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The map label for this gene is yvaG [H]

Identifier: 213158622

GI number: 213158622

Start: 2667591

End: 2668385

Strand: Reverse

Name: yvaG [H]

Synonym: AB57_2576

Alternate gene names: 213158622

Gene position: 2668385-2667591 (Counterclockwise)

Preceding gene: 213158623

Following gene: 213158621

Centisome position: 65.88

GC content: 44.28

Gene sequence:

>795_bases
ATGAAATTAGATCTTCAAAATAAGATCGCCGTTGTCAGTGGTTCAACTTCGGGGATCGGTTTAGGTATTGCTAAAGGCTT
AGCATCTGCGGGTGCTACGGTTGTGGTTGTTGGCCGTAAGCAAGCTGGTGTTGATGAAGCAATTGCACATATTCGTCAAA
GTGTTCCAGAAGCGAGTTTACGTGGTGTTGATGCAGATTTGACCACTGAACAAGGTGCAGCAGCTTTATTTGCAGCTGAA
CCAAAGGCAGATATTTTGGTGAACAATCTTGGCATTTTTAATGACGAAGATTTCTTTAGTGTACCTGACGAAGAGTGGAT
GCGTTTTTACCAAGTTAACGTGTTATCTGGCGTGCGTTTGGCTCGACATTATGCACCATCGATGGTTGAGCAAGGCTGGG
GCAGAATTATCTTTATTTCTTCTGAATCTGGTGTAGCCATTCCGGGTGACATGATTAATTACGGTGTGACCAAAAGTGCC
AATTTAGCAGTTTCTCATGGTTTAGCTAAACGTTTGGCGGGTACAGGCGTGACTGTAAATGCGGTTTTACCAGGGCCAAC
ATTTACAGATGGTCTAGAAAATATGCTAGCGGATGCAGCAGCAAAAGCAGGGCGTAGTACACGTGATCAGGCTGACGAAT
TTGTCAAAGTGTTACGTCCAAGTTCAATTATTCAACGTGCAGCAGAAGTAGACGAAGTCGCAAATATGGTTGTTTATATT
GCTTCGCCACTTTCATCTGCAACTTCGGGTGCCGCATTACGTGTTGATGGCGGTGTTGTCGATACACTCGTTTAA

Upstream 100 bases:

>100_bases
TGGGAAGAGATGCGCCGCCAAGGTCTTGTATCTGAATTTGCACCATTACCTATCCGTTAATTTTTAAGGAGGGCGGTAGC
CCTCCACAGCGAGTTTTATC

Downstream 100 bases:

>100_bases
TTTACTCACTCATTTACTGAAATATTCGGAGAAAACTCATGGCTAATGCAATCGCAACTTTAGAAATTCCAGCTTCACCT
GAACAAGTTTGGCAACTTAT

Product: oxidoreductase, short chain dehydrogenase/reductase family

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKLDLQNKIAVVSGSTSGIGLGIAKGLASAGATVVVVGRKQAGVDEAIAHIRQSVPEASLRGVDADLTTEQGAAALFAAE
PKADILVNNLGIFNDEDFFSVPDEEWMRFYQVNVLSGVRLARHYAPSMVEQGWGRIIFISSESGVAIPGDMINYGVTKSA
NLAVSHGLAKRLAGTGVTVNAVLPGPTFTDGLENMLADAAAKAGRSTRDQADEFVKVLRPSSIIQRAAEVDEVANMVVYI
ASPLSSATSGAALRVDGGVVDTLV

Sequences:

>Translated_264_residues
MKLDLQNKIAVVSGSTSGIGLGIAKGLASAGATVVVVGRKQAGVDEAIAHIRQSVPEASLRGVDADLTTEQGAAALFAAE
PKADILVNNLGIFNDEDFFSVPDEEWMRFYQVNVLSGVRLARHYAPSMVEQGWGRIIFISSESGVAIPGDMINYGVTKSA
NLAVSHGLAKRLAGTGVTVNAVLPGPTFTDGLENMLADAAAKAGRSTRDQADEFVKVLRPSSIIQRAAEVDEVANMVVYI
ASPLSSATSGAALRVDGGVVDTLV
>Mature_264_residues
MKLDLQNKIAVVSGSTSGIGLGIAKGLASAGATVVVVGRKQAGVDEAIAHIRQSVPEASLRGVDADLTTEQGAAALFAAE
PKADILVNNLGIFNDEDFFSVPDEEWMRFYQVNVLSGVRLARHYAPSMVEQGWGRIIFISSESGVAIPGDMINYGVTKSA
NLAVSHGLAKRLAGTGVTVNAVLPGPTFTDGLENMLADAAAKAGRSTRDQADEFVKVLRPSSIIQRAAEVDEVANMVVYI
ASPLSSATSGAALRVDGGVVDTLV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=267, Percent_Identity=29.2134831460674, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=30.1158301158301, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI7705855, Length=221, Percent_Identity=31.2217194570136, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI33667109, Length=266, Percent_Identity=30.8270676691729, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=31.7204301075269, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI126723750, Length=270, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=26.2548262548263, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=191, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7706318, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI15277342, Length=276, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI10190746, Length=217, Percent_Identity=28.110599078341, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787905, Length=269, Percent_Identity=31.2267657992565, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789057, Length=264, Percent_Identity=28.7878787878788, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=27.9245283018868, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=28.4090909090909, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=29.8449612403101, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=25, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789378, Length=265, Percent_Identity=29.0566037735849, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=29.5019157088123, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=27.9527559055118, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788459, Length=266, Percent_Identity=28.1954887218045, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=26.9662921348315, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787820, Length=178, Percent_Identity=31.4606741573034, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=266, Percent_Identity=31.9548872180451, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=32.0610687022901, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=30.078125, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=261, Percent_Identity=29.8850574712644, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=28.6274509803922, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=28.0769230769231, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=31.1787072243346, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=32.7067669172932, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=30.4182509505703, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=27.5092936802974, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=28.6458333333333, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=189, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=215, Percent_Identity=31.1627906976744, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=26.9372693726937, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=194, Percent_Identity=26.8041237113402, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=32.046332046332, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=31.6793893129771, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=29.3436293436293, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355319, Length=206, Percent_Identity=34.4660194174757, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=27.8625954198473, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=27.5193798449612, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=29.0816326530612, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27465; Mature: 27465

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDLQNKIAVVSGSTSGIGLGIAKGLASAGATVVVVGRKQAGVDEAIAHIRQSVPEASL
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCHHHH
RGVDADLTTEQGAAALFAAEPKADILVNNLGIFNDEDFFSVPDEEWMRFYQVNVLSGVRL
CCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ARHYAPSMVEQGWGRIIFISSESGVAIPGDMINYGVTKSANLAVSHGLAKRLAGTGVTVN
HHHHCHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEE
AVLPGPTFTDGLENMLADAAAKAGRSTRDQADEFVKVLRPSSIIQRAAEVDEVANMVVYI
EEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEE
ASPLSSATSGAALRVDGGVVDTLV
ECCCCCCCCCCEEEECCCCHHHCC
>Mature Secondary Structure
MKLDLQNKIAVVSGSTSGIGLGIAKGLASAGATVVVVGRKQAGVDEAIAHIRQSVPEASL
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCHHHH
RGVDADLTTEQGAAALFAAEPKADILVNNLGIFNDEDFFSVPDEEWMRFYQVNVLSGVRL
CCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ARHYAPSMVEQGWGRIIFISSESGVAIPGDMINYGVTKSANLAVSHGLAKRLAGTGVTVN
HHHHCHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEE
AVLPGPTFTDGLENMLADAAAKAGRSTRDQADEFVKVLRPSSIIQRAAEVDEVANMVVYI
EEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEE
ASPLSSATSGAALRVDGGVVDTLV
ECCCCCCCCCCEEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]