Click here to switch to the map view.

The map label for this gene is ftsI [H]

Identifier: 213158954

GI number: 213158954

Start: 3766223

End: 3768055

Strand: Reverse

Name: ftsI [H]

Synonym: AB57_3655

Alternate gene names: 213158954

Gene position: 3768055-3766223 (Counterclockwise)

Preceding gene: 213158955

Following gene: 213158953

Centisome position: 93.03

GC content: 41.19

Gene sequence:

>1833_bases
ATGGTAGATAAGCGAACAAAGCAAACACGAAAAAAACAGCAGTCTATTTCGGAAAAACCAAGTCTTGCCTTTGATATGTG
GCGGTTTTATCTGCTCTGGGCAGTAGTGCTACTGTGTTTTGTGGTATTAATTGCACGTGCATTTTATGTTCAAGTCATTA
ATAAAGACTTTTTGCAAAATAAGGCCAATGCCAATATTTTGCGTACTGAACGTATAGAGGCTATGCGTGGAGTGATTAGT
GATCGCCACGGTGTACCTTTAGCGATTAGTAGTCCAATCATGAAAATTGTGATTGATCCGCGTGATTATTTTGAGACCAA
GCATTTATATGATCAAATTACGGCTGAACTAAAACAAGATCCAAACAACCGTAAATTAAAACGCCAATTGCCAGATAAAA
ATTTAAATCTTGATGAACTTGCCGACGTGGTGGGTGTTGATCGTGCTGATCTTAAAAAACAGATGAATGCGCGTCCGCGT
TCTCGCTATCTGGTTTTGAAAAAAGAAGTACCTCCTCAGCAAGCTGACCTCATTATGAAAGGTAATTTCCAAGGGGTGTA
TGCAGAAAAAACTTATAAACGTTATTACCCGCAACCTCAGCCAAATGCCCAAATTATTGGTTTGACCAATAGTGAAGGTC
AAGGTATCGAAGGCTTGGAAATGCAGTTGAATAAGCAACTGTCAGGTGTAGACGGTGAGCAAAAAATTATTCGCGATAAG
CGTGGTAACCGTTTAAAAGTTTCTGAGGTAATTCGTGAGGGTGAACCAGGTGAAAATATCACTTTAAGTATCGACTCACG
TTTGCAGTACATTATGTACCGTGAATTAACGGCTGCAGGTGTGGCTAACAATGCGCGTTCAGCAACGGCGATTGCAGTTG
ATGTTAAAACGGGTGAAATTCTGGCAATGACCAGTTGGCCATCTTATAACCCGAATGATAAGAATGGCTTATCAAATAAA
GATGCTATGCGTAACCGTGGTGCGATCGATATGTTCGAGCCAGGTTCAACCATGAAACCTTTTACTATTTCTGCAGCTTT
AGAAACTGGTCAATATACGCCAAATACGATTGTAAATACCTCTCCTGGCTCAATGCGTTTAGGCTGGCATACTATTCGTG
ATACCCATAACTATGGGGCTTTGACCGTAAGTGGTGTCATTATTAAGTCTTCAAACGTGGGTTCTGCAAAAATTGCATTA
TCACTTCCGAAAGAAACTTTGCCGAGCTTCTTTAATCGTGTTGGTTTTGGTAAGCGTTCTGCAGTAAGGTTCCCTGGGGA
AAGTTCAGGTCTGGTTTTACCTGTTAATAAATTAAACTCTTCTCAAATCGGGACCATGGCATATGGTTATGGCTTAAACG
CGACAATCCTTCAATTGGCTCAAGGTTATGCCATGCTTGCAAATCATGGTGTCAAAATGCCATTAAGCTTGCATAAACTA
GATCAGCCACCTAAAGGTGAGCAAGTTTTAAATCCGAAAATTGCCGATCAAGTTTTGTTAATGCTTGAGCAAGTGACTAT
GCCGGGTGGTACTGCAAAACAAGCCAATATTCCTGGTTATAGGGTAGGTGGTAAAACAGGTACTGCACATAAATTGCGTG
CAGATGGTAAAGGATATTCAAATAATGAGTATCGTGCCTTATTTGCGGGTGTCGCACCAATTAGTGATCCACGTTTAGCC
GTTATTGTAGTGGTGGAAAACCCACAAGGTCGCTATTACGGTGGTTTGGTTGCCGCTCCAGTTTTTGCTCGTATTATGCA
AGAGTCGTTGCGCTTAATGAATGTGCCGCTTGATAAGCCACTTAATACTCCAGAAAATCCTATTCGCAGGTAA

Upstream 100 bases:

>100_bases
GTGCTGTGACACAATTACGAATGTTTTCGCCACCTGCTGCAGAAACGGTGGTAATTTCTTTACCGATGACCTCAGAGCAA
AATAAGTAAGGCCTTGCTGT

Downstream 100 bases:

>100_bases
GCTATGACTGTTTCTTTTCAAGAAATTCATCCAATCGAAATTGATGCTCAATGGCCTCAACAGCCATTTCACGGCTTTAG
TTTAGATAGTCGTAAAGTTG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MVDKRTKQTRKKQQSISEKPSLAFDMWRFYLLWAVVLLCFVVLIARAFYVQVINKDFLQNKANANILRTERIEAMRGVIS
DRHGVPLAISSPIMKIVIDPRDYFETKHLYDQITAELKQDPNNRKLKRQLPDKNLNLDELADVVGVDRADLKKQMNARPR
SRYLVLKKEVPPQQADLIMKGNFQGVYAEKTYKRYYPQPQPNAQIIGLTNSEGQGIEGLEMQLNKQLSGVDGEQKIIRDK
RGNRLKVSEVIREGEPGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEILAMTSWPSYNPNDKNGLSNK
DAMRNRGAIDMFEPGSTMKPFTISAALETGQYTPNTIVNTSPGSMRLGWHTIRDTHNYGALTVSGVIIKSSNVGSAKIAL
SLPKETLPSFFNRVGFGKRSAVRFPGESSGLVLPVNKLNSSQIGTMAYGYGLNATILQLAQGYAMLANHGVKMPLSLHKL
DQPPKGEQVLNPKIADQVLLMLEQVTMPGGTAKQANIPGYRVGGKTGTAHKLRADGKGYSNNEYRALFAGVAPISDPRLA
VIVVVENPQGRYYGGLVAAPVFARIMQESLRLMNVPLDKPLNTPENPIRR

Sequences:

>Translated_610_residues
MVDKRTKQTRKKQQSISEKPSLAFDMWRFYLLWAVVLLCFVVLIARAFYVQVINKDFLQNKANANILRTERIEAMRGVIS
DRHGVPLAISSPIMKIVIDPRDYFETKHLYDQITAELKQDPNNRKLKRQLPDKNLNLDELADVVGVDRADLKKQMNARPR
SRYLVLKKEVPPQQADLIMKGNFQGVYAEKTYKRYYPQPQPNAQIIGLTNSEGQGIEGLEMQLNKQLSGVDGEQKIIRDK
RGNRLKVSEVIREGEPGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEILAMTSWPSYNPNDKNGLSNK
DAMRNRGAIDMFEPGSTMKPFTISAALETGQYTPNTIVNTSPGSMRLGWHTIRDTHNYGALTVSGVIIKSSNVGSAKIAL
SLPKETLPSFFNRVGFGKRSAVRFPGESSGLVLPVNKLNSSQIGTMAYGYGLNATILQLAQGYAMLANHGVKMPLSLHKL
DQPPKGEQVLNPKIADQVLLMLEQVTMPGGTAKQANIPGYRVGGKTGTAHKLRADGKGYSNNEYRALFAGVAPISDPRLA
VIVVVENPQGRYYGGLVAAPVFARIMQESLRLMNVPLDKPLNTPENPIRR
>Mature_610_residues
MVDKRTKQTRKKQQSISEKPSLAFDMWRFYLLWAVVLLCFVVLIARAFYVQVINKDFLQNKANANILRTERIEAMRGVIS
DRHGVPLAISSPIMKIVIDPRDYFETKHLYDQITAELKQDPNNRKLKRQLPDKNLNLDELADVVGVDRADLKKQMNARPR
SRYLVLKKEVPPQQADLIMKGNFQGVYAEKTYKRYYPQPQPNAQIIGLTNSEGQGIEGLEMQLNKQLSGVDGEQKIIRDK
RGNRLKVSEVIREGEPGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEILAMTSWPSYNPNDKNGLSNK
DAMRNRGAIDMFEPGSTMKPFTISAALETGQYTPNTIVNTSPGSMRLGWHTIRDTHNYGALTVSGVIIKSSNVGSAKIAL
SLPKETLPSFFNRVGFGKRSAVRFPGESSGLVLPVNKLNSSQIGTMAYGYGLNATILQLAQGYAMLANHGVKMPLSLHKL
DQPPKGEQVLNPKIADQVLLMLEQVTMPGGTAKQANIPGYRVGGKTGTAHKLRADGKGYSNNEYRALFAGVAPISDPRLA
VIVVVENPQGRYYGGLVAAPVFARIMQESLRLMNVPLDKPLNTPENPIRR

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=593, Percent_Identity=39.460370994941, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1786854, Length=632, Percent_Identity=25, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 67660; Mature: 67660

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDKRTKQTRKKQQSISEKPSLAFDMWRFYLLWAVVLLCFVVLIARAFYVQVINKDFLQN
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KANANILRTERIEAMRGVISDRHGVPLAISSPIMKIVIDPRDYFETKHLYDQITAELKQD
CCCCCEEHHHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHCC
PNNRKLKRQLPDKNLNLDELADVVGVDRADLKKQMNARPRSRYLVLKKEVPPQQADLIMK
CCCCHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHCEEEE
GNFQGVYAEKTYKRYYPQPQPNAQIIGLTNSEGQGIEGLEMQLNKQLSGVDGEQKIIRDK
CCCCEEEHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHC
RGNRLKVSEVIREGEPGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEI
CCCEEEHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCE
LAMTSWPSYNPNDKNGLSNKDAMRNRGAIDMFEPGSTMKPFTISAALETGQYTPNTIVNT
EEEECCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCEEEC
SPGSMRLGWHTIRDTHNYGALTVSGVIIKSSNVGSAKIALSLPKETLPSFFNRVGFGKRS
CCCCEEECEEEECCCCCCCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHCCCCCC
AVRFPGESSGLVLPVNKLNSSQIGTMAYGYGLNATILQLAQGYAMLANHGVKMPLSLHKL
EEECCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHC
DQPPKGEQVLNPKIADQVLLMLEQVTMPGGTAKQANIPGYRVGGKTGTAHKLRADGKGYS
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCEEECCCCCCC
NNEYRALFAGVAPISDPRLAVIVVVENPQGRYYGGLVAAPVFARIMQESLRLMNVPLDKP
CCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
LNTPENPIRR
CCCCCCCCCC
>Mature Secondary Structure
MVDKRTKQTRKKQQSISEKPSLAFDMWRFYLLWAVVLLCFVVLIARAFYVQVINKDFLQN
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KANANILRTERIEAMRGVISDRHGVPLAISSPIMKIVIDPRDYFETKHLYDQITAELKQD
CCCCCEEHHHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHCC
PNNRKLKRQLPDKNLNLDELADVVGVDRADLKKQMNARPRSRYLVLKKEVPPQQADLIMK
CCCCHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHCEEEE
GNFQGVYAEKTYKRYYPQPQPNAQIIGLTNSEGQGIEGLEMQLNKQLSGVDGEQKIIRDK
CCCCEEEHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHC
RGNRLKVSEVIREGEPGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEI
CCCEEEHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCE
LAMTSWPSYNPNDKNGLSNKDAMRNRGAIDMFEPGSTMKPFTISAALETGQYTPNTIVNT
EEEECCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCEEEC
SPGSMRLGWHTIRDTHNYGALTVSGVIIKSSNVGSAKIALSLPKETLPSFFNRVGFGKRS
CCCCEEECEEEECCCCCCCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHCCCCCC
AVRFPGESSGLVLPVNKLNSSQIGTMAYGYGLNATILQLAQGYAMLANHGVKMPLSLHKL
EEECCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHC
DQPPKGEQVLNPKIADQVLLMLEQVTMPGGTAKQANIPGYRVGGKTGTAHKLRADGKGYS
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCEEECCCCCCC
NNEYRALFAGVAPISDPRLAVIVVVENPQGRYYGGLVAAPVFARIMQESLRLMNVPLDKP
CCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
LNTPENPIRR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]