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The map label for this gene is icd [H]

Identifier: 213691935

GI number: 213691935

Start: 1233565

End: 1234785

Strand: Reverse

Name: icd [H]

Synonym: Blon_1051

Alternate gene names: 213691935

Gene position: 1234785-1233565 (Counterclockwise)

Preceding gene: 213691946

Following gene: 213691934

Centisome position: 43.59

GC content: 61.59

Gene sequence:

>1221_bases
ATGGCCAAAATCAAGGTCGAAGGCACTGTCGTCGAACTCGACGGCGACGAAATGACCCGCGTGATCTGGAAAGACATCAA
GGATCGTCTGATCCTGCCGTACCTCGACGTGAACCTCGACTACTACGATCTGGGCATCGAGCACCGCGACGAGACCGATG
ACCAGGTGACCATCGACGCCGCCCACGCCATCCAGAAGCACCATGTCGGCGTCAAGTGCGCCACCATCACCCCCGATGAG
GCCCGAGTCAAGGAATTCGGTCTCAAGAAGATGTGGAAGTCCCCCAACGGCACCATCCGCAACATCCTGGGCGGCACGAT
CTTCCGCGAGCCGATTGTGATGAGCAACGTGCCTCGTCTGGTGCCCGGCTGGACCAAGCCGATCGTCGTGGCCCGTCACG
CATTCGGCGACCAGTACAAGGCCACCGATTTCAAGGTTCCGGGAGCCGGCCAGCTGACCGTCACCTTCACTCCGGACGAT
GGCTCCGAGCCGATTCAGCACGTGGTCTACAACTACGGCGAAGACGGCGGCGTGGCCCAAGTGCAGTACAACGTCAACGA
TTCGATCCGCGGTTTCGCTCGCGCCTGCTTCAACTACGGCCTGATGCGTCATTACCCGGTGTACTTGTCCACCAAGAACA
CGATTTTGAAGGCCTACGACGGCCAGTTCAAGGACATCTTTGCCGAGGTGTTCGAGACCGAATACAAGGACAAGTACGCC
GAGGCCGGCCTGACTTACGAGCACCGCCTGATCGACGACATGGTGGCCAGCTCCCTGAAGTGGCACGGCGGTTACATCTG
GGCCTGCAAGAACTACGATGGCGATGTGCAGTCCGACTCCGTGGCCCAGGGCTTTGGTTCGCTGGGCCTCATGACCTCCG
TGCTCATGACCCCGGACGGCCAGACCGTCGAGTCCGAAGCGGCGCACGGCACCGTGACCCGTCACTACCGCCGCTGGCAG
AAGGGCGAGAAGACCTCCACCAACCCGATCGCCTCCATCTTCGCGTGGACCGGCGGCCTTAAGCACCGCGCCGATCTGGA
CGGCACGCCCGAAGTCCGTCACTTCGCCAAGACGCTGGAGAAGGTCATCGTCGACACCGTTGAAGGCGGTCAGATGACCA
AGGATCTGGCCATGCTCATCGGCCCGGACGAGCCGTGGCTCGACACCGACGGCTTCATGAACGCGCTGGACGAGAACCTG
GCCAAGGCTCTGGCCGAGTAA

Upstream 100 bases:

>100_bases
CGCCAACAAGGCCGTTTCCCACGGACCGGACGATTGCTTCAAGTCGTTACAAACATGCGCTATGACTAAATCATCTTCAC
ACCATCTATCAGGAGGAAGC

Downstream 100 bases:

>100_bases
ATCATCGAACACACCGTACGGACCTACATGGGTCATGTCATGTCGCCAACTGTCATGATTGTCGTGCTTCATCCGGAATG
TTCCTCAGCACGATAATCAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDAAHAIQKHHVGVKCATITPDE
ARVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRLVPGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDD
GSEPIQHVVYNYGEDGGVAQVQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDKYA
EAGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTPDGQTVESEAAHGTVTRHYRRWQ
KGEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKTLEKVIVDTVEGGQMTKDLAMLIGPDEPWLDTDGFMNALDENL
AKALAE

Sequences:

>Translated_406_residues
MAKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDAAHAIQKHHVGVKCATITPDE
ARVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRLVPGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDD
GSEPIQHVVYNYGEDGGVAQVQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDKYA
EAGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTPDGQTVESEAAHGTVTRHYRRWQ
KGEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKTLEKVIVDTVEGGQMTKDLAMLIGPDEPWLDTDGFMNALDENL
AKALAE
>Mature_405_residues
AKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDAAHAIQKHHVGVKCATITPDEA
RVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRLVPGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDDG
SEPIQHVVYNYGEDGGVAQVQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDKYAE
AGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTPDGQTVESEAAHGTVTRHYRRWQK
GEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKTLEKVIVDTVEGGQMTKDLAMLIGPDEPWLDTDGFMNALDENLA
KALAE

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=411, Percent_Identity=62.287104622871, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI28178832, Length=410, Percent_Identity=63.4146341463415, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17550822, Length=410, Percent_Identity=62.4390243902439, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17540874, Length=413, Percent_Identity=63.1961259079903, Blast_Score=539, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=60.9336609336609, Blast_Score=525, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=60.9876543209877, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320137, Length=409, Percent_Identity=61.3691931540342, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21356561, Length=412, Percent_Identity=61.6504854368932, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221330987, Length=412, Percent_Identity=61.6504854368932, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221330985, Length=412, Percent_Identity=61.6504854368932, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI28574947, Length=412, Percent_Identity=61.6504854368932, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24660849, Length=412, Percent_Identity=61.6504854368932, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24660856, Length=412, Percent_Identity=61.6504854368932, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221330983, Length=412, Percent_Identity=61.6504854368932, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24660868, Length=412, Percent_Identity=61.6504854368932, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24660860, Length=412, Percent_Identity=61.6504854368932, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45376; Mature: 45245

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDA
CCEEEEEEEEEEECCHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCCCCCCEEEEHH
AHAIQKHHVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHCCCCCC
VPGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDDGSEPIQHVVYNYGEDGGVAQ
CCCCCCCEEEEEHHCCCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
VQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDKYA
EEECCCHHHHHHHHHHHHCCHHHHCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHH
EAGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTPDG
HCCCCHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEECCCC
QTVESEAAHGTVTRHYRRWQKGEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKTLE
CCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
KVIVDTVEGGQMTKDLAMLIGPDEPWLDTDGFMNALDENLAKALAE
HHHHHCCCCCCHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDA
CEEEEEEEEEEECCHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCCCCCCEEEEHH
AHAIQKHHVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHCCCCCC
VPGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDDGSEPIQHVVYNYGEDGGVAQ
CCCCCCCEEEEEHHCCCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
VQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDKYA
EEECCCHHHHHHHHHHHHCCHHHHCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHH
EAGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTPDG
HCCCCHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEECCCC
QTVESEAAHGTVTRHYRRWQKGEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKTLE
CCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
KVIVDTVEGGQMTKDLAMLIGPDEPWLDTDGFMNALDENLAKALAE
HHHHHCCCCCCHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]