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The map label for this gene is ttcA [H]

Identifier: 213158341

GI number: 213158341

Start: 3165754

End: 3166659

Strand: Reverse

Name: ttcA [H]

Synonym: AB57_3071

Alternate gene names: 213158341

Gene position: 3166659-3165754 (Counterclockwise)

Preceding gene: 213158344

Following gene: 213158340

Centisome position: 78.18

GC content: 41.06

Gene sequence:

>906_bases
ATGTACGCGCCAGTTGAGTCCAACGAAGGATTTAATTTTAAGCCTGAACTTCCAACAAGCTCGGCCTATTATCGTTTGCT
TAAGAAGCTTCGCCGTCAAGTTGGACATGCCATCCGTGACTTCAATATGATTGAAGATGGTGACAAGGTCATGGTGTGTG
TGTCTGGTGGTAAAGACAGTTATACCTTGCTCGACATTTTGTTGCAGTTCAAACGTATTGCACCAATCAATTTTGATATT
GTTGCGGTTAACCTTGACCAAAAGCAGCCGGGTTTCCCTGAAGATGTCTTACCACGTTATATGGAAGAGAATAACATTCC
GTATTACATTTTGGAAAAAGACACTTACAGCATTACCAAACGTTTAACTCCTGAAGGTAAAACGTACTGTGCTGTGTGTT
CACGTTTACGCCGTGGTTCGCTTTATGGCTTTGCTCAAGAAATTGGTGCAACCAAAGTTGCGCTAGGGCATCACCGTGAT
GACATCATTGCTACTTTCTTCTTGAACTTATTCCATGGCGGTAGCTTAAAGGCAATGCCACCTAAGCTTTTATCGTCAGA
TAAGAAAAATATTTTGATTCGTCCTTTGGCTTATGTTGAAGAAAAGGACATTATCAAATATGCAGAGTTACGTAAGTTCC
CGATTATTCCGTGTAACCTTTGTGGTTCACAAGAGAACTTGCAACGTGCCATGATCAATGAAATGCTTCGTGAATGGGAC
AAACAGTATCCAAAACGTTTACACAGCATTTTTGGTGCGTTACAGAACGTTTCACCTTCACAACTTGCTGACCGTGATTT
GTTCGATTTCGAAGTTCTTGACTCGCAGCGCGAATTAGACTTTAAAGATCCGGAAGAACTGAAAAAACGTTTAGATGTAG
TGAACTTAAGCTTTGCTGCTGAATAA

Upstream 100 bases:

>100_bases
ATTATGACGACTTCAAGAATTGAAACTATTCTTTTGATGCGATTCTCATCCGAATCATATAAAATTGCGCGGTATTTTTA
TTTATGGGTATATCTCGTCT

Downstream 100 bases:

>100_bases
AACGAATTAATAAGTCAATTGAAGGCACTTTATAAACAAGTGCCTTTAATGTATCAAAATACTAAAAAATGAATGTTCCG
TACAAAAAGTCATAGCTCAA

Product: PP-loop domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MYAPVESNEGFNFKPELPTSSAYYRLLKKLRRQVGHAIRDFNMIEDGDKVMVCVSGGKDSYTLLDILLQFKRIAPINFDI
VAVNLDQKQPGFPEDVLPRYMEENNIPYYILEKDTYSITKRLTPEGKTYCAVCSRLRRGSLYGFAQEIGATKVALGHHRD
DIIATFFLNLFHGGSLKAMPPKLLSSDKKNILIRPLAYVEEKDIIKYAELRKFPIIPCNLCGSQENLQRAMINEMLREWD
KQYPKRLHSIFGALQNVSPSQLADRDLFDFEVLDSQRELDFKDPEELKKRLDVVNLSFAAE

Sequences:

>Translated_301_residues
MYAPVESNEGFNFKPELPTSSAYYRLLKKLRRQVGHAIRDFNMIEDGDKVMVCVSGGKDSYTLLDILLQFKRIAPINFDI
VAVNLDQKQPGFPEDVLPRYMEENNIPYYILEKDTYSITKRLTPEGKTYCAVCSRLRRGSLYGFAQEIGATKVALGHHRD
DIIATFFLNLFHGGSLKAMPPKLLSSDKKNILIRPLAYVEEKDIIKYAELRKFPIIPCNLCGSQENLQRAMINEMLREWD
KQYPKRLHSIFGALQNVSPSQLADRDLFDFEVLDSQRELDFKDPEELKKRLDVVNLSFAAE
>Mature_301_residues
MYAPVESNEGFNFKPELPTSSAYYRLLKKLRRQVGHAIRDFNMIEDGDKVMVCVSGGKDSYTLLDILLQFKRIAPINFDI
VAVNLDQKQPGFPEDVLPRYMEENNIPYYILEKDTYSITKRLTPEGKTYCAVCSRLRRGSLYGFAQEIGATKVALGHHRD
DIIATFFLNLFHGGSLKAMPPKLLSSDKKNILIRPLAYVEEKDIIKYAELRKFPIIPCNLCGSQENLQRAMINEMLREWD
KQYPKRLHSIFGALQNVSPSQLADRDLFDFEVLDSQRELDFKDPEELKKRLDVVNLSFAAE

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=255, Percent_Identity=62.7450980392157, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI193211090, Length=233, Percent_Identity=32.618025751073, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17540090, Length=234, Percent_Identity=26.4957264957265, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24651972, Length=229, Percent_Identity=25.3275109170306, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 34637; Mature: 34637

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAPVESNEGFNFKPELPTSSAYYRLLKKLRRQVGHAIRDFNMIEDGDKVMVCVSGGKDS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
YTLLDILLQFKRIAPINFDIVAVNLDQKQPGFPEDVLPRYMEENNIPYYILEKDTYSITK
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHH
RLTPEGKTYCAVCSRLRRGSLYGFAQEIGATKVALGHHRDDIIATFFLNLFHGGSLKAMP
HCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCC
PKLLSSDKKNILIRPLAYVEEKDIIKYAELRKFPIIPCNLCGSQENLQRAMINEMLREWD
HHHHCCCCCCEEECHHHHHCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KQYPKRLHSIFGALQNVSPSQLADRDLFDFEVLDSQRELDFKDPEELKKRLDVVNLSFAA
HHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCEEEEC
E
C
>Mature Secondary Structure
MYAPVESNEGFNFKPELPTSSAYYRLLKKLRRQVGHAIRDFNMIEDGDKVMVCVSGGKDS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
YTLLDILLQFKRIAPINFDIVAVNLDQKQPGFPEDVLPRYMEENNIPYYILEKDTYSITK
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHH
RLTPEGKTYCAVCSRLRRGSLYGFAQEIGATKVALGHHRDDIIATFFLNLFHGGSLKAMP
HCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCC
PKLLSSDKKNILIRPLAYVEEKDIIKYAELRKFPIIPCNLCGSQENLQRAMINEMLREWD
HHHHCCCCCCEEECHHHHHCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KQYPKRLHSIFGALQNVSPSQLADRDLFDFEVLDSQRELDFKDPEELKKRLDVVNLSFAA
HHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCEEEEC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA