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The map label for this gene is gabP [H]

Identifier: 213158638

GI number: 213158638

Start: 2681913

End: 2683310

Strand: Reverse

Name: gabP [H]

Synonym: AB57_2592

Alternate gene names: 213158638

Gene position: 2683310-2681913 (Counterclockwise)

Preceding gene: 213158639

Following gene: 213158636

Centisome position: 66.25

GC content: 41.13

Gene sequence:

>1398_bases
ATGAATAATGATAGAACAAAAAAATTAGGCGAAGGACTTTCAAATCGCCATATCACAATGATTAGTATTGGCGGTGTTAT
TGGTGCAGGTTTATTTGTCGGTTCATCTTCTGCAATTGCCAAAGCAGGCCCCGCGGTGATTCTTGCGTACCTGATTACCA
GCATTATGGTATTTCTGGTGATGCGTATGTTAGGTGAAATGGCCGTTTTAGAGCCGGACACCGGTTCATTTTCTACCTAT
GCCCGTAAAGCAATTGGCCCGTGGGCAGGCTTTACCATTGGCTGGTTGTATTGGTGGTTTTGGGTACTTGCGATTCCGGT
AGAAGCCATTGCAGGTGCTGAAATTTTACATTCGTGGTTTCCGAGCATTTCGGTCTCTATCTATGCATTTTGCTTTATTG
TGTTCTTAAGCTTGGCCAACTTTTTTAGTACCAAAAGTTTTGGTGAGTTTGAGTTCTGGTTTTCTTTGGTCAAAGTGGTT
GCCATTATTGGGTTCATTATTATTGGTATTTTGGCAATTTCAGGTATTTGGCCTTTAGCTAAAAATGTCAGTGGTGTTGC
CAATTTATACAACAACGCTGGTTTTATGCCGCACGGGATGGGAGGCATTTTAGCTGCCATTTTAATTACGGCATTTTCAT
TCTTTGGTGTGGAAATTGTCTCGATTGCCGCAGCAGAGTCATCTAACCCTAAACAGAAAATTAGACGTGCCACCAATTTG
GTGTTGTACCGTATTATTCTTTTTTTCGTGGTCTCAATGTTTATTGCGGTTTCACTTGTCGATTGGCGTTCACCGGACTT
ACAAAAGTACGGGACATTCCAATACGTTTTAATGAGCTTAAACGTACCAGGCACTAAACTTATTATTGATACGGTCGTGT
TTATCGCCGTGGCGAGCTGTATGAATGCGGCAATTTATACATCTTCTCGTATGTTATTTCGTTTGGGAACACGTAATGAA
GCACCACAGGCAGTCACTAAAGTGAACTATGCCGGTGTACCAGCAATTGCGGTGTTTTCCTCAACTTTTATTGGTTTAGT
GTGCTGTGTCATTAACTATGTATTTCCAGGAAAAGTTTTTGGCTTATTGCTCTCAAGCACAGGGTCAATTGCTTTACTCG
TGTACTTGGTTATTGCGTTTTCACAACTACGTTTAAGACATAAGCTAGAAGCGGCTGGAGCGGAAATTCCATTTAAAATG
TGGTTATTCCCATGGCTGACTTGGTTTGTGATTATCATTATTTTAAGTGTATTGGCTTATATGTTCTTCTCACCAGCCTA
TAGTTATGAAACGACTCTATCTTTAGGTGTAACCTTAGGTGTGGTGGTTTGCGGTTTGTTTGTGACCCGAAAGCGTAAAG
CAACCCGTTCGGTTGCGATCAATCAGAGTAATTTATAA

Upstream 100 bases:

>100_bases
TTGCAACAAGGGGAAAACATTAGGTTTTCCCTTTTTCATAACATAGGATTTTGAACATGTAATAGATTGTTTTTATGGAT
ATATTTTTAAGGAATGAAAT

Downstream 100 bases:

>100_bases
ATATTAAATTAAAATTTTAACCATATAAATAAAAGCTCCTTAATAAAAAGGAGTCTTTTTTATTTTTTTAATTCTAATTA
TTTTATTTTAATTGTAGTTG

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNNDRTKKLGEGLSNRHITMISIGGVIGAGLFVGSSSAIAKAGPAVILAYLITSIMVFLVMRMLGEMAVLEPDTGSFSTY
ARKAIGPWAGFTIGWLYWWFWVLAIPVEAIAGAEILHSWFPSISVSIYAFCFIVFLSLANFFSTKSFGEFEFWFSLVKVV
AIIGFIIIGILAISGIWPLAKNVSGVANLYNNAGFMPHGMGGILAAILITAFSFFGVEIVSIAAAESSNPKQKIRRATNL
VLYRIILFFVVSMFIAVSLVDWRSPDLQKYGTFQYVLMSLNVPGTKLIIDTVVFIAVASCMNAAIYTSSRMLFRLGTRNE
APQAVTKVNYAGVPAIAVFSSTFIGLVCCVINYVFPGKVFGLLLSSTGSIALLVYLVIAFSQLRLRHKLEAAGAEIPFKM
WLFPWLTWFVIIIILSVLAYMFFSPAYSYETTLSLGVTLGVVVCGLFVTRKRKATRSVAINQSNL

Sequences:

>Translated_465_residues
MNNDRTKKLGEGLSNRHITMISIGGVIGAGLFVGSSSAIAKAGPAVILAYLITSIMVFLVMRMLGEMAVLEPDTGSFSTY
ARKAIGPWAGFTIGWLYWWFWVLAIPVEAIAGAEILHSWFPSISVSIYAFCFIVFLSLANFFSTKSFGEFEFWFSLVKVV
AIIGFIIIGILAISGIWPLAKNVSGVANLYNNAGFMPHGMGGILAAILITAFSFFGVEIVSIAAAESSNPKQKIRRATNL
VLYRIILFFVVSMFIAVSLVDWRSPDLQKYGTFQYVLMSLNVPGTKLIIDTVVFIAVASCMNAAIYTSSRMLFRLGTRNE
APQAVTKVNYAGVPAIAVFSSTFIGLVCCVINYVFPGKVFGLLLSSTGSIALLVYLVIAFSQLRLRHKLEAAGAEIPFKM
WLFPWLTWFVIIIILSVLAYMFFSPAYSYETTLSLGVTLGVVVCGLFVTRKRKATRSVAINQSNL
>Mature_465_residues
MNNDRTKKLGEGLSNRHITMISIGGVIGAGLFVGSSSAIAKAGPAVILAYLITSIMVFLVMRMLGEMAVLEPDTGSFSTY
ARKAIGPWAGFTIGWLYWWFWVLAIPVEAIAGAEILHSWFPSISVSIYAFCFIVFLSLANFFSTKSFGEFEFWFSLVKVV
AIIGFIIIGILAISGIWPLAKNVSGVANLYNNAGFMPHGMGGILAAILITAFSFFGVEIVSIAAAESSNPKQKIRRATNL
VLYRIILFFVVSMFIAVSLVDWRSPDLQKYGTFQYVLMSLNVPGTKLIIDTVVFIAVASCMNAAIYTSSRMLFRLGTRNE
APQAVTKVNYAGVPAIAVFSSTFIGLVCCVINYVFPGKVFGLLLSSTGSIALLVYLVIAFSQLRLRHKLEAAGAEIPFKM
WLFPWLTWFVIIIILSVLAYMFFSPAYSYETTLSLGVTLGVVVCGLFVTRKRKATRSVAINQSNL

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=452, Percent_Identity=52.212389380531, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1786302, Length=460, Percent_Identity=35.6521739130435, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1786789, Length=420, Percent_Identity=36.6666666666667, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=35.632183908046, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=33.0434782608696, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1788480, Length=414, Percent_Identity=34.0579710144928, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081915, Length=457, Percent_Identity=32.3851203501094, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=32.9032258064516, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1786602, Length=467, Percent_Identity=32.5481798715203, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI87081869, Length=274, Percent_Identity=24.4525547445255, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=30.0668151447661, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=446, Percent_Identity=29.372197309417, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=451, Percent_Identity=29.490022172949, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=29.2191435768262, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320717, Length=440, Percent_Identity=26.8181818181818, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=459, Percent_Identity=27.8867102396514, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=435, Percent_Identity=26.8965517241379, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=433, Percent_Identity=27.2517321016166, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=431, Percent_Identity=30.3944315545244, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319824, Length=445, Percent_Identity=26.5168539325843, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=29.8765432098765, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321053, Length=414, Percent_Identity=27.2946859903382, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=421, Percent_Identity=26.603325415677, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324990, Length=367, Percent_Identity=30.2452316076294, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=27.6807980049875, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324981, Length=400, Percent_Identity=29.25, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=419, Percent_Identity=25.2983293556086, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=22.1774193548387, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24666159, Length=290, Percent_Identity=24.8275862068966, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221512776, Length=290, Percent_Identity=24.8275862068966, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24668806, Length=411, Percent_Identity=22.6277372262774, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356285, Length=411, Percent_Identity=22.6277372262774, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668802, Length=411, Percent_Identity=22.6277372262774, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50856; Mature: 50856

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDRTKKLGEGLSNRHITMISIGGVIGAGLFVGSSSAIAKAGPAVILAYLITSIMVFLV
CCCCHHHHHHCCCCCCCEEEEEECHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHH
MRMLGEMAVLEPDTGSFSTYARKAIGPWAGFTIGWLYWWFWVLAIPVEAIAGAEILHSWF
HHHHCHHEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSISVSIYAFCFIVFLSLANFFSTKSFGEFEFWFSLVKVVAIIGFIIIGILAISGIWPLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNVSGVANLYNNAGFMPHGMGGILAAILITAFSFFGVEIVSIAAAESSNPKQKIRRATNL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLYRIILFFVVSMFIAVSLVDWRSPDLQKYGTFQYVLMSLNVPGTKLIIDTVVFIAVASC
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEEECCCCCHHHHHHHHHHHHHHHH
MNAAIYTSSRMLFRLGTRNEAPQAVTKVNYAGVPAIAVFSSTFIGLVCCVINYVFPGKVF
HHHHHHHCCHHHEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLLLSSTGSIALLVYLVIAFSQLRLRHKLEAAGAEIPFKMWLFPWLTWFVIIIILSVLAY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MFFSPAYSYETTLSLGVTLGVVVCGLFVTRKRKATRSVAINQSNL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNNDRTKKLGEGLSNRHITMISIGGVIGAGLFVGSSSAIAKAGPAVILAYLITSIMVFLV
CCCCHHHHHHCCCCCCCEEEEEECHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHH
MRMLGEMAVLEPDTGSFSTYARKAIGPWAGFTIGWLYWWFWVLAIPVEAIAGAEILHSWF
HHHHCHHEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSISVSIYAFCFIVFLSLANFFSTKSFGEFEFWFSLVKVVAIIGFIIIGILAISGIWPLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNVSGVANLYNNAGFMPHGMGGILAAILITAFSFFGVEIVSIAAAESSNPKQKIRRATNL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLYRIILFFVVSMFIAVSLVDWRSPDLQKYGTFQYVLMSLNVPGTKLIIDTVVFIAVASC
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEEECCCCCHHHHHHHHHHHHHHHH
MNAAIYTSSRMLFRLGTRNEAPQAVTKVNYAGVPAIAVFSSTFIGLVCCVINYVFPGKVF
HHHHHHHCCHHHEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLLLSSTGSIALLVYLVIAFSQLRLRHKLEAAGAEIPFKMWLFPWLTWFVIIIILSVLAY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MFFSPAYSYETTLSLGVTLGVVVCGLFVTRKRKATRSVAINQSNL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]