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The map label for this gene is guaB [H]

Identifier: 213159060

GI number: 213159060

Start: 3886594

End: 3888060

Strand: Reverse

Name: guaB [H]

Synonym: AB57_3770

Alternate gene names: 213159060

Gene position: 3888060-3886594 (Counterclockwise)

Preceding gene: 213159061

Following gene: 213159059

Centisome position: 95.99

GC content: 43.97

Gene sequence:

>1467_bases
ATGCTGACCATCGTTCAAGAAGCGCTAACCTTCGATGATGTCTTATTACTTCCTGCCTACTCTACTGTTCTCCCAAAAGA
TGTCTCTCTAAAGACACGTTTAACTCGCGGCATTTATTTAAATATCCCATTAGTTTCAGCTGCAATGGATACAGTGACTG
AGTCACGTATGGCGATTGCAATGGCCCAAAATGGTGGTATCGGGATTTTGCACAAAAACATGGATATTGCTGCTCAAGCT
GCAGAAGTACGCCGTGTGAAAAAATTCGAAGCGGGTATGGTGAAAGACCCTATCACTGTAAGCCCTGAAACTACAGTACG
TGAACTGATTGCAATTACCTCTGCTAATAACATTAGTGGTGTACCTGTTGTTAAAGACGGCAAGGTTGTTGGTATTGTGA
CAGGCCGTGATACGCGTTTTGAAACCAATTTAGAACAACCTGTTAGCAACATCATGACAGGCCAAGATCGTTTAGTCACT
GTACGTGAAGGCGAGTCTAAAGAAAATATTCAAGCATTATTGCAAAAACACCGTATTGAAAAAGTCTTGGTCGTTGGCGA
GAGCAACGAACTTAAAGGCTTAATTACAGTGACTGACTTCCGCAAAGCTGAGAGTTATCCAAACAGTTGTAAAGATGATC
TTGGTCGTTTACGTGTTGGTGCTGCGGTAGGTACAGGTGCTGATACACCAAGTCGTGTGGAAGCATTGGTTGAAGCTGGT
GTTGACGTCATTGTTGTTGATACAGCACATGGCCACTCTGCTGGTGTAATTGAACGTGTACGTTGGGTGAAACAAAACTT
CCCTCAAGTACAAGTGATTGGTGGCAACATTGCAACTGGTGATGCTGCATTAGCATTATTAGATGCAGGTGCAGATGCTG
TAAAAGTGGGTATTGGTCCTGGTTCTATCTGTACAACACGTATTGTGGCTGGTATCGGTATGCCACAAATTTCTGCAATT
GACAGCGTTGCTAGCGCACTAAAAGATCAAATTCCTTTAATTGCAGATGGCGGTATCCGCTTCTCTGGCGATATGGCAAA
AGCGATCGGTGCGGGTGCAAGTACGATCATGGTTGGTTCATTACTTGCAGGTACTGAAGAAGCGCCGGGCGAAGTTGAGT
TTTTCCAAGGTCGTTACTACAAAGCATATCGTGGTATGGGTTCATTAGGTGCAATGGCGGGAGCAACTGGTTCTGCTGAC
CGTTATTTCCAAGATTCAAAAGCGGGTGCTGAGAAGTTAGTACCAGAAGGAATCGAAGGCCGTGTTCCATATAAAGGCCC
AATGGGTAACATCGTTCATCAAATGATGGGTGGTTTACGTTCATCGATGGGTTATACAGGTTCAGCTGTGATTGAAGATC
TTCGCCAAAATGCGAAATTTGTGAAAATTACTTCAGCAGGCATGTCTGAGTCACATGTTCATGATGTAACGATTACTAAA
GAAGCTCCGAACTATCGTGTTGGTTAG

Upstream 100 bases:

>100_bases
AGAGTAGGCGAATATCTATTGCTGAAAAAGGCAAAGATAATATGAAAATTGCATCGAAATTTGTTTATAATAGCTCACGG
AATTTACCAGTGAGATTGTT

Downstream 100 bases:

>100_bases
ATTTTGGTAACCAAAACAATCAAGAAAGCCGTCAGTACACTGACGGCTTTTTGTTTTTGGTGTAAAGTAAATCCGATGAA
AAGAGATATGGCGGAATAGC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQA
AEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISGVPVVKDGKVVGIVTGRDTRFETNLEQPVSNIMTGQDRLVT
VREGESKENIQALLQKHRIEKVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAG
VDVIVVDTAHGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGMPQISAI
DSVASALKDQIPLIADGGIRFSGDMAKAIGAGASTIMVGSLLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGATGSAD
RYFQDSKAGAEKLVPEGIEGRVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITK
EAPNYRVG

Sequences:

>Translated_488_residues
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQA
AEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISGVPVVKDGKVVGIVTGRDTRFETNLEQPVSNIMTGQDRLVT
VREGESKENIQALLQKHRIEKVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAG
VDVIVVDTAHGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGMPQISAI
DSVASALKDQIPLIADGGIRFSGDMAKAIGAGASTIMVGSLLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGATGSAD
RYFQDSKAGAEKLVPEGIEGRVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITK
EAPNYRVG
>Mature_488_residues
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQA
AEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISGVPVVKDGKVVGIVTGRDTRFETNLEQPVSNIMTGQDRLVT
VREGESKENIQALLQKHRIEKVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAG
VDVIVVDTAHGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGMPQISAI
DSVASALKDQIPLIADGGIRFSGDMAKAIGAGASTIMVGSLLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGATGSAD
RYFQDSKAGAEKLVPEGIEGRVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITK
EAPNYRVG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=41.25, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=40.5797101449275, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=41.25, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=41.25, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=41.25, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=41.3502109704641, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=40.4166666666667, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=38.5416666666667, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI50541956, Length=252, Percent_Identity=38.8888888888889, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI50541954, Length=252, Percent_Identity=38.8888888888889, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI50541952, Length=252, Percent_Identity=38.8888888888889, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI50541948, Length=252, Percent_Identity=38.8888888888889, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI156104880, Length=251, Percent_Identity=38.2470119521912, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=63.265306122449, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=35.2678571428571, Blast_Score=145, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=37.8, Blast_Score=297, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=41.5676959619952, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=224, Percent_Identity=38.3928571428571, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=38.4928716904277, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=37.9876796714579, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.3374741200828, Blast_Score=305, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.5964912280702, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=123, Percent_Identity=38.2113821138211, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=41.8556701030928, Blast_Score=341, Evalue=8e-94,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=41.8556701030928, Blast_Score=341, Evalue=8e-94,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=41.9864559819413, Blast_Score=306, Evalue=3e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51475; Mature: 51475

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIA
CCEEHHHHHCCCCEEEECCHHHHCCCCCCHHHEECCCEEEECCHHHHHHHHHHHHHEEEE
MAQNGGIGILHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCCC
VPVVKDGKVVGIVTGRDTRFETNLEQPVSNIMTGQDRLVTVREGESKENIQALLQKHRIE
CEEEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCC
KVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAG
EEEEEECCCCCCEEEEEECCHHHCCCCCHHHHHHHHEEECEEECCCCCCHHHHHHHHHCC
VDVIVVDTAHGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEEECCCCEEEEECCC
GSICTTRIVAGIGMPQISAIDSVASALKDQIPLIADGGIRFSGDMAKAIGAGASTIMVGS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHCCCHHHHHHHH
LLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGATGSADRYFQDSKAGAEKLVPEGIEG
HHCCCCCCCCCEEEECCCHHHHHCCCCCHHHHCCCCCCCHHHHCCCCCCHHHHCCCCCCC
RVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITK
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEE
EAPNYRVG
CCCCCCCC
>Mature Secondary Structure
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIA
CCEEHHHHHCCCCEEEECCHHHHCCCCCCHHHEECCCEEEECCHHHHHHHHHHHHHEEEE
MAQNGGIGILHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCCC
VPVVKDGKVVGIVTGRDTRFETNLEQPVSNIMTGQDRLVTVREGESKENIQALLQKHRIE
CEEEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCC
KVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAG
EEEEEECCCCCCEEEEEECCHHHCCCCCHHHHHHHHEEECEEECCCCCCHHHHHHHHHCC
VDVIVVDTAHGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEEECCCCEEEEECCC
GSICTTRIVAGIGMPQISAIDSVASALKDQIPLIADGGIRFSGDMAKAIGAGASTIMVGS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHCCCHHHHHHHH
LLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGATGSADRYFQDSKAGAEKLVPEGIEG
HHCCCCCCCCCEEEECCCHHHHHCCCCCHHHHCCCCCCCHHHHCCCCCCHHHHCCCCCCC
RVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITK
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEE
EAPNYRVG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA