATG

Downstream 100 bases:

>100_bases
TTACGTGCGTGTTTGTTCGCGGAAAGCACACAATGCGAGACGCGACATGGCGTAGTCTTTCGGTAAATACCGACAGTATG
ATATAAATGAACACTTGTGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSAILEGKPDKNLILVTGRIHPKLAEDVAEQLGIDVLETTAYDFANGEMYVRYTESVRGADVFVLQSHYKPINKAIMEQL
IMIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRLVFDLLKTAGADRIMSVDLHAAQSQGFFDGPVDHLVAMPVL
VDYIRDRFQDHLDNVAVVSPDAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAVANRVVGDVAGKDCVLVDDLIDTAG
TIAGACHVLQDAGAKSVTVVATHGVLSGPAIERLKNCGAREVVLTDTVPIPEEKRWDGLTVLSIAPLLASAIRAVFEDGS
VAELFDTYPEHHGQGFLFA

Sequences:

>Translated_339_residues
MSAILEGKPDKNLILVTGRIHPKLAEDVAEQLGIDVLETTAYDFANGEMYVRYTESVRGADVFVLQSHYKPINKAIMEQL
IMIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRLVFDLLKTAGADRIMSVDLHAAQSQGFFDGPVDHLVAMPVL
VDYIRDRFQDHLDNVAVVSPDAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAVANRVVGDVAGKDCVLVDDLIDTAG
TIAGACHVLQDAGAKSVTVVATHGVLSGPAIERLKNCGAREVVLTDTVPIPEEKRWDGLTVLSIAPLLASAIRAVFEDGS
VAELFDTYPEHHGQGFLFA
>Mature_338_residues
SAILEGKPDKNLILVTGRIHPKLAEDVAEQLGIDVLETTAYDFANGEMYVRYTESVRGADVFVLQSHYKPINKAIMEQLI
MIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRLVFDLLKTAGADRIMSVDLHAAQSQGFFDGPVDHLVAMPVLV
DYIRDRFQDHLDNVAVVSPDAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAVANRVVGDVAGKDCVLVDDLIDTAGT
IAGACHVLQDAGAKSVTVVATHGVLSGPAIERLKNCGAREVVLTDTVPIPEEKRWDGLTVLSIAPLLASAIRAVFEDGSV
AELFDTYPEHHGQGFLFA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=319, Percent_Identity=42.6332288401254, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4506127, Length=319, Percent_Identity=42.3197492163009, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI84875539, Length=322, Percent_Identity=42.2360248447205, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI28557709, Length=319, Percent_Identity=41.692789968652, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI194018537, Length=333, Percent_Identity=36.036036036036, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4506133, Length=332, Percent_Identity=33.1325301204819, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1787458, Length=317, Percent_Identity=41.9558359621451, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI25149168, Length=319, Percent_Identity=41.692789968652, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17554702, Length=319, Percent_Identity=41.692789968652, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71989924, Length=319, Percent_Identity=41.692789968652, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17554704, Length=316, Percent_Identity=41.7721518987342, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=35.693215339233, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=41.9558359621451, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319403, Length=321, Percent_Identity=42.6791277258567, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=323, Percent_Identity=42.1052631578947, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6322667, Length=174, Percent_Identity=44.8275862068966, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=35.4545454545455, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355239, Length=319, Percent_Identity=42.0062695924765, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI45551540, Length=342, Percent_Identity=39.4736842105263, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24651458, Length=363, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24651456, Length=363, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI281362873, Length=363, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24651454, Length=363, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24651462, Length=200, Percent_Identity=38.5, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24651464, Length=200, Percent_Identity=38.5, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45552010, Length=200, Percent_Identity=38.5, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36837; Mature: 36705

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAILEGKPDKNLILVTGRIHPKLAEDVAEQLGIDVLETTAYDFANGEMYVRYTESVRGA
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCC
DVFVLQSHYKPINKAIMEQLIMIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRL
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHH
VFDLLKTAGADRIMSVDLHAAQSQGFFDGPVDHLVAMPVLVDYIRDRFQDHLDNVAVVSP
HHHHHHHCCCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
DAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAVANRVVGDVAGKDCVLVDDLIDTAG
CCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHH
TIAGACHVLQDAGAKSVTVVATHGVLSGPAIERLKNCGAREVVLTDTVPIPEEKRWDGLT
HHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCH
VLSIAPLLASAIRAVFEDGSVAELFDTYPEHHGQGFLFA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
SAILEGKPDKNLILVTGRIHPKLAEDVAEQLGIDVLETTAYDFANGEMYVRYTESVRGA
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCC
DVFVLQSHYKPINKAIMEQLIMIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRL
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHH
VFDLLKTAGADRIMSVDLHAAQSQGFFDGPVDHLVAMPVLVDYIRDRFQDHLDNVAVVSP
HHHHHHHCCCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
DAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAVANRVVGDVAGKDCVLVDDLIDTAG
CCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHH
TIAGACHVLQDAGAKSVTVVATHGVLSGPAIERLKNCGAREVVLTDTVPIPEEKRWDGLT
HHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCH
VLSIAPLLASAIRAVFEDGSVAELFDTYPEHHGQGFLFA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]