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The map label for this gene is hemE [H]

Identifier: 213158088

GI number: 213158088

Start: 2877890

End: 2878963

Strand: Reverse

Name: hemE [H]

Synonym: AB57_2800

Alternate gene names: 213158088

Gene position: 2878963-2877890 (Counterclockwise)

Preceding gene: 213158090

Following gene: 213158087

Centisome position: 71.08

GC content: 43.11

Gene sequence:

>1074_bases
ATGACGACACTTAAAAATGATCGTTTCTTACGTGCTTTATTACGTGAGCCTGTAGATACCACTCCAATATGGATGATGCG
CCAAGCAGGACGTTATTTGCCTGAATATCGGGAAACACGCTCAAAAGCTGGTGACTTTCTATCTTTATGCAAAAATACAG
AATTTGCTTGTGAAGTGACTTTACAGCCTTTGCGTCGCTACGATTTAGACGCAGCAATTTTATTTTCAGATATTTTAACT
ATTCCAGACGCATTAGGACTTGGACTGTATTTTGAAACTGGAGAAGGTCCGAAGTTTCATAAAACGGTACGTACTGAACA
AGATGTGGCTAACTTACCTAAGCTTAATGCTAAAGCCGATCTTGATTATGTCATGAACGCAGTAAGTACGATTCGTTCTG
CTTTAGGTGGACAAGTTCCACTGATTGGTTTTTCGGGTAGTCCTTGGACACTGGCGACTTATATGGTTGAAGGCGGTTCA
AGCAAAGAGTTCCGTTTTACCAAGCAAATGATGTATGCGCAGCCAGAAGTTTTGCATGCGTTGCTCGACCATTTAGCAGA
TTCAGTCATTGATTACTTAAATGCGCAAATTGATGCAGGCGCTCAGGCAATTCAAATCTTTGATAGTTGGGGTGGGGCTT
TAGCACACCGTGAATATGTAGAGTTCTCTCTTAACTATATGAAGAAGATTATCGCGGGCTTACAACGTGAAAAAGATGGA
CGCCGTATTCCAGTGATTGTGTTCACTAAAGGTGGCGGTCAATGGTTAGAACCAATGATCACGACAGGTGCCGATGCATT
AGGGCTGGACTGGACGACACCATTAAATACGGCTCGAACCACGGTGGCAGGTCGTGTTGCCCTACAAGGGAACCTTGACC
CGGCTGTTTTATATGGTTCGGCGGCTTCAATTGAAAAAGCTGTAAAAGCAATGTTAGATGATGCTTATGCAAACGGTGAG
AAGACCGGTTATGTTGCTAACTTAGGGCACGGTATTACCCAATGGGTAGATCCGGCGCAGCCAAAAATCTTTGTAGATAC
GGTACATGAATATAGTGCTAAATATCTAGGATAG

Upstream 100 bases:

>100_bases
ATTTTTTAGTAGATTGGCAAGTTTTTTATGTGAAATTGAAATTATAAAAACACTCACCTTTTGTTATGATGCTGCCACAT
GAAAAAGATAGAGATCGGCA

Downstream 100 bases:

>100_bases
TTTTTTGTGCAATATCTGTTTTTACCTCTTCAATTTATTGGCAAGGCTGTTTCGGCAGCCTTGTTTGGTATTTTGCTTCT
CATTGCTTTTGCCCTAACTG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILT
IPDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKADLDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGS
SKEFRFTKQMMYAQPEVLHALLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMKKIIAGLQREKDG
RRIPVIVFTKGGGQWLEPMITTGADALGLDWTTPLNTARTTVAGRVALQGNLDPAVLYGSAASIEKAVKAMLDDAYANGE
KTGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG

Sequences:

>Translated_357_residues
MTTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILT
IPDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKADLDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGS
SKEFRFTKQMMYAQPEVLHALLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMKKIIAGLQREKDG
RRIPVIVFTKGGGQWLEPMITTGADALGLDWTTPLNTARTTVAGRVALQGNLDPAVLYGSAASIEKAVKAMLDDAYANGE
KTGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG
>Mature_356_residues
TTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILTI
PDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKADLDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGSS
KEFRFTKQMMYAQPEVLHALLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMKKIIAGLQREKDGR
RIPVIVFTKGGGQWLEPMITTGADALGLDWTTPLNTARTTVAGRVALQGNLDPAVLYGSAASIEKAVKAMLDDAYANGEK
TGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=47.4576271186441, Blast_Score=317, Evalue=9e-87,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=66.4788732394366, Blast_Score=483, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6320252, Length=358, Percent_Identity=43.0167597765363, Blast_Score=297, Evalue=2e-81,
Organism=Drosophila melanogaster, GI19921920, Length=351, Percent_Identity=42.4501424501425, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI221330099, Length=351, Percent_Identity=42.4501424501425, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39410; Mature: 39278

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKAD
HHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHHHCCCCCCCCCC
LDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGSSKEFRFTKQMMYAQPEVLHA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
LLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMKKIIAGLQREKDG
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RRIPVIVFTKGGGQWLEPMITTGADALGLDWTTPLNTARTTVAGRVALQGNLDPAVLYGS
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEEEECCCCHHEEECC
AASIEKAVKAMLDDAYANGEKTGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
TTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKAD
HHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHHHCCCCCCCCCC
LDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGSSKEFRFTKQMMYAQPEVLHA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
LLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMKKIIAGLQREKDG
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RRIPVIVFTKGGGQWLEPMITTGADALGLDWTTPLNTARTTVAGRVALQGNLDPAVLYGS
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEEEECCCCHHEEECC
AASIEKAVKAMLDDAYANGEKTGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA