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The map label for this gene is tdcB [H]

Identifier: 213158111

GI number: 213158111

Start: 2907984

End: 2908715

Strand: Direct

Name: tdcB [H]

Synonym: AB57_2823

Alternate gene names: 213158111

Gene position: 2907984-2908715 (Clockwise)

Preceding gene: 213158110

Following gene: 213158112

Centisome position: 71.79

GC content: 41.26

Gene sequence:

>732_bases
ATGAAAAATTTAACCCTTCCAAATTATGAAGATGTCGCAGCCGCTGCTGAACGTATAAAAGATTTTATAAATAAAACCCC
TGTTTTAACTTCACGTACAGTGAACAATGAATTTGAAGCAGAAGTGTTCTTTAAATGTGAGAATTTTCAGCGTGTAGGCG
CTTTCAAATTTCGTGGTGCCATGAATGCACTTTTGCAATTTAGTGAGACTCAAAAGAAAGCAGGTGTAGTTGCTTTTTCT
TCGGGAAATCATGCACAAGCCATTGCGCTTTCATCAAAAATTCTTGGTATTCCAGCAACCATTATCATGCCTAAAGATGC
ACCTGCTGCAAAAATGGCAGCAACGCGAGAATACGGCGGCAATATTGTTGAATTTGACCGTTACACGGAAGATCGGGAAA
AAATTGGAAAAGAGATTGCCGAAAAAAATGGTCTGACATTAATTCCGTCTTATGACCATCCGCATGTGATTGCAGGTCAA
GGTACGGCTGCTAAAGAGTTATTTGAAGAAGTCGGTGATTTAGATTACCTGTTTGTATGTTTAGGTGGCGGCGGTTTGTT
GGCGGGTTCTGCCCTGTCTGCTCGCCAGCTTTCTCCGAACTGCAAAATATATGGCGTTGAACCTGCCCTAGGAAATGATG
GGCAAATGTCTTTTAGAAAAGGAGAAATTGTTCATATAAATACCCCACCAACCATTGCCGATGGCGCGCAACTCAATATT
TGGGCAAATTGA

Upstream 100 bases:

>100_bases
TAAATATATATATTTTATCTAAACAAGGTCAATAGATTGTGCTTTCCTTGGCAATACGAAATCTTGCATCCGAAAACATT
GAATAGAATCAGGTTTAATT

Downstream 100 bases:

>100_bases
CCTTCCCTATTATTCAACAAAAAGTTAGATGACATTTTGACTGTTACAGACGAAGAACTCATCAACGCTATGAAGTTCTT
TGCTGAAAGAATGAAGATGG

Product: threonine ammonia-lyase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKNLTLPNYEDVAAAAERIKDFINKTPVLTSRTVNNEFEAEVFFKCENFQRVGAFKFRGAMNALLQFSETQKKAGVVAFS
SGNHAQAIALSSKILGIPATIIMPKDAPAAKMAATREYGGNIVEFDRYTEDREKIGKEIAEKNGLTLIPSYDHPHVIAGQ
GTAAKELFEEVGDLDYLFVCLGGGGLLAGSALSARQLSPNCKIYGVEPALGNDGQMSFRKGEIVHINTPPTIADGAQLNI
WAN

Sequences:

>Translated_243_residues
MKNLTLPNYEDVAAAAERIKDFINKTPVLTSRTVNNEFEAEVFFKCENFQRVGAFKFRGAMNALLQFSETQKKAGVVAFS
SGNHAQAIALSSKILGIPATIIMPKDAPAAKMAATREYGGNIVEFDRYTEDREKIGKEIAEKNGLTLIPSYDHPHVIAGQ
GTAAKELFEEVGDLDYLFVCLGGGGLLAGSALSARQLSPNCKIYGVEPALGNDGQMSFRKGEIVHINTPPTIADGAQLNI
WAN
>Mature_243_residues
MKNLTLPNYEDVAAAAERIKDFINKTPVLTSRTVNNEFEAEVFFKCENFQRVGAFKFRGAMNALLQFSETQKKAGVVAFS
SGNHAQAIALSSKILGIPATIIMPKDAPAAKMAATREYGGNIVEFDRYTEDREKIGKEIAEKNGLTLIPSYDHPHVIAGQ
GTAAKELFEEVGDLDYLFVCLGGGGLLAGSALSARQLSPNCKIYGVEPALGNDGQMSFRKGEIVHINTPPTIADGAQLNI
WAN

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=242, Percent_Identity=41.3223140495868, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI19923959, Length=145, Percent_Identity=30.3448275862069, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789505, Length=231, Percent_Identity=40.2597402597403, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1790207, Length=182, Percent_Identity=39.010989010989, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17508781, Length=234, Percent_Identity=35.8974358974359, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71991565, Length=228, Percent_Identity=35.0877192982456, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17537387, Length=235, Percent_Identity=37.4468085106383, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322631, Length=234, Percent_Identity=67.5213675213675, Blast_Score=311, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6320930, Length=237, Percent_Identity=33.7552742616034, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21355833, Length=236, Percent_Identity=36.864406779661, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 26268; Mature: 26268

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTLPNYEDVAAAAERIKDFINKTPVLTSRTVNNEFEAEVFFKCENFQRVGAFKFRGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHH
MNALLQFSETQKKAGVVAFSSGNHAQAIALSSKILGIPATIIMPKDAPAAKMAATREYGG
HHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCEECCCEEEEECCCCCHHHHHHHHHHCC
NIVEFDRYTEDREKIGKEIAEKNGLTLIPSYDHPHVIAGQGTAAKELFEEVGDLDYLFVC
CEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCHHHHHHHHHHCCCEEEEEE
LGGGGLLAGSALSARQLSPNCKIYGVEPALGNDGQMSFRKGEIVHINTPPTIADGAQLNI
ECCCCEEECCCCHHHHCCCCCEEEECCCCCCCCCCEEEECCCEEEECCCCCCCCCCEEEE
WAN
EEC
>Mature Secondary Structure
MKNLTLPNYEDVAAAAERIKDFINKTPVLTSRTVNNEFEAEVFFKCENFQRVGAFKFRGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHH
MNALLQFSETQKKAGVVAFSSGNHAQAIALSSKILGIPATIIMPKDAPAAKMAATREYGG
HHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCEECCCEEEEECCCCCHHHHHHHHHHCC
NIVEFDRYTEDREKIGKEIAEKNGLTLIPSYDHPHVIAGQGTAAKELFEEVGDLDYLFVC
CEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCHHHHHHHHHHCCCEEEEEE
LGGGGLLAGSALSARQLSPNCKIYGVEPALGNDGQMSFRKGEIVHINTPPTIADGAQLNI
ECCCCEEECCCCHHHHCCCCCEEEECCCCCCCCCCEEEECCCEEEECCCCCCCCCCEEEE
WAN
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]