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The map label for this gene is lrp [H]

Identifier: 213158465

GI number: 213158465

Start: 2501332

End: 2501829

Strand: Direct

Name: lrp [H]

Synonym: AB57_2414

Alternate gene names: 213158465

Gene position: 2501332-2501829 (Clockwise)

Preceding gene: 213158463

Following gene: 213158476

Centisome position: 61.75

GC content: 41.37

Gene sequence:

>498_bases
TTGGTTTATATTTTGAACAGCACAGAATACACACTAGATCGCATAGATCGGAAAATATTATCTGCCCTACGTAGAAATGG
CCGTTTAACGGTTGCACAGCTCGCCGAAGAAGTCGGGCTTTCATCTTCGCCTTGCTGGACTCGACTCAAACGTTTAGAAA
GTCTAAAAATTATTGAAGGCTATACCGTAAACGTAAACCCCAAAGCGATTGGCATTCATGAGTTGTTTTTTATCGAAATT
ACCCTAGAACGCCACGATGATGAAATGTTAGAAAACTTTAGCGAGGCTTTGGCAGACATTCCAGAAGTGGTCGAAGCGCA
TTTAGTTACGGGCGACTATGATTATTTGGTGAAAGTGGCCGTAAAAGATGCCGAGCATTACGAACGTTTTTTACGTAAAA
AGCTCTACTCGATTAAAGGAATCCGCCACACGCGTTCAACCTTTGCTTTACGACCACTTAAATCTGCCAATACTGCCGAT
TTAATGTTGATTGAATAA

Upstream 100 bases:

>100_bases
GTATGGCTGTGTCGCTCAAAATGTTTACTGAATTTTCAGTTTTTTTAAATGATATCAGCATAAAAATCACGTATATTTAA
AATTAACAGAAGAATCTTCT

Downstream 100 bases:

>100_bases
TTTGCTTATAGGGAGGGCTTTGGGTGGTTCATTGTTTTAATTTGATTTTATTCAATGTTACACATAAAGCTCTCTTGTCA
GCTTCTTTAAGTTGAGGATG

Product: transcriptional regulator, AsnC family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MVYILNSTEYTLDRIDRKILSALRRNGRLTVAQLAEEVGLSSSPCWTRLKRLESLKIIEGYTVNVNPKAIGIHELFFIEI
TLERHDDEMLENFSEALADIPEVVEAHLVTGDYDYLVKVAVKDAEHYERFLRKKLYSIKGIRHTRSTFALRPLKSANTAD
LMLIE

Sequences:

>Translated_165_residues
MVYILNSTEYTLDRIDRKILSALRRNGRLTVAQLAEEVGLSSSPCWTRLKRLESLKIIEGYTVNVNPKAIGIHELFFIEI
TLERHDDEMLENFSEALADIPEVVEAHLVTGDYDYLVKVAVKDAEHYERFLRKKLYSIKGIRHTRSTFALRPLKSANTAD
LMLIE
>Mature_165_residues
MVYILNSTEYTLDRIDRKILSALRRNGRLTVAQLAEEVGLSSSPCWTRLKRLESLKIIEGYTVNVNPKAIGIHELFFIEI
TLERHDDEMLENFSEALADIPEVVEAHLVTGDYDYLVKVAVKDAEHYERFLRKKLYSIKGIRHTRSTFALRPLKSANTAD
LMLIE

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=146, Percent_Identity=40.4109589041096, Blast_Score=124, Evalue=2e-30,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=36.3636363636364, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790182, Length=145, Percent_Identity=31.7241379310345, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19008; Mature: 19008

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYILNSTEYTLDRIDRKILSALRRNGRLTVAQLAEEVGLSSSPCWTRLKRLESLKIIEG
CEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEEEECC
YTVNVNPKAIGIHELFFIEITLERHDDEMLENFSEALADIPEVVEAHLVTGDYDYLVKVA
EEEECCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEE
VKDAEHYERFLRKKLYSIKGIRHTRSTFALRPLKSANTADLMLIE
HHCHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCCEEEEEC
>Mature Secondary Structure
MVYILNSTEYTLDRIDRKILSALRRNGRLTVAQLAEEVGLSSSPCWTRLKRLESLKIIEG
CEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEEEECC
YTVNVNPKAIGIHELFFIEITLERHDDEMLENFSEALADIPEVVEAHLVTGDYDYLVKVA
EEEECCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEE
VKDAEHYERFLRKKLYSIKGIRHTRSTFALRPLKSANTADLMLIE
HHCHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]