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The map label for this gene is dsbD [H]

Identifier: 213159086

GI number: 213159086

Start: 3916725

End: 3918539

Strand: Reverse

Name: dsbD [H]

Synonym: AB57_3796

Alternate gene names: 213159086

Gene position: 3918539-3916725 (Counterclockwise)

Preceding gene: 213159088

Following gene: 213159084

Centisome position: 96.74

GC content: 41.21

Gene sequence:

>1815_bases
ATGAAAAAGCTTATTTCTCAGGGAATTATTTATTTTCTAGTAGCCGCTACTTTTGTATTGAGTCAGTTTGTCTTTGCAGA
AGATAAGTTATTGTCACCCGAACAGGCTTTTTCATTTTCGGTTGAATCGCCACAATCGCATACCGCAAAGTTATCGTGGC
AGATTCAGCCGAATTATTATTTATATCAACATAAATTTACCGTACAACAGGGCAATCAGCCTTTAACTTTAAATTTGCCT
AAAGCAGTTTCTCAATATGATGAGAACTATGGCCAAAGCCAAGTTTATTACCATCAAGTCAACTTCCAGATTAAAACCAA
GCCTTCAGAGCACTACACTGTAACTTGGCAAGGCTGTGCCAAAGACCGTATTTGTTATCCGCCACAAACTATTGAGTTTC
AAACTGATGCAAATGGTCTGGTCGGTCTGCAAAATCAGGCTGGTGCAGCACCAAAACGCTTATTAGATTTGGCAAATACC
CAAGCATCAAGCTCTACGGAGTCTTTAGAGAATCAGAGTTCAGCTACTCAAGCTGAAGGAGCTGCTCCAGAGATTGCCCA
AGATCAGGTTTGGTCAGCAAAGTTAATTGAACACTCGCTTTGGTATGGTGTTTTATTATTTTTAGGTTTAGGCATGCTGC
TTGCATTTACGCCATGTTCTTTACCGATGCTGCCTATTTTAACCTCGTTGATCATTCGAGATCACAAAGGTTTAAAAGCT
TGGACGATTGCACTTACTTTTGTGTGTAGTATGGCATTGGTCTATGCAGGTCTAGGCTTGATTGCTTCTTCAGCGGGTTT
AAATTTCCAACGCTGGCTACAACAGCCTGCTACTCTTATTGCGTTTAGTTTGTTGTTTGTGGTTTTTGCACTAAATCTGT
TTGGGCTTTTTGAGCTTCGGTTACCTCAGACATGGTTAAATCGCCTTGATCGTATTCAGTCTATGCAACAAGGCGGCACT
TTAGTTGGTGCAGGCGTTATGGGCGTGGTTTCTGCGCTCTTGGTTGGCCCATGCATGACTGCGCCTTTGGCTGGAACTTT
ATTATTTATTTCTCAAACCCAGAACCAATGGCAAGGTGCTTTGCTTTTATTCTGTCTCGGTTTTGGCATGGGAATACCTT
TACTCATCGCGAGTGTTTTAGGTGCAAAGTTCTTACCTAAAGCGGGCGACTGGATGCATCAGATTAAAGTGATTTTTGCT
TTTATGATGTTGGGGTTAAGCCTTTATTTCATCCGCCCTTTATTACCAGATTGGGGGATGCAAGCACTTAGTTTTGTACT
TGGGCTAGCTTTTATTATCTATGCGCTGTATCAGTTCTTTTGGAAAAAAGGGCAGTTACAGTGGCTTTATGCGCTCCTGT
TCTTATTGGTAACGCCATTTGTGGTTTATAACCAGTATCAACATATTCAAAATCGTAGCTTACAAAATTCTGAGCATATG
GCTGAGTGGCATGTGGCGACCACGGCAGCAGATTTTCAAAAGATTTTAGCAGCAGCTCCTGCTGATCGGGCTATTGTTGT
TGATGTCTATGCTGATTGGTGCGTGGCTTGTCAGCCTATTGAACATCGTATTTTAAAATCACCTGAGGTTCAGACGGCTC
TTGTGCCTTACTATCTCATTAAACTTGATTTGAGTCATTATGACCAGTCACATGAAGCATTGCTCAAACAATGGAATATT
CTTGGGCCTCCTACATATCTCTTTTTAAACAAGCAACAGCAAGAAATTCGTTCTTTACGTTTAACAGGCGCCTTTAGTCA
GCAAGAGCTTTTACAACAGCTGGCAAGCTTATCAAAAGCTAAAGATTCAAATTGA

Upstream 100 bases:

>100_bases
AATATTGGTGTGGACTTAGAAGGTCAAGATAAGAGCTACAAAGGTGGCTTAGGCATGGCATTCTTATTCTGATCAGACTA
ACTTGAACTCATTATTATTG

Downstream 100 bases:

>100_bases
TTTGATCTGAGGTAGTTGATGAAAAGTGCGTACTTGATTACGCCCAGAGGCCTTTACCGCATAGAGCGCTTGATCGGCTT
GTCTAATCACAAGATAGGGG

Product: thiol:disulfide interchange protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MKKLISQGIIYFLVAATFVLSQFVFAEDKLLSPEQAFSFSVESPQSHTAKLSWQIQPNYYLYQHKFTVQQGNQPLTLNLP
KAVSQYDENYGQSQVYYHQVNFQIKTKPSEHYTVTWQGCAKDRICYPPQTIEFQTDANGLVGLQNQAGAAPKRLLDLANT
QASSSTESLENQSSATQAEGAAPEIAQDQVWSAKLIEHSLWYGVLLFLGLGMLLAFTPCSLPMLPILTSLIIRDHKGLKA
WTIALTFVCSMALVYAGLGLIASSAGLNFQRWLQQPATLIAFSLLFVVFALNLFGLFELRLPQTWLNRLDRIQSMQQGGT
LVGAGVMGVVSALLVGPCMTAPLAGTLLFISQTQNQWQGALLLFCLGFGMGIPLLIASVLGAKFLPKAGDWMHQIKVIFA
FMMLGLSLYFIRPLLPDWGMQALSFVLGLAFIIYALYQFFWKKGQLQWLYALLFLLVTPFVVYNQYQHIQNRSLQNSEHM
AEWHVATTAADFQKILAAAPADRAIVVDVYADWCVACQPIEHRILKSPEVQTALVPYYLIKLDLSHYDQSHEALLKQWNI
LGPPTYLFLNKQQQEIRSLRLTGAFSQQELLQQLASLSKAKDSN

Sequences:

>Translated_604_residues
MKKLISQGIIYFLVAATFVLSQFVFAEDKLLSPEQAFSFSVESPQSHTAKLSWQIQPNYYLYQHKFTVQQGNQPLTLNLP
KAVSQYDENYGQSQVYYHQVNFQIKTKPSEHYTVTWQGCAKDRICYPPQTIEFQTDANGLVGLQNQAGAAPKRLLDLANT
QASSSTESLENQSSATQAEGAAPEIAQDQVWSAKLIEHSLWYGVLLFLGLGMLLAFTPCSLPMLPILTSLIIRDHKGLKA
WTIALTFVCSMALVYAGLGLIASSAGLNFQRWLQQPATLIAFSLLFVVFALNLFGLFELRLPQTWLNRLDRIQSMQQGGT
LVGAGVMGVVSALLVGPCMTAPLAGTLLFISQTQNQWQGALLLFCLGFGMGIPLLIASVLGAKFLPKAGDWMHQIKVIFA
FMMLGLSLYFIRPLLPDWGMQALSFVLGLAFIIYALYQFFWKKGQLQWLYALLFLLVTPFVVYNQYQHIQNRSLQNSEHM
AEWHVATTAADFQKILAAAPADRAIVVDVYADWCVACQPIEHRILKSPEVQTALVPYYLIKLDLSHYDQSHEALLKQWNI
LGPPTYLFLNKQQQEIRSLRLTGAFSQQELLQQLASLSKAKDSN
>Mature_604_residues
MKKLISQGIIYFLVAATFVLSQFVFAEDKLLSPEQAFSFSVESPQSHTAKLSWQIQPNYYLYQHKFTVQQGNQPLTLNLP
KAVSQYDENYGQSQVYYHQVNFQIKTKPSEHYTVTWQGCAKDRICYPPQTIEFQTDANGLVGLQNQAGAAPKRLLDLANT
QASSSTESLENQSSATQAEGAAPEIAQDQVWSAKLIEHSLWYGVLLFLGLGMLLAFTPCSLPMLPILTSLIIRDHKGLKA
WTIALTFVCSMALVYAGLGLIASSAGLNFQRWLQQPATLIAFSLLFVVFALNLFGLFELRLPQTWLNRLDRIQSMQQGGT
LVGAGVMGVVSALLVGPCMTAPLAGTLLFISQTQNQWQGALLLFCLGFGMGIPLLIASVLGAKFLPKAGDWMHQIKVIFA
FMMLGLSLYFIRPLLPDWGMQALSFVLGLAFIIYALYQFFWKKGQLQWLYALLFLLVTPFVVYNQYQHIQNRSLQNSEHM
AEWHVATTAADFQKILAAAPADRAIVVDVYADWCVACQPIEHRILKSPEVQTALVPYYLIKLDLSHYDQSHEALLKQWNI
LGPPTYLFLNKQQQEIRSLRLTGAFSQQELLQQLASLSKAKDSN

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=579, Percent_Identity=32.8151986183074, Blast_Score=293, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 67640; Mature: 67640

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLISQGIIYFLVAATFVLSQFVFAEDKLLSPEQAFSFSVESPQSHTAKLSWQIQPNYY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCEECCCCCCCCCEEEEEEECCCEE
LYQHKFTVQQGNQPLTLNLPKAVSQYDENYGQSQVYYHQVNFQIKTKPSEHYTVTWQGCA
EEEEEEEEECCCCCEEEECHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCEEEEECCCC
KDRICYPPQTIEFQTDANGLVGLQNQAGAAPKRLLDLANTQASSSTESLENQSSATQAEG
CCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHCCCCCCCHHHHHCCCCHHHCCC
AAPEIAQDQVWSAKLIEHSLWYGVLLFLGLGMLLAFTPCSLPMLPILTSLIIRDHKGLKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHH
WTIALTFVCSMALVYAGLGLIASSAGLNFQRWLQQPATLIAFSLLFVVFALNLFGLFELR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHC
LPQTWLNRLDRIQSMQQGGTLVGAGVMGVVSALLVGPCMTAPLAGTLLFISQTQNQWQGA
CCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCHHHHH
LLLFCLGFGMGIPLLIASVLGAKFLPKAGDWMHQIKVIFAFMMLGLSLYFIRPLLPDWGM
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QALSFVLGLAFIIYALYQFFWKKGQLQWLYALLFLLVTPFVVYNQYQHIQNRSLQNSEHM
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AEWHVATTAADFQKILAAAPADRAIVVDVYADWCVACQPIEHRILKSPEVQTALVPYYLI
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHE
KLDLSHYDQSHEALLKQWNILGPPTYLFLNKQQQEIRSLRLTGAFSQQELLQQLASLSKA
EEEHHHCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
KDSN
CCCC
>Mature Secondary Structure
MKKLISQGIIYFLVAATFVLSQFVFAEDKLLSPEQAFSFSVESPQSHTAKLSWQIQPNYY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCEECCCCCCCCCEEEEEEECCCEE
LYQHKFTVQQGNQPLTLNLPKAVSQYDENYGQSQVYYHQVNFQIKTKPSEHYTVTWQGCA
EEEEEEEEECCCCCEEEECHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCEEEEECCCC
KDRICYPPQTIEFQTDANGLVGLQNQAGAAPKRLLDLANTQASSSTESLENQSSATQAEG
CCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHCCCCCCCHHHHHCCCCHHHCCC
AAPEIAQDQVWSAKLIEHSLWYGVLLFLGLGMLLAFTPCSLPMLPILTSLIIRDHKGLKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHH
WTIALTFVCSMALVYAGLGLIASSAGLNFQRWLQQPATLIAFSLLFVVFALNLFGLFELR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHC
LPQTWLNRLDRIQSMQQGGTLVGAGVMGVVSALLVGPCMTAPLAGTLLFISQTQNQWQGA
CCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCHHHHH
LLLFCLGFGMGIPLLIASVLGAKFLPKAGDWMHQIKVIFAFMMLGLSLYFIRPLLPDWGM
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QALSFVLGLAFIIYALYQFFWKKGQLQWLYALLFLLVTPFVVYNQYQHIQNRSLQNSEHM
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AEWHVATTAADFQKILAAAPADRAIVVDVYADWCVACQPIEHRILKSPEVQTALVPYYLI
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHE
KLDLSHYDQSHEALLKQWNILGPPTYLFLNKQQQEIRSLRLTGAFSQQELLQQLASLSKA
EEEHHHCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
KDSN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]