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The map label for this gene is rlmA [H]

Identifier: 213158949

GI number: 213158949

Start: 3760972

End: 3761778

Strand: Reverse

Name: rlmA [H]

Synonym: AB57_3650

Alternate gene names: 213158949

Gene position: 3761778-3760972 (Counterclockwise)

Preceding gene: 213158950

Following gene: 213158947

Centisome position: 92.87

GC content: 41.26

Gene sequence:

>807_bases
ATGTGCCCTGTATGTCGTCAACGACTTGAGCTGGTAAGCAAAACATGGCGGTGTGAACAGGGCCATAGCTATGACATTGC
AAAGCAAGGTTATGTGAACTTACATGTTGTACAACACAAACATAGTAAAAATCCGGGAGATACTCCTGAGTCTGTAGATG
CGCGCCGTGCTTTTTTACAAGGTGGCTATTATCAACCTTTACAGCAAGCAGTAGTTCATTTGCTGAAGCAGCTTAAAGCT
AAAACGGTACTTGATATTGGCTGTGGCGAGGGCTATTACACCAGCGCAATGCAACAGGTCGTTGAACAGTGTATAGGTGT
AGATATTGCAAAAAATGCAGTACAACGCGCAGCAAAGTTAAATGACAAAGTGACATGGGTGGTTGGTACAGGAGCAACTT
TACCGGTCATCGATCAAAGCATGGATGTGTGTACGAGTCTTTTTAGCCCGATTCCCCAAACGGAAATTCTGCGTGTTTTA
AAAGATGATGGTTATTTAATTGTTGTGACTCCGGCAACCGATCACTTGTATGCAATGCGTGAGGCGTTGTTTGAACAGGT
TAATCCTCACACACCACAGAAGTTTGTTGAACAACTACAAGATTTATTTGAGTTGAAAGAACAGCAAGTTATTGATGCTC
CTTTAGTACTTGACCAGCAAGCTTTAAAAAATCTTATTGCTATGACTCCCTATGCTTATAAGGCATCTCCAGAGCGTCGT
ATGCAATTAGAACAGAAAGCACACTTACAAGTGACCGCATCTTTTCAAATTTATCTTTTTCAAAAGCGTAATAAAAAAGC
CATCTAA

Upstream 100 bases:

>100_bases
AGGGAACAAATGCAGGCCGTACATTTGTTGGAATGCACGCTAAGGCTTATTTACAACAAAAAGAACAAGAGAATAATTAA
ACGTGACTACGCAAAATTTA

Downstream 100 bases:

>100_bases
CGATGGCTTTTTTATTTTTATTCAATTTGATTAATCAAGTTTTCTAATTCATCTTTTTCACGCTTCGGCGCTGCCCCTTG
CGAAGGTTTCATTGCTGGAG

Product: ribosomal RNA large subunit methyltransferase A

Products: NA

Alternate protein names: 23S rRNA m1G745 methyltransferase; rRNA (guanine-N(1)-)-methyltransferase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MCPVCRQRLELVSKTWRCEQGHSYDIAKQGYVNLHVVQHKHSKNPGDTPESVDARRAFLQGGYYQPLQQAVVHLLKQLKA
KTVLDIGCGEGYYTSAMQQVVEQCIGVDIAKNAVQRAAKLNDKVTWVVGTGATLPVIDQSMDVCTSLFSPIPQTEILRVL
KDDGYLIVVTPATDHLYAMREALFEQVNPHTPQKFVEQLQDLFELKEQQVIDAPLVLDQQALKNLIAMTPYAYKASPERR
MQLEQKAHLQVTASFQIYLFQKRNKKAI

Sequences:

>Translated_268_residues
MCPVCRQRLELVSKTWRCEQGHSYDIAKQGYVNLHVVQHKHSKNPGDTPESVDARRAFLQGGYYQPLQQAVVHLLKQLKA
KTVLDIGCGEGYYTSAMQQVVEQCIGVDIAKNAVQRAAKLNDKVTWVVGTGATLPVIDQSMDVCTSLFSPIPQTEILRVL
KDDGYLIVVTPATDHLYAMREALFEQVNPHTPQKFVEQLQDLFELKEQQVIDAPLVLDQQALKNLIAMTPYAYKASPERR
MQLEQKAHLQVTASFQIYLFQKRNKKAI
>Mature_268_residues
MCPVCRQRLELVSKTWRCEQGHSYDIAKQGYVNLHVVQHKHSKNPGDTPESVDARRAFLQGGYYQPLQQAVVHLLKQLKA
KTVLDIGCGEGYYTSAMQQVVEQCIGVDIAKNAVQRAAKLNDKVTWVVGTGATLPVIDQSMDVCTSLFSPIPQTEILRVL
KDDGYLIVVTPATDHLYAMREALFEQVNPHTPQKFVEQLQDLFELKEQQVIDAPLVLDQQALKNLIAMTPYAYKASPERR
MQLEQKAHLQVTASFQIYLFQKRNKKAI

Specific function: Specifically methylates the guanosine in position 745 of 23S rRNA [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=266, Percent_Identity=39.4736842105263, Blast_Score=197, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: =2.1.1.187 [H]

Molecular weight: Translated: 30336; Mature: 30336

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPVCRQRLELVSKTWRCEQGHSYDIAKQGYVNLHVVQHKHSKNPGDTPESVDARRAFLQ
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHC
GGYYQPLQQAVVHLLKQLKAKTVLDIGCGEGYYTSAMQQVVEQCIGVDIAKNAVQRAAKL
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
NDKVTWVVGTGATLPVIDQSMDVCTSLFSPIPQTEILRVLKDDGYLIVVTPATDHLYAMR
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHH
EALFEQVNPHTPQKFVEQLQDLFELKEQQVIDAPLVLDQQALKNLIAMTPYAYKASPERR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCCCCHHHH
MQLEQKAHLQVTASFQIYLFQKRNKKAI
HHHHHHHCEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MCPVCRQRLELVSKTWRCEQGHSYDIAKQGYVNLHVVQHKHSKNPGDTPESVDARRAFLQ
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHC
GGYYQPLQQAVVHLLKQLKAKTVLDIGCGEGYYTSAMQQVVEQCIGVDIAKNAVQRAAKL
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
NDKVTWVVGTGATLPVIDQSMDVCTSLFSPIPQTEILRVLKDDGYLIVVTPATDHLYAMR
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHH
EALFEQVNPHTPQKFVEQLQDLFELKEQQVIDAPLVLDQQALKNLIAMTPYAYKASPERR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCCCCHHHH
MQLEQKAHLQVTASFQIYLFQKRNKKAI
HHHHHHHCEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7984109; 9097040; 9278503; 9440525 [H]