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The map label for this gene is yiaY [H]

Identifier: 213158481

GI number: 213158481

Start: 2518014

End: 2519186

Strand: Direct

Name: yiaY [H]

Synonym: AB57_2430

Alternate gene names: 213158481

Gene position: 2518014-2519186 (Clockwise)

Preceding gene: 213158478

Following gene: 213158483

Centisome position: 62.17

GC content: 44.08

Gene sequence:

>1173_bases
ATGGCTTTTAAAAATATTGCAGATCAAACAAACGGTTTTTATATTCCTTGCGTATCACTCTTTGGACCAGGATGTGCCAA
AGAAATTGGAACAAAGGCGCAGAACCTCGGCGCAAAAAAAGCATTAATTGTGACCGATGAAGGGCTATTTAAATTTGGCG
TTGCAGATCTTATCGCAAGCTATTTAACCGAAGCAGGCGTAGCGAGCCATATTTTCCCGGGCGCGGAACCTAACCCAACC
GATATTAATGTTCACAACGGTGTGAATGCCTATAACGAAAATGGCTGTGACTTTATTGTGTCGTTAGGCGGCGGCTCATC
TCATGACTGTGCAAAAGGGATTGGCTTAGTGACTGCGGGTGGTGGTCATATTCGTGACTACGAAGGCATCGATAAAAGTA
AAGTCCCAATGACGCCATTGATTGCAGTGAATACAACGGCTGGTACGGCATCTGAAATGACTCGTTTCTGTATTATTACC
AATACCGATACTCACGTAAAAATGGCTATTGTGGACTGGCGTTGTACTCCACTTATTGCGATCGATGACCCGAAACTCAT
GATTGCAAAACCGGCTGGTTTAACCGCTGCAACAGGTATGGATGCATTAACCCATGCAGTTGAAGCATATGTTTCTACAG
CAGCAAACCCAATTACTGATGCGTGTGCAGAAAAAGCAATCACCATGATTAGTCAATGGTTACAACCCGCTGTCGCAAAT
GGTGAAAACATCGAAGCTCGTGATGCGATGAGCTATGCGCAGTACTTGGCTGGTATGGCATTTAACAATGCATCTTTAGG
TTATGTTCATGCAATGGCACACCAGTTGGGCGGGTTCTACAACCTACCTCATGGTGTATGTAACGCAATCTTGCTACCAC
ATGTTTGTGAATTTAACTTAATTGCTTGTCCAGATCGTTATGCAAAAATCGCAGAATTAATGGGTGTAAATACCCACGGT
CTCACCGTAACAGAAGCTGCATATGCTGCAATTGATGCCATCCGTAAACTGTCTTCTTCAATTGGTATCCCATCTGGCTT
AACAGAACTTGGCGTAAAAACTGAGGACCTCGCGGTGATGGCCGAAAATGCTCAAAAAGACGCATGTATGCTCACCAACC
CTCGTAAAGCAAACCATGCACAAGTTGTGGAGATTTTCAAAGCAGCACTTTAA

Upstream 100 bases:

>100_bases
TTGGTAGGTAGGAAAATAATCTACACATCACAATACTAAGGCCATGGTGAGGCTCACCTGTAATAACAAACAATGGATTT
ATGGAAAAAGGAATCACTCC

Downstream 100 bases:

>100_bases
TACTGATGTAACGCTATGTTCCTGTAGTAAGTCAAATCCCTCCGACCGTTGACTTACTTTTTGGGGAATACTTAGCTCCA
GCGGTATTCCCTTTTTTTAA

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDEGLFKFGVADLIASYLTEAGVASHIFPGAEPNPT
DINVHNGVNAYNENGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSKVPMTPLIAVNTTAGTASEMTRFCIIT
NTDTHVKMAIVDWRCTPLIAIDDPKLMIAKPAGLTAATGMDALTHAVEAYVSTAANPITDACAEKAITMISQWLQPAVAN
GENIEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVCEFNLIACPDRYAKIAELMGVNTHG
LTVTEAAYAAIDAIRKLSSSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVEIFKAAL

Sequences:

>Translated_390_residues
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDEGLFKFGVADLIASYLTEAGVASHIFPGAEPNPT
DINVHNGVNAYNENGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSKVPMTPLIAVNTTAGTASEMTRFCIIT
NTDTHVKMAIVDWRCTPLIAIDDPKLMIAKPAGLTAATGMDALTHAVEAYVSTAANPITDACAEKAITMISQWLQPAVAN
GENIEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVCEFNLIACPDRYAKIAELMGVNTHG
LTVTEAAYAAIDAIRKLSSSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVEIFKAAL
>Mature_389_residues
AFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDEGLFKFGVADLIASYLTEAGVASHIFPGAEPNPTD
INVHNGVNAYNENGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSKVPMTPLIAVNTTAGTASEMTRFCIITN
TDTHVKMAIVDWRCTPLIAIDDPKLMIAKPAGLTAATGMDALTHAVEAYVSTAANPITDACAEKAITMISQWLQPAVANG
ENIEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVCEFNLIACPDRYAKIAELMGVNTHGL
TVTEAAYAAIDAIRKLSSSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVEIFKAAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=380, Percent_Identity=28.1578947368421, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=58.2010582010582, Blast_Score=440, Evalue=1e-125,
Organism=Escherichia coli, GI1789163, Length=373, Percent_Identity=39.9463806970509, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082107, Length=382, Percent_Identity=35.8638743455497, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1787493, Length=370, Percent_Identity=35.4054054054054, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789386, Length=363, Percent_Identity=26.9972451790634, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=420, Percent_Identity=25.4761904761905, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=51.5873015873016, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24657991, Length=409, Percent_Identity=27.3838630806846, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41018; Mature: 40887

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDEGLFKFGVADLIAS
CCCCHHHHCCCCEEEEEHHHCCCCHHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHHHHH
YLTEAGVASHIFPGAEPNPTDINVHNGVNAYNENGCDFIVSLGGGSSHDCAKGIGLVTAG
HHHHCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCHHCCCEEEECC
GGHIRDYEGIDKSKVPMTPLIAVNTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPLIA
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEECCCEEEE
IDDPKLMIAKPAGLTAATGMDALTHAVEAYVSTAANPITDACAEKAITMISQWLQPAVAN
ECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GENIEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVCEFNL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCE
IACPDRYAKIAELMGVNTHGLTVTEAAYAAIDAIRKLSSSIGIPSGLTELGVKTEDLAVM
EECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHEE
AENAQKDACMLTNPRKANHAQVVEIFKAAL
ECCCCCCEEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDEGLFKFGVADLIAS
CCCHHHHCCCCEEEEEHHHCCCCHHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHHHHH
YLTEAGVASHIFPGAEPNPTDINVHNGVNAYNENGCDFIVSLGGGSSHDCAKGIGLVTAG
HHHHCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCHHCCCEEEECC
GGHIRDYEGIDKSKVPMTPLIAVNTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPLIA
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEECCCEEEE
IDDPKLMIAKPAGLTAATGMDALTHAVEAYVSTAANPITDACAEKAITMISQWLQPAVAN
ECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GENIEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVCEFNL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCE
IACPDRYAKIAELMGVNTHGLTVTEAAYAAIDAIRKLSSSIGIPSGLTELGVKTEDLAVM
EECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHEE
AENAQKDACMLTNPRKANHAQVVEIFKAAL
ECCCCCCEEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]