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The map label for this gene is nhaA [H]

Identifier: 213158294

GI number: 213158294

Start: 3110048

End: 3111064

Strand: Reverse

Name: nhaA [H]

Synonym: AB57_3017

Alternate gene names: 213158294

Gene position: 3111064-3110048 (Counterclockwise)

Preceding gene: 213158296

Following gene: 213158293

Centisome position: 76.81

GC content: 40.41

Gene sequence:

>1017_bases
ATGTCCGATTGGCCACCAAAACCACAAAATGAACCTATAACCCCTAAACAGAACGGACCGGAATGGCAAATCCTTGAGAA
AGCTGTACTGGCTTCTGTAGAAGAACAACGCCGTAGTCGTCGCTGGGGTATATTCTTTAAAACACTTACTTTTATTTATC
TATTGTTCATTATCGTCTTAATGGGCAAAGGCTGTTCGACCACTAAAGATGGCTCTACAGCAAGTAGTAGCAGTGCTCAC
CTTGCAGTAGTTGATATTATTGGAACTATTGATGCTTCAAGCAATCAGGCTGTGAATAGTGAAGATACAAACAAAGCGCT
TAAACGTGCTTTTGAGGCATCGAATAGTAAAGCAATTGCCCTTAATATTAATTCTCCTGGTGGTTCACCTGTTCAGTCAG
ATGAAATCTGGCAGGAAATTCGCTATTTGAAAAAAGAGCATCCTGACAAGAAAGTCTATGCGGTAATTGGCGATATGGGT
GCTTCGGGTGCTTATTATATTGCTTCTGCTGCCGATGAAATTATTGTGAATCCATCAAGTTTGGTAGGTTCAATTGGTGT
CATTATGCCAAACTATGGCATTACTGGTTTAGCTCAAAAACTAGGAATTGAAGACCGAACTCTTACAGCGGGGACGAATA
AAGACATTTTAAGTATGACAAAACCGATTAATCCTGTACAAAGACAACATATCCAATCTGTACTCGATAATGTTCATACT
CACTTTATTAACGCAGTTAAAGAAGGACGTGGGAAACGCTTAAAAACTAATGATCCTGCTATTTTCTCTGGTCTTTTCTG
GACTGGCGAGCAAGCAATTCAGTTAGGCGTAGCTGACCGTTCAGGTAACATTACAAGCTTGATGCGTGAACTGAAGCTTG
ATAATAAAGTTGACTACACGATTGAACGTAACCCATTACAATCCATTCTAGGGCGAATGGGATCAGAAATGGGGAAAGGT
TTAAGTGAGTCGGTTGCTGAACGCTTACAAACAAGTCAGGACGCAAAACTACAATAA

Upstream 100 bases:

>100_bases
AAAGACAAAAATATTATAAATGAAATCATATTATTTAGACAGTTTTTATCAAATCAACGTATATAATGACATCATTTCGA
TTGATTTGGATTGGAATTTT

Downstream 100 bases:

>100_bases
TTTAAGCAGGATAACGGTATGTCAGTAAAACCGGTTATACACTTTGCGCATGCCAACGGCGTGCCATCTATGGTGTATCA
AAAATTGTTTGATCAATTAA

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSDWPPKPQNEPITPKQNGPEWQILEKAVLASVEEQRRSRRWGIFFKTLTFIYLLFIIVLMGKGCSTTKDGSTASSSSAH
LAVVDIIGTIDASSNQAVNSEDTNKALKRAFEASNSKAIALNINSPGGSPVQSDEIWQEIRYLKKEHPDKKVYAVIGDMG
ASGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTAGTNKDILSMTKPINPVQRQHIQSVLDNVHT
HFINAVKEGRGKRLKTNDPAIFSGLFWTGEQAIQLGVADRSGNITSLMRELKLDNKVDYTIERNPLQSILGRMGSEMGKG
LSESVAERLQTSQDAKLQ

Sequences:

>Translated_338_residues
MSDWPPKPQNEPITPKQNGPEWQILEKAVLASVEEQRRSRRWGIFFKTLTFIYLLFIIVLMGKGCSTTKDGSTASSSSAH
LAVVDIIGTIDASSNQAVNSEDTNKALKRAFEASNSKAIALNINSPGGSPVQSDEIWQEIRYLKKEHPDKKVYAVIGDMG
ASGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTAGTNKDILSMTKPINPVQRQHIQSVLDNVHT
HFINAVKEGRGKRLKTNDPAIFSGLFWTGEQAIQLGVADRSGNITSLMRELKLDNKVDYTIERNPLQSILGRMGSEMGKG
LSESVAERLQTSQDAKLQ
>Mature_337_residues
SDWPPKPQNEPITPKQNGPEWQILEKAVLASVEEQRRSRRWGIFFKTLTFIYLLFIIVLMGKGCSTTKDGSTASSSSAHL
AVVDIIGTIDASSNQAVNSEDTNKALKRAFEASNSKAIALNINSPGGSPVQSDEIWQEIRYLKKEHPDKKVYAVIGDMGA
SGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTAGTNKDILSMTKPINPVQRQHIQSVLDNVHTH
FINAVKEGRGKRLKTNDPAIFSGLFWTGEQAIQLGVADRSGNITSLMRELKLDNKVDYTIERNPLQSILGRMGSEMGKGL
SESVAERLQTSQDAKLQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=168, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787527, Length=213, Percent_Identity=28.169014084507, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 36926; Mature: 36795

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDWPPKPQNEPITPKQNGPEWQILEKAVLASVEEQRRSRRWGIFFKTLTFIYLLFIIVL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGKGCSTTKDGSTASSSSAHLAVVDIIGTIDASSNQAVNSEDTNKALKRAFEASNSKAIA
HCCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LNINSPGGSPVQSDEIWQEIRYLKKEHPDKKVYAVIGDMGASGAYYIASAADEIIVNPSS
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEECCHH
LVGSIGVIMPNYGITGLAQKLGIEDRTLTAGTNKDILSMTKPINPVQRQHIQSVLDNVHT
HHHHHHHEECCCCHHHHHHHHCCCCCEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
HFINAVKEGRGKRLKTNDPAIFSGLFWTGEQAIQLGVADRSGNITSLMRELKLDNKVDYT
HHHHHHHHCCCCCCCCCCCHHEEHHEECCCHHEEEECCCCCCCHHHHHHHHHCCCCCCEE
IERNPLQSILGRMGSEMGKGLSESVAERLQTSQDAKLQ
ECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDWPPKPQNEPITPKQNGPEWQILEKAVLASVEEQRRSRRWGIFFKTLTFIYLLFIIVL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGKGCSTTKDGSTASSSSAHLAVVDIIGTIDASSNQAVNSEDTNKALKRAFEASNSKAIA
HCCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LNINSPGGSPVQSDEIWQEIRYLKKEHPDKKVYAVIGDMGASGAYYIASAADEIIVNPSS
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEECCHH
LVGSIGVIMPNYGITGLAQKLGIEDRTLTAGTNKDILSMTKPINPVQRQHIQSVLDNVHT
HHHHHHHEECCCCHHHHHHHHCCCCCEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
HFINAVKEGRGKRLKTNDPAIFSGLFWTGEQAIQLGVADRSGNITSLMRELKLDNKVDYT
HHHHHHHHCCCCCCCCCCCHHEEHHEECCCHHEEEECCCCCCCHHHHHHHHHCCCCCCEE
IERNPLQSILGRMGSEMGKGLSESVAERLQTSQDAKLQ
ECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA