Click here to switch to the map view.

The map label for this gene is tetA [H]

Identifier: 213158871

GI number: 213158871

Start: 3676118

End: 3677302

Strand: Reverse

Name: tetA [H]

Synonym: AB57_3570

Alternate gene names: 213158871

Gene position: 3677302-3676118 (Counterclockwise)

Preceding gene: 213158876

Following gene: 213158870

Centisome position: 90.79

GC content: 40.59

Gene sequence:

>1185_bases
ATGAATCGATCTCTATTTATTATCTTTGCAACTATTGCTTTAGATGCTATTGGTATCGGTCTTATTTTTCCGATTCTTCC
TTTATTATTACAAGATATGACGCATAGCACTCATATTTCTATATATATGGGTATATTGGCCAGTCTCTATGCGGCCATGC
AATTTATCTTCTCTCCTTTATTAGGTGCGTTAAGTGACAGATGGGGGCGTAGACCGGTCTTGCTTATTTCACTGGCTGGG
TCAGCAGTTAATTATCTCTTTCTAACTTTTTCACATAGCCTAATTTTATTGCTAGTAGGTCGCATTATTGCTGGAATCAC
CAGTGCCAACATGGCTGTTGCAAGTGCTTATATTGTCGATGTTTTGCACGAAAATAACCGCGCAAAATATTTTGGTTTAA
TCAATGCTATGTTTGGTGCAGGCTTCATTATTGGCCCTGTATTGGGCGGATTCTTGAGTGAATATGGATTAAGACTTCCT
TTCTTTGCGGCAGCTATATTGACAGGGCTTAATCTTTTATCTGCCTATTTTGTTTTGCCTGAATCCCGAAAAGTGACTTT
GGAGAACAAACAATTATCTACATTAAACCCTTTTAAAATATTTGCTGGTATTAGCTCTATTCGTGGTGTACTTCCACTTA
TTACGACCTTTTTTATCTTTAGTGCCATAGGGGAGGTATATGGAGTCTGCTGGGCATTATGGGGACATGACACATTTCAG
TGGAGCGGTTTCTGGGTAGGTCTTTCTCTAGGCGCATTTGGTCTATGTCAAATGCTGGTACAGGCTCTTATTCCGAGTCA
TGCTTCAAGATTGCTGGGTAATCGTAATGCTGTGCTGGCTGGTATTGCTTGTTCTTGTTTTGCTTTAGCAGTAATGGCTT
TCGCCCAAAGTGGTTGGATGATTTTTGCTATTATGCCTATTTTTGCGCTAGGGAGTATGGGGACACCTTCATTACAAGCC
TTAGCTTCTCAAAAGGTTTCTGCTGACCAGCAAGGACAGTTTCAGGGAGTGATAGCATCTACGGTAAGTATGGCCTCTAT
GATTGCCCCTATGTTTTTCTCCACTCTTTATTTTCAGTTTCAGGAAAAATGGCCGGGAGCAAATTGGTTGAGCGTGATTT
TGATTTACCTGCTCACCTTACCGATCATTTTGTATAGTACCCGACCAGTCGTACAACAAAGATAG

Upstream 100 bases:

>100_bases
CTTTAAGATTCGGCCAGCGTTCATCAGGGCTTGAGTTGTTATCAAGCATCGTTAACAGGTTTTCACATTTACTGTGCCTG
ACTTTTCGATAGGACGCTTT

Downstream 100 bases:

>100_bases
TAATGTAGAGTTAAATTCTCTATTTATCCTAAATAGAGAAGATCTATGGCCTACTCCCTTAGATCATTCTAATTTAAAAC
GTCACTTCATGACGCCGAGC

Product: tetracycline resistance protein TetA

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MNRSLFIIFATIALDAIGIGLIFPILPLLLQDMTHSTHISIYMGILASLYAAMQFIFSPLLGALSDRWGRRPVLLISLAG
SAVNYLFLTFSHSLILLLVGRIIAGITSANMAVASAYIVDVLHENNRAKYFGLINAMFGAGFIIGPVLGGFLSEYGLRLP
FFAAAILTGLNLLSAYFVLPESRKVTLENKQLSTLNPFKIFAGISSIRGVLPLITTFFIFSAIGEVYGVCWALWGHDTFQ
WSGFWVGLSLGAFGLCQMLVQALIPSHASRLLGNRNAVLAGIACSCFALAVMAFAQSGWMIFAIMPIFALGSMGTPSLQA
LASQKVSADQQGQFQGVIASTVSMASMIAPMFFSTLYFQFQEKWPGANWLSVILIYLLTLPIILYSTRPVVQQR

Sequences:

>Translated_394_residues
MNRSLFIIFATIALDAIGIGLIFPILPLLLQDMTHSTHISIYMGILASLYAAMQFIFSPLLGALSDRWGRRPVLLISLAG
SAVNYLFLTFSHSLILLLVGRIIAGITSANMAVASAYIVDVLHENNRAKYFGLINAMFGAGFIIGPVLGGFLSEYGLRLP
FFAAAILTGLNLLSAYFVLPESRKVTLENKQLSTLNPFKIFAGISSIRGVLPLITTFFIFSAIGEVYGVCWALWGHDTFQ
WSGFWVGLSLGAFGLCQMLVQALIPSHASRLLGNRNAVLAGIACSCFALAVMAFAQSGWMIFAIMPIFALGSMGTPSLQA
LASQKVSADQQGQFQGVIASTVSMASMIAPMFFSTLYFQFQEKWPGANWLSVILIYLLTLPIILYSTRPVVQQR
>Mature_394_residues
MNRSLFIIFATIALDAIGIGLIFPILPLLLQDMTHSTHISIYMGILASLYAAMQFIFSPLLGALSDRWGRRPVLLISLAG
SAVNYLFLTFSHSLILLLVGRIIAGITSANMAVASAYIVDVLHENNRAKYFGLINAMFGAGFIIGPVLGGFLSEYGLRLP
FFAAAILTGLNLLSAYFVLPESRKVTLENKQLSTLNPFKIFAGISSIRGVLPLITTFFIFSAIGEVYGVCWALWGHDTFQ
WSGFWVGLSLGAFGLCQMLVQALIPSHASRLLGNRNAVLAGIACSCFALAVMAFAQSGWMIFAIMPIFALGSMGTPSLQA
LASQKVSADQQGQFQGVIASTVSMASMIAPMFFSTLYFQFQEKWPGANWLSVILIYLLTLPIILYSTRPVVQQR

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=344, Percent_Identity=24.4186046511628, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI94721311, Length=348, Percent_Identity=25.8620689655172, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI225703104, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI225703102, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI217416366, Length=153, Percent_Identity=33.9869281045752, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71996331, Length=353, Percent_Identity=23.5127478753541, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17551570, Length=345, Percent_Identity=25.7971014492754, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319871, Length=164, Percent_Identity=29.8780487804878, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357569, Length=353, Percent_Identity=25.2124645892351, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI161080926, Length=353, Percent_Identity=25.2124645892351, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161080924, Length=353, Percent_Identity=25.2124645892351, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656463, Length=353, Percent_Identity=25.2124645892351, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656468, Length=353, Percent_Identity=25.2124645892351, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221513297, Length=355, Percent_Identity=23.943661971831, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17738085, Length=342, Percent_Identity=25.7309941520468, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42839; Mature: 42839

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSLFIIFATIALDAIGIGLIFPILPLLLQDMTHSTHISIYMGILASLYAAMQFIFSPL
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGALSDRWGRRPVLLISLAGSAVNYLFLTFSHSLILLLVGRIIAGITSANMAVASAYIVD
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLHENNRAKYFGLINAMFGAGFIIGPVLGGFLSEYGLRLPFFAAAILTGLNLLSAYFVLP
HHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
ESRKVTLENKQLSTLNPFKIFAGISSIRGVLPLITTFFIFSAIGEVYGVCWALWGHDTFQ
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
WSGFWVGLSLGAFGLCQMLVQALIPSHASRLLGNRNAVLAGIACSCFALAVMAFAQSGWM
ECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
IFAIMPIFALGSMGTPSLQALASQKVSADQQGQFQGVIASTVSMASMIAPMFFSTLYFQF
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKWPGANWLSVILIYLLTLPIILYSTRPVVQQR
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MNRSLFIIFATIALDAIGIGLIFPILPLLLQDMTHSTHISIYMGILASLYAAMQFIFSPL
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGALSDRWGRRPVLLISLAGSAVNYLFLTFSHSLILLLVGRIIAGITSANMAVASAYIVD
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLHENNRAKYFGLINAMFGAGFIIGPVLGGFLSEYGLRLPFFAAAILTGLNLLSAYFVLP
HHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
ESRKVTLENKQLSTLNPFKIFAGISSIRGVLPLITTFFIFSAIGEVYGVCWALWGHDTFQ
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
WSGFWVGLSLGAFGLCQMLVQALIPSHASRLLGNRNAVLAGIACSCFALAVMAFAQSGWM
ECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
IFAIMPIFALGSMGTPSLQALASQKVSADQQGQFQGVIASTVSMASMIAPMFFSTLYFQF
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKWPGANWLSVILIYLLTLPIILYSTRPVVQQR
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]