Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 213159020

GI number: 213159020

Start: 3838898

End: 3840190

Strand: Reverse

Name: gabT [H]

Synonym: AB57_3728

Alternate gene names: 213159020

Gene position: 3840190-3838898 (Counterclockwise)

Preceding gene: 213159022

Following gene: 213159019

Centisome position: 94.81

GC content: 44.93

Gene sequence:

>1293_bases
ATGGATAATCAACATTCTGCACTTAACGTACGTAAACAGCAAGCAACTCCACGTGGTGTAGGCGTGATGTGTCAGTGGTA
TGCGGAAAAAGCTGAAAATGCCACGCTTTGGGACAAGGAAGGCAACCAATTTATCGACTTTGCTGGTGGTATCGCGGTTT
TAAACACAGGCCATCGCCACCCTAAAGTGATTGCAGCGGTGACTGAACAACTTACTAAATTTACGCATACTGCCTATCAA
GTAACACCATATGAAAGCTATGTCGCTTTAGCTGAGCGTATTAATGAACGCGCGCCAATTGCTGGTCCTGCAAAGTCTGC
TTTTTTCACAACAGGTGCAGAAGCAGTTGAAAATGCAGTGAAGATTGCTCGTTGTTACACAGGTCGTCACGGCATTATCA
CGTTTGGTAACGGTTTCCACGGCCGTTCATTCATGACGATGGCAATGACAGGTAAAACTGCGCCTTACAAACGTGATTTC
GGTGTAATGCCAGCGGGTGTGTTCCACGCACGTTACCCAGTACCTGCTAAAGGTATTTCAGTAGATGCGGCAATTGAAAG
CGTTGAAGATATTTTCAGTGAAGATATTGCACCACATGACGTTGCAGCAATTGTGCTAGAGCCAGTACAAGGTGAAGGCG
GTTTCAATGTGGTGCCAGCCGAGTTCTTAAAACGTTTACGTGCAATTTGTGATAAGCACGGTATTTTACTTGTCGCTGAT
GAAGTGCAATCTGGTTTTGCTCGTACTGGTAAGTTATTTGCGATGAACCATTATGAAACTAAAGCAGACCTCATCACGAT
GGCGAAAAGCTTGGGCGGTGGTTTCCCTATTTCGGGTGTTGTGGGCCGTGCAGAAGTGATGGATGCACCAAACCCGGGTG
GTCTAGGCGGTACTTACGCAGGTAGCCCAATTGCGGTTGCTGCTGCGCACGCAGTGATTGATGCGATTGAAGAAGAAAAC
TTGTGTGACCGTGCAAATGAATTAGGTGCAGAGTTAGTTGCTACCCTTAAAGATATTCAACAAGCAACAGGCGATGTCGT
AACTGATATTCGTGCATTGGGTTCAATGGTTGCAGTAGAGCTTGAAACAGCTGAACAAGCAAAAGTTGTACAAAACTATG
CAATGGAAAACGGGTTGTTACTTCTTACTTGTGGTAAATACGGTAATGTAATTCGTTTCTTATATCCATTAACCATTCCT
GCTGAGCAATTCCGTCAAGGTCTTGATATCTTGAAACAAGGTTTTGCGACACTAAAAGCAGGTAGTGCAAAAGCAATGGA
GCAATCTGCATGA

Upstream 100 bases:

>100_bases
AATTACATGCATAGGCAGTCGTTGTAAAGCACCCTGAAAATTAAGCACAGGATGCAAGAAACCAAAGCTGCAACTGATGA
TGAAAATATGAGGGAATCAA

Downstream 100 bases:

>100_bases
TTCAAAATAATTTGCAGTATTTATTAAAACATCCTGATATTTCATTAGAAGCACCTGCATCAAATGACTATATCGAGGTG
AATGATGCTGCTACGGGTGA

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDNQHSALNVRKQQATPRGVGVMCQWYAEKAENATLWDKEGNQFIDFAGGIAVLNTGHRHPKVIAAVTEQLTKFTHTAYQ
VTPYESYVALAERINERAPIAGPAKSAFFTTGAEAVENAVKIARCYTGRHGIITFGNGFHGRSFMTMAMTGKTAPYKRDF
GVMPAGVFHARYPVPAKGISVDAAIESVEDIFSEDIAPHDVAAIVLEPVQGEGGFNVVPAEFLKRLRAICDKHGILLVAD
EVQSGFARTGKLFAMNHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGSPIAVAAAHAVIDAIEEEN
LCDRANELGAELVATLKDIQQATGDVVTDIRALGSMVAVELETAEQAKVVQNYAMENGLLLLTCGKYGNVIRFLYPLTIP
AEQFRQGLDILKQGFATLKAGSAKAMEQSA

Sequences:

>Translated_430_residues
MDNQHSALNVRKQQATPRGVGVMCQWYAEKAENATLWDKEGNQFIDFAGGIAVLNTGHRHPKVIAAVTEQLTKFTHTAYQ
VTPYESYVALAERINERAPIAGPAKSAFFTTGAEAVENAVKIARCYTGRHGIITFGNGFHGRSFMTMAMTGKTAPYKRDF
GVMPAGVFHARYPVPAKGISVDAAIESVEDIFSEDIAPHDVAAIVLEPVQGEGGFNVVPAEFLKRLRAICDKHGILLVAD
EVQSGFARTGKLFAMNHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGSPIAVAAAHAVIDAIEEEN
LCDRANELGAELVATLKDIQQATGDVVTDIRALGSMVAVELETAEQAKVVQNYAMENGLLLLTCGKYGNVIRFLYPLTIP
AEQFRQGLDILKQGFATLKAGSAKAMEQSA
>Mature_430_residues
MDNQHSALNVRKQQATPRGVGVMCQWYAEKAENATLWDKEGNQFIDFAGGIAVLNTGHRHPKVIAAVTEQLTKFTHTAYQ
VTPYESYVALAERINERAPIAGPAKSAFFTTGAEAVENAVKIARCYTGRHGIITFGNGFHGRSFMTMAMTGKTAPYKRDF
GVMPAGVFHARYPVPAKGISVDAAIESVEDIFSEDIAPHDVAAIVLEPVQGEGGFNVVPAEFLKRLRAICDKHGILLVAD
EVQSGFARTGKLFAMNHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGSPIAVAAAHAVIDAIEEEN
LCDRANELGAELVATLKDIQQATGDVVTDIRALGSMVAVELETAEQAKVVQNYAMENGLLLLTCGKYGNVIRFLYPLTIP
AEQFRQGLDILKQGFATLKAGSAKAMEQSA

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=404, Percent_Identity=31.1881188118812, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI13994255, Length=355, Percent_Identity=30.9859154929577, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=32.2884012539185, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=27.0783847980998, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI24119277, Length=404, Percent_Identity=28.2178217821782, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=26.6826923076923, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=27.319587628866, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI188536080, Length=441, Percent_Identity=25.8503401360544, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38679950, Length=441, Percent_Identity=25.8503401360544, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38679946, Length=441, Percent_Identity=25.8503401360544, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1787560, Length=413, Percent_Identity=61.501210653753, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=52.4705882352941, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=37.3401534526854, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=36.9509043927649, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=33.0024813895782, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786991, Length=394, Percent_Identity=28.9340101522843, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786349, Length=356, Percent_Identity=31.1797752808989, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=396, Percent_Identity=32.0707070707071, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=31.7351598173516, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=28.246013667426, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=282, Percent_Identity=32.9787234042553, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=433, Percent_Identity=24.2494226327945, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=31.7961165048544, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=31.1881188118812, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321456, Length=408, Percent_Identity=24.5098039215686, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=384, Percent_Identity=23.4375, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=31.7016317016317, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574759, Length=411, Percent_Identity=32.1167883211679, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=31.6831683168317, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21356575, Length=438, Percent_Identity=26.2557077625571, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366494, Length=396, Percent_Identity=26.010101010101, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24667139, Length=396, Percent_Identity=26.010101010101, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24667143, Length=396, Percent_Identity=26.010101010101, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 45975; Mature: 45975

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNQHSALNVRKQQATPRGVGVMCQWYAEKAENATLWDKEGNQFIDFAGGIAVLNTGHRH
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEECCCCCEEEEECCCEEEECCCCCC
PKVIAAVTEQLTKFTHTAYQVTPYESYVALAERINERAPIAGPAKSAFFTTGAEAVENAV
CHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCCCCCCCHHEECCHHHHHHHH
KIARCYTGRHGIITFGNGFHGRSFMTMAMTGKTAPYKRDFGVMPAGVFHARYPVPAKGIS
HHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCCCC
VDAAIESVEDIFSEDIAPHDVAAIVLEPVQGEGGFNVVPAEFLKRLRAICDKHGILLVAD
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEH
EVQSGFARTGKLFAMNHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYA
HHHCCHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
GSPIAVAAAHAVIDAIEEENLCDRANELGAELVATLKDIQQATGDVVTDIRALGSMVAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LETAEQAKVVQNYAMENGLLLLTCGKYGNVIRFLYPLTIPAEQFRQGLDILKQGFATLKA
EHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
GSAKAMEQSA
CCHHHHHCCC
>Mature Secondary Structure
MDNQHSALNVRKQQATPRGVGVMCQWYAEKAENATLWDKEGNQFIDFAGGIAVLNTGHRH
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEECCCCCEEEEECCCEEEECCCCCC
PKVIAAVTEQLTKFTHTAYQVTPYESYVALAERINERAPIAGPAKSAFFTTGAEAVENAV
CHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCCCCCCCHHEECCHHHHHHHH
KIARCYTGRHGIITFGNGFHGRSFMTMAMTGKTAPYKRDFGVMPAGVFHARYPVPAKGIS
HHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCCCC
VDAAIESVEDIFSEDIAPHDVAAIVLEPVQGEGGFNVVPAEFLKRLRAICDKHGILLVAD
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEH
EVQSGFARTGKLFAMNHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYA
HHHCCHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
GSPIAVAAAHAVIDAIEEENLCDRANELGAELVATLKDIQQATGDVVTDIRALGSMVAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LETAEQAKVVQNYAMENGLLLLTCGKYGNVIRFLYPLTIPAEQFRQGLDILKQGFATLKA
EHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
GSAKAMEQSA
CCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]