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The map label for this gene is fhs [H]

Identifier: 213691102

GI number: 213691102

Start: 215787

End: 217304

Strand: Direct

Name: fhs [H]

Synonym: Blon_0181

Alternate gene names: 213691102

Gene position: 215787-217304 (Clockwise)

Preceding gene: 213691101

Following gene: 213691104

Centisome position: 7.62

GC content: 65.22

Gene sequence:

>1518_bases
ATGACCACCATCGAAGACTTCACCAGCCAGTACGGCCTGGTCCAGAAGATCGACGCATTCGGCTACATGAAGTACCTGAC
CGAGAACCCGGACGCCCCGTGCAAGCACGGCAAGGTGGTGCTCGTCACCGCCGATACGCCGCTCAAGGCATCGCGCGGCG
AAGGCAAGACCACCACGACCATCGCCTTGATCGACGCCCTGAACAAGCGTGGCATTGATGCGGCCGCCGTGCTGCGTCAG
CCGAGCATGGGCATCACCGCAGCCGGTTCCAAGGGCGGTGCCTCCGGCGGCGGCAAGGCATCCCTGACCCACCCCGAGCT
CATCGACTGGGGTCTGTGCGGCGAAATGGGCGCCATCGAGGCGGCCCAGAACCTGCTCGTCTCCTTCGCCGAGAAGGCCA
TCGATGAAGGCAAGCTTGACACGATTCTCGTGCCGCGTGTCTCCGAGGTGCCGAGCCGCTCCCTGCGCTCCACCGCCGTG
GACTACGGCAAGGGCAACGTGCCGGAGAAGGTCGTGCTCACGCCGACCTGCGAGCTCATGCAGATCATGGTGCTCTCCCG
CTCGATGGACGAGATTTCCGAGCGTGTATCCAAGATGATCGCCGGCACCAAGGACGGCAAGGCCGTGACCTTCGGCGAGT
TCGTGGACCTGTGGCGCATCACCGGCATTCTGGCCGACGCGGTCAAGCCGGCCAAGACCGAGACCGTGAACGGCTCCCCG
GTCTACGTGCACGGTGGCCCGTTCGCCAACGTGTCCATCGGCATTCCGACGCTGGTTTCCGTGGAAATGGCCTGCGCTCT
GCATGATGTGGTTGTCGTCGAAGCCGGTTACGGCACCGACGCCGGTGCCCAGAAGTGGCTGGACATCGCCTGTCGCGAGT
ATGGCGCGCAGTGGCCGTCCGCCGCCATCGTGGTGACCCGCGCCTCCACCTGGCGCGACGATCCCGAGCTGGCCTGGCGC
TACCCGTTCCACGTGCAGCGCCTGGAGAACCTGGACATTCCGACCTTCCCGCTCATCAACCTGTGGGAAGGCGAGGACGA
TCAGGTCCCGTCCCTGCAGGCCACCGCCGACGAGCTGGGCTTCCGCACGCCGATCGTCGGCAATCTGTTCCGCGACGGCG
GCGAGGCGCTGGTCCCGCAGCTTGACGGTTTCGTCGATGCGTTGCAGAACGGCTCCATGCCGGCCGAACCGCATTCGCAC
AAGGGCATGGCCCTGACCGAGAACGCCAAGTGGGTGGCCGAGAACGCCTACGGCGTACCGGCCGAGCGCGTGATCTACAA
GCCGGGCTTCACCGAGTCTGTGTCCAAGGCCATGGAACTGTGCCAGAGCGCAGGCATCTCGCTGGACAATCTGACGTTCG
TGGCGGTCAAGTCCCCGGCGACCATGACCGACAACGACCGTGCCCCCGAAGAAGAGCGCACCGTGACCCTGAAGAAGGTC
GAGGTGCATGCCGGTGCCGGTCTGGTCCACGTCAACCTGACCACCAGCCTCACCACCCCTATGCCCAAGATTGTGTGA

Upstream 100 bases:

>100_bases
CTAAGCTGTTAAGAAACAGCCCAGTGGGCTGTTTCTAGGCGAAGAGGCGGCGGCCGCCCCACCACCCCGCTCCGCCATCA
TCAACACAGAAAGGCATTAA

Downstream 100 bases:

>100_bases
TGACAGGCACGAGGTGAGGTAACTCGCTTTCGAGGGGCGGATTTCCGGTTTTCCGGAGGTCCATCTGCGTTTCGAGGGGC
TCTTCGATTGCGAAACCCGG

Product: Formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTTIEDFTSQYGLVQKIDAFGYMKYLTENPDAPCKHGKVVLVTADTPLKASRGEGKTTTTIALIDALNKRGIDAAAVLRQ
PSMGITAAGSKGGASGGGKASLTHPELIDWGLCGEMGAIEAAQNLLVSFAEKAIDEGKLDTILVPRVSEVPSRSLRSTAV
DYGKGNVPEKVVLTPTCELMQIMVLSRSMDEISERVSKMIAGTKDGKAVTFGEFVDLWRITGILADAVKPAKTETVNGSP
VYVHGGPFANVSIGIPTLVSVEMACALHDVVVVEAGYGTDAGAQKWLDIACREYGAQWPSAAIVVTRASTWRDDPELAWR
YPFHVQRLENLDIPTFPLINLWEGEDDQVPSLQATADELGFRTPIVGNLFRDGGEALVPQLDGFVDALQNGSMPAEPHSH
KGMALTENAKWVAENAYGVPAERVIYKPGFTESVSKAMELCQSAGISLDNLTFVAVKSPATMTDNDRAPEEERTVTLKKV
EVHAGAGLVHVNLTTSLTTPMPKIV

Sequences:

>Translated_505_residues
MTTIEDFTSQYGLVQKIDAFGYMKYLTENPDAPCKHGKVVLVTADTPLKASRGEGKTTTTIALIDALNKRGIDAAAVLRQ
PSMGITAAGSKGGASGGGKASLTHPELIDWGLCGEMGAIEAAQNLLVSFAEKAIDEGKLDTILVPRVSEVPSRSLRSTAV
DYGKGNVPEKVVLTPTCELMQIMVLSRSMDEISERVSKMIAGTKDGKAVTFGEFVDLWRITGILADAVKPAKTETVNGSP
VYVHGGPFANVSIGIPTLVSVEMACALHDVVVVEAGYGTDAGAQKWLDIACREYGAQWPSAAIVVTRASTWRDDPELAWR
YPFHVQRLENLDIPTFPLINLWEGEDDQVPSLQATADELGFRTPIVGNLFRDGGEALVPQLDGFVDALQNGSMPAEPHSH
KGMALTENAKWVAENAYGVPAERVIYKPGFTESVSKAMELCQSAGISLDNLTFVAVKSPATMTDNDRAPEEERTVTLKKV
EVHAGAGLVHVNLTTSLTTPMPKIV
>Mature_504_residues
TTIEDFTSQYGLVQKIDAFGYMKYLTENPDAPCKHGKVVLVTADTPLKASRGEGKTTTTIALIDALNKRGIDAAAVLRQP
SMGITAAGSKGGASGGGKASLTHPELIDWGLCGEMGAIEAAQNLLVSFAEKAIDEGKLDTILVPRVSEVPSRSLRSTAVD
YGKGNVPEKVVLTPTCELMQIMVLSRSMDEISERVSKMIAGTKDGKAVTFGEFVDLWRITGILADAVKPAKTETVNGSPV
YVHGGPFANVSIGIPTLVSVEMACALHDVVVVEAGYGTDAGAQKWLDIACREYGAQWPSAAIVVTRASTWRDDPELAWRY
PFHVQRLENLDIPTFPLINLWEGEDDQVPSLQATADELGFRTPIVGNLFRDGGEALVPQLDGFVDALQNGSMPAEPHSHK
GMALTENAKWVAENAYGVPAERVIYKPGFTESVSKAMELCQSAGISLDNLTFVAVKSPATMTDNDRAPEEERTVTLKKVE
VHAGAGLVHVNLTTSLTTPMPKIV

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=360, Percent_Identity=29.1666666666667, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI36796743, Length=336, Percent_Identity=30.6547619047619, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17568737, Length=199, Percent_Identity=34.1708542713568, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17568739, Length=199, Percent_Identity=34.1708542713568, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319558, Length=458, Percent_Identity=27.5109170305677, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321643, Length=303, Percent_Identity=24.0924092409241, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645718, Length=396, Percent_Identity=26.5151515151515, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137370, Length=396, Percent_Identity=26.5151515151515, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI62472483, Length=396, Percent_Identity=26.5151515151515, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551871, Length=396, Percent_Identity=26.5151515151515, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 54079; Mature: 53948

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIEDFTSQYGLVQKIDAFGYMKYLTENPDAPCKHGKVVLVTADTPLKASRGEGKTTTT
CCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEE
IALIDALNKRGIDAAAVLRQPSMGITAAGSKGGASGGGKASLTHPELIDWGLCGEMGAIE
EHEEHHHHHCCCCHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHH
AAQNLLVSFAEKAIDEGKLDTILVPRVSEVPSRSLRSTAVDYGKGNVPEKVVLTPTCELM
HHHHHHHHHHHHHHCCCCCCEEECCCCHHCCCHHHHHHHHHCCCCCCCCEEEECCCHHHH
QIMVLSRSMDEISERVSKMIAGTKDGKAVTFGEFVDLWRITGILADAVKPAKTETVNGSP
HHHHHHCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VYVHGGPFANVSIGIPTLVSVEMACALHDVVVVEAGYGTDAGAQKWLDIACREYGAQWPS
EEEECCCCCEEEECCCHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
AAIVVTRASTWRDDPELAWRYPFHVQRLENLDIPTFPLINLWEGEDDQVPSLQATADELG
EEEEEEECCCCCCCCCCEEECCHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHC
FRTPIVGNLFRDGGEALVPQLDGFVDALQNGSMPAEPHSHKGMALTENAKWVAENAYGVP
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEECCCCCCC
AERVIYKPGFTESVSKAMELCQSAGISLDNLTFVAVKSPATMTDNDRAPEEERTVTLKKV
HHHEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHEEEEEEE
EVHAGAGLVHVNLTTSLTTPMPKIV
EEECCCCEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TTIEDFTSQYGLVQKIDAFGYMKYLTENPDAPCKHGKVVLVTADTPLKASRGEGKTTTT
CCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEE
IALIDALNKRGIDAAAVLRQPSMGITAAGSKGGASGGGKASLTHPELIDWGLCGEMGAIE
EHEEHHHHHCCCCHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHH
AAQNLLVSFAEKAIDEGKLDTILVPRVSEVPSRSLRSTAVDYGKGNVPEKVVLTPTCELM
HHHHHHHHHHHHHHCCCCCCEEECCCCHHCCCHHHHHHHHHCCCCCCCCEEEECCCHHHH
QIMVLSRSMDEISERVSKMIAGTKDGKAVTFGEFVDLWRITGILADAVKPAKTETVNGSP
HHHHHHCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VYVHGGPFANVSIGIPTLVSVEMACALHDVVVVEAGYGTDAGAQKWLDIACREYGAQWPS
EEEECCCCCEEEECCCHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
AAIVVTRASTWRDDPELAWRYPFHVQRLENLDIPTFPLINLWEGEDDQVPSLQATADELG
EEEEEEECCCCCCCCCCEEECCHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHC
FRTPIVGNLFRDGGEALVPQLDGFVDALQNGSMPAEPHSHKGMALTENAKWVAENAYGVP
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEECCCCCCC
AERVIYKPGFTESVSKAMELCQSAGISLDNLTFVAVKSPATMTDNDRAPEEERTVTLKKV
HHHEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHEEEEEEE
EVHAGAGLVHVNLTTSLTTPMPKIV
EEECCCCEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]