Click here to switch to the map view.

The map label for this gene is aroB [H]

Identifier: 213692468

GI number: 213692468

Start: 1749818

End: 1751440

Strand: Reverse

Name: aroB [H]

Synonym: Blon_1597

Alternate gene names: 213692468

Gene position: 1751440-1749818 (Counterclockwise)

Preceding gene: 213692469

Following gene: 213692467

Centisome position: 61.83

GC content: 59.58

Gene sequence:

>1623_bases
ATGACCGCACGCCCCCGCGCCGTCATCATCGGCATGATGGGAGCCGGCAAAACACGTGTCGGTAAGGAAGTGGCGCATAT
GTTGCGTCTGCCGTTCGCCGATGCCGATGTGGAGATCGAACGTGAAGTGGGCATGAAGATTCCCTCCTACTTCGAGGAAT
ACGGTGAGCCGGCATTCCGCGAGGTCGAGGCCGATCTCATCGCCGATATGCTTGAGGATTTCGACGGTATCTTTTCGCTG
GGCGGTGGCGCTCCCATGACGTCCTCCACCCAGCATGCCCTCGCCTCCTACATCGACCATGGCGGTCGTGTGGTCTACCT
TGATGCCGATCCGGCGGAAGCCATGGAACGCGCGAACCGTGGGGGAGGCCGGCCCATGCTCAATGGCAACGCCAACTCCC
GTTGGAAAAAACTGTTCAAGCAGCGTGACCCAGTATTCCGCGAGGTCGCCAACGTTCATGTCCATACCCGGGGGCTTACG
CCTCAGGGCGCAGCGAAGAAAGTGATTGATATGGTATCTGAGCGAGCAGTGCATGTTACCGGAGCGGCAATTGAGCCGTA
TGATGTGGTCATTGGCGAAGGTGCCATGAACCATCTGGCCGATGTGCTGGGACCCAAACCCGCCAAAATCGCGCTTATCC
ACACTCAGTCGGTGCAGCGACACTCCGATCGTGCCCGCGCTCTGTTGCGTCAGGGCGGCTATGAGGTTTCCGACATCGTG
ATTCCGGATGCCGAACCCGGCAAGACCATTACCGTGGCCAACGGCATTTGGGAACGCCTTGGCAACGAAGGTTTCACCCG
ATCCGATGCCGTGGTGGGGCTTGGCGGCGGTGCCGCAACCGATTTGGCCGGTTTCGTGGCCGCCACGTGGATGCGTGGCG
TGCGCTATGTGAACTGCCCGACCTCGCTGCTGGCCATGGTCGATGCCTCCACCGGTGGCAAAACCGGCATCAACACCCCG
CAGGGCAAGAACCTCGTCGGCTCGTTCTACACGCCTGCCGGTGTGCTGGCCGACACCAAGACGCTGGCTACGCTACCCAA
TGACATCTTCATCGAGGGTCTCGGCGAAGTCGCCAAATCCGGTTTCATCCGCGATCCCGAAATCCTTCATATCCTCGAAG
ACCACGCAGCTGAACTGCGCGCTTTCGTCGGCTCTACATTCCTTGGCTCGCCGCTCGAAGACGTGGTTGCCGAGCTCATT
GAGCGCACGGTAAAGGTCAAGGTCTATCACGTCTCCTCCGATTTGAAGGAGAAGGGTCTTCGTGAATTCCTCAACTACGG
GCACACGATGGGCCATGCCATCGAAAAGCTCGAGCACTTCCGCTGGAGGCATGGCAATGCGGTGGCCGTCGGTATGGTGT
ATGCCGCCGAGCTGGCCCATCTGATCGGTTACATCGATCAGGATCTGGTTGACTATCACCGCTCGTTGCTCGCTTCGCTG
GGTCTGCCGACGTCGTGGCATGGCGGCTCGTTCGACGACGTGCTCGCATTGATGCATCGCGACAAGAAAGCCCGTGGCAA
CGAACTGCGTTTCGTGGTCCTTGACGAGATTGGTCACGTCGTACACCTCGACAACCCGCCCGCCGACGCCGTAGAAGAAG
CCTTCCATCGTATCCAGCAATAA

Upstream 100 bases:

>100_bases
CCGGAGCACATGCGCTGAACGAAGGGCGTATGGTTTCGTGACGACTGCCACGGAACCATCAGCAACTGTACCCACCAATC
GTCGAGAGGATTCGTAGATT

Downstream 100 bases:

>100_bases
TTGAACGGCCACAGGCCGTGCCGTTCGCCATCCCCTCAGAAAAAAGTACTTGGCTCCCCTCTAACGGAGGTGCCCCGGAG
TCGGATCTACCTTCTTCCTC

Product: bifunctional shikimate kinase/3-dehydroquinate synthase

Products: NA

Alternate protein names: Shikimate kinase; SK; 3-dehydroquinate synthase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTARPRAVIIGMMGAGKTRVGKEVAHMLRLPFADADVEIEREVGMKIPSYFEEYGEPAFREVEADLIADMLEDFDGIFSL
GGGAPMTSSTQHALASYIDHGGRVVYLDADPAEAMERANRGGGRPMLNGNANSRWKKLFKQRDPVFREVANVHVHTRGLT
PQGAAKKVIDMVSERAVHVTGAAIEPYDVVIGEGAMNHLADVLGPKPAKIALIHTQSVQRHSDRARALLRQGGYEVSDIV
IPDAEPGKTITVANGIWERLGNEGFTRSDAVVGLGGGAATDLAGFVAATWMRGVRYVNCPTSLLAMVDASTGGKTGINTP
QGKNLVGSFYTPAGVLADTKTLATLPNDIFIEGLGEVAKSGFIRDPEILHILEDHAAELRAFVGSTFLGSPLEDVVAELI
ERTVKVKVYHVSSDLKEKGLREFLNYGHTMGHAIEKLEHFRWRHGNAVAVGMVYAAELAHLIGYIDQDLVDYHRSLLASL
GLPTSWHGGSFDDVLALMHRDKKARGNELRFVVLDEIGHVVHLDNPPADAVEEAFHRIQQ

Sequences:

>Translated_540_residues
MTARPRAVIIGMMGAGKTRVGKEVAHMLRLPFADADVEIEREVGMKIPSYFEEYGEPAFREVEADLIADMLEDFDGIFSL
GGGAPMTSSTQHALASYIDHGGRVVYLDADPAEAMERANRGGGRPMLNGNANSRWKKLFKQRDPVFREVANVHVHTRGLT
PQGAAKKVIDMVSERAVHVTGAAIEPYDVVIGEGAMNHLADVLGPKPAKIALIHTQSVQRHSDRARALLRQGGYEVSDIV
IPDAEPGKTITVANGIWERLGNEGFTRSDAVVGLGGGAATDLAGFVAATWMRGVRYVNCPTSLLAMVDASTGGKTGINTP
QGKNLVGSFYTPAGVLADTKTLATLPNDIFIEGLGEVAKSGFIRDPEILHILEDHAAELRAFVGSTFLGSPLEDVVAELI
ERTVKVKVYHVSSDLKEKGLREFLNYGHTMGHAIEKLEHFRWRHGNAVAVGMVYAAELAHLIGYIDQDLVDYHRSLLASL
GLPTSWHGGSFDDVLALMHRDKKARGNELRFVVLDEIGHVVHLDNPPADAVEEAFHRIQQ
>Mature_539_residues
TARPRAVIIGMMGAGKTRVGKEVAHMLRLPFADADVEIEREVGMKIPSYFEEYGEPAFREVEADLIADMLEDFDGIFSLG
GGAPMTSSTQHALASYIDHGGRVVYLDADPAEAMERANRGGGRPMLNGNANSRWKKLFKQRDPVFREVANVHVHTRGLTP
QGAAKKVIDMVSERAVHVTGAAIEPYDVVIGEGAMNHLADVLGPKPAKIALIHTQSVQRHSDRARALLRQGGYEVSDIVI
PDAEPGKTITVANGIWERLGNEGFTRSDAVVGLGGGAATDLAGFVAATWMRGVRYVNCPTSLLAMVDASTGGKTGINTPQ
GKNLVGSFYTPAGVLADTKTLATLPNDIFIEGLGEVAKSGFIRDPEILHILEDHAAELRAFVGSTFLGSPLEDVVAELIE
RTVKVKVYHVSSDLKEKGLREFLNYGHTMGHAIEKLEHFRWRHGNAVAVGMVYAAELAHLIGYIDQDLVDYHRSLLASLG
LPTSWHGGSFDDVLALMHRDKKARGNELRFVVLDEIGHVVHLDNPPADAVEEAFHRIQQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the dehydroquinate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=336, Percent_Identity=36.6071428571429, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082255, Length=174, Percent_Identity=29.3103448275862, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=324, Percent_Identity=36.1111111111111, Blast_Score=180, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002658
- InterPro:   IPR016037
- InterPro:   IPR000623 [H]

