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The map label for this gene is trpE [H]

Identifier: 213691949

GI number: 213691949

Start: 1247450

End: 1249006

Strand: Direct

Name: trpE [H]

Synonym: Blon_1065

Alternate gene names: 213691949

Gene position: 1247450-1249006 (Clockwise)

Preceding gene: 213691948

Following gene: 213691953

Centisome position: 44.04

GC content: 64.03

Gene sequence:

>1557_bases
ATGAGCGAATGCAGCGTCAAACACCTGAAGTGGGGCGCCACCTGGCCCAGTCGCGAACAGTTCCACGAACTGGCCGACGC
CGGCTACCGTGTGATTCCGATCGTGCGCCGTCTGCTCGCCGACTCGCTCACCCCGGTCGGCTTCTACGAGCGTCTCGCCG
GCGGCCGATCCGGCACCTTCATCCTCGAATCGGCGGAATACGGCGGCACGTGGAGCCGTTACAGCTTCATCGGCGTCAAC
TCGATGGCCCAACTGCGCTCCAACAACGGTCAGGCCGACTGGCTGGGCAAGGTCCCGGTCGGCGTGCCCGTCACCGGTGA
CGTGGTCGAAGTCGCTCACGCCACGTTGAAGACTCTGAAGGCCCCGCATGTGGAAGGCCTGCCGAACCTGACCAGCGGTC
TGATCGGCACGGTCGGCTGGGATGCCATCCGCCACTGGGAACCGACCCTGCGCGCCGAAGCTCCGGACGAGACCGGACAG
CCTGAGACCGTGCTTGCCCTGGCCACCGATATCGCCGTGGTCGACCACGTATCCGGTTCGGTATGGCTCATCGCCAATGC
GGTGAATGTGGATGATAAATCCACTCGCGCCGACGCCGCCTACAACGAGGCCGTCGCTCGACTCGACCAGATGCAGCGCG
ATGCCGCCACCCCGGCTCCGGACGAGTCCCGCGTCAACATTCTGGACGAAACGGTCACCCAACCCGAGCTGCGCTTCCGC
ACCGAGAAGAGCCACTACGAGCAGGCCGTCAAACGCGCCAAGCAGCACATCGTCGACGGCGACGTGTTCCAGGTGGTCAT
CTCCCAGCGCCTCGACATCGATTCGCCTGCTGACCCGTTCGACGTGTACCGTGTGTTGCGCACGCTGAACCCGAGCCCGT
ACATGTATTTCATGGCGTTGACCGACGCTCAGGGCCGCGACTTCAACGTGATCGGCTCCAGCCCGGAAACCCTCATCAAG
GTGGACAACGGCCACGCGATGACCTTCCCGATTGCTGGATCCCGCCCTCGCGGCGCCACCCCTGAGGAAGACGAGAAATT
CGCCAAGGAGCTGCTTGCCGATCCGAAGGAACGCAGCGAGCACATCATGCTCGTCGACCTGTCTCGCAACGACCTGAGTA
AGGTGTGCGTGCCGCAGTCCGTGGAAGTCGTGCAGCTCATGGACATCAAGCGTTTCAGCCACATCATGCACATCTGCTCG
ACGGTCACCGGCAAGGTCGACCCCTCGCTGACTGCATTCGATGTGTTCAAGTCCGCGTTCCCGGCCGGCACGCTGTCTGG
CGCTCCTAAGCCGCGCGCAGTCGAAATCATCGACGAGTTGGAACCGGCCGACCGCGGCATCTACGGCGGCACCGTCGGCT
ACTTCGATTTCTCCGGCAACATGGACATGGCCATCGCCATCCGCACCGCGTTCCTGCGTGACCATGAGGCGAGCGTGCAG
GCCGGTGCCGGCATTGTGCTCGACTCCGTGCCCGCCACCGAATGGCAGGAGACGCGCAACAAGGCCGAGGCCAGCGTCGA
ATCCATCCAGATCGCCGCCCAGCTGCGCGAACTGTAA

