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The map label for this gene is fadI [H]

Identifier: 213158434

GI number: 213158434

Start: 2470543

End: 2472111

Strand: Direct

Name: fadI [H]

Synonym: AB57_2383

Alternate gene names: 213158434

Gene position: 2470543-2472111 (Clockwise)

Preceding gene: 213158430

Following gene: 213158436

Centisome position: 60.99

GC content: 42.96

Gene sequence:

>1569_bases
ATGAGCAAAACAACTCAAGAAAATCCAGCAGTCGAGAATTCTGCTCAGGAAAAAGTGTCAAATACATCAAAGTCGGCTTC
TAACACGGCTAAGCGTAACAGCACTACTCCTAAAGCAGCAACTAATACACCAAAAACGACACGTACTCGTTCAACGACTG
CACCTGCACGTAGCCCTCGTAGTAAGAGCGCTGCTTCAGCAACCCCGTCTACATCTTCAAATGTAGCTGCAGCACCAAAA
GCAACAAAAACCAAAACTTCTGTTCAACAGGATAAAACCATGAGTCAAAACACTGTTCGCCGCGTTGCAATCCTTGGTGG
CAACCGTATTCCATTTGCACGTTCAAATACTGCTTATTTTAAAGCGTCTAATTCTGACATGCTGACAGCAGCATTGAATG
GTTTGGTTGAACGCTTTAACTTACAAGGTAAGCGTATTGGCGAAGTTGTTGCGGGCGCTGTTTTAAAACATAGCCGTGAC
TTCAACATGACTCGTGAAGTTGTATTGAGCACAGATCTTGCTCCTGAAACTCCTGCTTACGACATCCAAATTGCATGTGG
TACAGGTTTACAAGCAGCATTTGTTGTTGCTAACAAAATTGCGCTTGGTCAAATCGACGTAGGTATTGCAGGTGGCGTAG
ATACAACTTCTGACGCACCGATTGCTGTAGGTGATGGTTTACGTAAAGTTTTACTTGAGCTTAATGTTGCTAAAACAGGT
AAAGACCGTCTTAAAGCTTTAACAAAGATTGATTTTAAAAAGCTTCTTGATGCTCCAAGCAATGGTGAACCACGTACTGG
CCTTTCAATGGGTGAGCACCAAGCAATCACTGCATTAGAATGGGGTATCACTCGTGAAGCACAAGACGAGCTAGCTGCAA
GCAGCCATCAAAAACTTGCTGCTGCTTATGAGCGTGGTTTCTTTGATGACTTAATGACTCCATTCTTAGGTCTTAACCGT
GACAACAACTTACGTCCTGACAGTACAGTTGAAAAACTTGCTAAGTTAAAACCAGTTTTCGGTAAAGGTGAAACTGCAAC
AATGACAGCGGGTAACTCAACTCCGTTGACTGATGGTGCTTCTGTGGTATTGCTTGCTTCTGAAGAATGGGCAAAAGAAA
ACGGACATGAAGTTTTAGCTTATCTTTCTTTCTCTGAAACAGCAGCTGTTGACTTCATTGGCAAGAACGGCCCTAAAGAA
GGCTTATTGATGGCTCCTGCTTATGCAGTACCTCGTATGCTTAAGCGTGCTAACCTTAAGCTTCAAGACTTCGATTTCTA
CGAAATCCATGAAGCATTTGCATCCCAAGTACTCTCTACCCTAAAAGCTTGGGAAGATGAAAAATTCTGTAAAGAACGTC
TTGGCTTAGATGCACCATTGGGTTCAATTGACCGCTCTAAACTGAACGTAAATGGTTCATCTTTAGGTGCAGGTCATCCA
TTTGCTGCAACTGGTGGTCGTATCTTGGCTACTGCAGCTAAATTAATTAATGAAAAAGGTTCAGGCCGCGCATTAATCTC
GATCTGTACAGCAGGCGGTGAAGGTGTGGTTGCGATTGTAGAAAAATAA

Upstream 100 bases:

>100_bases
CCTGAATGCTATCTACAATGTCATTCTAGTCAATACAGGTCTATTTGAATTGTGTTAAGGTAGCTAACAAGAATATCGTT
ATTATGCTTGGAAAAGCCTT

Downstream 100 bases:

>100_bases
TTTCTATTTATCGACCAAAAAAAATAAGCACCCATCTGGGTGCTTATTTCATTTCAATCTATGTGAATTAATGAAGTGAT
GCTGCTTTAGCATTTGGGAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSKTTQENPAVENSAQEKVSNTSKSASNTAKRNSTTPKAATNTPKTTRTRSTTAPARSPRSKSAASATPSTSSNVAAAPK
ATKTKTSVQQDKTMSQNTVRRVAILGGNRIPFARSNTAYFKASNSDMLTAALNGLVERFNLQGKRIGEVVAGAVLKHSRD
FNMTREVVLSTDLAPETPAYDIQIACGTGLQAAFVVANKIALGQIDVGIAGGVDTTSDAPIAVGDGLRKVLLELNVAKTG
KDRLKALTKIDFKKLLDAPSNGEPRTGLSMGEHQAITALEWGITREAQDELAASSHQKLAAAYERGFFDDLMTPFLGLNR
DNNLRPDSTVEKLAKLKPVFGKGETATMTAGNSTPLTDGASVVLLASEEWAKENGHEVLAYLSFSETAAVDFIGKNGPKE
GLLMAPAYAVPRMLKRANLKLQDFDFYEIHEAFASQVLSTLKAWEDEKFCKERLGLDAPLGSIDRSKLNVNGSSLGAGHP
FAATGGRILATAAKLINEKGSGRALISICTAGGEGVVAIVEK

Sequences:

>Translated_522_residues
MSKTTQENPAVENSAQEKVSNTSKSASNTAKRNSTTPKAATNTPKTTRTRSTTAPARSPRSKSAASATPSTSSNVAAAPK
ATKTKTSVQQDKTMSQNTVRRVAILGGNRIPFARSNTAYFKASNSDMLTAALNGLVERFNLQGKRIGEVVAGAVLKHSRD
FNMTREVVLSTDLAPETPAYDIQIACGTGLQAAFVVANKIALGQIDVGIAGGVDTTSDAPIAVGDGLRKVLLELNVAKTG
KDRLKALTKIDFKKLLDAPSNGEPRTGLSMGEHQAITALEWGITREAQDELAASSHQKLAAAYERGFFDDLMTPFLGLNR
DNNLRPDSTVEKLAKLKPVFGKGETATMTAGNSTPLTDGASVVLLASEEWAKENGHEVLAYLSFSETAAVDFIGKNGPKE
GLLMAPAYAVPRMLKRANLKLQDFDFYEIHEAFASQVLSTLKAWEDEKFCKERLGLDAPLGSIDRSKLNVNGSSLGAGHP
FAATGGRILATAAKLINEKGSGRALISICTAGGEGVVAIVEK
>Mature_521_residues
SKTTQENPAVENSAQEKVSNTSKSASNTAKRNSTTPKAATNTPKTTRTRSTTAPARSPRSKSAASATPSTSSNVAAAPKA
TKTKTSVQQDKTMSQNTVRRVAILGGNRIPFARSNTAYFKASNSDMLTAALNGLVERFNLQGKRIGEVVAGAVLKHSRDF
NMTREVVLSTDLAPETPAYDIQIACGTGLQAAFVVANKIALGQIDVGIAGGVDTTSDAPIAVGDGLRKVLLELNVAKTGK
DRLKALTKIDFKKLLDAPSNGEPRTGLSMGEHQAITALEWGITREAQDELAASSHQKLAAAYERGFFDDLMTPFLGLNRD
NNLRPDSTVEKLAKLKPVFGKGETATMTAGNSTPLTDGASVVLLASEEWAKENGHEVLAYLSFSETAAVDFIGKNGPKEG
LLMAPAYAVPRMLKRANLKLQDFDFYEIHEAFASQVLSTLKAWEDEKFCKERLGLDAPLGSIDRSKLNVNGSSLGAGHPF
AATGGRILATAAKLINEKGSGRALISICTAGGEGVVAIVEK

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=459, Percent_Identity=36.8191721132898, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4501853, Length=441, Percent_Identity=29.0249433106576, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI167614485, Length=434, Percent_Identity=28.8018433179723, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI148539872, Length=432, Percent_Identity=26.6203703703704, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4557237, Length=446, Percent_Identity=27.5784753363229, Blast_Score=136, Evalue=6e-32,
Organism=Escherichia coli, GI1788683, Length=414, Percent_Identity=38.1642512077295, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87082165, Length=438, Percent_Identity=29.2237442922374, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1788554, Length=439, Percent_Identity=29.1571753986333, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI48994986, Length=437, Percent_Identity=28.1464530892449, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI1787663, Length=437, Percent_Identity=28.604118993135, Blast_Score=135, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17551802, Length=436, Percent_Identity=35.5504587155963, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI133906874, Length=430, Percent_Identity=28.6046511627907, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17535921, Length=437, Percent_Identity=26.5446224256293, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI25147385, Length=431, Percent_Identity=25.5220417633411, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=437, Percent_Identity=31.5789473684211, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=442, Percent_Identity=28.7330316742081, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17137578, Length=437, Percent_Identity=37.2997711670481, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24655093, Length=429, Percent_Identity=28.2051282051282, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=29.7709923664122, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24640423, Length=438, Percent_Identity=26.027397260274, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 55280; Mature: 55149

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTTQENPAVENSAQEKVSNTSKSASNTAKRNSTTPKAATNTPKTTRTRSTTAPARSPR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SKSAASATPSTSSNVAAAPKATKTKTSVQQDKTMSQNTVRRVAILGGNRIPFARSNTAYF
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEE
KASNSDMLTAALNGLVERFNLQGKRIGEVVAGAVLKHSRDFNMTREVVLSTDLAPETPAY
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCCCE
DIQIACGTGLQAAFVVANKIALGQIDVGIAGGVDTTSDAPIAVGDGLRKVLLELNVAKTG
EEEEEECCCCHHHHHHHHHEEECEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCCCC
KDRLKALTKIDFKKLLDAPSNGEPRTGLSMGEHQAITALEWGITREAQDELAASSHQKLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
AAYERGFFDDLMTPFLGLNRDNNLRPDSTVEKLAKLKPVFGKGETATMTAGNSTPLTDGA
HHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
SVVLLASEEWAKENGHEVLAYLSFSETAAVDFIGKNGPKEGLLMAPAYAVPRMLKRANLK
CEEEEECHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCHHHHHHHHHHCCCC
LQDFDFYEIHEAFASQVLSTLKAWEDEKFCKERLGLDAPLGSIDRSKLNVNGSSLGAGHP
EECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCC
FAATGGRILATAAKLINEKGSGRALISICTAGGEGVVAIVEK
CCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEC
>Mature Secondary Structure 
SKTTQENPAVENSAQEKVSNTSKSASNTAKRNSTTPKAATNTPKTTRTRSTTAPARSPR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SKSAASATPSTSSNVAAAPKATKTKTSVQQDKTMSQNTVRRVAILGGNRIPFARSNTAYF
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEE
KASNSDMLTAALNGLVERFNLQGKRIGEVVAGAVLKHSRDFNMTREVVLSTDLAPETPAY
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCCCE
DIQIACGTGLQAAFVVANKIALGQIDVGIAGGVDTTSDAPIAVGDGLRKVLLELNVAKTG
EEEEEECCCCHHHHHHHHHEEECEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCCCC
KDRLKALTKIDFKKLLDAPSNGEPRTGLSMGEHQAITALEWGITREAQDELAASSHQKLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
AAYERGFFDDLMTPFLGLNRDNNLRPDSTVEKLAKLKPVFGKGETATMTAGNSTPLTDGA
HHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
SVVLLASEEWAKENGHEVLAYLSFSETAAVDFIGKNGPKEGLLMAPAYAVPRMLKRANLK
CEEEEECHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCHHHHHHHHHHCCCC
LQDFDFYEIHEAFASQVLSTLKAWEDEKFCKERLGLDAPLGSIDRSKLNVNGSSLGAGHP
EECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCC
FAATGGRILATAAKLINEKGSGRALISICTAGGEGVVAIVEK
CCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA