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The map label for this gene is aqpZ [H]

Identifier: 213158992

GI number: 213158992

Start: 3812130

End: 3812819

Strand: Direct

Name: aqpZ [H]

Synonym: AB57_3696

Alternate gene names: 213158992

Gene position: 3812130-3812819 (Clockwise)

Preceding gene: 213158991

Following gene: 213158996

Centisome position: 94.11

GC content: 44.78

Gene sequence:

>690_bases
ATGAATAAATATTTTGCTGAATTCCTAGGTACGTTTTGGCTAGTCTTTGGTGGTTGTGGTAGCGCAGTTTTAGCCGCAGC
TTTCCCTGAACTTGGTATTGGCTTTGCAGGTGTAGCCCTTGCCTTTGGTTTAACCGTACTCACAGGTGCTTATGCTCTAG
GGCATATCTCAGGTGGACATTTCAATCCCGCGGTAAGTGTTGGCCTTTGGGTCGGTGGCCGCTTCGATGTTAAAGATTTA
ATTCCGTATATTGTTGCGCAAGTGGTTGGTGCGACTGCTGCTGCATTTGTTCTTTATATTATTGCTCAAGGCCAAGCAGG
CTTTAGTGGTGTTGGCGGGTTTGCGACCAATGGTTTTGGTGACTTATCACCAAATAAATTTGGTTTAGGTTCTGCTTTCA
TTATTGAAGTGGTTCTTACTGCTTTCTTCTTAATCATTATTTTAGGAGCAACTGACCGCCGTGCGCCTGCTGGCTTCGCT
CCTATCGCGATTGGTTTAGGCTTAACACTCATTCACTTAATCAGTATTCCGGTGACGAACACTTCGGTAAACCCAGCACG
TAGTACAGGTGTTGCATTCTTTGCTGAAACGGCTGCATTAAGTCAGTTGTGGTTGTTCTGGATAGCACCGATTCTAGGAG
CTGTGATTGGGGCAATTATTTATAAGGTAGTTGCTGGGGACAAAGATTAA

Upstream 100 bases:

>100_bases
AAACAACACTGAAAACAAAAATTTCATATAGTCACATGCTTAATTTTTTGTGACGTATTTCACATTAATTAAAAAATAGA
TCAATAGATGAGTAATCACA

Downstream 100 bases:

>100_bases
CTCTTCTTAGACTCAATCTACTATCGCGGAAGGTGACATGGATGTCACCTGTTGAGCAGGGGTACATGGATGTACCCTCT
GATCAACAAAGCCTTTTGTT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MNKYFAEFLGTFWLVFGGCGSAVLAAAFPELGIGFAGVALAFGLTVLTGAYALGHISGGHFNPAVSVGLWVGGRFDVKDL
IPYIVAQVVGATAAAFVLYIIAQGQAGFSGVGGFATNGFGDLSPNKFGLGSAFIIEVVLTAFFLIIILGATDRRAPAGFA
PIAIGLGLTLIHLISIPVTNTSVNPARSTGVAFFAETAALSQLWLFWIAPILGAVIGAIIYKVVAGDKD

Sequences:

>Translated_229_residues
MNKYFAEFLGTFWLVFGGCGSAVLAAAFPELGIGFAGVALAFGLTVLTGAYALGHISGGHFNPAVSVGLWVGGRFDVKDL
IPYIVAQVVGATAAAFVLYIIAQGQAGFSGVGGFATNGFGDLSPNKFGLGSAFIIEVVLTAFFLIIILGATDRRAPAGFA
PIAIGLGLTLIHLISIPVTNTSVNPARSTGVAFFAETAALSQLWLFWIAPILGAVIGAIIYKVVAGDKD
>Mature_229_residues
MNKYFAEFLGTFWLVFGGCGSAVLAAAFPELGIGFAGVALAFGLTVLTGAYALGHISGGHFNPAVSVGLWVGGRFDVKDL
IPYIVAQVVGATAAAFVLYIIAQGQAGFSGVGGFATNGFGDLSPNKFGLGSAFIIEVVLTAFFLIIILGATDRRAPAGFA
PIAIGLGLTLIHLISIPVTNTSVNPARSTGVAFFAETAALSQLWLFWIAPILGAVIGAIIYKVVAGDKD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=39.4618834080717, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=37.3873873873874, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI37694062, Length=226, Percent_Identity=38.0530973451327, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI6912506, Length=220, Percent_Identity=35, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI4755125, Length=223, Percent_Identity=32.2869955156951, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502181, Length=223, Percent_Identity=32.2869955156951, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI86792455, Length=220, Percent_Identity=32.7272727272727, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI157266307, Length=244, Percent_Identity=34.8360655737705, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI45446752, Length=203, Percent_Identity=30.0492610837438, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI22538420, Length=247, Percent_Identity=27.5303643724696, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI297307120, Length=97, Percent_Identity=38.1443298969072, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4502187, Length=246, Percent_Identity=28.4552845528455, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4826645, Length=250, Percent_Identity=29.2, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI297307116, Length=97, Percent_Identity=38.1443298969072, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI297307118, Length=97, Percent_Identity=38.1443298969072, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1787101, Length=229, Percent_Identity=65.938864628821, Blast_Score=277, Evalue=3e-76,
Organism=Escherichia coli, GI1790362, Length=248, Percent_Identity=31.8548387096774, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71993722, Length=237, Percent_Identity=32.0675105485232, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=244, Percent_Identity=29.9180327868852, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=228, Percent_Identity=31.140350877193, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=228, Percent_Identity=31.140350877193, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=238, Percent_Identity=30.2521008403361, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558372, Length=233, Percent_Identity=27.8969957081545, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=91, Percent_Identity=40.6593406593407, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652747, Length=229, Percent_Identity=35.8078602620087, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551084, Length=229, Percent_Identity=35.8078602620087, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24652751, Length=222, Percent_Identity=35.5855855855856, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922038, Length=226, Percent_Identity=35.3982300884956, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24762346, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762348, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20130305, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762344, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550503, Length=223, Percent_Identity=29.1479820627803, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136672, Length=236, Percent_Identity=27.9661016949153, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24762342, Length=233, Percent_Identity=27.4678111587983, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23488; Mature: 23488

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYFAEFLGTFWLVFGGCGSAVLAAAFPELGIGFAGVALAFGLTVLTGAYALGHISGGH
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FNPAVSVGLWVGGRFDVKDLIPYIVAQVVGATAAAFVLYIIAQGQAGFSGVGGFATNGFG
CCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DLSPNKFGLGSAFIIEVVLTAFFLIIILGATDRRAPAGFAPIAIGLGLTLIHLISIPVTN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGVAFFAETAALSQLWLFWIAPILGAVIGAIIYKVVAGDKD
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKYFAEFLGTFWLVFGGCGSAVLAAAFPELGIGFAGVALAFGLTVLTGAYALGHISGGH
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FNPAVSVGLWVGGRFDVKDLIPYIVAQVVGATAAAFVLYIIAQGQAGFSGVGGFATNGFG
CCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DLSPNKFGLGSAFIIEVVLTAFFLIIILGATDRRAPAGFAPIAIGLGLTLIHLISIPVTN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGVAFFAETAALSQLWLFWIAPILGAVIGAIIYKVVAGDKD
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]