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The map label for this gene is ldh1 [H]

Identifier: 213691972

GI number: 213691972

Start: 1275934

End: 1276947

Strand: Direct

Name: ldh1 [H]

Synonym: Blon_1090

Alternate gene names: 213691972

Gene position: 1275934-1276947 (Clockwise)

Preceding gene: 213691971

Following gene: 213691973

Centisome position: 45.04

GC content: 63.51

Gene sequence:

>1014_bases
ATGACCGTTACCGTCGGTCATGGGTCGTATGCGTTCTATCGAGTATTACGAAAGGACATCACCATGGTCACTATGAACCG
CAACAAAGTCGTTATCGTCGGCACCGGCCAGGTCGGTGCCACCGCCGCCTTCGGCATCGTCACGCACGGCCTGTGCAATG
AGCTTGTGCTCATCGACCGTTCCGCCGCCAAGGCCCTGGGGGAGGCCCGCGACCTCGATGATGGCAGCGAATTCCAGGAC
CGCCACGTCAAGGTGCGCGCCGGCGACTACGCCGACTGCAAGGACGCGGACATCGTCGTCATCACCGTGGGCCGCAAGCC
GCCGGCCAACTCCAACCGCATGGCCGAACTCGGCTTCACCGTGGGTCTTGTGGGCGAAGTGGTCGACAACGTCATGGCCT
CCGGCTTTGACGGCGTGATCGTCATGGTCTCCAACCCGGTCGACGTGATGGCTTGGTATGCCTGGAAACGTTCCGGTCTG
CCTCGCACCCAGGTGCTCGGTACCGGCACTGCGCTCGACACCTCGCGTCTCAAGACCATCATCGGCGAAGAGACCGGCCT
TGACCCGCGCAACGTGGGTGGCTTCGTGATGGGCGAGCACGGCGACTCCCAGTTCACCGCATGGTCCACCGTCTCGCTCG
GCGGCAAGCCATTCGCCCGCTTCCTGGCCGACAACCAAGACCGTTTCGCCTCCGTGTCCACCACCGAAATCGAAGAGAAG
ACCCGCACCCGTGGCGATGAGATCGTCGCGGCCAAGGGCGGCACCAACTTCGGCATCGCCTCCACCGTGGCCGGCATCGT
GCAGACCATCCTGTGGGACGAACGCCGTATCGTGCCCGTCTCCACCCTGCTGGACGGCGAATACGGCGAACATGACGTGT
TTCTCGGCGTCCCCACTGAACTGCGGGCCAATGGTGCCAACGAGATCGTCGAACTCGATCTGAGCGAGGACGAGCGGGCC
AAACTGCACCATTCCGCCGAACTCGTGCGTGACCACTGCAAGGGGCTGCTGTGA

Upstream 100 bases:

>100_bases
CTCTGGTGTGGGTGGCCTTGATCATCGGCCTCGACATGATGACCAAGTTCAACCTCGGCTGATCGGCTTGCACGCCATAT
AGACTTGTCGCTCGCGACCC

Downstream 100 bases:

>100_bases
TTCTCGACGCCATCACACCGAAACAACCCCGACTGCTGGTCGCCGACCTCGACGGCACGTTGCTGCACGACGCCGAGGTA
TTCGAGGACCGGTTCATCAC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 1 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTVTVGHGSYAFYRVLRKDITMVTMNRNKVVIVGTGQVGATAAFGIVTHGLCNELVLIDRSAAKALGEARDLDDGSEFQD
RHVKVRAGDYADCKDADIVVITVGRKPPANSNRMAELGFTVGLVGEVVDNVMASGFDGVIVMVSNPVDVMAWYAWKRSGL
PRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEK
TRTRGDEIVAAKGGTNFGIASTVAGIVQTILWDERRIVPVSTLLDGEYGEHDVFLGVPTELRANGANEIVELDLSEDERA
KLHHSAELVRDHCKGLL

Sequences:

>Translated_337_residues
MTVTVGHGSYAFYRVLRKDITMVTMNRNKVVIVGTGQVGATAAFGIVTHGLCNELVLIDRSAAKALGEARDLDDGSEFQD
RHVKVRAGDYADCKDADIVVITVGRKPPANSNRMAELGFTVGLVGEVVDNVMASGFDGVIVMVSNPVDVMAWYAWKRSGL
PRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEK
TRTRGDEIVAAKGGTNFGIASTVAGIVQTILWDERRIVPVSTLLDGEYGEHDVFLGVPTELRANGANEIVELDLSEDERA
KLHHSAELVRDHCKGLL
>Mature_336_residues
TVTVGHGSYAFYRVLRKDITMVTMNRNKVVIVGTGQVGATAAFGIVTHGLCNELVLIDRSAAKALGEARDLDDGSEFQDR
HVKVRAGDYADCKDADIVVITVGRKPPANSNRMAELGFTVGLVGEVVDNVMASGFDGVIVMVSNPVDVMAWYAWKRSGLP
RTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEKT
RTRGDEIVAAKGGTNFGIASTVAGIVQTILWDERRIVPVSTLLDGEYGEHDVFLGVPTELRANGANEIVELDLSEDERAK
LHHSAELVRDHCKGLL

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=304, Percent_Identity=35.1973684210526, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI221136809, Length=304, Percent_Identity=35.1973684210526, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI291575128, Length=314, Percent_Identity=33.7579617834395, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4557032, Length=314, Percent_Identity=33.7579617834395, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI260099723, Length=317, Percent_Identity=32.807570977918, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI15082234, Length=304, Percent_Identity=32.5657894736842, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI5031857, Length=317, Percent_Identity=32.807570977918, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI9257228, Length=316, Percent_Identity=33.8607594936709, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4504973, Length=316, Percent_Identity=33.8607594936709, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI207028494, Length=206, Percent_Identity=34.9514563106796, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI260099727, Length=204, Percent_Identity=33.8235294117647, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI260099725, Length=204, Percent_Identity=33.8235294117647, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI103472011, Length=301, Percent_Identity=26.578073089701, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI103472015, Length=182, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17535107, Length=294, Percent_Identity=34.6938775510204, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17136226, Length=313, Percent_Identity=32.5878594249201, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI45550422, Length=309, Percent_Identity=32.3624595469256, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 36308; Mature: 36176

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTVGHGSYAFYRVLRKDITMVTMNRNKVVIVGTGQVGATAAFGIVTHGLCNELVLIDR
CEEEEECCCHHHHHHHHHCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEC
SAAKALGEARDLDDGSEFQDRHVKVRAGDYADCKDADIVVITVGRKPPANSNRMAELGFT
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCHH
VGLVGEVVDNVMASGFDGVIVMVSNPVDVMAWYAWKRSGLPRTQVLGTGTALDTSRLKTI
HHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHEEECCCCCCHHHHHHH
IGEETGLDPRNVGGFVMGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEK
HCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHCCCCHHEEECCHHHHHHH
TRTRGDEIVAAKGGTNFGIASTVAGIVQTILWDERRIVPVSTLLDGEYGEHDVFLGVPTE
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCEEEEECCHH
LRANGANEIVELDLSEDERAKLHHSAELVRDHCKGLL
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVTVGHGSYAFYRVLRKDITMVTMNRNKVVIVGTGQVGATAAFGIVTHGLCNELVLIDR
EEEEECCCHHHHHHHHHCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEC
SAAKALGEARDLDDGSEFQDRHVKVRAGDYADCKDADIVVITVGRKPPANSNRMAELGFT
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCHH
VGLVGEVVDNVMASGFDGVIVMVSNPVDVMAWYAWKRSGLPRTQVLGTGTALDTSRLKTI
HHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHEEECCCCCCHHHHHHH
IGEETGLDPRNVGGFVMGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEK
HCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHCCCCHHEEECCHHHHHHH
TRTRGDEIVAAKGGTNFGIASTVAGIVQTILWDERRIVPVSTLLDGEYGEHDVFLGVPTE
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCEEEEECCHH
LRANGANEIVELDLSEDERAKLHHSAELVRDHCKGLL
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]