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The map label for this gene is pncB1 [H]

Identifier: 213691322

GI number: 213691322

Start: 469018

End: 470340

Strand: Direct

Name: pncB1 [H]

Synonym: Blon_0409

Alternate gene names: 213691322

Gene position: 469018-470340 (Clockwise)

Preceding gene: 213691320

Following gene: 213691323

Centisome position: 16.56

GC content: 61.15

Gene sequence:

>1323_bases
ATGGTCGATTATTCGCCGGCTCTGATGACCGACATGTATGAATACACGATGCTCGACGCCGCTCTGAAAGACGGTACCGC
CGACCGCAAATGCGTGTTCGAGGTGTTCACGCGTCGCCTGCCCGAAGGCCGTCGCTATGGCGTGGTGGCCGGCACCGGCC
GCATTCTGGATGCGCTGGAACATTTCCACTTGGACGAAGCGGACCTGAAGTTCCTGGCCGACCGTCACGTGGTAAGCCCC
GAGACCATTAAGTGGCTGGAGAACTTCCACTTCTCCGGTACGATTCGCGGTTACCGCGAAGGTGAGATGTTCTTCCCGAA
CTCCCCGATTTTGCAGGTCGAAGGCACGTTCGGCGAATGCACGCTACTGGAGACGTTGATTCTATCCGTGCTGAACTACG
ATTCCGCAGTGGCCTCCGCCGCCTCACGTATGGCGTCGGCAGCCAAAGATCGCCCTTGCATGGATATGGGCGGACGCCGC
ACTAACGAGTGGGCCGCCGTGGCCGCCGCTCGAGCCGCCGTAGTGGGCGGATTCAAGGGTACCGCCAATCTGCTGGCCGC
CCGGCTGTATGGTCTGAAGGCCATTGGCACCGCCGCGCATTGCTTCACGTTGGTGCATGATTCCGAACGTGACGCCTTCG
AATCGCAGATCGAGGCTTTGGGCAAGAACACCACGCTGCTGGTGGACACCTACAACATCGAGGAAGCCGTGAAAACCGCC
GTCGAAGTGGCTGGTCCCGAACTGGGTGGCGTGCGCATCGACTCCGGCGACCTAGCCGCCATGGCCCAGCGTGTGCGCAA
CCAGTTGGACGCCCTGGGTGCCACGAACACCACCATTACCGTGACCAACGATTTGGATGAGTACGCGCTCGCCGCATTGC
AGACCGCGCCGGTCGACTCCTATGGCGTGGGCACCATGCTGGTCACCGGCTCCGGCGCTCCCACTTGTGCGATGGTGTAC
AAGCTCACCGAACGTGAAGGCGCTGACGGCACGATGGTTCCGGTCATGAAGAAGTCCAAGGACAAGGCCACAGTGCCCGG
TCGCAAGTTGGCATTCCGCTCCTACGAATACGCGCTAGCCGAAGCCGAACACGTGATTTCCGGCTCGGAAGAGAAGCTGG
CCGGTTTCACGCCCGAACCGACATGGAAGAACCTGCTGGTCGATTTCGTGGACCACGGCCATATCGATGCGCAATGGCAG
GGCCATGACGCCATCATGGCCGCCCACGACTACCGCGCCAAGGCGTTGTCCGAACTGCCCATCACCGCACAAAGCCTGAT
GAAGGGCGAGCCCGTGATTCCGACGGAGACTCAGGTTCTCTGA

Upstream 100 bases:

>100_bases
ATCTCATGCATCGAGTCTACCGCTTCGCCAGTGGGCTGTATGGCTTTGCCCGGACTACACTTAGGTGCAACTTCACCACT
TATGTAGGAAAGGCCTTGCA

Downstream 100 bases:

>100_bases
CGAGAACTTCCGTCTCCATAGGAATCCGTCGCAGCATAGCTGCTCCCCTTACCTACGGACGGCCCACTGGGCTGTCCGCT
TAACGGTTCGACCACAGAGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MVDYSPALMTDMYEYTMLDAALKDGTADRKCVFEVFTRRLPEGRRYGVVAGTGRILDALEHFHLDEADLKFLADRHVVSP
ETIKWLENFHFSGTIRGYREGEMFFPNSPILQVEGTFGECTLLETLILSVLNYDSAVASAASRMASAAKDRPCMDMGGRR
TNEWAAVAAARAAVVGGFKGTANLLAARLYGLKAIGTAAHCFTLVHDSERDAFESQIEALGKNTTLLVDTYNIEEAVKTA
VEVAGPELGGVRIDSGDLAAMAQRVRNQLDALGATNTTITVTNDLDEYALAALQTAPVDSYGVGTMLVTGSGAPTCAMVY
KLTEREGADGTMVPVMKKSKDKATVPGRKLAFRSYEYALAEAEHVISGSEEKLAGFTPEPTWKNLLVDFVDHGHIDAQWQ
GHDAIMAAHDYRAKALSELPITAQSLMKGEPVIPTETQVL

Sequences:

>Translated_440_residues
MVDYSPALMTDMYEYTMLDAALKDGTADRKCVFEVFTRRLPEGRRYGVVAGTGRILDALEHFHLDEADLKFLADRHVVSP
ETIKWLENFHFSGTIRGYREGEMFFPNSPILQVEGTFGECTLLETLILSVLNYDSAVASAASRMASAAKDRPCMDMGGRR
TNEWAAVAAARAAVVGGFKGTANLLAARLYGLKAIGTAAHCFTLVHDSERDAFESQIEALGKNTTLLVDTYNIEEAVKTA
VEVAGPELGGVRIDSGDLAAMAQRVRNQLDALGATNTTITVTNDLDEYALAALQTAPVDSYGVGTMLVTGSGAPTCAMVY
KLTEREGADGTMVPVMKKSKDKATVPGRKLAFRSYEYALAEAEHVISGSEEKLAGFTPEPTWKNLLVDFVDHGHIDAQWQ
GHDAIMAAHDYRAKALSELPITAQSLMKGEPVIPTETQVL
>Mature_440_residues
MVDYSPALMTDMYEYTMLDAALKDGTADRKCVFEVFTRRLPEGRRYGVVAGTGRILDALEHFHLDEADLKFLADRHVVSP
ETIKWLENFHFSGTIRGYREGEMFFPNSPILQVEGTFGECTLLETLILSVLNYDSAVASAASRMASAAKDRPCMDMGGRR
TNEWAAVAAARAAVVGGFKGTANLLAARLYGLKAIGTAAHCFTLVHDSERDAFESQIEALGKNTTLLVDTYNIEEAVKTA
VEVAGPELGGVRIDSGDLAAMAQRVRNQLDALGATNTTITVTNDLDEYALAALQTAPVDSYGVGTMLVTGSGAPTCAMVY
KLTEREGADGTMVPVMKKSKDKATVPGRKLAFRSYEYALAEAEHVISGSEEKLAGFTPEPTWKNLLVDFVDHGHIDAQWQ
GHDAIMAAHDYRAKALSELPITAQSLMKGEPVIPTETQVL

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=417, Percent_Identity=31.89448441247, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71997952, Length=419, Percent_Identity=28.8782816229117, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71997947, Length=419, Percent_Identity=28.8782816229117, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71997955, Length=206, Percent_Identity=34.4660194174757, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24581587, Length=420, Percent_Identity=29.5238095238095, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 47713; Mature: 47713

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDYSPALMTDMYEYTMLDAALKDGTADRKCVFEVFTRRLPEGRRYGVVAGTGRILDALE
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
HFHLDEADLKFLADRHVVSPETIKWLENFHFSGTIRGYREGEMFFPNSPILQVEGTFGEC
HHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCEECCCCCCCEECCCCCEEEEECCCCHH
TLLETLILSVLNYDSAVASAASRMASAAKDRPCMDMGGRRTNEWAAVAAARAAVVGGFKG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCH
TANLLAARLYGLKAIGTAAHCFTLVHDSERDAFESQIEALGKNTTLLVDTYNIEEAVKTA
HHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
VEVAGPELGGVRIDSGDLAAMAQRVRNQLDALGATNTTITVTNDLDEYALAALQTAPVDS
HHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCC
YGVGTMLVTGSGAPTCAMVYKLTEREGADGTMVPVMKKSKDKATVPGRKLAFRSYEYALA
CCCCEEEEECCCCCHHHHEEEEHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHH
EAEHVISGSEEKLAGFTPEPTWKNLLVDFVDHGHIDAQWQGHDAIMAAHDYRAKALSELP
HHHHHHCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCEECCCCEEEEECHHHHHHHHCCC
ITAQSLMKGEPVIPTETQVL
CCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVDYSPALMTDMYEYTMLDAALKDGTADRKCVFEVFTRRLPEGRRYGVVAGTGRILDALE
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
HFHLDEADLKFLADRHVVSPETIKWLENFHFSGTIRGYREGEMFFPNSPILQVEGTFGEC
HHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCEECCCCCCCEECCCCCEEEEECCCCHH
TLLETLILSVLNYDSAVASAASRMASAAKDRPCMDMGGRRTNEWAAVAAARAAVVGGFKG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCH
TANLLAARLYGLKAIGTAAHCFTLVHDSERDAFESQIEALGKNTTLLVDTYNIEEAVKTA
HHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
VEVAGPELGGVRIDSGDLAAMAQRVRNQLDALGATNTTITVTNDLDEYALAALQTAPVDS
HHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCC
YGVGTMLVTGSGAPTCAMVYKLTEREGADGTMVPVMKKSKDKATVPGRKLAFRSYEYALA
CCCCEEEEECCCCCHHHHEEEEHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHH
EAEHVISGSEEKLAGFTPEPTWKNLLVDFVDHGHIDAQWQGHDAIMAAHDYRAKALSELP
HHHHHHCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCEECCCCEEEEECHHHHHHHHCCC
ITAQSLMKGEPVIPTETQVL
CCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]