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The map label for this gene is aroP [H]

Identifier: 213159155

GI number: 213159155

Start: 3991240

End: 3992628

Strand: Reverse

Name: aroP [H]

Synonym: AB57_3866

Alternate gene names: 213159155

Gene position: 3992628-3991240 (Counterclockwise)

Preceding gene: 213159160

Following gene: 213159154

Centisome position: 98.57

GC content: 40.6

Gene sequence:

>1389_bases
ATGTCAACACAAGAGCAAGGAAACCTGAAACATGGTTTGAGTAATCGTCACATCCAGCTGATTGCGTTGGGTGGAGCGAT
TGGTACAGGGCTGTTTCTTGGTATATCACAATCGATTAAATTGGCAGGTCCATCGGTAATCTTGGGTTATGCGATTGCAG
GATTTATTGCTTTTTTAATGATGCGCCAGCTCGGTGAAATGGTCGTAGAAGAACCTGTAAGTGGGTCTTTTAGCCACTTC
GCTTACAAATATTGGGGACCTTTTGCAGGCTTCATGTCAGGATGGAATTACTGGGTACTTAATGTACTTGTGTGTATGGC
AGAGTTAAGTGCAATTGGTCTTTATATTCAATATTGGTGGCCGCAAATCCCAACGTGGGCATCTGCTCTAACGTTCTTTA
TTCTCATTAATGGTATCAATTTACTGCATGTTAAGTTTTTTGGCGAAATGGAATTTTGGTTTTCCATTGTTAAAATCTTA
GCAATTTTAGCCATGATCGGTTTCGGTTCATATTTACTTGCAACCGGCACAGCAGGGCCTCAGGCCAGTATTTCTAACCT
TTGGGCATTAGGTGGTTTCTTCCCATTTGGTATTGAAGGCTTGGTTATGGCTATGGCTGTGATTATTTTTGCTTTTGGCG
GTATTGAGCTTTTTGGTATTACTGCTGCTGAAGCGCGTGATCCAGACAAAACTTTACCTAAAGCTGTAAACCAGATTATC
TATCGTATTTTGATTTTCTATATTGCGACACTTTTTGTTTTATTCTCATTATTTCCGTGGAATCAAATGGCAGAAGGTGG
CAGTCCTTTTGTGATGGTCTTTGCCTCTTTAGATAGCCAAGGTGTTGCGACATTATTAAATTTCGTTATTTTGACAGCTG
CGGTTTCCGTCTATAACGGAACCAGCTATTGCAGCAGCCGTATGCTTTTAGGTCTTGCCCAACAAGGTAATGCCCCGAAA
GCTCTTGCCCGTATTAATAAACGCGGTATTCCAACCAATGCGGTTCTAGTCTCTGCATTTGTAACGGTATTGTGTGTTTT
ACTTAATTATATTTTCCCTGAAAAAGCATTCGGTTTACTCATGATGCTTGTTGTAGCAGCGATTGTAATTAACTGGGTTG
TGATTTCATGGACACATTTAAAATTCCGTAAATTCATGCAACGCCAAGGTCAAACGACTAAATTCCCAAGCTTCATGTAT
CCATTTAGCAACTATCTTTGCATGGCATTCATGCTTGGAATTTTAGTTGTGATGTCTTTAACGCCAGACATGCGTGTGGC
GGTTATGATGATTCCAGGATGGATTTTGTGTTTGATGGTGGCTTATCAATTTAAGCGCCGTAAAATAAAAGCTGAGCAGC
CTGTACATGCTTTAGAAGCCGATATGTAA

Upstream 100 bases:

>100_bases
ACGCAATTATTTTTTCATCAATCTCTATGAAAATCCGATCAATTTATGATATACGTAATTTATTGGAAAAAAATTACGTG
ACAAGGATGAGAATAATCAT

Downstream 100 bases:

>100_bases
TTAGGTCTTAGATAGAAGCTAAAAAGGACGTATAAATACGTCCTTTTTTATTTTTTAAAATTTACAACAGAAATTAAAGG
ATTTAATAATTGTTATATTA

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSTQEQGNLKHGLSNRHIQLIALGGAIGTGLFLGISQSIKLAGPSVILGYAIAGFIAFLMMRQLGEMVVEEPVSGSFSHF
AYKYWGPFAGFMSGWNYWVLNVLVCMAELSAIGLYIQYWWPQIPTWASALTFFILINGINLLHVKFFGEMEFWFSIVKIL
AILAMIGFGSYLLATGTAGPQASISNLWALGGFFPFGIEGLVMAMAVIIFAFGGIELFGITAAEARDPDKTLPKAVNQII
YRILIFYIATLFVLFSLFPWNQMAEGGSPFVMVFASLDSQGVATLLNFVILTAAVSVYNGTSYCSSRMLLGLAQQGNAPK
ALARINKRGIPTNAVLVSAFVTVLCVLLNYIFPEKAFGLLMMLVVAAIVINWVVISWTHLKFRKFMQRQGQTTKFPSFMY
PFSNYLCMAFMLGILVVMSLTPDMRVAVMMIPGWILCLMVAYQFKRRKIKAEQPVHALEADM

Sequences:

>Translated_462_residues
MSTQEQGNLKHGLSNRHIQLIALGGAIGTGLFLGISQSIKLAGPSVILGYAIAGFIAFLMMRQLGEMVVEEPVSGSFSHF
AYKYWGPFAGFMSGWNYWVLNVLVCMAELSAIGLYIQYWWPQIPTWASALTFFILINGINLLHVKFFGEMEFWFSIVKIL
AILAMIGFGSYLLATGTAGPQASISNLWALGGFFPFGIEGLVMAMAVIIFAFGGIELFGITAAEARDPDKTLPKAVNQII
YRILIFYIATLFVLFSLFPWNQMAEGGSPFVMVFASLDSQGVATLLNFVILTAAVSVYNGTSYCSSRMLLGLAQQGNAPK
ALARINKRGIPTNAVLVSAFVTVLCVLLNYIFPEKAFGLLMMLVVAAIVINWVVISWTHLKFRKFMQRQGQTTKFPSFMY
PFSNYLCMAFMLGILVVMSLTPDMRVAVMMIPGWILCLMVAYQFKRRKIKAEQPVHALEADM
>Mature_461_residues
STQEQGNLKHGLSNRHIQLIALGGAIGTGLFLGISQSIKLAGPSVILGYAIAGFIAFLMMRQLGEMVVEEPVSGSFSHFA
YKYWGPFAGFMSGWNYWVLNVLVCMAELSAIGLYIQYWWPQIPTWASALTFFILINGINLLHVKFFGEMEFWFSIVKILA
ILAMIGFGSYLLATGTAGPQASISNLWALGGFFPFGIEGLVMAMAVIIFAFGGIELFGITAAEARDPDKTLPKAVNQIIY
RILIFYIATLFVLFSLFPWNQMAEGGSPFVMVFASLDSQGVATLLNFVILTAAVSVYNGTSYCSSRMLLGLAQQGNAPKA
LARINKRGIPTNAVLVSAFVTVLCVLLNYIFPEKAFGLLMMLVVAAIVINWVVISWTHLKFRKFMQRQGQTTKFPSFMYP
FSNYLCMAFMLGILVVMSLTPDMRVAVMMIPGWILCLMVAYQFKRRKIKAEQPVHALEADM

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=414, Percent_Identity=22.463768115942, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786302, Length=452, Percent_Identity=63.9380530973451, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=59.9552572706935, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=42.0353982300885, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1790653, Length=452, Percent_Identity=39.8230088495575, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI48994972, Length=460, Percent_Identity=38.9130434782609, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI87081915, Length=458, Percent_Identity=34.2794759825328, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1789017, Length=461, Percent_Identity=34.9240780911063, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI87081708, Length=467, Percent_Identity=34.475374732334, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788480, Length=429, Percent_Identity=32.4009324009324, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17532491, Length=369, Percent_Identity=25.2032520325203, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=385, Percent_Identity=23.1168831168831, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=337, Percent_Identity=24.0356083086053, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=32.6530612244898, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=33.0316742081448, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=33.1695331695332, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=405, Percent_Identity=32.3456790123457, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321053, Length=416, Percent_Identity=29.5673076923077, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=30.75, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=412, Percent_Identity=29.8543689320388, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=32.1266968325792, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=420, Percent_Identity=31.4285714285714, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=407, Percent_Identity=30.958230958231, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=31.8987341772152, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=447, Percent_Identity=29.7539149888143, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319543, Length=404, Percent_Identity=29.2079207920792, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=407, Percent_Identity=29.97542997543, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=400, Percent_Identity=30.25, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319608, Length=423, Percent_Identity=28.3687943262411, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=29.2191435768262, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=489, Percent_Identity=23.3128834355828, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667468, Length=410, Percent_Identity=22.6829268292683, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51081; Mature: 50949

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQEQGNLKHGLSNRHIQLIALGGAIGTGLFLGISQSIKLAGPSVILGYAIAGFIAFLM
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
MRQLGEMVVEEPVSGSFSHFAYKYWGPFAGFMSGWNYWVLNVLVCMAELSAIGLYIQYWW
HHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PQIPTWASALTFFILINGINLLHVKFFGEMEFWFSIVKILAILAMIGFGSYLLATGTAGP
CCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCC
QASISNLWALGGFFPFGIEGLVMAMAVIIFAFGGIELFGITAAEARDPDKTLPKAVNQII
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHHHHH
YRILIFYIATLFVLFSLFPWNQMAEGGSPFVMVFASLDSQGVATLLNFVILTAAVSVYNG
HHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
TSYCSSRMLLGLAQQGNAPKALARINKRGIPTNAVLVSAFVTVLCVLLNYIFPEKAFGLL
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MMLVVAAIVINWVVISWTHLKFRKFMQRQGQTTKFPSFMYPFSNYLCMAFMLGILVVMSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHC
TPDMRVAVMMIPGWILCLMVAYQFKRRKIKAEQPVHALEADM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC
>Mature Secondary Structure 
STQEQGNLKHGLSNRHIQLIALGGAIGTGLFLGISQSIKLAGPSVILGYAIAGFIAFLM
CCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
MRQLGEMVVEEPVSGSFSHFAYKYWGPFAGFMSGWNYWVLNVLVCMAELSAIGLYIQYWW
HHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PQIPTWASALTFFILINGINLLHVKFFGEMEFWFSIVKILAILAMIGFGSYLLATGTAGP
CCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCC
QASISNLWALGGFFPFGIEGLVMAMAVIIFAFGGIELFGITAAEARDPDKTLPKAVNQII
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHHHHH
YRILIFYIATLFVLFSLFPWNQMAEGGSPFVMVFASLDSQGVATLLNFVILTAAVSVYNG
HHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
TSYCSSRMLLGLAQQGNAPKALARINKRGIPTNAVLVSAFVTVLCVLLNYIFPEKAFGLL
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MMLVVAAIVINWVVISWTHLKFRKFMQRQGQTTKFPSFMYPFSNYLCMAFMLGILVVMSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHC
TPDMRVAVMMIPGWILCLMVAYQFKRRKIKAEQPVHALEADM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]