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The map label for this gene is accC [H]

Identifier: 213158412

GI number: 213158412

Start: 2443401

End: 2444771

Strand: Direct

Name: accC [H]

Synonym: AB57_2360

Alternate gene names: 213158412

Gene position: 2443401-2444771 (Clockwise)

Preceding gene: 213158411

Following gene: 213158416

Centisome position: 60.32

GC content: 41.43

Gene sequence:

>1371_bases
ATGTTGCAAAAAGTTTTAATTGCAAACCGTGGTGAAATCGCTTTACGAATTACCCGGGCTTGCAAAACATTAGGAATCAA
AACTGTTGGGATCTATTCAGATGCCGATAAAGATTTGATGCATTTACGTTTCGTTGATGAAGCAGTATGTATTGGTCCGG
GTGCAAGTAGTGACAGCTATTTAAACATCCCGGCAATTATTACTGCTGCAGAAATTACTGGTGCCGATGCAATTCATCCA
GGTTATGGCTTCCTTTCGGAAAATGCCGAGTTTGCTGAAATTGTAGAAAGCTCAGGTTTCACATTTATTGGCCCTCGCCC
AGAACATATTCGTTTAATGGGTAACAAGGTTTCTGCAATTGTTGCAATGAAAAAAGCTGGCGTACCTACGGTACCTGGCT
GTGACCATGCTGTAACTATCCACAATGCCTTGGCTGAAGCGAAAGAAATCGGTTTCCCGCTTATTGTTAAAGCGGCAGCT
GGTGGCGGTGGTCGTGGTATGCGTATTGTTGAACGTGTAGATACACTACTTGAGTCAGTTCAAGCGGCTCAACGTGATGC
AGAAATGTGGTTCGGCGATGATACCGTATACATGGAACGCTTCTTACAAAAACCTCGCCATGTCGAAGTTCAAGTTTTGG
GTGATGGTAATGGCCACGCGATTCATTTATATGACCGTGACTGTTCATTACAACGTCGTCACCAAAAAGTGTTAGAAGAA
GCTCCTGCTCCAAATCTACCGGAACAAGCACGTGCTGATATTTTACAAGCCTGTGTCCACGCATGTCAGTTAATGCAATA
TCGTGGTGCTGGTACGTTTGAATTCTTATTTGAAGATGGTGAATTCTTCTTCATTGAAATGAATACTCGTGTTCAGGTTG
AGCACCCTGTAACTGAAATGGTAACTGGGGTTGACATTATTGAACAGCAATTACGTATTGCAGCTGGTTTAGGCTTAGAG
CTTCAACAAGAAGATATTGAAGTTCGTGGTCATGCCATTGAATGTCGTATCAATGCCGAAGATCCAACAACATTCTTACC
TTCACCAGGTAAAATTGAAAGTTTCTATGCACCAGGCGGTGCGGGTATTCGTTTAGATTCTCATATCTATCCTGGATATA
GCATTCCGCCATATTACGATTCAATGATTGCAAAATTGATTGCTCATGGTAAAGATCGTGAAACTTCACTTGCCCGCATG
CGTCAAGCGTTAGATGAAATGATCCTTACAGGAATTAAAACCAATATTCCTTTACATAAAGATCTTATTTTGCAGGATAA
AAACTTCTGTTCTCAAGCAATGGACATCCATTACCTTGAAAAACACTTGTTAAAGCAAGTGGAAGAAGAAAAGAAAGCTG
AAACTGCTTAA

Upstream 100 bases:

>100_bases
CAAAGCGGTGTGATTGAAGAAATTTTAGTGAAAAATGGTGAAGTGATCCAATTCGGTCAACCTTTATTCCGTTATCGCGC
GTAATACCCCGGGGACATCT

Downstream 100 bases:

>100_bases
TCTGCTTCATATAAAAAAGCCTCTTAAATAAGAGGCTTTTTTATATCTACTTGTTTATGGCAACATTCGGCGTAAAGTTG
CGAAACATTGCTCACCCTTA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSYLNIPAIITAAEITGADAIHP
GYGFLSENAEFAEIVESSGFTFIGPRPEHIRLMGNKVSAIVAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAA
GGGGRGMRIVERVDTLLESVQAAQRDAEMWFGDDTVYMERFLQKPRHVEVQVLGDGNGHAIHLYDRDCSLQRRHQKVLEE
APAPNLPEQARADILQACVHACQLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEMVTGVDIIEQQLRIAAGLGLE
LQQEDIEVRGHAIECRINAEDPTTFLPSPGKIESFYAPGGAGIRLDSHIYPGYSIPPYYDSMIAKLIAHGKDRETSLARM
RQALDEMILTGIKTNIPLHKDLILQDKNFCSQAMDIHYLEKHLLKQVEEEKKAETA

Sequences:

>Translated_456_residues
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSYLNIPAIITAAEITGADAIHP
GYGFLSENAEFAEIVESSGFTFIGPRPEHIRLMGNKVSAIVAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAA
GGGGRGMRIVERVDTLLESVQAAQRDAEMWFGDDTVYMERFLQKPRHVEVQVLGDGNGHAIHLYDRDCSLQRRHQKVLEE
APAPNLPEQARADILQACVHACQLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEMVTGVDIIEQQLRIAAGLGLE
LQQEDIEVRGHAIECRINAEDPTTFLPSPGKIESFYAPGGAGIRLDSHIYPGYSIPPYYDSMIAKLIAHGKDRETSLARM
RQALDEMILTGIKTNIPLHKDLILQDKNFCSQAMDIHYLEKHLLKQVEEEKKAETA
>Mature_456_residues
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSYLNIPAIITAAEITGADAIHP
GYGFLSENAEFAEIVESSGFTFIGPRPEHIRLMGNKVSAIVAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAA
GGGGRGMRIVERVDTLLESVQAAQRDAEMWFGDDTVYMERFLQKPRHVEVQVLGDGNGHAIHLYDRDCSLQRRHQKVLEE
APAPNLPEQARADILQACVHACQLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEMVTGVDIIEQQLRIAAGLGLE
LQQEDIEVRGHAIECRINAEDPTTFLPSPGKIESFYAPGGAGIRLDSHIYPGYSIPPYYDSMIAKLIAHGKDRETSLARM
RQALDEMILTGIKTNIPLHKDLILQDKNFCSQAMDIHYLEKHLLKQVEEEKKAETA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=419, Percent_Identity=47.7326968973747, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=431, Percent_Identity=46.4037122969838, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI295821183, Length=431, Percent_Identity=46.4037122969838, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=431, Percent_Identity=46.4037122969838, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=46.7706013363029, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=46.7706013363029, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=46.7706013363029, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38679960, Length=524, Percent_Identity=28.2442748091603, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679971, Length=524, Percent_Identity=28.2442748091603, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679974, Length=524, Percent_Identity=28.8167938931298, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679977, Length=524, Percent_Identity=28.2442748091603, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI38679967, Length=524, Percent_Identity=28.2442748091603, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI134142062, Length=522, Percent_Identity=28.3524904214559, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=64.0449438202247, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1786216, Length=246, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=419, Percent_Identity=45.5847255369928, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=43.1151241534989, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=44.7661469933185, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=29.4715447154472, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=452, Percent_Identity=27.8761061946903, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=452, Percent_Identity=27.8761061946903, Blast_Score=191, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=45.2214452214452, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=426, Percent_Identity=46.4788732394366, Blast_Score=345, Evalue=9e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=426, Percent_Identity=47.4178403755869, Blast_Score=332, Evalue=9e-92,
Organism=Saccharomyces cerevisiae, GI6323863, Length=472, Percent_Identity=31.7796610169492, Blast_Score=226, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=532, Percent_Identity=29.1353383458647, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=47.8841870824053, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651757, Length=426, Percent_Identity=46.7136150234742, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=388, Percent_Identity=46.6494845360825, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI161076409, Length=517, Percent_Identity=28.2398452611219, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24586458, Length=517, Percent_Identity=28.2398452611219, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI161076407, Length=517, Percent_Identity=28.2398452611219, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24586460, Length=517, Percent_Identity=28.2398452611219, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50354; Mature: 50354

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSY
CCCCEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCCHHHHHEECCCEEEECCCCCCCCE
LNIPAIITAAEITGADAIHPGYGFLSENAEFAEIVESSGFTFIGPRPEHIRLMGNKVSAI
EECCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCEEEEECCCCEEH
VAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAAGGGGRGMRIVERVDTLLESV
EEHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
QAAQRDAEMWFGDDTVYMERFLQKPRHVEVQVLGDGNGHAIHLYDRDCSLQRRHQKVLEE
HHHHHCCHHEECCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
APAPNLPEQARADILQACVHACQLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEM
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
VTGVDIIEQQLRIAAGLGLELQQEDIEVRGHAIECRINAEDPTTFLPSPGKIESFYAPGG
HHHHHHHHHHHHHHHCCCCEEECCCCEECCEEEEEEECCCCCCCCCCCCCCCCEEECCCC
AGIRLDSHIYPGYSIPPYYDSMIAKLIAHGKDRETSLARMRQALDEMILTGIKTNIPLHK
CCEEECCEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
DLILQDKNFCSQAMDIHYLEKHLLKQVEEEKKAETA
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSY
CCCCEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCCHHHHHEECCCEEEECCCCCCCCE
LNIPAIITAAEITGADAIHPGYGFLSENAEFAEIVESSGFTFIGPRPEHIRLMGNKVSAI
EECCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCEEEEECCCCEEH
VAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAAGGGGRGMRIVERVDTLLESV
EEHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
QAAQRDAEMWFGDDTVYMERFLQKPRHVEVQVLGDGNGHAIHLYDRDCSLQRRHQKVLEE
HHHHHCCHHEECCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
APAPNLPEQARADILQACVHACQLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEM
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
VTGVDIIEQQLRIAAGLGLELQQEDIEVRGHAIECRINAEDPTTFLPSPGKIESFYAPGG
HHHHHHHHHHHHHHHCCCCEEECCCCEECCEEEEEEECCCCCCCCCCCCCCCCEEECCCC
AGIRLDSHIYPGYSIPPYYDSMIAKLIAHGKDRETSLARMRQALDEMILTGIKTNIPLHK
CCEEECCEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
DLILQDKNFCSQAMDIHYLEKHLLKQVEEEKKAETA
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]