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The map label for this gene is parE [H]

Identifier: 213159099

GI number: 213159099

Start: 3927825

End: 3929708

Strand: Reverse

Name: parE [H]

Synonym: AB57_3809

Alternate gene names: 213159099

Gene position: 3929708-3927825 (Counterclockwise)

Preceding gene: 213159100

Following gene: 213159096

Centisome position: 97.02

GC content: 42.99

Gene sequence:

>1884_bases
GTGACACAATATACGGCTCAATCGCTTGAAGTTCTTTCCGGTTTAGACCCTGTTCGTCGTCGTCCGGGGATGTATACCGA
TACTTCTCGTCCTAACCATTTAGCCCAAGAAGTTATTGATAATGCTGTCGATGAAGCCTTAGCCGGTCATGCCGACAAAA
TCTGTGTCACGGTTTATAAAGATGGTTCATTGTCAGTTGAAGATAATGGCCGTGGTATGCCAGTCGATATTCACCCTGAA
TATGGCCAAAGTGGTATCGAAATCATTTTAACCAAGCTGCATGCTGGTGGTAAGTTTAGTACCGATAACTATCAGTTTTC
AGGTGGTTTACATGGTGTGGGGATTTCGGTTGTAAATGCTTTATCAACTCGTGTTGAGGTAGAAGTTCAGCGTCAGGGTA
ATTTATACCAGATGGCCTTTGAGCAAGGTGAACCTGTTGCGCCTTTGGCAGTGCTAGAAGGCAAAGCACCAAAACGTGCG
ACTGGTACAACGGTACGTTTCTGGCCTGAAGCTAAATATTTTGATAGTCCAAAATTTGCGTTAAAAGCACTCAAACATAA
TTTAAAAGCCAAAGCTGTTTTAGCAGCTGGTTTAAAAATTACTTATATCGATCAAATTAATGATGAAAAAATCGAATGGC
AATTTGAAAATGGCCTTGTCGATTATTTGATGGATGAATTACAAGATCGTGAAATTTTGCCAAACCCTGCATTTGTAAGC
AGTGGCCAAGCAGACCGTGCAGCATGTGAATTTGCGATTTGCTGGAATGTAGAAGGTGGTGAACAGGTTCAAGAAAGTTA
TGTCAACCTGATTCCAACTGCACAAGGTGGTACTCATGTGAACGGTTTGCGTTCGGGGGTGACCGAAGCGCTACGTGAAT
TCTGTGAGTTACGCAATTTATTACCACGTAATCTTAAACTTTCGGCTGAAGATGTTTGGGATGGCGTGAACTATATTTTA
TCGCTTAAGTTCCAAGAACCACAGTTCTCTGGTCAAACCAAAGAGCGTCTTTCAAGTCGTGAAGCTGCCAATATTGTTTT
AAACATTGCTAAAGATGCGTTTGCGCTCTGGCTCAACCAGCATGCTGAAATTGCCATGCAACTTGCTGAAATGGCAATTT
CTAAAGCAGGGCGCCGTTTAAAAGCTGCAAAAAAAGTTGAGCGTAAAAAGATTGTTTCTGGCCCGGCTTTACCGGGTAAG
CTGGCGGACTGCGTGGGCCAAACACGTGAAGAAAGTGAACTCTTTATTGTCGAGGGTGACTCTGCGGGCGGTAGTGCCAA
GCAGGCGCGTGATAAGAACTTTCAAGCTATCATGCCAATTCGTGGAAAAATCTTAAATACATGGGAAGTTTCTTCAGATG
AAGTACTTGCTTCTCAGGAAGTTCACGACATTGCCATTGCAATTGGTGTAGACCCGGGTAGTGATGATTTATCTGAATTA
CGTTACGGCAAAATCTGTATTTTGGCCGATGCCGACTCGGATGGTTTACACATTGCGACTTTGCTTTGCGCTTTATTCGT
TAAACATTTTCCAGCATTGGTTGAAGAAGGGCATTTGTATGTAGCAATGCCACCATTGTTCCGTATCGACATTGGTAAAG
ATGTTCATTACGCGCTAGATGATGAAGAGCTTGAAACCATTTTGAAAAATGTTAAAGGCAATAAGAACCCGCAAATTACC
CGATTCAAAGGGTTGGGTGAGATGAACGCAATTCAACTACGTGAAACAACAATGGATCCGAACACCCGTCGTTTGGTGCA
ACTCGATCTAGATGATGCACATTTAACGGCAGGTTTACTCGACAAGCTCCTTGCAAAAAAACGTGCAGCAGACCGTAAGC
AATGGCTTGAGCAGAAGGGTAACTTAGCTGATATTACGGTTTAA

Upstream 100 bases:

>100_bases
CGGATGCTCATGGCAATCATGCCATGGAAGATTTTGAAGAAAAATTACCCTTAGTGATCGAATTCTTTGCGCACACCATC
AAATAAGGAAAACGTACAAC

Downstream 100 bases:

>100_bases
AAATAAATGAAAAATCCCCGCTCAAATGGCGGGGATTTTTTGTGTAAATCTAAATTGTTGAAAATCACCACAACGGGTTC
TACTATTAAATTAAAAAATA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTQYTAQSLEVLSGLDPVRRRPGMYTDTSRPNHLAQEVIDNAVDEALAGHADKICVTVYKDGSLSVEDNGRGMPVDIHPE
YGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNALSTRVEVEVQRQGNLYQMAFEQGEPVAPLAVLEGKAPKRA
TGTTVRFWPEAKYFDSPKFALKALKHNLKAKAVLAAGLKITYIDQINDEKIEWQFENGLVDYLMDELQDREILPNPAFVS
SGQADRAACEFAICWNVEGGEQVQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNLLPRNLKLSAEDVWDGVNYIL
SLKFQEPQFSGQTKERLSSREAANIVLNIAKDAFALWLNQHAEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGK
LADCVGQTREESELFIVEGDSAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDIGKDVHYALDDEELETILKNVKGNKNPQIT
RFKGLGEMNAIQLRETTMDPNTRRLVQLDLDDAHLTAGLLDKLLAKKRAADRKQWLEQKGNLADITV

Sequences:

>Translated_627_residues
MTQYTAQSLEVLSGLDPVRRRPGMYTDTSRPNHLAQEVIDNAVDEALAGHADKICVTVYKDGSLSVEDNGRGMPVDIHPE
YGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNALSTRVEVEVQRQGNLYQMAFEQGEPVAPLAVLEGKAPKRA
TGTTVRFWPEAKYFDSPKFALKALKHNLKAKAVLAAGLKITYIDQINDEKIEWQFENGLVDYLMDELQDREILPNPAFVS
SGQADRAACEFAICWNVEGGEQVQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNLLPRNLKLSAEDVWDGVNYIL
SLKFQEPQFSGQTKERLSSREAANIVLNIAKDAFALWLNQHAEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGK
LADCVGQTREESELFIVEGDSAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDIGKDVHYALDDEELETILKNVKGNKNPQIT
RFKGLGEMNAIQLRETTMDPNTRRLVQLDLDDAHLTAGLLDKLLAKKRAADRKQWLEQKGNLADITV
>Mature_626_residues
TQYTAQSLEVLSGLDPVRRRPGMYTDTSRPNHLAQEVIDNAVDEALAGHADKICVTVYKDGSLSVEDNGRGMPVDIHPEY
GQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNALSTRVEVEVQRQGNLYQMAFEQGEPVAPLAVLEGKAPKRAT
GTTVRFWPEAKYFDSPKFALKALKHNLKAKAVLAAGLKITYIDQINDEKIEWQFENGLVDYLMDELQDREILPNPAFVSS
GQADRAACEFAICWNVEGGEQVQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNLLPRNLKLSAEDVWDGVNYILS
LKFQEPQFSGQTKERLSSREAANIVLNIAKDAFALWLNQHAEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGKL
ADCVGQTREESELFIVEGDSAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSELR
YGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDIGKDVHYALDDEELETILKNVKGNKNPQITR
FKGLGEMNAIQLRETTMDPNTRRLVQLDLDDAHLTAGLLDKLLAKKRAADRKQWLEQKGNLADITV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=635, Percent_Identity=25.8267716535433, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI19913406, Length=624, Percent_Identity=25.3205128205128, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1789408, Length=631, Percent_Identity=65.2931854199683, Blast_Score=855, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=557, Percent_Identity=41.2926391382406, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=634, Percent_Identity=24.1324921135647, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=585, Percent_Identity=23.9316239316239, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=641, Percent_Identity=24.1809672386895, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136538, Length=623, Percent_Identity=24.3980738362761, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69075; Mature: 68944

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYTAQSLEVLSGLDPVRRRPGMYTDTSRPNHLAQEVIDNAVDEALAGHADKICVTVYK
CCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
DGSLSVEDNGRGMPVDIHPEYGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNA
CCEEEECCCCCCCCEEECCCCCCCCHHEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHH
LSTRVEVEVQRQGNLYQMAFEQGEPVAPLAVLEGKAPKRATGTTVRFWPEAKYFDSPKFA
HHHEEEEEEECCCCEEEEHHHCCCCCCCCCEECCCCCCCCCCCEEEECCCCCCCCCHHHH
LKALKHNLKAKAVLAAGLKITYIDQINDEKIEWQFENGLVDYLMDELQDREILPNPAFVS
HHHHHHCCHHHEEEECCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCC
SGQADRAACEFAICWNVEGGEQVQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNL
CCCCCCCEEEEEEEEECCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
LPRNLKLSAEDVWDGVNYILSLKFQEPQFSGQTKERLSSREAANIVLNIAKDAFALWLNQ
CCCCCEECHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEHHHHHHHHHHHH
HAEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGKLADCVGQTREESELFIVEGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECC
SAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
CCCCCHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHCCCEEEEEEEECCCCCCHHHHC
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDIGKDVHYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCEEECC
DEELETILKNVKGNKNPQITRFKGLGEMNAIQLRETTMDPNTRRLVQLDLDDAHLTAGLL
HHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHH
DKLLAKKRAADRKQWLEQKGNLADITV
HHHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
TQYTAQSLEVLSGLDPVRRRPGMYTDTSRPNHLAQEVIDNAVDEALAGHADKICVTVYK
CCCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
DGSLSVEDNGRGMPVDIHPEYGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNA
CCEEEECCCCCCCCEEECCCCCCCCHHEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHH
LSTRVEVEVQRQGNLYQMAFEQGEPVAPLAVLEGKAPKRATGTTVRFWPEAKYFDSPKFA
HHHEEEEEEECCCCEEEEHHHCCCCCCCCCEECCCCCCCCCCCEEEECCCCCCCCCHHHH
LKALKHNLKAKAVLAAGLKITYIDQINDEKIEWQFENGLVDYLMDELQDREILPNPAFVS
HHHHHHCCHHHEEEECCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCC
SGQADRAACEFAICWNVEGGEQVQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNL
CCCCCCCEEEEEEEEECCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
LPRNLKLSAEDVWDGVNYILSLKFQEPQFSGQTKERLSSREAANIVLNIAKDAFALWLNQ
CCCCCEECHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEHHHHHHHHHHHH
HAEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGKLADCVGQTREESELFIVEGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECC
SAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
CCCCCHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHCCCEEEEEEEECCCCCCHHHHC
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDIGKDVHYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCEEECC
DEELETILKNVKGNKNPQITRFKGLGEMNAIQLRETTMDPNTRRLVQLDLDDAHLTAGLL
HHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHH
DKLLAKKRAADRKQWLEQKGNLADITV
HHHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]