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The map label for this gene is pepD [H]

Identifier: 213158674

GI number: 213158674

Start: 2715163

End: 2716623

Strand: Reverse

Name: pepD [H]

Synonym: AB57_2628

Alternate gene names: 213158674

Gene position: 2716623-2715163 (Counterclockwise)

Preceding gene: 213158675

Following gene: 213158671

Centisome position: 67.07

GC content: 41.2

Gene sequence:

>1461_bases
ATGACACAAGTTGATATTGCAGCATTATCTCCTCAAGTCGTTTGGCAGCATTTTCAAACACTTTGTACTATTCCTCGTCC
GTCAAAGCATGAACAGCAACTTCGTGAGTTTTTACAAAACTGGGCCGAAAGTCGGAATTTAGAAACTTATGTAGATGAAG
TAGGAAATTTGATTATCCGTAAAAATGCGACTCCGGGTAAAGAACATATGTCTGGAGTTATTCTTCAGGGCCATTTAGAT
ATGGTTACACAAGCCAATACTGGTACGGTACATGACTTCTTTAAAGACCCGATTCGTCCAGTTCTTGAGGATGGCTGGTT
AATTGCCAAAGACACTACTTTAGGTGCTGATAATGGCATTGGGGTAGCTTTGGCATTAGCTGTTTTAGATTCAAATGATA
TTGCTCATGGCCCAATAGAAGTTCTTTTAACAGTCGATGAAGAAGCAGGGATGAGTGGGGCACGGCTATTACAGGCGGGT
GTACTAAAAGGAAAATGGCTATTTAATATTGATACGGAAGAGTGGGGTGAGTTGTATCTCGGATGTGCTGGCAGTATTGA
TGTTGAGGTAGAGCAGCCGCTTAGTTATGAACCAATCCCTGAAAATTTGAGTATTGTGAATATTCAGGTTGCTGGTCTTA
AAGGTGGTCACTCTGGCGTAGATATTCATTTAGGACGTGGCAATGCCAACGTTATTCTGGCACGCTTTTTAAATGAGTAT
TTGGCAAAGCTGGGTGGACACCTTGTTGAATTTACAGGTGGTACAGCTCGTAATGCTTTACCTCGAGAAGCATTGGCAAC
CATTGCTATTTCGTCTAACCAATTACCTGAATTAGAAAAATTACTCGCTGAATATCAAACGACATGGAAAGAACAGCTAA
AGGGTATTGATGACAACTTGCAATTAAGTATTCAATCCACTGGTGCTGAAGTGACCGAAGTGATTACTCAACAACAGCAA
AACGAATGGTTGCAAGCTTTGGCAACAAGTCCTTATGGCGTTACAAGTATGAGTCAGGTTCTACCAGATGTAGTTGAAAC
CTCAAATAACATTGGGGTGGTGAGACTAAATCGAGAAGGTGGAAAAGCTGTTTTAATGGTCCGTTCAATGGTGAACCAAG
AAGCTCAAGATTTTGCAGAGAAAATTCAGGCACATTTTAGCCAATTTAATATCGGCTCTACACTTACGCCGTTAGTGTCG
GGTTGGACACCAAATCCAGATTCGGCTGCTCTAAAGTGCTTACAACAAGCTTATCAAAATACATTTAATATTGAGCCAAA
TCTAAAAGTAATTCATGCAGGCTTAGAATGTGGGATTATTGCTGAACATTACCCTCATTTACAGATGGTTTCGTTTGGAC
CGGATATTCAAGGTGCACATGCACCGGGCGAACGAGTTAAAGTTGATACTGTAGAGAAATGCTGGAAGCTACTGGTAACC
GCTTTGGCATCTGTAGAGTAG

Upstream 100 bases:

>100_bases
ATATAAAAATACAAAATCTTTCCCGAAATCGCTACCTATCTTTAATGCTTTGTGTATATTGAAATTATTAAGATATTTAC
ATAATTAGAGTGTAGTTTTC

Downstream 100 bases:

>100_bases
TTTTTTAAGAGATAAGAAGCTCAATTATGAGCTTCTTAAACTTTTATATGGAAATGATATGTAGCTAATTCGATCTCACA
ACAAATATGATTTTTACTCG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTQVDIAALSPQVVWQHFQTLCTIPRPSKHEQQLREFLQNWAESRNLETYVDEVGNLIIRKNATPGKEHMSGVILQGHLD
MVTQANTGTVHDFFKDPIRPVLEDGWLIAKDTTLGADNGIGVALALAVLDSNDIAHGPIEVLLTVDEEAGMSGARLLQAG
VLKGKWLFNIDTEEWGELYLGCAGSIDVEVEQPLSYEPIPENLSIVNIQVAGLKGGHSGVDIHLGRGNANVILARFLNEY
LAKLGGHLVEFTGGTARNALPREALATIAISSNQLPELEKLLAEYQTTWKEQLKGIDDNLQLSIQSTGAEVTEVITQQQQ
NEWLQALATSPYGVTSMSQVLPDVVETSNNIGVVRLNREGGKAVLMVRSMVNQEAQDFAEKIQAHFSQFNIGSTLTPLVS
GWTPNPDSAALKCLQQAYQNTFNIEPNLKVIHAGLECGIIAEHYPHLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLVT
ALASVE

Sequences:

>Translated_486_residues
MTQVDIAALSPQVVWQHFQTLCTIPRPSKHEQQLREFLQNWAESRNLETYVDEVGNLIIRKNATPGKEHMSGVILQGHLD
MVTQANTGTVHDFFKDPIRPVLEDGWLIAKDTTLGADNGIGVALALAVLDSNDIAHGPIEVLLTVDEEAGMSGARLLQAG
VLKGKWLFNIDTEEWGELYLGCAGSIDVEVEQPLSYEPIPENLSIVNIQVAGLKGGHSGVDIHLGRGNANVILARFLNEY
LAKLGGHLVEFTGGTARNALPREALATIAISSNQLPELEKLLAEYQTTWKEQLKGIDDNLQLSIQSTGAEVTEVITQQQQ
NEWLQALATSPYGVTSMSQVLPDVVETSNNIGVVRLNREGGKAVLMVRSMVNQEAQDFAEKIQAHFSQFNIGSTLTPLVS
GWTPNPDSAALKCLQQAYQNTFNIEPNLKVIHAGLECGIIAEHYPHLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLVT
ALASVE
>Mature_485_residues
TQVDIAALSPQVVWQHFQTLCTIPRPSKHEQQLREFLQNWAESRNLETYVDEVGNLIIRKNATPGKEHMSGVILQGHLDM
VTQANTGTVHDFFKDPIRPVLEDGWLIAKDTTLGADNGIGVALALAVLDSNDIAHGPIEVLLTVDEEAGMSGARLLQAGV
LKGKWLFNIDTEEWGELYLGCAGSIDVEVEQPLSYEPIPENLSIVNIQVAGLKGGHSGVDIHLGRGNANVILARFLNEYL
AKLGGHLVEFTGGTARNALPREALATIAISSNQLPELEKLLAEYQTTWKEQLKGIDDNLQLSIQSTGAEVTEVITQQQQN
EWLQALATSPYGVTSMSQVLPDVVETSNNIGVVRLNREGGKAVLMVRSMVNQEAQDFAEKIQAHFSQFNIGSTLTPLVSG
WTPNPDSAALKCLQQAYQNTFNIEPNLKVIHAGLECGIIAEHYPHLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLVTA
LASVE

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=482, Percent_Identity=42.3236514522822, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53063; Mature: 52932

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVDIAALSPQVVWQHFQTLCTIPRPSKHEQQLREFLQNWAESRNLETYVDEVGNLIIR
CCCCCHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEE
KNATPGKEHMSGVILQGHLDMVTQANTGTVHDFFKDPIRPVLEDGWLIAKDTTLGADNGI
CCCCCCHHHHCCEEEECCCHHEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
GVALALAVLDSNDIAHGPIEVLLTVDEEAGMSGARLLQAGVLKGKWLFNIDTEEWGELYL
CHHHEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCHHHCCEEE
GCAGSIDVEVEQPLSYEPIPENLSIVNIQVAGLKGGHSGVDIHLGRGNANVILARFLNEY
ECCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHH
LAKLGGHLVEFTGGTARNALPREALATIAISSNQLPELEKLLAEYQTTWKEQLKGIDDNL
HHHHCCEEEEECCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
QLSIQSTGAEVTEVITQQQQNEWLQALATSPYGVTSMSQVLPDVVETSNNIGVVRLNREG
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
GKAVLMVRSMVNQEAQDFAEKIQAHFSQFNIGSTLTPLVSGWTPNPDSAALKCLQQAYQN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHC
TFNIEPNLKVIHAGLECGIIAEHYPHLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLVT
CCCCCCCCEEEEECCCCCEECCCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHH
ALASVE
HHHCCC
>Mature Secondary Structure 
TQVDIAALSPQVVWQHFQTLCTIPRPSKHEQQLREFLQNWAESRNLETYVDEVGNLIIR
CCCCHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEE
KNATPGKEHMSGVILQGHLDMVTQANTGTVHDFFKDPIRPVLEDGWLIAKDTTLGADNGI
CCCCCCHHHHCCEEEECCCHHEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
GVALALAVLDSNDIAHGPIEVLLTVDEEAGMSGARLLQAGVLKGKWLFNIDTEEWGELYL
CHHHEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCHHHCCEEE
GCAGSIDVEVEQPLSYEPIPENLSIVNIQVAGLKGGHSGVDIHLGRGNANVILARFLNEY
ECCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHH
LAKLGGHLVEFTGGTARNALPREALATIAISSNQLPELEKLLAEYQTTWKEQLKGIDDNL
HHHHCCEEEEECCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
QLSIQSTGAEVTEVITQQQQNEWLQALATSPYGVTSMSQVLPDVVETSNNIGVVRLNREG
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
GKAVLMVRSMVNQEAQDFAEKIQAHFSQFNIGSTLTPLVSGWTPNPDSAALKCLQQAYQN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHC
TFNIEPNLKVIHAGLECGIIAEHYPHLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLVT
CCCCCCCCEEEEECCCCCEECCCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHH
ALASVE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]