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The map label for this gene is ethA [H]

Identifier: 213158808

GI number: 213158808

Start: 3620677

End: 3622167

Strand: Reverse

Name: ethA [H]

Synonym: AB57_3503

Alternate gene names: 213158808

Gene position: 3622167-3620677 (Counterclockwise)

Preceding gene: 213158809

Following gene: 213158806

Centisome position: 89.42

GC content: 38.36

Gene sequence:

>1491_bases
ATGGAAAAGCAAGTTGATGTATTAATCATTGGTGCAGGCATATCAGGAATAGGAGTTGCTGCCCATTTATCTAAAAACTC
TCCACAACGTCAGTTTGAAATTTTGGAGCGTCGTGAATCGTTTGGTGGAACTTGGGATCTTTTCCGCTATCCTGGTATCC
GTTCTGATTCAGATATGTCTACTTTTGGTTTTAACTTTAAACCATGGCGCAAAGCCAATGTTCTCGCTGATGGTGCCTCT
ATTAAAGGATATCTAGGGGAAGTGATTGATGAGTTTAAGTTAAAAGAAAAAATTCATTTTGGCCATCGTGTCCTTTCTGC
GAATTATGATTCTGCCTCGAAAAAGTGGCATGTTATTGTCGAGGACAATAAGAAAAAACAGCAGACTTGGGTTGCTAACT
TCGTTGTAGGTTGTACTGGTTATTATAATTATGACCAAGGTTACGCGCCGACTTTCCCAAATCAAGAAGCTTTCAAAGGT
CAACTCATTCATCCACAACATTGGCCGGAAAATTTGGATTATAAGGGTAAAAAAGTAGTAATTATTGGTAGCGGAGCTAC
AGCAATTACACTGGTGCCTGCAATGTCAAAAGGTGGAGCAGGTCATGTAACGATGTTGCAACGTTCACCAACTTATATTG
CTTCTGTTCCGTCTATTGATTTCATCTATGAAAAAACTCGTAGATTTATGTCTGAAGAAGCAGCCTATAAATTTACGCGT
GCTCGTAATATTGGTATGCAACGAGCAATTTATGCATTGTCTCAAAAGCATCCTAAAACAGTTCGTCGTTTACTCTTAAA
AGCAATTGAAATGCAACTTAAGGGTAAAGTTGATATGAAACATTTTACACCTTCATATAACCCTTGGGATCAGCGTCTAT
GCGTAGTTCCTGATGGTGATTTATTCAAAATTCTTCGTGAAGGTAAGGCGAGTGTTGAAACTGATCAAATTGAAAAATTT
ACTGAGACTGGTATTCAATTAAAATCAGGCAAGCACCTTGATGCCGATATTATCGTATCTGCAACAGGTTTGCAGGTTCA
AATCATGGGCGGTGTGCAGGCAACTATTGATGGGGAGCCAGTTAAATCATCTGAACACATGCTTTATAACGGCGTAATGC
TCAGCGATGTACCAAACATGGCGATGATTATTGGCTATGTAAATGCTTCATGGACATTAAAAGTTGATATTGCAGCAGAT
TATATCTGCCGTTTATTAAACTACATGGATAAGAATAATTATGATGAAGTCATTCCATCTGGTGATAAGAGTGTGATGGA
AGAGGACACAGTCATGGGTAGCTTATCATCTGGTTATATTAGTCGTGCTGCCGACGTGATTCCTAAACAAGGTAAACAAG
CACCATGGCAGGTAACCAATAATTATCTTGAAGATCGAAAATCATTAAAAAATGCAAAATTTGATGATGGTGTTCTACGT
TTTCATAAGCATTCAGAAGTTACCACACGTAAACCAAAATTAGTGTCTTGA

Upstream 100 bases:

>100_bases
GTGACATAAAAAAACGGATAAACGGTCAAACTTGACATTGTGTATTGTCAAAATTGTGATTTAATAAAGACATATTCTCA
ACAATGGGTATAAAAATAAA

Downstream 100 bases:

>100_bases
TATTCGAAAATAAAAAGGAGGCTATAAGCCTCCTTTTTTATAGTAAAGATTAAAGAGTTCTAGAGATTAATTCTTTCATA
ATTTCATTGGTGCCTGCATA

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MEKQVDVLIIGAGISGIGVAAHLSKNSPQRQFEILERRESFGGTWDLFRYPGIRSDSDMSTFGFNFKPWRKANVLADGAS
IKGYLGEVIDEFKLKEKIHFGHRVLSANYDSASKKWHVIVEDNKKKQQTWVANFVVGCTGYYNYDQGYAPTFPNQEAFKG
QLIHPQHWPENLDYKGKKVVIIGSGATAITLVPAMSKGGAGHVTMLQRSPTYIASVPSIDFIYEKTRRFMSEEAAYKFTR
ARNIGMQRAIYALSQKHPKTVRRLLLKAIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILREGKASVETDQIEKF
TETGIQLKSGKHLDADIIVSATGLQVQIMGGVQATIDGEPVKSSEHMLYNGVMLSDVPNMAMIIGYVNASWTLKVDIAAD
YICRLLNYMDKNNYDEVIPSGDKSVMEEDTVMGSLSSGYISRAADVIPKQGKQAPWQVTNNYLEDRKSLKNAKFDDGVLR
FHKHSEVTTRKPKLVS

Sequences:

>Translated_496_residues
MEKQVDVLIIGAGISGIGVAAHLSKNSPQRQFEILERRESFGGTWDLFRYPGIRSDSDMSTFGFNFKPWRKANVLADGAS
IKGYLGEVIDEFKLKEKIHFGHRVLSANYDSASKKWHVIVEDNKKKQQTWVANFVVGCTGYYNYDQGYAPTFPNQEAFKG
QLIHPQHWPENLDYKGKKVVIIGSGATAITLVPAMSKGGAGHVTMLQRSPTYIASVPSIDFIYEKTRRFMSEEAAYKFTR
ARNIGMQRAIYALSQKHPKTVRRLLLKAIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILREGKASVETDQIEKF
TETGIQLKSGKHLDADIIVSATGLQVQIMGGVQATIDGEPVKSSEHMLYNGVMLSDVPNMAMIIGYVNASWTLKVDIAAD
YICRLLNYMDKNNYDEVIPSGDKSVMEEDTVMGSLSSGYISRAADVIPKQGKQAPWQVTNNYLEDRKSLKNAKFDDGVLR
FHKHSEVTTRKPKLVS
>Mature_496_residues
MEKQVDVLIIGAGISGIGVAAHLSKNSPQRQFEILERRESFGGTWDLFRYPGIRSDSDMSTFGFNFKPWRKANVLADGAS
IKGYLGEVIDEFKLKEKIHFGHRVLSANYDSASKKWHVIVEDNKKKQQTWVANFVVGCTGYYNYDQGYAPTFPNQEAFKG
QLIHPQHWPENLDYKGKKVVIIGSGATAITLVPAMSKGGAGHVTMLQRSPTYIASVPSIDFIYEKTRRFMSEEAAYKFTR
ARNIGMQRAIYALSQKHPKTVRRLLLKAIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILREGKASVETDQIEKF
TETGIQLKSGKHLDADIIVSATGLQVQIMGGVQATIDGEPVKSSEHMLYNGVMLSDVPNMAMIIGYVNASWTLKVDIAAD
YICRLLNYMDKNNYDEVIPSGDKSVMEEDTVMGSLSSGYISRAADVIPKQGKQAPWQVTNNYLEDRKSLKNAKFDDGVLR
FHKHSEVTTRKPKLVS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=229, Percent_Identity=27.0742358078603, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561948, Length=385, Percent_Identity=22.3376623376623, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555726, Length=282, Percent_Identity=23.758865248227, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193202226, Length=215, Percent_Identity=28.3720930232558, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55695; Mature: 55695

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQVDVLIIGAGISGIGVAAHLSKNSPQRQFEILERRESFGGTWDLFRYPGIRSDSDMS
CCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCC
TFGFNFKPWRKANVLADGASIKGYLGEVIDEFKLKEKIHFGHRVLSANYDSASKKWHVIV
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEEE
EDNKKKQQTWVANFVVGCTGYYNYDQGYAPTFPNQEAFKGQLIHPQHWPENLDYKGKKVV
ECCCCHHHHHHHHHHEECCEEECCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEE
IIGSGATAITLVPAMSKGGAGHVTMLQRSPTYIASVPSIDFIYEKTRRFMSEEAAYKFTR
EEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ARNIGMQRAIYALSQKHPKTVRRLLLKAIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGD
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCEEEECCCCH
LFKILREGKASVETDQIEKFTETGIQLKSGKHLDADIIVSATGLQVQIMGGVQATIDGEP
HHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEECCEEEEECCCC
VKSSEHMLYNGVMLSDVPNMAMIIGYVNASWTLKVDIAADYICRLLNYMDKNNYDEVIPS
CCCCCCEEECCEEECCCCCEEEEEEEECCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCC
GDKSVMEEDTVMGSLSSGYISRAADVIPKQGKQAPWQVTNNYLEDRKSLKNAKFDDGVLR
CCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHE
FHKHSEVTTRKPKLVS
EECCCCCCCCCCCCCC
>Mature Secondary Structure
MEKQVDVLIIGAGISGIGVAAHLSKNSPQRQFEILERRESFGGTWDLFRYPGIRSDSDMS
CCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCC
TFGFNFKPWRKANVLADGASIKGYLGEVIDEFKLKEKIHFGHRVLSANYDSASKKWHVIV
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEEE
EDNKKKQQTWVANFVVGCTGYYNYDQGYAPTFPNQEAFKGQLIHPQHWPENLDYKGKKVV
ECCCCHHHHHHHHHHEECCEEECCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEE
IIGSGATAITLVPAMSKGGAGHVTMLQRSPTYIASVPSIDFIYEKTRRFMSEEAAYKFTR
EEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ARNIGMQRAIYALSQKHPKTVRRLLLKAIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGD
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCEEEECCCCH
LFKILREGKASVETDQIEKFTETGIQLKSGKHLDADIIVSATGLQVQIMGGVQATIDGEP
HHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEECCEEEEECCCC
VKSSEHMLYNGVMLSDVPNMAMIIGYVNASWTLKVDIAADYICRLLNYMDKNNYDEVIPS
CCCCCCEEECCEEECCCCCEEEEEEEECCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCC
GDKSVMEEDTVMGSLSSGYISRAADVIPKQGKQAPWQVTNNYLEDRKSLKNAKFDDGVLR
CCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHE
FHKHSEVTTRKPKLVS
EECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA