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The map label for this gene is yedX [H]

Identifier: 213158599

GI number: 213158599

Start: 2647129

End: 2647530

Strand: Direct

Name: yedX [H]

Synonym: AB57_2553

Alternate gene names: 213158599

Gene position: 2647129-2647530 (Clockwise)

Preceding gene: 213158598

Following gene: 213158607

Centisome position: 65.35

GC content: 38.06

Gene sequence:

>402_bases
ATGACTAAATCATTTATTGCTTTATCTTCTTTATTTATAGCCTCAGCTACATTTGCACAAACCAATCCGCTTAGTGTGCA
TGTGTTAAACCTAGAGACAGGTTTACCCTCTTCTCAGGTTGAAGTAGTTTTGGAGAAAAACACCAATAACCAGTGGGTGA
AACTCAACCAACAAGTGACAGACTCAAATGGCCGTATAACTGCGCTCTATCCGGAAAATAAAAAACTAGAACAAGGTGTT
TATAAAGTTACGTTTAAAACTGAAGAATGGTTTAAAAAGAACAAACAGCAAACGTTCTTTAGCGAAGTACCCGTGATTTT
TAAAGTGGACGGCAGTGTAAATCACTACCATATTCCCTTACTGCTCAGCCCTTACGGTTACTCAACCTATAGAGGCAACT
AA

Upstream 100 bases:

>100_bases
GGCGCAATTGGGGTTGCGGGTGCTGGCGGCGCGCAAAATGACAATCAGTGTGCAAGCAAAGCCATTGAAACCGTTTTTAA
CTCATAAGGAGCTACATCAC

Downstream 100 bases:

>100_bases
AATAAAAAAACCTTTATCTGTTTTAGGCAGATAAAGGGTTTTGTTAAAACACCTTGCTACGAACAAATACCATTGTTGAC
GACTACTTTTTTATTTGAAT

Product: transthyretin

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MTKSFIALSSLFIASATFAQTNPLSVHVLNLETGLPSSQVEVVLEKNTNNQWVKLNQQVTDSNGRITALYPENKKLEQGV
YKVTFKTEEWFKKNKQQTFFSEVPVIFKVDGSVNHYHIPLLLSPYGYSTYRGN

Sequences:

>Translated_133_residues
MTKSFIALSSLFIASATFAQTNPLSVHVLNLETGLPSSQVEVVLEKNTNNQWVKLNQQVTDSNGRITALYPENKKLEQGV
YKVTFKTEEWFKKNKQQTFFSEVPVIFKVDGSVNHYHIPLLLSPYGYSTYRGN
>Mature_132_residues
TKSFIALSSLFIASATFAQTNPLSVHVLNLETGLPSSQVEVVLEKNTNNQWVKLNQQVTDSNGRITALYPENKKLEQGVY
KVTFKTEEWFKKNKQQTFFSEVPVIFKVDGSVNHYHIPLLLSPYGYSTYRGN

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=141, Percent_Identity=48.2269503546099, Blast_Score=130, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI115532920, Length=130, Percent_Identity=34.6153846153846, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115532922, Length=113, Percent_Identity=36.283185840708, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115534555, Length=131, Percent_Identity=34.3511450381679, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24652571, Length=111, Percent_Identity=36.036036036036, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 15118; Mature: 14987

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSFIALSSLFIASATFAQTNPLSVHVLNLETGLPSSQVEVVLEKNTNNQWVKLNQQVT
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEEEEEEE
DSNGRITALYPENKKLEQGVYKVTFKTEEWFKKNKQQTFFSEVPVIFKVDGSVNHYHIPL
CCCCEEEEECCCCCCCCCCEEEEEEECHHHHHCCCCCCHHHCCCEEEEECCCCCEEEEEE
LLSPYGYSTYRGN
EECCCCCCEECCC
>Mature Secondary Structure 
TKSFIALSSLFIASATFAQTNPLSVHVLNLETGLPSSQVEVVLEKNTNNQWVKLNQQVT
CCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEEEEEEE
DSNGRITALYPENKKLEQGVYKVTFKTEEWFKKNKQQTFFSEVPVIFKVDGSVNHYHIPL
CCCCEEEEECCCCCCCCCCEEEEEEECHHHHHCCCCCCHHHCCCEEEEECCCCCEEEEEE
LLSPYGYSTYRGN
EECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]