Pfam domain/function: PF01761 DHQ_synthase; PF01202 SKI [H]

EC number: =2.7.1.71; =4.2.3.4 [H]

Molecular weight: Translated: 58649; Mature: 58517

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARPRAVIIGMMGAGKTRVGKEVAHMLRLPFADADVEIEREVGMKIPSYFEEYGEPAFR
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCHHHHHHHCCHHHH
EVEADLIADMLEDFDGIFSLGGGAPMTSSTQHALASYIDHGGRVVYLDADPAEAMERANR
HHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHC
GGGRPMLNGNANSRWKKLFKQRDPVFREVANVHVHTRGLTPQGAAKKVIDMVSERAVHVT
CCCCCEECCCCCHHHHHHHHHCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCEEEE
GAAIEPYDVVIGEGAMNHLADVLGPKPAKIALIHTQSVQRHSDRARALLRQGGYEVSDIV
CCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEE
IPDAEPGKTITVANGIWERLGNEGFTRSDAVVGLGGGAATDLAGFVAATWMRGVRYVNCP
ECCCCCCCEEEECHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEECCH
TSLLAMVDASTGGKTGINTPQGKNLVGSFYTPAGVLADTKTLATLPNDIFIEGLGEVAKS
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHCCCHHHHHHHHHHHHC
GFIRDPEILHILEDHAAELRAFVGSTFLGSPLEDVVAELIERTVKVKVYHVSSDLKEKGL
CCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHEEEEEEECCHHHHHHH
REFLNYGHTMGHAIEKLEHFRWRHGNAVAVGMVYAAELAHLIGYIDQDLVDYHRSLLASL
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLPTSWHGGSFDDVLALMHRDKKARGNELRFVVLDEIGHVVHLDNPPADAVEEAFHRIQQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TARPRAVIIGMMGAGKTRVGKEVAHMLRLPFADADVEIEREVGMKIPSYFEEYGEPAFR
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCHHHHHHHCCHHHH
EVEADLIADMLEDFDGIFSLGGGAPMTSSTQHALASYIDHGGRVVYLDADPAEAMERANR
HHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHC
GGGRPMLNGNANSRWKKLFKQRDPVFREVANVHVHTRGLTPQGAAKKVIDMVSERAVHVT
CCCCCEECCCCCHHHHHHHHHCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCEEEE
GAAIEPYDVVIGEGAMNHLADVLGPKPAKIALIHTQSVQRHSDRARALLRQGGYEVSDIV
CCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEE
IPDAEPGKTITVANGIWERLGNEGFTRSDAVVGLGGGAATDLAGFVAATWMRGVRYVNCP
ECCCCCCCEEEECHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEECCH
TSLLAMVDASTGGKTGINTPQGKNLVGSFYTPAGVLADTKTLATLPNDIFIEGLGEVAKS
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHCCCHHHHHHHHHHHHC
GFIRDPEILHILEDHAAELRAFVGSTFLGSPLEDVVAELIERTVKVKVYHVSSDLKEKGL
CCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHEEEEEEECCHHHHHHH
REFLNYGHTMGHAIEKLEHFRWRHGNAVAVGMVYAAELAHLIGYIDQDLVDYHRSLLASL
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLPTSWHGGSFDDVLALMHRDKKARGNELRFVVLDEIGHVVHLDNPPADAVEEAFHRIQQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]