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The map label for this gene is czcS [H]

Identifier: 213158596

GI number: 213158596

Start: 2644451

End: 2645854

Strand: Reverse

Name: czcS [H]

Synonym: AB57_2550

Alternate gene names: 213158596

Gene position: 2645854-2644451 (Counterclockwise)

Preceding gene: 213158597

Following gene: 213158595

Centisome position: 65.32

GC content: 37.82

Gene sequence:

>1404_bases
ATGAACTTTAAATTTCTACGTTCTCTTGAAGTCCGTATTACATTACTGGTCACGCTTTGTTCTGCCTTAATTTTATGTTC
AGTCGGCTTTATGACCTATTTGGGTATTAACCAGATTTTATTAAAGCAACAAGATAAAGCTTTAGCAGACAGAATTAACC
GTTTGGAAATTTTGCTGCAAGATAGCGAAAATGTAGAGCAAATCATTGCGCGGCCTAAGCTGTATCAAAACATGCTTGGC
AATCAAGACAACTTGTTTCTACTTATTCATAAAGACAAAACTTTAATTAATATCAATCCACTTCACATTCAACTACCTCC
GCTTGCACAGCGCGACAGTCTTCAATTTCAAGATTTAGCTAACAACTCATATCCAACGCGCATTGCGTGGAAAACCATAA
AAATTAATAACGAACCTTATCTGCTCATTGCAGGTAAACAATGGTCGGAACGCATTAATATTCTTTTACCTTTTCAAGAA
AGTCTCTTGATGTATGTGGTCGGGAGCGTGTTTGCGATCTTTGTGCTTTGCATTTTAGTGTGTCATTTAGGTTTAAAGTC
GCTACAACAGCTTCGCAAGCAAACTCATTCTATTAACGTAAATCAGCTACAGAAACGGTTAAACCTCCCAAATTCACCTT
TAGAAGTTGATCTGCTTTCAAAAGATATAAACCACATGCTTGAGCGTATTGAAAAGGGCTATACGCAGCTCAACCGTTTT
TCTGAAGATATCGCACATGAGTTCCGCACACCTTTAAATAATCTGATTGGGCAAACCGAGATTGCCTTAACTGGCGAACG
TTCGGTTGAACAATATGAAGATTTACTGGTTTCTCATTTAGACGATTACCACAGATTAAAACGCATGATTGATAGCATGC
TTTTCTTGGCAAGAGCCGATCAGAAAATGGTGCTTGTAAATAAACAAGAAATAAATATCCAAGATGTTATTGATAGGTTA
TGCCAGATTTTTGAATATCAGGCCGAGGAACAAGACTGTCATTTTAGTTTTAACTTAGAAGCTAAAACGTTATTTGCAGA
TCCTGAGCTTTTTCAAAGAGCCGTTTATAACCTGATTTTAAATGCGTTGGTTCACGGTGGTGACAAGCGAACTATTTATA
TCACAACAAAACATAAGATGATTGAGCATAAGCAATGGTTCAGCCTGACAGTGGTCACGGGAGGCATTTCAATTGCAGAT
CATCAACTTGAGCATCTTTTTGAAAGATTCTACCAATGCCACTCAAGTCGAAGTGATGAGAATCAAACAGGTGGATTAGG
TTTGTCGATTGTTGCTTCAATTATGGATCTACATCATGGCCGCTATCGAGTTTATAACACGGTTGAGGGCGTGTGCTTTG
AGCTTGATTTTCCAGTTGCAGATGCTCTAAAGAAATACAATTAA

Upstream 100 bases:

>100_bases
ACGTTGCAGTACGCCGTTTAAGAAGCAAAATTGATGAAGAATATGAACCAAAACTTATCCATACCATCCGTGGCTTGGGC
TATAAAATTTCGGTTAGCTT

Downstream 100 bases:

>100_bases
ATCCTTATTAATGTTGCTTAATTTTTAAAATTCACACTTTGTTCACAGCCCTCTGACGTATGTTTAAACGTATGAAATAA
ACAGAAGAGGGCAATCATGA

Product: two-component heavy metal sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNFKFLRSLEVRITLLVTLCSALILCSVGFMTYLGINQILLKQQDKALADRINRLEILLQDSENVEQIIARPKLYQNMLG
NQDNLFLLIHKDKTLININPLHIQLPPLAQRDSLQFQDLANNSYPTRIAWKTIKINNEPYLLIAGKQWSERINILLPFQE
SLLMYVVGSVFAIFVLCILVCHLGLKSLQQLRKQTHSINVNQLQKRLNLPNSPLEVDLLSKDINHMLERIEKGYTQLNRF
SEDIAHEFRTPLNNLIGQTEIALTGERSVEQYEDLLVSHLDDYHRLKRMIDSMLFLARADQKMVLVNKQEINIQDVIDRL
CQIFEYQAEEQDCHFSFNLEAKTLFADPELFQRAVYNLILNALVHGGDKRTIYITTKHKMIEHKQWFSLTVVTGGISIAD
HQLEHLFERFYQCHSSRSDENQTGGLGLSIVASIMDLHHGRYRVYNTVEGVCFELDFPVADALKKYN

Sequences:

>Translated_467_residues
MNFKFLRSLEVRITLLVTLCSALILCSVGFMTYLGINQILLKQQDKALADRINRLEILLQDSENVEQIIARPKLYQNMLG
NQDNLFLLIHKDKTLININPLHIQLPPLAQRDSLQFQDLANNSYPTRIAWKTIKINNEPYLLIAGKQWSERINILLPFQE
SLLMYVVGSVFAIFVLCILVCHLGLKSLQQLRKQTHSINVNQLQKRLNLPNSPLEVDLLSKDINHMLERIEKGYTQLNRF
SEDIAHEFRTPLNNLIGQTEIALTGERSVEQYEDLLVSHLDDYHRLKRMIDSMLFLARADQKMVLVNKQEINIQDVIDRL
CQIFEYQAEEQDCHFSFNLEAKTLFADPELFQRAVYNLILNALVHGGDKRTIYITTKHKMIEHKQWFSLTVVTGGISIAD
HQLEHLFERFYQCHSSRSDENQTGGLGLSIVASIMDLHHGRYRVYNTVEGVCFELDFPVADALKKYN
>Mature_467_residues
MNFKFLRSLEVRITLLVTLCSALILCSVGFMTYLGINQILLKQQDKALADRINRLEILLQDSENVEQIIARPKLYQNMLG
NQDNLFLLIHKDKTLININPLHIQLPPLAQRDSLQFQDLANNSYPTRIAWKTIKINNEPYLLIAGKQWSERINILLPFQE
SLLMYVVGSVFAIFVLCILVCHLGLKSLQQLRKQTHSINVNQLQKRLNLPNSPLEVDLLSKDINHMLERIEKGYTQLNRF
SEDIAHEFRTPLNNLIGQTEIALTGERSVEQYEDLLVSHLDDYHRLKRMIDSMLFLARADQKMVLVNKQEINIQDVIDRL
CQIFEYQAEEQDCHFSFNLEAKTLFADPELFQRAVYNLILNALVHGGDKRTIYITTKHKMIEHKQWFSLTVVTGGISIAD
HQLEHLFERFYQCHSSRSDENQTGGLGLSIVASIMDLHHGRYRVYNTVEGVCFELDFPVADALKKYN

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=34.6801346801347, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788279, Length=461, Percent_Identity=27.114967462039, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=24.7349823321555, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789403, Length=469, Percent_Identity=24.5202558635394, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=25.8426966292135, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082128, Length=277, Percent_Identity=25.9927797833935, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=24.6575342465753, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=23.9382239382239, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=26.2443438914027, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=246, Percent_Identity=21.1382113821138, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54091; Mature: 54091

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKFLRSLEVRITLLVTLCSALILCSVGFMTYLGINQILLKQQDKALADRINRLEILLQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
DSENVEQIIARPKLYQNMLGNQDNLFLLIHKDKTLININPLHIQLPPLAQRDSLQFQDLA
CCCCHHHHHHCHHHHHHHHCCCCCEEEEEECCCEEEEECCEEEECCCCCCCCCCCHHHHC
NNSYPTRIAWKTIKINNEPYLLIAGKQWSERINILLPFQESLLMYVVGSVFAIFVLCILV
CCCCCCEEEEEEEEECCCCEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
CHLGLKSLQQLRKQTHSINVNQLQKRLNLPNSPLEVDLLSKDINHMLERIEKGYTQLNRF
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SEDIAHEFRTPLNNLIGQTEIALTGERSVEQYEDLLVSHLDDYHRLKRMIDSMLFLARAD
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QKMVLVNKQEINIQDVIDRLCQIFEYQAEEQDCHFSFNLEAKTLFADPELFQRAVYNLIL
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHHH
NALVHGGDKRTIYITTKHKMIEHKQWFSLTVVTGGISIADHQLEHLFERFYQCHSSRSDE
HHHHCCCCCEEEEEEECHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
NQTGGLGLSIVASIMDLHHGRYRVYNTVEGVCFELDFPVADALKKYN
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHHCCC
>Mature Secondary Structure
MNFKFLRSLEVRITLLVTLCSALILCSVGFMTYLGINQILLKQQDKALADRINRLEILLQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
DSENVEQIIARPKLYQNMLGNQDNLFLLIHKDKTLININPLHIQLPPLAQRDSLQFQDLA
CCCCHHHHHHCHHHHHHHHCCCCCEEEEEECCCEEEEECCEEEECCCCCCCCCCCHHHHC
NNSYPTRIAWKTIKINNEPYLLIAGKQWSERINILLPFQESLLMYVVGSVFAIFVLCILV
CCCCCCEEEEEEEEECCCCEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
CHLGLKSLQQLRKQTHSINVNQLQKRLNLPNSPLEVDLLSKDINHMLERIEKGYTQLNRF
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SEDIAHEFRTPLNNLIGQTEIALTGERSVEQYEDLLVSHLDDYHRLKRMIDSMLFLARAD
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QKMVLVNKQEINIQDVIDRLCQIFEYQAEEQDCHFSFNLEAKTLFADPELFQRAVYNLIL
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHHH
NALVHGGDKRTIYITTKHKMIEHKQWFSLTVVTGGISIADHQLEHLFERFYQCHSSRSDE
HHHHCCCCCEEEEEEECHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
NQTGGLGLSIVASIMDLHHGRYRVYNTVEGVCFELDFPVADALKKYN
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]