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The map label for this gene is hisI

Identifier: 213691948

GI number: 213691948

Start: 1246973

End: 1247383

Strand: Direct

Name: hisI

Synonym: Blon_1064

Alternate gene names: 213691948

Gene position: 1246973-1247383 (Clockwise)

Preceding gene: 213691947

Following gene: 213691949

Centisome position: 44.02

GC content: 63.26

Gene sequence:

>411_bases
ATGACAGACACTACATACGACAATTCCACTGAACTCGATCCCCGTATTGCCGCGCGCCTGAAGCGTGACGTCAAGGGTCT
GGTCGCCGCCGTCATCCAGCAGTACGACACACACGAGGTGCTGATGGTCGGCTACATGAACGACGAGGCATTACGCCGCA
CGCTGACCACCGGCCGCGTGACCTTCTGGTCCCGGTCCCGTCAGGAATACTGGCGCAAGGGTGATACCTCCGGCCATGTG
CAATACGTCAAGGGCGTGTCCCTGGATTGCGACGGCGACGCACTGCTCGTCGAAGTCGACCAAGTCGGCGCCGCATGCCA
CACCGGCAAGCGCAGCTGCTTCCTCGAAGGCGGCCCCCTGCCCGTGGTCGAAGGCCATCGCCCGGCCGAGCAGCAGAACG
GGCTTTCCTGA

Upstream 100 bases:

>100_bases
CAGTGGATTGTTCGTGGCAGTGCGCTATGCGCACGTCGCACATAATCCGGGAGCTGTCAGCGAAGCTGACTGGGGGGTGG
CCCACAAAAAGAAGATAGGT

Downstream 100 bases:

>100_bases
CTGAGGGAAGCCGAGCGACCGCGTACCATGAAGCAAGACATCGAGTTTGTAGGTAAAGGAGCGAATATGAGCGAATGCAG
CGTCAAACACCTGAAGTGGG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MTDTTYDNSTELDPRIAARLKRDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHV
QYVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGHRPAEQQNGLS

Sequences:

>Translated_136_residues
MTDTTYDNSTELDPRIAARLKRDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHV
QYVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGHRPAEQQNGLS
>Mature_135_residues
TDTTYDNSTELDPRIAARLKRDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQ
YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGHRPAEQQNGLS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=49.438202247191, Blast_Score=100, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319819, Length=88, Percent_Identity=40.9090909090909, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_BIFLI (B7GQS6)

Other databases:

- EMBL:   CP001095
- RefSeq:   YP_002322534.1
- GeneID:   7054684
- GenomeReviews:   CP001095_GR
- KEGG:   bln:Blon_1064
- HOGENOM:   HBG294308
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15113; Mature: 14982

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTYDNSTELDPRIAARLKRDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCEE
TFWSRSRQEYWRKGDTSGHVQYVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPL
EEHHCHHHHHHHCCCCCCCEEEEECCEECCCCCEEEEEECCCCCHHCCCCCEEEECCCCC
PVVEGHRPAEQQNGLS
CEECCCCCCCCCCCCC
>Mature Secondary Structure 
TDTTYDNSTELDPRIAARLKRDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCEE
TFWSRSRQEYWRKGDTSGHVQYVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPL
EEHHCHHHHHHHCCCCCCCEEEEECCEECCCCCEEEEEECCCCCHHCCCCCEEEECCCCC
PVVEGHRPAEQQNGLS
CEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA