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The map label for this gene is metC [H]

Identifier: 213158838

GI number: 213158838

Start: 3637055

End: 3638245

Strand: Direct

Name: metC [H]

Synonym: AB57_3533

Alternate gene names: 213158838

Gene position: 3637055-3638245 (Clockwise)

Preceding gene: 213158807

Following gene: 213158839

Centisome position: 89.79

GC content: 39.88

Gene sequence:

>1191_bases
ATGAAAAAGCATAACAATTTCCAAACCCAACTCATTCATGCACCACGAAAAGCACCTCAATTTATTGAAACCGTGCAGCC
TCCCTTATTTCGTGCATCAACTATTATTTTTAAATCAACTTCGCACCTTTTTGACCGTCACTGGACCGATCCTTATGACT
ATAGTTATGGCACCCACGGTACGCCTACGACATTTACACTAGGCGACAATATTGCTCAAATTGAGGGTGGTTTATACTGC
CTACTTGCTCCAAGCGGGTTATCTGCGATTAATCTCGTAAATTCTGCTGTGTTAGCAACAGGTGACGAAGTTTGGGTGCC
AGACAACATATATGGTCCGAATCTGGAACACTTAAACTACTTAAAAGATCAATATGGAATTAATGTTCAAGTTTATAACC
CGATCGATGTCTCAAGTTTCCATCCTTCTGATAAAACCAAGTTGCTATGGTTAGAAGCAGCAGGTTCTGTCACTCTTGAA
TTTCCAGATCTCAAAGCGTTAGTAAAAAAAGCAAAAGCGCATGGCGTTTTAACTGCACTCGATAATACTTGGGGAGCTGG
CCTCGCCTTTAATGCTTTTGATTTTTCCGATGAGCATTTATCAGTGGATTTAACCATTCATGCGCTTACCAAATATCCAA
GTGGTGGTGGCGATATTTTAATGGGAAGTGTGGTAACTCGTGATGAGGAGTTACATCACCGTTTGTTCCGAATGCATGCC
ATTTTAGGGATTTCGGTATCTGGTGATGATACCGCCCAAATTCAACGCAGTCTTGCGCATATGTCATTAAGGTATGAGCA
ACAATCGAATAATGCTAAAACCCTACTGACATGGTTAAAAGAACAATCTCAGTTTGCACAAGTTCTACATCCAAGCGATA
AAGCTTCACCTGGTCATCAATACTGGCAAGAAATTTGCTCAACAGGTAGAAGTGCAGGCTTAGTGAGTGTTGTTTTCAAA
TCTGATTATGATATTTCAGCAGTACGCCGTTTTTGTGATGCTCTTAAGCTATTCAAACTTGGTTTTAGTTGGGGAGGACC
GGTGAGTCTCGTCATGCTTTATGATTTAAAAATGATGAGAAAACTTGAAAATACACATTTACAACAAGGTTTGTTGGTTC
GCTTCTGTATAGGGCTAGAAGATCCACAAGATTTAATTCAAGATATCGAAAATGCTCTGAAACAAATGTAA

Upstream 100 bases:

>100_bases
ATGTTACACTAGTAACGAAACATCTTAGAAATAATCAAAAATCTAGCAGTTAAGTAAGTTTTCTCTTAATCTAATCTCAT
TATGTAAAGTATAGCGCCCC

Downstream 100 bases:

>100_bases
AACGACAACATCAATAGTGGCTCACACTAAGGGATAAAATATATGGGTACACCGATTGTTATTGCAAAAAATATTAACGA
CACATCAAAAGAAATTGTTT

Product: cystathionine beta-lyase PLP-dependent

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYC
LLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFHPSDKTKLLWLEAAGSVTLE
FPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFDFSDEHLSVDLTIHALTKYPSGGGDILMGSVVTRDEELHHRLFRMHA
ILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQSQFAQVLHPSDKASPGHQYWQEICSTGRSAGLVSVVFK
SDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHLQQGLLVRFCIGLEDPQDLIQDIENALKQM

Sequences:

>Translated_396_residues
MKKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYC
LLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFHPSDKTKLLWLEAAGSVTLE
FPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFDFSDEHLSVDLTIHALTKYPSGGGDILMGSVVTRDEELHHRLFRMHA
ILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQSQFAQVLHPSDKASPGHQYWQEICSTGRSAGLVSVVFK
SDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHLQQGLLVRFCIGLEDPQDLIQDIENALKQM
>Mature_396_residues
MKKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYC
LLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFHPSDKTKLLWLEAAGSVTLE
FPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFDFSDEHLSVDLTIHALTKYPSGGGDILMGSVVTRDEELHHRLFRMHA
ILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQSQFAQVLHPSDKASPGHQYWQEICSTGRSAGLVSVVFK
SDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHLQQGLLVRFCIGLEDPQDLIQDIENALKQM

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=352, Percent_Identity=26.4204545454545, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI25453487, Length=349, Percent_Identity=25.7879656160458, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI299473759, Length=352, Percent_Identity=23.8636363636364, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789383, Length=400, Percent_Identity=29, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=26.5957446808511, Blast_Score=128, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71980708, Length=384, Percent_Identity=26.3020833333333, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560056, Length=408, Percent_Identity=28.6764705882353, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17538055, Length=404, Percent_Identity=27.4752475247525, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321170, Length=344, Percent_Identity=31.6860465116279, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319307, Length=408, Percent_Identity=25, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=24.3107769423559, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321254, Length=409, Percent_Identity=24.2053789731051, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323333, Length=441, Percent_Identity=21.9954648526077, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19922554, Length=404, Percent_Identity=30.1980198019802, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44261; Mature: 44261

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHG
CCCCCCCHHHEECCCCCCHHHHHHCCCCHHHHEEEEEECHHHHHHCCCCCCCCCCCCCCC
TPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNY
CCEEEEECCCEEEECCCEEEEECCCCCHHHHHHHHHHEECCCCEECCCCCCCCCHHHHHH
LKDQYGINVQVYNPIDVSSFHPSDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTAL
HHHHHCCEEEEECCCCCCCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHCCEEEEE
DNTWGAGLAFNAFDFSDEHLSVDLTIHALTKYPSGGGDILMGSVVTRDEELHHRLFRMHA
CCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCCCEEECHHHCCCHHHHHHHHHHHH
ILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQSQFAQVLHPSDKASPGHQ
HEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
YWQEICSTGRSAGLVSVVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMR
HHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KLENTHLQQGLLVRFCIGLEDPQDLIQDIENALKQM
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHG
CCCCCCCHHHEECCCCCCHHHHHHCCCCHHHHEEEEEECHHHHHHCCCCCCCCCCCCCCC
TPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNY
CCEEEEECCCEEEECCCEEEEECCCCCHHHHHHHHHHEECCCCEECCCCCCCCCHHHHHH
LKDQYGINVQVYNPIDVSSFHPSDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTAL
HHHHHCCEEEEECCCCCCCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHCCEEEEE
DNTWGAGLAFNAFDFSDEHLSVDLTIHALTKYPSGGGDILMGSVVTRDEELHHRLFRMHA
CCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCCCEEECHHHCCCHHHHHHHHHHHH
ILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQSQFAQVLHPSDKASPGHQ
HEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
YWQEICSTGRSAGLVSVVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMR
HHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KLENTHLQQGLLVRFCIGLEDPQDLIQDIENALKQM
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]