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The map label for this gene is ispH [H]

Identifier: 213158925

GI number: 213158925

Start: 3731865

End: 3732815

Strand: Reverse

Name: ispH [H]

Synonym: AB57_3626

Alternate gene names: 213158925

Gene position: 3732815-3731865 (Counterclockwise)

Preceding gene: 213158932

Following gene: 213158924

Centisome position: 92.16

GC content: 40.59

Gene sequence:

>951_bases
ATGGAAATTGTGTTAGCTAATCCGCGTGGTTTTTGTGCCGGTGTTGATCGAGCCATAGCAATCGTCAATCGGGCTTTGGA
ATGTTTTAATCCTCCTATTTATGTACGTCATGAAGTTGTACACAATAAATTTGTGGTAGATGACTTACGCCAAAGAGGGG
CTGTTTTCGTTGATGAGCTGGACCAAGTGCCAGATGATTCTATTGTAATTTTCAGTGCGCACGGTGTTTCAAAAGCAGTT
CAGCAAGAAGCAGAGCGTCGAGGCTTAAAAGTTTTTGATGCAACTTGTCCATTGGTGACTAAAGTACATATTGAAGTAAC
TAAATATGCTCGCGAAGGGACAGAAGCTATTTTAATTGGTCATGAAGGGCACCCAGAAGTTGAAGGTACGATGGGACAAT
ATGACAAATTAAAAGGTGGAGATATTTATCTGGTTGAAGATGAGGCTGATGTGGCAGCACTCGAGGTTAGACATCCGGAA
AAATTAGCATTTGTTACGCAAACGACCTTATCTATTGATGATACAGCAAAAGTGATTGATGCTTTGCGTGCGAAATTCCC
GAATATTCAAGGTCCGCGTAAAGATGACATCTGTTATGCAACTCAAAATAGACAAGATGCAGTACGTGACTTAGCTGAAA
AATGTGATGTTGTGCTGGTTGTTGGCTCACCTAACTCGTCAAATTCGAATCGTTTACGTGAGCTTGCTGAGCGTATGGGG
AAAGCTGCTTATCTAGTAGATAATGCAGATCAACTTGAACAATCATGGTTCAATGATACTTGTAAAATTGGTGTTACAGC
GGGAGCTTCAGCTCCAGAAATTTTAATTAAGCAAGTGATTCAACGTTTACAAGATTGGGGAGCTCAGGCGCCTAAAGAAT
TAGAAGGACGTGAGGAAAATATTACTTTTAGTCTTCCTAAAGAATTACGTATTCATGTGACCCAAGCATAA

Upstream 100 bases:

>100_bases
AATATCTTCGCTATTGTAGTGTACCGTGCGTTTAAACTGAATAGTTTTAACTGCAAATATTTACGAGAAGTTCCCCTGTT
TTATTAATTTTGAGGCTGTT

Downstream 100 bases:

>100_bases
AATGTGACTTATTTAACATACTGATTTTAAATAGTTAAACAGATAATTGTTAACATGACAGTTATCTGTTTTTTTATACC
CTTTGTCTGTTTTGTATTTG

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDELDQVPDDSIVIFSAHGVSKAV
QQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIGHEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPE
KLAFVTQTTLSIDDTAKVIDALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMG
KAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREENITFSLPKELRIHVTQA

Sequences:

>Translated_316_residues
MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDELDQVPDDSIVIFSAHGVSKAV
QQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIGHEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPE
KLAFVTQTTLSIDDTAKVIDALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMG
KAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREENITFSLPKELRIHVTQA
>Mature_316_residues
MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDELDQVPDDSIVIFSAHGVSKAV
QQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIGHEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPE
KLAFVTQTTLSIDDTAKVIDALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMG
KAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREENITFSLPKELRIHVTQA

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=315, Percent_Identity=64.4444444444444, Blast_Score=427, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35037; Mature: 35037

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDEL
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCEEEHHH
DQVPDDSIVIFSAHGVSKAVQQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIG
HCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEHHHCCCCCEEEEE
HEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPEKLAFVTQTTLSIDDTAKVID
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEECCCHHHHHHH
ALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMG
HHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHC
KAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREEN
CEEEEECCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
ITFSLPKELRIHVTQA
EEEECCCEEEEEEECC
>Mature Secondary Structure
MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDEL
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCEEEHHH
DQVPDDSIVIFSAHGVSKAVQQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIG
HCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEHHHCCCCCEEEEE
HEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPEKLAFVTQTTLSIDDTAKVID
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEECCCHHHHHHH
ALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMG
HHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHC
KAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREEN
CEEEEECCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
ITFSLPKELRIHVTQA
EEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10763755 [H]