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The map label for this gene is irlR [H]

Identifier: 213158597

GI number: 213158597

Start: 2645851

End: 2646522

Strand: Reverse

Name: irlR [H]

Synonym: AB57_2551

Alternate gene names: 213158597

Gene position: 2646522-2645851 (Counterclockwise)

Preceding gene: 213158600

Following gene: 213158596

Centisome position: 65.34

GC content: 38.24

Gene sequence:

>672_bases
ATGCGTATTCTTATTATTGAAGACGAGATCAAAATCGCCACTTATTTGGTCAAAGGGTTAAAAGAATCCGGATACCAAGC
CGAGTGCGTACATTTAGGACTTCAAGGTTTGGAAATGCTAAAAAGAGATCAATATGACTTGCTTATTCTTGATGTGATGT
TGCCGGACATAGAGGGCTGGAGCGTACTACAGGTACTACGCCAGTTTTCAAAAATTCCGGTGATTTTCTTAACGGCAAAA
GATCAGGTCATGGATAGAGTGAAAGGGTTAGAGTTAGGTGCAGATGACTACTTGGCTAAACCCTTTTCCTATATTGAACT
CTTGGCACGCATTAAAAGTTTGTTAAGACGACAGCAGTATTTGCAAGAAAATGAGTTGTCTATAAGTGATCTAAAAATGG
ATTTGGTGGGGCATAAAGTATGGCGTAATGGCAACTTAATCGAACTGAGTAAAACCGAATTTAACTTATTACGTTATTTA
TTGGTCAATAAAGAACAAATCGTGACGCGTAGACAAATCGGTTCTGAGGTTTGGAATATTAACTTTGACACCGATACCAA
CTTTATTGACGTTGCAGTACGCCGTTTAAGAAGCAAAATTGATGAAGAATATGAACCAAAACTTATCCATACCATCCGTG
GCTTGGGCTATAAAATTTCGGTTAGCTTATGA

Upstream 100 bases:

>100_bases
ATTGCCTCTATGTCGCTTTGAAAATCTTAAACAAATTGCCTAATTTCAAGCATGACAATCACATTACAAAGTTGTCATTT
TTCTAATGAGTCTCTACAAA

Downstream 100 bases:

>100_bases
ACTTTAAATTTCTACGTTCTCTTGAAGTCCGTATTACATTACTGGTCACGCTTTGTTCTGCCTTAATTTTATGTTCAGTC
GGCTTTATGACCTATTTGGG

Product: two-component heavy metal response regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILIIEDEIKIATYLVKGLKESGYQAECVHLGLQGLEMLKRDQYDLLILDVMLPDIEGWSVLQVLRQFSKIPVIFLTAK
DQVMDRVKGLELGADDYLAKPFSYIELLARIKSLLRRQQYLQENELSISDLKMDLVGHKVWRNGNLIELSKTEFNLLRYL
LVNKEQIVTRRQIGSEVWNINFDTDTNFIDVAVRRLRSKIDEEYEPKLIHTIRGLGYKISVSL

Sequences:

>Translated_223_residues
MRILIIEDEIKIATYLVKGLKESGYQAECVHLGLQGLEMLKRDQYDLLILDVMLPDIEGWSVLQVLRQFSKIPVIFLTAK
DQVMDRVKGLELGADDYLAKPFSYIELLARIKSLLRRQQYLQENELSISDLKMDLVGHKVWRNGNLIELSKTEFNLLRYL
LVNKEQIVTRRQIGSEVWNINFDTDTNFIDVAVRRLRSKIDEEYEPKLIHTIRGLGYKISVSL
>Mature_223_residues
MRILIIEDEIKIATYLVKGLKESGYQAECVHLGLQGLEMLKRDQYDLLILDVMLPDIEGWSVLQVLRQFSKIPVIFLTAK
DQVMDRVKGLELGADDYLAKPFSYIELLARIKSLLRRQQYLQENELSISDLKMDLVGHKVWRNGNLIELSKTEFNLLRYL
LVNKEQIVTRRQIGSEVWNINFDTDTNFIDVAVRRLRSKIDEEYEPKLIHTIRGLGYKISVSL

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=49.5535714285714, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=49.5412844036697, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=35.2678571428571, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=35.2941176470588, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=34.8623853211009, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=35.4260089686099, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=29.8165137614679, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=36, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=30.0429184549356, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=29.3859649122807, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1790437, Length=136, Percent_Identity=28.6764705882353, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=30.0813008130081, Blast_Score=67, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=108, Percent_Identity=28.7037037037037, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25983; Mature: 25983

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIIEDEIKIATYLVKGLKESGYQAECVHLGLQGLEMLKRDQYDLLILDVMLPDIEGW
CEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCH
SVLQVLRQFSKIPVIFLTAKDQVMDRVKGLELGADDYLAKPFSYIELLARIKSLLRRQQY
HHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHH
LQENELSISDLKMDLVGHKVWRNGNLIELSKTEFNLLRYLLVNKEQIVTRRQIGSEVWNI
HHHCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHHCCHHEEE
NFDTDTNFIDVAVRRLRSKIDEEYEPKLIHTIRGLGYKISVSL
ECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEC
>Mature Secondary Structure
MRILIIEDEIKIATYLVKGLKESGYQAECVHLGLQGLEMLKRDQYDLLILDVMLPDIEGW
CEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCH
SVLQVLRQFSKIPVIFLTAKDQVMDRVKGLELGADDYLAKPFSYIELLARIKSLLRRQQY
HHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHH
LQENELSISDLKMDLVGHKVWRNGNLIELSKTEFNLLRYLLVNKEQIVTRRQIGSEVWNI
HHHCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHHCCHHEEE
NFDTDTNFIDVAVRRLRSKIDEEYEPKLIHTIRGLGYKISVSL
ECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]