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The map label for this gene is hisB [H]

Identifier: 213691720

GI number: 213691720

Start: 972197

End: 972796

Strand: Direct

Name: hisB [H]

Synonym: Blon_0825

Alternate gene names: 213691720

Gene position: 972197-972796 (Clockwise)

Preceding gene: 213691719

Following gene: 213691721

Centisome position: 34.32

GC content: 63.17

Gene sequence:

>600_bases
ATGGCAAGAACCGCGCACATCGTCCGCGAAACCAGCGAATCACACATCGACCTCGAACTGAACCTCGACGGCACCGGCAA
AACCGATATCGATACATCCGTGCCGTTCTACAACCATATGATGACCGCGCTCGGCAAGCATTCGCTGATCGACCTGACCA
TCCACGCCCACGGCGACACCGACATCGATGTGCACCACACCGTGGAAGATACGGCCATCGTGTTCGGCGAAGCCCTGAAG
CAGGCTCTCGGCGACAAGAAAGGCATCCGCCGCTTCGCCGATGCCACCGTGCCGCTCGACGAGGCGCTGGCCAAGGCCGT
TGTCGACATTTCCGGGCGCCCGTACTGCGTGTGCAGCGGCGAGCCCGAAGGCTACGAATTCTGCATGATCGGCGGGCACT
TCACCGGCTCTCTGGTCCGCCACGTCATGGAATCCATCGCCTTCCACGCCGGCATCTGCCTGCACATGCAGGTGCTCGCC
GGCCGCGACCCGCACCACATCGCTGAAGCCGAATTCAAGGCGCTGGCCCGTGCGCTGCGCTTCGCCATGGAAATCGACCC
GCGTGTAGACGGCGTGCCCAGCACCAAGGGAGCCCTGTGA

Upstream 100 bases:

>100_bases
GTGGAAGCAGCATAAGGGACGTTTCTTTCCGATTGCGGCGAGACCCGAAGCGATTCGAGTCCCGCCGCAATCCAATATGA
CGAATCACACAGGAGACATG

Downstream 100 bases:

>100_bases
TGGCCGACGACAAGTTCGATCCGGACGAATCGCACTTCTCCGACGAGGAGCTTGAGGCCGCGCTCGCCGGATTCGAGAAA
GAATTCGCGGACGATTCGGC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MARTAHIVRETSESHIDLELNLDGTGKTDIDTSVPFYNHMMTALGKHSLIDLTIHAHGDTDIDVHHTVEDTAIVFGEALK
QALGDKKGIRRFADATVPLDEALAKAVVDISGRPYCVCSGEPEGYEFCMIGGHFTGSLVRHVMESIAFHAGICLHMQVLA
GRDPHHIAEAEFKALARALRFAMEIDPRVDGVPSTKGAL

Sequences:

>Translated_199_residues
MARTAHIVRETSESHIDLELNLDGTGKTDIDTSVPFYNHMMTALGKHSLIDLTIHAHGDTDIDVHHTVEDTAIVFGEALK
QALGDKKGIRRFADATVPLDEALAKAVVDISGRPYCVCSGEPEGYEFCMIGGHFTGSLVRHVMESIAFHAGICLHMQVLA
GRDPHHIAEAEFKALARALRFAMEIDPRVDGVPSTKGAL
>Mature_198_residues
ARTAHIVRETSESHIDLELNLDGTGKTDIDTSVPFYNHMMTALGKHSLIDLTIHAHGDTDIDVHHTVEDTAIVFGEALKQ
ALGDKKGIRRFADATVPLDEALAKAVVDISGRPYCVCSGEPEGYEFCMIGGHFTGSLVRHVMESIAFHAGICLHMQVLAG
RDPHHIAEAEFKALARALRFAMEIDPRVDGVPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=197, Percent_Identity=40.6091370558376, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324776, Length=171, Percent_Identity=42.6900584795322, Blast_Score=128, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21622; Mature: 21491

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTAHIVRETSESHIDLELNLDGTGKTDIDTSVPFYNHMMTALGKHSLIDLTIHAHGDT
CCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCC
DIDVHHTVEDTAIVFGEALKQALGDKKGIRRFADATVPLDEALAKAVVDISGRPYCVCSG
CCEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECC
EPEGYEFCMIGGHFTGSLVRHVMESIAFHAGICLHMQVLAGRDPHHIAEAEFKALARALR
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FAMEIDPRVDGVPSTKGAL
HHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARTAHIVRETSESHIDLELNLDGTGKTDIDTSVPFYNHMMTALGKHSLIDLTIHAHGDT
CCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCC
DIDVHHTVEDTAIVFGEALKQALGDKKGIRRFADATVPLDEALAKAVVDISGRPYCVCSG
CCEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECC
EPEGYEFCMIGGHFTGSLVRHVMESIAFHAGICLHMQVLAGRDPHHIAEAEFKALARALR
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FAMEIDPRVDGVPSTKGAL
HHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA