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The map label for this gene is thiL [H]

Identifier: 213159131

GI number: 213159131

Start: 3962759

End: 3963676

Strand: Direct

Name: thiL [H]

Synonym: AB57_3841

Alternate gene names: 213159131

Gene position: 3962759-3963676 (Clockwise)

Preceding gene: 213159130

Following gene: 213159132

Centisome position: 97.83

GC content: 42.81

Gene sequence:

>918_bases
ATGGCTGAGTTCTCAATTATTGATCAATACTTTAATCGTCAGTCACATCCTGACGTTGCGCTTGGTATTGGTGATGACTC
AGCCTTAATTACTCCCCCTCCAAATCAACAACTGGTGATCTGTGCAGATACACTTGTTGCTGGACGTCACTTCCCTCTTG
AAACCTCGCCCCATGCGATTGGCTGGAAAAGTGTTGCCGTAAATCTGTCTGATATTGCTGCAATGGGCGCCAAACCACAT
AGTATTTTACTTGCGATCAGCTTGCCTCAAGTTGACCATGAATGGCTTGAAGGATTTAGTCAGGGAATCTATGACTGTTG
TAATCAATTTGGAGTTGCCTTAATTGGCGGAGATACCACTCAAGGTCCACACCTCACCATTACCGTCACGGCCATGGGCT
GGATTGAAACAGGAAAAGCTGTATTACGTTCAGGTGCTAAGGTGGGTGATTATGTTTGTGTAAGTGGTCAGATTGGTGAT
GCTGCTTATGGACTTCAGCATTTAGGACATTCTCTACAACAAAGACTGGACTATCCGACGCCACGTTGTAAGCTTGGAGA
AGAGCTAAAAGGGCTCGCCTCTAGCATGATCGATGTGTCAGATGGTTTAGCTCAAGATTTAGGACATATTTTAAAAGCGT
CCAAGGTTGGAGCACGACTCATCCTGGAAAAATTACCTGTCGATCCTGTACTGCAACAAATAGAAGAACAACAACGTTGG
CAATATGCCTTGGCAGGTGGTGATGACTACGAATTATGTTTTACAATAACACCGCAAAATTATGAAAAACTTTTGCAAAA
ACAACTAGACGTTAAGATTACAATGATCGGACAGATCGTTGAGCAAACAAAACTAACTTTTGAGCATTTGGGTTCAGATT
ACCCATTGCAAATTCATGGATACCAACACTTTGCATAA

Upstream 100 bases:

>100_bases
AGCAGACAGTCATAAATACATCAATGGTGTATTAGACCGTTTAAGTTCGACACTGCGTAGCGCAGAAAAACAACAAGCAA
AATAATAGGCTTGATGTTCT

Downstream 100 bases:

>100_bases
ACCGCCGATTCATTTTAAAGACATGTCTTGGTTCAACCGCTGCATCGTTTTCTGTGGGGTTGGTTTTGGATCTGGTCTTG
CTCCTAAAGCACCTGGTACT

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAEFSIIDQYFNRQSHPDVALGIGDDSALITPPPNQQLVICADTLVAGRHFPLETSPHAIGWKSVAVNLSDIAAMGAKPH
SILLAISLPQVDHEWLEGFSQGIYDCCNQFGVALIGGDTTQGPHLTITVTAMGWIETGKAVLRSGAKVGDYVCVSGQIGD
AAYGLQHLGHSLQQRLDYPTPRCKLGEELKGLASSMIDVSDGLAQDLGHILKASKVGARLILEKLPVDPVLQQIEEQQRW
QYALAGGDDYELCFTITPQNYEKLLQKQLDVKITMIGQIVEQTKLTFEHLGSDYPLQIHGYQHFA

Sequences:

>Translated_305_residues
MAEFSIIDQYFNRQSHPDVALGIGDDSALITPPPNQQLVICADTLVAGRHFPLETSPHAIGWKSVAVNLSDIAAMGAKPH
SILLAISLPQVDHEWLEGFSQGIYDCCNQFGVALIGGDTTQGPHLTITVTAMGWIETGKAVLRSGAKVGDYVCVSGQIGD
AAYGLQHLGHSLQQRLDYPTPRCKLGEELKGLASSMIDVSDGLAQDLGHILKASKVGARLILEKLPVDPVLQQIEEQQRW
QYALAGGDDYELCFTITPQNYEKLLQKQLDVKITMIGQIVEQTKLTFEHLGSDYPLQIHGYQHFA
>Mature_304_residues
AEFSIIDQYFNRQSHPDVALGIGDDSALITPPPNQQLVICADTLVAGRHFPLETSPHAIGWKSVAVNLSDIAAMGAKPHS
ILLAISLPQVDHEWLEGFSQGIYDCCNQFGVALIGGDTTQGPHLTITVTAMGWIETGKAVLRSGAKVGDYVCVSGQIGDA
AYGLQHLGHSLQQRLDYPTPRCKLGEELKGLASSMIDVSDGLAQDLGHILKASKVGARLILEKLPVDPVLQQIEEQQRWQ
YALAGGDDYELCFTITPQNYEKLLQKQLDVKITMIGQIVEQTKLTFEHLGSDYPLQIHGYQHFA

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=320, Percent_Identity=46.5625, Blast_Score=254, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33297; Mature: 33166

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFSIIDQYFNRQSHPDVALGIGDDSALITPPPNQQLVICADTLVAGRHFPLETSPHAI
CCCHHHHHHHHCCCCCCCEEEEECCCCCEECCCCCCEEEEEECHHHCCCCCCCCCCCCCC
GWKSVAVNLSDIAAMGAKPHSILLAISLPQVDHEWLEGFSQGIYDCCNQFGVALIGGDTT
CHHHEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCC
QGPHLTITVTAMGWIETGKAVLRSGAKVGDYVCVSGQIGDAAYGLQHLGHSLQQRLDYPT
CCCEEEEEEEEECHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
PRCKLGEELKGLASSMIDVSDGLAQDLGHILKASKVGARLILEKLPVDPVLQQIEEQQRW
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QYALAGGDDYELCFTITPQNYEKLLQKQLDVKITMIGQIVEQTKLTFEHLGSDYPLQIHG
EEEECCCCCEEEEEEECCHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEC
YQHFA
CCCCC
>Mature Secondary Structure 
AEFSIIDQYFNRQSHPDVALGIGDDSALITPPPNQQLVICADTLVAGRHFPLETSPHAI
CCHHHHHHHHCCCCCCCEEEEECCCCCEECCCCCCEEEEEECHHHCCCCCCCCCCCCCC
GWKSVAVNLSDIAAMGAKPHSILLAISLPQVDHEWLEGFSQGIYDCCNQFGVALIGGDTT
CHHHEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCC
QGPHLTITVTAMGWIETGKAVLRSGAKVGDYVCVSGQIGDAAYGLQHLGHSLQQRLDYPT
CCCEEEEEEEEECHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
PRCKLGEELKGLASSMIDVSDGLAQDLGHILKASKVGARLILEKLPVDPVLQQIEEQQRW
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QYALAGGDDYELCFTITPQNYEKLLQKQLDVKITMIGQIVEQTKLTFEHLGSDYPLQIHG
EEEECCCCCEEEEEEECCHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEC
YQHFA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]