Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 213158046

GI number: 213158046

Start: 2821900

End: 2822727

Strand: Direct

Name: map [H]

Synonym: AB57_2757

Alternate gene names: 213158046

Gene position: 2821900-2822727 (Clockwise)

Preceding gene: 213158040

Following gene: 213158047

Centisome position: 69.67

GC content: 41.43

Gene sequence:

>828_bases
ATGAACAGTACTTATACAGCTCCACGTCGATTAATCAAAACTCCAGATGAAATTGAAAAAATGCGCATTGCAGGACGACT
GGCGGCTGAAGTTCTAGATATGATCAAGCCGCATATTAAAGCTGGTGTAAGCACACTCGAGCTTGATACGATATGTCGTA
ATCATATTGAAAATGTACAGCACGCTATTCCGGCCTGTGTAGGTTACGGTGGTGCGCCAGGACGCCCTGCTTTTCAACAC
TCTATCTGTACTTCGGTTAACCATGTTGTATGTCATGGTATTCCTTCTGAAAATAAAATCTTAAAAAACGGCGATATCCT
TAACATCGACGTGACCGTCATTAAAGATGGTTATCATGGCGATACCAACATGATGTATATCGTGGGTGGTGAAACCTCTA
TTCTGGCAAATCGTTTATGTAAAGTAGCTCAAGAAGCGATGTATCGCGGAATGGCAACAGTTAGAGATGGTTCGTATTTA
GGCGATATTGGACATGCCATCCAAAAATATGTCGAATCAGAACGTTTTAGCGTAGTACGTGAATATTGTGGTCATGGCAT
TGGTACCGTTTTCCATGATGAACCTCAAGTGTTGCACTATGGCCAAGCTGGTACGGGCATGCGTTTAGAAGCTGGTATGA
CTTTCACTATTGAACCTATGGTAAATGCGGGTGTTTGGCAAACCAAATTGCTTGGTGACAAATGGACAGTTGTAACCAAA
GACCATAAACTTTCAGCTCAATATGAACATACTATTTTAGTCACTAAAACAGGGATTGAAGTATTAACAGCTCGCCCAGA
AGAAGATCTTTCACGCTTCAATCAATAA

Upstream 100 bases:

>100_bases
TCAAAATTCTTCGTAAAAGATATTCACGAAAAGCATTTGATAAAATGGGCGGCTATTTATACCATAGACGCTTGTAAATT
ACCAAAAGTTTTTAGAGATC

Downstream 100 bases:

>100_bases
TTTAATCAAAATTAATAAAAGGCTACTTTATGTAGCCTTTTCTTTTTTATTTTGTACTTTTTATTAATAAATATTTCCAA
ATATAAACAAATATTTCAAA

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MNSTYTAPRRLIKTPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQHAIPACVGYGGAPGRPAFQH
SICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHGDTNMMYIVGGETSILANRLCKVAQEAMYRGMATVRDGSYL
GDIGHAIQKYVESERFSVVREYCGHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTK
DHKLSAQYEHTILVTKTGIEVLTARPEEDLSRFNQ

Sequences:

>Translated_275_residues
MNSTYTAPRRLIKTPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQHAIPACVGYGGAPGRPAFQH
SICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHGDTNMMYIVGGETSILANRLCKVAQEAMYRGMATVRDGSYL
GDIGHAIQKYVESERFSVVREYCGHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTK
DHKLSAQYEHTILVTKTGIEVLTARPEEDLSRFNQ
>Mature_275_residues
MNSTYTAPRRLIKTPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQHAIPACVGYGGAPGRPAFQH
SICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHGDTNMMYIVGGETSILANRLCKVAQEAMYRGMATVRDGSYL
GDIGHAIQKYVESERFSVVREYCGHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTK
DHKLSAQYEHTILVTKTGIEVLTARPEEDLSRFNQ

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=265, Percent_Identity=42.2641509433962, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI40385867, Length=258, Percent_Identity=39.5348837209302, Blast_Score=185, Evalue=3e-47,
Organism=Escherichia coli, GI1786364, Length=259, Percent_Identity=60.6177606177606, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71996291, Length=259, Percent_Identity=42.0849420849421, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=42.2310756972112, Blast_Score=207, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21355531, Length=255, Percent_Identity=44.3137254901961, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24583427, Length=252, Percent_Identity=37.3015873015873, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30374; Mature: 30374

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTYTAPRRLIKTPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQ
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
HAIPACVGYGGAPGRPAFQHSICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHG
HHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCEECCCCEEEEEEEEEECCCCC
DTNMMYIVGGETSILANRLCKVAQEAMYRGMATVRDGSYLGDIGHAIQKYVESERFSVVR
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
EYCGHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTK
HHHCCCCCCEECCCCCEEEECCCCCCEEEECCCEEEECCCCCCCCEEEEECCCEEEEEEC
DHKLSAQYEHTILVTKTGIEVLTARPEEDLSRFNQ
CCCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCC
>Mature Secondary Structure
MNSTYTAPRRLIKTPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQ
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
HAIPACVGYGGAPGRPAFQHSICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHG
HHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCEECCCCEEEEEEEEEECCCCC
DTNMMYIVGGETSILANRLCKVAQEAMYRGMATVRDGSYLGDIGHAIQKYVESERFSVVR
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
EYCGHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTK
HHHCCCCCCEECCCCCEEEECCCCCCEEEECCCEEEECCCCCCCCEEEEECCCEEEEEEC
DHKLSAQYEHTILVTKTGIEVLTARPEEDLSRFNQ
CCCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]