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The map label for this gene is uvrB [H]

Identifier: 213158228

GI number: 213158228

Start: 3044428

End: 3046449

Strand: Reverse

Name: uvrB [H]

Synonym: AB57_2947

Alternate gene names: 213158228

Gene position: 3046449-3044428 (Counterclockwise)

Preceding gene: 213158231

Following gene: 213158227

Centisome position: 75.21

GC content: 42.38

Gene sequence:

>2022_bases
GTGAACGAAAATCAACCTTTCGATTTGGTCACTCATTACCAGCCAGCGGGTGATCAGCCACAGGCAATTGAAAAGCTGGT
GAATGGTATCGAAAAGGGTTTTCGTAATCAGTTACTGCTAGGCGTGACCGGTTCAGGTAAGACCTATACCATGGCAAATG
TGATTGCCCAAACTCAGCGTCCGACGATTGTGATGGCGCATAATAAGACCTTGGCAGCCCAGCTCTATGGTGAGTTTAAA
GCCTTCTTCCCAAACAATGCAGTTGAGTATTTCGTAAGTTATTACGACTACTATCAACCCGAGGCTTATGTTCCGTCGTC
AGATACATTTATTGAAAAAGACGCGGCAATTAATGACCATATTGACCAGATGCGATTATCGGCAACGCGTGCTTTGTTAG
AACGTCGTGATGCGATTATTGTTGCTTCTGTTTCGGCCATTTATGGTTTGGGTGACCCAAATGCTTATATGCAAATGTTA
TTGCATGTGGTCCAAGGTGACCGAGTAAGTCGAGACGAAATTATTCGCCGTTTGGTTGAAATGCAATATACGCGTAATGA
GCTTGAATTCTTACGTGGTACGTATCGTATCCGTGGTGAAATTATTGATATTTTCCCGGCAGAATCCGACCAACATGCGA
TTCGTATTGAACTCTTTGATGACGAAGTAGACTCAATTCGCTGGTTTGATCCGCTGACCGGTAAAATGGTCCGCAAAGTA
CCACGTGTCACGATTTACCCGAAAAGCCATTATGTGACGCCAAAAGACAACCTAACACGCGCTATCGATACTATTAAGGA
TGAATTGCAAGACCAGCTTAAGTTCTTCCGTGAACATGACAAGTTACTCGAAGCGCAGCGTATCGAGCAACGTACGCGTT
ATGATTTGGAAATGATGCAGCAGTTAGGATACACCAATGGTATCGAAAACTACTCACGTCATTTATCGGGACGACCAGCA
GGGGAAGCACCACCGACTTTATTTGACTATGTACCAGAAGATGCCTTACTTATTATCGATGAGTCGCATGTAACGGTTCC
TCAAATTGGCGCAATGTATAAAGGTGACCGTTCGCGTAAAGAAAACTTGGTGAATTACGGTTTCCGTTTACCAAGTGCGC
TTGATAACCGCCCAATGAAATTTGAAGAGTGGGAGCGTATTGTTCCGACCACTATTTTTGTGAGTGCCACACCAGCTAGA
TATGAACTGGAAAAATCAGAACAAGTGGTTGAGCAGGTTGTTCGACCAACAGGCTTGATTGATCCTGAAATTGAAGTTCG
TCCGGTGCTTACCCAAGTCGATGATGTTTTGTCTGAGATTAATATTCGTAAGAACTTAAATGAGCGTGTATTGGTAACGA
CTTTAACCAAGCGTATGGCGGAAGATTTAACTTCTTATTTAAAAGAATATGGCGTTAAGGTTGCTTATCTGCACTCGGAT
ATTGATACAGTTGAACGTGTCAAAATTATTCATGAATTACGTACAGGCGTATTTGATGTACTAGTGGGTATTAACTTGCT
GCGAGAAGGCTTAGATATGCCGGAAGTTTCTTTAGTTGCTATTTTAGATGCAGATAAAGAAGGTTTCTTACGTTCTGAGC
GTTCGCTTATTCAGACGATTGGTCGTGCTGCGCGAAATGTGAAAGGTAAAGCAATTTTATATGCTGATACAATCACTGAT
TCTATGCGAAAGGCAATTGATGAGACAGAGCGCCGACGTACAAAACAAATCGAGTTTAATGAGCAGCATGGTATTACACC
ACGTAGTGCAGTTCGTCAGGCTGTGAAAGAAATTGATACGGGTGAAGTACTTTCTGATGATCAGATTGATGAGAAAGTAC
TAGAGCAGGCACAAGCACTTAGCGCAGATGAACGACATATTCTTTCTGACCCTAAATTGTTTAGTAAGCACATTACTAAG
CTAGAGAAAGAAATGTTAAAGGCGTCGAAGGATTTACAATTCGAGCAAGCGGCGCGTATTCGTGATGAAATTGTTCGTTT
AAAAGCGCAAATGTTGCAATAA

Upstream 100 bases:

>100_bases
TTCGATATAGATTAATCTCACTATAGACTTTAAATTAGGGAAAAAATCCCCATTAATTTGCTAGACGATAAATTCAAATT
TTTTATAAAGAGAGAGAACT

Downstream 100 bases:

>100_bases
ATGGATACATAACACTACATGATTTGTTTAAAAAACAAGCTACTGTAGATATTTAAGTTATTTTGTATTCACAACAAAGA
GTTGAGGGCAACAATGGCAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MNENQPFDLVTHYQPAGDQPQAIEKLVNGIEKGFRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGEFK
AFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPNAYMQML
LHVVQGDRVSRDEIIRRLVEMQYTRNELEFLRGTYRIRGEIIDIFPAESDQHAIRIELFDDEVDSIRWFDPLTGKMVRKV
PRVTIYPKSHYVTPKDNLTRAIDTIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGRPA
GEAPPTLFDYVPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTIFVSATPAR
YELEKSEQVVEQVVRPTGLIDPEIEVRPVLTQVDDVLSEINIRKNLNERVLVTTLTKRMAEDLTSYLKEYGVKVAYLHSD
IDTVERVKIIHELRTGVFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVKGKAILYADTITD
SMRKAIDETERRRTKQIEFNEQHGITPRSAVRQAVKEIDTGEVLSDDQIDEKVLEQAQALSADERHILSDPKLFSKHITK
LEKEMLKASKDLQFEQAARIRDEIVRLKAQMLQ

Sequences:

>Translated_673_residues
MNENQPFDLVTHYQPAGDQPQAIEKLVNGIEKGFRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGEFK
AFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPNAYMQML
LHVVQGDRVSRDEIIRRLVEMQYTRNELEFLRGTYRIRGEIIDIFPAESDQHAIRIELFDDEVDSIRWFDPLTGKMVRKV
PRVTIYPKSHYVTPKDNLTRAIDTIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGRPA
GEAPPTLFDYVPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTIFVSATPAR
YELEKSEQVVEQVVRPTGLIDPEIEVRPVLTQVDDVLSEINIRKNLNERVLVTTLTKRMAEDLTSYLKEYGVKVAYLHSD
IDTVERVKIIHELRTGVFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVKGKAILYADTITD
SMRKAIDETERRRTKQIEFNEQHGITPRSAVRQAVKEIDTGEVLSDDQIDEKVLEQAQALSADERHILSDPKLFSKHITK
LEKEMLKASKDLQFEQAARIRDEIVRLKAQMLQ
>Mature_673_residues
MNENQPFDLVTHYQPAGDQPQAIEKLVNGIEKGFRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGEFK
AFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPNAYMQML
LHVVQGDRVSRDEIIRRLVEMQYTRNELEFLRGTYRIRGEIIDIFPAESDQHAIRIELFDDEVDSIRWFDPLTGKMVRKV
PRVTIYPKSHYVTPKDNLTRAIDTIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGRPA
GEAPPTLFDYVPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTIFVSATPAR
YELEKSEQVVEQVVRPTGLIDPEIEVRPVLTQVDDVLSEINIRKNLNERVLVTTLTKRMAEDLTSYLKEYGVKVAYLHSD
IDTVERVKIIHELRTGVFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVKGKAILYADTITD
SMRKAIDETERRRTKQIEFNEQHGITPRSAVRQAVKEIDTGEVLSDDQIDEKVLEQAQALSADERHILSDPKLFSKHITK
LEKEMLKASKDLQFEQAARIRDEIVRLKAQMLQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=65.015015015015, Blast_Score=878, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.4527687296417, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77309; Mature: 77309

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENQPFDLVTHYQPAGDQPQAIEKLVNGIEKGFRNQLLLGVTGSGKTYTMANVIAQTQR
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEHHHHHHHHCCC
PTIVMAHNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDH
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHH
IDQMRLSATRALLERRDAIIVASVSAIYGLGDPNAYMQMLLHVVQGDRVSRDEIIRRLVE
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
MQYTRNELEFLRGTYRIRGEIIDIFPAESDQHAIRIELFDDEVDSIRWFDPLTGKMVRKV
HHHHHHHHHHHHHHHEEECEEEEEECCCCCCCEEEEEEECCCCCCEECCCCHHHHHHHHC
PRVTIYPKSHYVTPKDNLTRAIDTIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQ
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGYTNGIENYSRHLSGRPAGEAPPTLFDYVPEDALLIIDESHVTVPQIGAMYKGDRSRK
HCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHH
ENLVNYGFRLPSALDNRPMKFEEWERIVPTTIFVSATPARYELEKSEQVVEQVVRPTGLI
HHHHHHCCCCCHHHCCCCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
DPEIEVRPVLTQVDDVLSEINIRKNLNERVLVTTLTKRMAEDLTSYLKEYGVKVAYLHSD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
IDTVERVKIIHELRTGVFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVKGKAILYADTITDSMRKAIDETERRRTKQIEFNEQHGITPRSAVRQAVKEIDT
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
GEVLSDDQIDEKVLEQAQALSADERHILSDPKLFSKHITKLEKEMLKASKDLQFEQAARI
CCCCCCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RDEIVRLKAQMLQ
HHHHHHHHHHHCC
>Mature Secondary Structure
MNENQPFDLVTHYQPAGDQPQAIEKLVNGIEKGFRNQLLLGVTGSGKTYTMANVIAQTQR
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEHHHHHHHHCCC
PTIVMAHNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDH
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHH
IDQMRLSATRALLERRDAIIVASVSAIYGLGDPNAYMQMLLHVVQGDRVSRDEIIRRLVE
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
MQYTRNELEFLRGTYRIRGEIIDIFPAESDQHAIRIELFDDEVDSIRWFDPLTGKMVRKV
HHHHHHHHHHHHHHHEEECEEEEEECCCCCCCEEEEEEECCCCCCEECCCCHHHHHHHHC
PRVTIYPKSHYVTPKDNLTRAIDTIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQ
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGYTNGIENYSRHLSGRPAGEAPPTLFDYVPEDALLIIDESHVTVPQIGAMYKGDRSRK
HCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHH
ENLVNYGFRLPSALDNRPMKFEEWERIVPTTIFVSATPARYELEKSEQVVEQVVRPTGLI
HHHHHHCCCCCHHHCCCCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
DPEIEVRPVLTQVDDVLSEINIRKNLNERVLVTTLTKRMAEDLTSYLKEYGVKVAYLHSD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
IDTVERVKIIHELRTGVFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVKGKAILYADTITDSMRKAIDETERRRTKQIEFNEQHGITPRSAVRQAVKEIDT
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
GEVLSDDQIDEKVLEQAQALSADERHILSDPKLFSKHITKLEKEMLKASKDLQFEQAARI
CCCCCCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RDEIVRLKAQMLQ
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA