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The map label for this gene is macB [H]

Identifier: 213692484

GI number: 213692484

Start: 1763915

End: 1764907

Strand: Reverse

Name: macB [H]

Synonym: Blon_1613

Alternate gene names: 213692484

Gene position: 1764907-1763915 (Counterclockwise)

Preceding gene: 213692485

Following gene: 213692483

Centisome position: 62.3

GC content: 63.54

Gene sequence:

>993_bases
ATGACTGAGACAACTACGCCGCTTCAGCCGACCACGGTTGGGCCGACCAATCTCCCGCCGACCACGCCAGCTCAGCCGAA
CGCGCCGACTGCGTCGGATTCGCCGCACGTAACCGAGACGCCCTCCCCGGACCATCTGTTGACCTTGACGGACCTGACCC
GCCAGTTCGTCCGCCGCGGCACGCCGTTCGACGCCGTCAGCCACGTGAACCTCACCGTCGATGCCGGCGAATTCATCGCC
ATCGTCGGCCGGTCGGGCAACGGCAAAAGCACGCTGATCAACATGGTCGCCGGGCTGATTCGCCCGACCTCGGGAACCGT
GAGCGTGGCTGGACGCAATGTGGCCGACTTGGGCGATAAAGCACTGTCCGTGCTGAGGAATCGCACCATCGGATTCGTGA
CCCAAAGCCAGACCCTGCTCGGCAACCTGACCGTGCTCGACAACGTGATTCTGCCCGCAACGATGTTTCCGGAGCCGCTG
CCGTTCGCCCAAAACGCAGAAGCAACGGATGCCGTTGCTCAGGTGGACGCTGTTGCGTCGACCGATGCCGTGGCACAAGC
CGCTGCCACCAATGATGAAGCAGCCGCCGACCTGTTCATGCCGGATGTCATTGCGCCAATCACAGACCGGGAAAACACGC
CGTCAAACACGGCTGCGAGCCGTCCGGACCTGTTCGCCACCCGAGCTCGCATGCTGCTCACCCAGCTTGGTGTCGCCGAT
CTGGCAGACAGCTACCCGCGCGAGCTGTCCGGCGGTGAAATGCGGCGCGTCTCCATCGCCCGCGCGCTGATGAACCAGCC
GAGCCTGCTCATCGCCGACGAGCCGACCGGCGACCTTGACCAGGAGAGCACCGACATCGTAATGCGTCTGCTCAGAGACC
AAGCCAACAACGGCACGGCGATTCTCATGGTCACCCATGATCCCGATGCACTCGAATACGCAGACCGGGTGTATCGCATG
GACGCCGGAGTGCTGTCCATAGCCTCGGTGTAA

Upstream 100 bases:

>100_bases
GTTGTGTGCTCTACGAGCATCGGCATCATCGGTTCGCTGGCCACCATGTGGCGTCTCGGCCGGCCCGAAGCCTACCTGAC
CCTGCGAGAGGGGGAGTGAT

Downstream 100 bases:

>100_bases
TATGGTCTGCTGGTGTCTGCCAGCAGGTAGATACCGTCTGGAGTCATAGCCCATCAGCGGGTCGGCGGTAGGTGATCGCA
AGAAAACCAACCCGTTCGTG

Product: ABC transporter

Products: 3-phospho-serine [Cytoplasm]; phosphite [Cytoplasm]; ADP; phosphate [Cytoplasm]; alkylphosphonate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTETTTPLQPTTVGPTNLPPTTPAQPNAPTASDSPHVTETPSPDHLLTLTDLTRQFVRRGTPFDAVSHVNLTVDAGEFIA
IVGRSGNGKSTLINMVAGLIRPTSGTVSVAGRNVADLGDKALSVLRNRTIGFVTQSQTLLGNLTVLDNVILPATMFPEPL
PFAQNAEATDAVAQVDAVASTDAVAQAAATNDEAAADLFMPDVIAPITDRENTPSNTAASRPDLFATRARMLLTQLGVAD
LADSYPRELSGGEMRRVSIARALMNQPSLLIADEPTGDLDQESTDIVMRLLRDQANNGTAILMVTHDPDALEYADRVYRM
DAGVLSIASV

Sequences:

>Translated_330_residues
MTETTTPLQPTTVGPTNLPPTTPAQPNAPTASDSPHVTETPSPDHLLTLTDLTRQFVRRGTPFDAVSHVNLTVDAGEFIA
IVGRSGNGKSTLINMVAGLIRPTSGTVSVAGRNVADLGDKALSVLRNRTIGFVTQSQTLLGNLTVLDNVILPATMFPEPL
PFAQNAEATDAVAQVDAVASTDAVAQAAATNDEAAADLFMPDVIAPITDRENTPSNTAASRPDLFATRARMLLTQLGVAD
LADSYPRELSGGEMRRVSIARALMNQPSLLIADEPTGDLDQESTDIVMRLLRDQANNGTAILMVTHDPDALEYADRVYRM
DAGVLSIASV
>Mature_329_residues
TETTTPLQPTTVGPTNLPPTTPAQPNAPTASDSPHVTETPSPDHLLTLTDLTRQFVRRGTPFDAVSHVNLTVDAGEFIAI
VGRSGNGKSTLINMVAGLIRPTSGTVSVAGRNVADLGDKALSVLRNRTIGFVTQSQTLLGNLTVLDNVILPATMFPEPLP
FAQNAEATDAVAQVDAVASTDAVAQAAATNDEAAADLFMPDVIAPITDRENTPSNTAASRPDLFATRARMLLTQLGVADL
ADSYPRELSGGEMRRVSIARALMNQPSLLIADEPTGDLDQESTDIVMRLLRDQANNGTAILMVTHDPDALEYADRVYRMD
AGVLSIASV

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1790544, Length=266, Percent_Identity=29.3233082706767, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786398, Length=268, Percent_Identity=28.7313432835821, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787105, Length=148, Percent_Identity=37.1621621621622, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1789672, Length=280, Percent_Identity=27.8571428571429, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789032, Length=261, Percent_Identity=29.8850574712644, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787759, Length=271, Percent_Identity=29.1512915129151, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786872, Length=243, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789873, Length=114, Percent_Identity=38.5964912280702, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081834, Length=153, Percent_Identity=35.2941176470588, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786703, Length=98, Percent_Identity=43.8775510204082, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787029, Length=167, Percent_Identity=31.1377245508982, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788225, Length=97, Percent_Identity=44.3298969072165, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787548, Length=122, Percent_Identity=39.344262295082, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787089, Length=111, Percent_Identity=38.7387387387387, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788761, Length=108, Percent_Identity=41.6666666666667, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787164, Length=97, Percent_Identity=38.1443298969072, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87081782, Length=123, Percent_Identity=34.1463414634146, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786698, Length=90, Percent_Identity=40, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788644, Length=81, Percent_Identity=43.2098765432099, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789891, Length=83, Percent_Identity=45.7831325301205, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786319, Length=108, Percent_Identity=37.037037037037, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788450, Length=112, Percent_Identity=39.2857142857143, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789963, Length=101, Percent_Identity=43.5643564356436, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790467, Length=109, Percent_Identity=33.9449541284404, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 34864; Mature: 34732

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTTPLQPTTVGPTNLPPTTPAQPNAPTASDSPHVTETPSPDHLLTLTDLTRQFVRRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCC
TPFDAVSHVNLTVDAGEFIAIVGRSGNGKSTLINMVAGLIRPTSGTVSVAGRNVADLGDK
CCCCCEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
ALSVLRNRTIGFVTQSQTLLGNLTVLDNVILPATMFPEPLPFAQNAEATDAVAQVDAVAS
HHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCHHHHHHHHHHHHH
TDAVAQAAATNDEAAADLFMPDVIAPITDRENTPSNTAASRPDLFATRARMLLTQLGVAD
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHH
LADSYPRELSGGEMRRVSIARALMNQPSLLIADEPTGDLDQESTDIVMRLLRDQANNGTA
HHHHCCHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEE
ILMVTHDPDALEYADRVYRMDAGVLSIASV
EEEEECCCHHHHHHHHHHHHCCCEEEECCC
>Mature Secondary Structure 
TETTTPLQPTTVGPTNLPPTTPAQPNAPTASDSPHVTETPSPDHLLTLTDLTRQFVRRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCC
TPFDAVSHVNLTVDAGEFIAIVGRSGNGKSTLINMVAGLIRPTSGTVSVAGRNVADLGDK
CCCCCEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
ALSVLRNRTIGFVTQSQTLLGNLTVLDNVILPATMFPEPLPFAQNAEATDAVAQVDAVAS
HHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCHHHHHHHHHHHHH
TDAVAQAAATNDEAAADLFMPDVIAPITDRENTPSNTAASRPDLFATRARMLLTQLGVAD
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHH
LADSYPRELSGGEMRRVSIARALMNQPSLLIADEPTGDLDQESTDIVMRLLRDQANNGTA
HHHHCCHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEE
ILMVTHDPDALEYADRVYRMDAGVLSIASV
EEEEECCCHHHHHHHHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-phospho-serine [Periplasm]; phosphite [Periplasm]; H2O; phosphate [Periplasm]; alkylphosphonate [Periplasm] [C]

Specific reaction: H2O + ATP + 3-phospho-serine [Periplasm] = ADP + phosphate + 3-phospho-serine [Cytoplasm] ATP + phosphite [Periplasm] + H2O = phosphite [Cytoplasm] + ADP + phosphate phosphate [Periplasm] + ATP + H2O = ADP + phosphate [Cytoplasm] + phosphate [Cytoplasm] A

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]