Upstream 100 bases:

>100_bases
TCGCCCGGCCGAGCAGCAGAACGGGCTTTCCTGACTGAGGGAAGCCGAGCGACCGCGTACCATGAAGCAAGACATCGAGT
TTGTAGGTAAAGGAGCGAAT

Downstream 100 bases:

>100_bases
CGTTCAACGCATAGCGATGCCCCCGCCGACAGAAGTTGTCAGTGGGGGCATCGCTGTCTGTATGTCAGTGGGTTGCGCCC
AGGATGTCGGTGGCGTCGGT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSECSVKHLKWGATWPSREQFHELADAGYRVIPIVRRLLADSLTPVGFYERLAGGRSGTFILESAEYGGTWSRYSFIGVN
SMAQLRSNNGQADWLGKVPVGVPVTGDVVEVAHATLKTLKAPHVEGLPNLTSGLIGTVGWDAIRHWEPTLRAEAPDETGQ
PETVLALATDIAVVDHVSGSVWLIANAVNVDDKSTRADAAYNEAVARLDQMQRDAATPAPDESRVNILDETVTQPELRFR
TEKSHYEQAVKRAKQHIVDGDVFQVVISQRLDIDSPADPFDVYRVLRTLNPSPYMYFMALTDAQGRDFNVIGSSPETLIK
VDNGHAMTFPIAGSRPRGATPEEDEKFAKELLADPKERSEHIMLVDLSRNDLSKVCVPQSVEVVQLMDIKRFSHIMHICS
TVTGKVDPSLTAFDVFKSAFPAGTLSGAPKPRAVEIIDELEPADRGIYGGTVGYFDFSGNMDMAIAIRTAFLRDHEASVQ
AGAGIVLDSVPATEWQETRNKAEASVESIQIAAQLREL

Sequences:

>Translated_518_residues
MSECSVKHLKWGATWPSREQFHELADAGYRVIPIVRRLLADSLTPVGFYERLAGGRSGTFILESAEYGGTWSRYSFIGVN
SMAQLRSNNGQADWLGKVPVGVPVTGDVVEVAHATLKTLKAPHVEGLPNLTSGLIGTVGWDAIRHWEPTLRAEAPDETGQ
PETVLALATDIAVVDHVSGSVWLIANAVNVDDKSTRADAAYNEAVARLDQMQRDAATPAPDESRVNILDETVTQPELRFR
TEKSHYEQAVKRAKQHIVDGDVFQVVISQRLDIDSPADPFDVYRVLRTLNPSPYMYFMALTDAQGRDFNVIGSSPETLIK
VDNGHAMTFPIAGSRPRGATPEEDEKFAKELLADPKERSEHIMLVDLSRNDLSKVCVPQSVEVVQLMDIKRFSHIMHICS
TVTGKVDPSLTAFDVFKSAFPAGTLSGAPKPRAVEIIDELEPADRGIYGGTVGYFDFSGNMDMAIAIRTAFLRDHEASVQ
AGAGIVLDSVPATEWQETRNKAEASVESIQIAAQLREL
>Mature_517_residues
SECSVKHLKWGATWPSREQFHELADAGYRVIPIVRRLLADSLTPVGFYERLAGGRSGTFILESAEYGGTWSRYSFIGVNS
MAQLRSNNGQADWLGKVPVGVPVTGDVVEVAHATLKTLKAPHVEGLPNLTSGLIGTVGWDAIRHWEPTLRAEAPDETGQP
ETVLALATDIAVVDHVSGSVWLIANAVNVDDKSTRADAAYNEAVARLDQMQRDAATPAPDESRVNILDETVTQPELRFRT
EKSHYEQAVKRAKQHIVDGDVFQVVISQRLDIDSPADPFDVYRVLRTLNPSPYMYFMALTDAQGRDFNVIGSSPETLIKV
DNGHAMTFPIAGSRPRGATPEEDEKFAKELLADPKERSEHIMLVDLSRNDLSKVCVPQSVEVVQLMDIKRFSHIMHICST
VTGKVDPSLTAFDVFKSAFPAGTLSGAPKPRAVEIIDELEPADRGIYGGTVGYFDFSGNMDMAIAIRTAFLRDHEASVQA
GAGIVLDSVPATEWQETRNKAEASVESIQIAAQLREL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=396, Percent_Identity=39.1414141414141, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1788114, Length=453, Percent_Identity=29.5805739514349, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786809, Length=263, Percent_Identity=32.319391634981, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082077, Length=270, Percent_Identity=25.1851851851852, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=503, Percent_Identity=37.375745526839, Blast_Score=306, Evalue=7e-84,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=24.8138957816377, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56750; Mature: 56618

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSECSVKHLKWGATWPSREQFHELADAGYRVIPIVRRLLADSLTPVGFYERLAGGRSGTF
CCCCCCCCEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEE
ILESAEYGGTWSRYSFIGVNSMAQLRSNNGQADWLGKVPVGVPVTGDVVEVAHATLKTLK
EEECCCCCCCCCEEEEECCCHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHC
APHVEGLPNLTSGLIGTVGWDAIRHWEPTLRAEAPDETGQPETVLALATDIAVVDHVSGS
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCC
VWLIANAVNVDDKSTRADAAYNEAVARLDQMQRDAATPAPDESRVNILDETVTQPELRFR
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHH
TEKSHYEQAVKRAKQHIVDGDVFQVVISQRLDIDSPADPFDVYRVLRTLNPSPYMYFMAL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEE
TDAQGRDFNVIGSSPETLIKVDNGHAMTFPIAGSRPRGATPEEDEKFAKELLADPKERSE
ECCCCCCEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
HIMLVDLSRNDLSKVCVPQSVEVVQLMDIKRFSHIMHICSTVTGKVDPSLTAFDVFKSAF
EEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
PAGTLSGAPKPRAVEIIDELEPADRGIYGGTVGYFDFSGNMDMAIAIRTAFLRDHEASVQ
CCCCCCCCCCCHHHHHHHHCCHHHCCCCCCEEEEEEECCCCCEEEEEHHHHHHCCHHHHH
AGAGIVLDSVPATEWQETRNKAEASVESIQIAAQLREL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SECSVKHLKWGATWPSREQFHELADAGYRVIPIVRRLLADSLTPVGFYERLAGGRSGTF
CCCCCCCEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEE
ILESAEYGGTWSRYSFIGVNSMAQLRSNNGQADWLGKVPVGVPVTGDVVEVAHATLKTLK
EEECCCCCCCCCEEEEECCCHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHC
APHVEGLPNLTSGLIGTVGWDAIRHWEPTLRAEAPDETGQPETVLALATDIAVVDHVSGS
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCC
VWLIANAVNVDDKSTRADAAYNEAVARLDQMQRDAATPAPDESRVNILDETVTQPELRFR
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHH
TEKSHYEQAVKRAKQHIVDGDVFQVVISQRLDIDSPADPFDVYRVLRTLNPSPYMYFMAL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEE
TDAQGRDFNVIGSSPETLIKVDNGHAMTFPIAGSRPRGATPEEDEKFAKELLADPKERSE
ECCCCCCEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
HIMLVDLSRNDLSKVCVPQSVEVVQLMDIKRFSHIMHICSTVTGKVDPSLTAFDVFKSAF
EEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
PAGTLSGAPKPRAVEIIDELEPADRGIYGGTVGYFDFSGNMDMAIAIRTAFLRDHEASVQ
CCCCCCCCCCCHHHHHHHHCCHHHCCCCCCEEEEEEECCCCCEEEEEHHHHHHCCHHHHH
AGAGIVLDSVPATEWQETRNKAEASVESIQIAAQLREL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA