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The map label for this gene is merA [H]

Identifier: 213157943

GI number: 213157943

Start: 3542751

End: 3544124

Strand: Direct

Name: merA [H]

Synonym: AB57_3436

Alternate gene names: 213157943

Gene position: 3542751-3544124 (Clockwise)

Preceding gene: 213157942

Following gene: 213157944

Centisome position: 87.46

GC content: 35.88

Gene sequence:

>1374_bases
ATGTTCGATCTTATTATCATTGGCGCGGGTACGGCTGGTATTAGCGCTTATAAAGAAGCAGTAAAATACACTAATAATCT
TTTAATTATAAATGATGGCCCTTGGGATACCACTTGCGCACGTGTAGGATGTATGCCAAGTAAAGTCTTAATCTCTACTG
CAAACCGTATGCATGATATACAAAATGCTCAAGAGGTTGGGCTGAGTGCTTCAGCAGATATTAATACTGATCAGGTTATG
GAGCATGTGAGAACCTTACGTGATCGTTTTACTAAGGCCACAGTAAAAGATGTCGAACAATGGCCCACTGAACATAAAAT
TTCGGGTAAAGCTCATTTTATTGATGCAAAAACTATTGAAGTAAATGGTAAACGGTATCAGTCAAAAAGTTTTATTTTAG
CAGTAGGCTCTACACCTAATTATGATCAAAGTTGGAAACAAGAATTAGGTGATCGTCTTATTACTACAGATCAAATATTT
GAATTAAACACCCTACCCAAGTCTATCGCTATTATTGGAAGTGGAGTAATTGCCTTAGAGATTGCCCAAGCCATGCATCG
TTTGGATGTAGAAACCACTATATTTGCTCGTAGTAAAAGAATCGGGATATTTACTAGTCCTAAGCTACAACAGCTCGCTC
AAGAAGAACTGAGTAAAGAGTTAAATTTTTTATTCGAGACATTGCCTCATGAGGTTAAGTCTACTTCTGATGGCGTTATA
TTGAATTATAAAATTGATGAAAAAGAGGAATCTATCCAAACTGAGTATGTGTTATCTGCAACAGGTCGTTCGAGCTTACT
TGACACGCTAAAGCTAGAAAATATTGATAAATCTTTTAAAGATATTAAATTACTACCTGTAAATGCAAAAACTAAACAAT
TAGATGACTATCCAATTTTTATTGCTGGTGATGCGTACACCTCTACGCCTTTACAACATGAAGCTGCCCATGAAGGTAAA
AAAGTTGTTTATAACTGTTTAAATTATCCACAGGTAAACGCAGTTAAGACACTTACTCCATTAGGAATTGTATTTAGTCA
TCCAGAAATGGCAATTGTGGGACAAAGTTATAAACAACTTAAAGATAATGGAGTAGATTTTGTTACAGGTGAAGCATCTT
ATGAAAGACAAGGAAGAGCTATCGTACTCGGGAAAAATAAGGGTGCTATTGAAGTTTATATAGAGCGAGAAAGTCAGAAA
TTGCTTGGTGCAGAGTTATTTACCGAAGCTACAGAACATATGGCTCATCTATTAAGCTGGATTATTGGAGAAAAGCTAAC
TTTAAATGATATTTTAGAGAAACCTTTCTATCATCCAACACTAGAAGAAGGCCTTCGTACTGCTCTTAAACATGCTCGCA
GACAGTTGAAATAA

Upstream 100 bases:

>100_bases
AATTTACATTTTAAGTCAAAATAAGCAAAACAAACCCTCTGCTTAGGAGGGTTTTTCTATATATTCTATATATCTATCTC
TAAAAAACAGCCCATTAAGA

Downstream 100 bases:

>100_bases
TTATTATTAAAAGAGAGCTCTCTTGCAAAGTTAGCTCTTTATACTTCAAGAAGCCTTCTTCTGTTGAGTGCTACATTTTT
GCTTGATTGAGGCTAAGTTT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFDLIIIGAGTAGISAYKEAVKYTNNLLIINDGPWDTTCARVGCMPSKVLISTANRMHDIQNAQEVGLSASADINTDQVM
EHVRTLRDRFTKATVKDVEQWPTEHKISGKAHFIDAKTIEVNGKRYQSKSFILAVGSTPNYDQSWKQELGDRLITTDQIF
ELNTLPKSIAIIGSGVIALEIAQAMHRLDVETTIFARSKRIGIFTSPKLQQLAQEELSKELNFLFETLPHEVKSTSDGVI
LNYKIDEKEESIQTEYVLSATGRSSLLDTLKLENIDKSFKDIKLLPVNAKTKQLDDYPIFIAGDAYTSTPLQHEAAHEGK
KVVYNCLNYPQVNAVKTLTPLGIVFSHPEMAIVGQSYKQLKDNGVDFVTGEASYERQGRAIVLGKNKGAIEVYIERESQK
LLGAELFTEATEHMAHLLSWIIGEKLTLNDILEKPFYHPTLEEGLRTALKHARRQLK

Sequences:

>Translated_457_residues
MFDLIIIGAGTAGISAYKEAVKYTNNLLIINDGPWDTTCARVGCMPSKVLISTANRMHDIQNAQEVGLSASADINTDQVM
EHVRTLRDRFTKATVKDVEQWPTEHKISGKAHFIDAKTIEVNGKRYQSKSFILAVGSTPNYDQSWKQELGDRLITTDQIF
ELNTLPKSIAIIGSGVIALEIAQAMHRLDVETTIFARSKRIGIFTSPKLQQLAQEELSKELNFLFETLPHEVKSTSDGVI
LNYKIDEKEESIQTEYVLSATGRSSLLDTLKLENIDKSFKDIKLLPVNAKTKQLDDYPIFIAGDAYTSTPLQHEAAHEGK
KVVYNCLNYPQVNAVKTLTPLGIVFSHPEMAIVGQSYKQLKDNGVDFVTGEASYERQGRAIVLGKNKGAIEVYIERESQK
LLGAELFTEATEHMAHLLSWIIGEKLTLNDILEKPFYHPTLEEGLRTALKHARRQLK
>Mature_457_residues
MFDLIIIGAGTAGISAYKEAVKYTNNLLIINDGPWDTTCARVGCMPSKVLISTANRMHDIQNAQEVGLSASADINTDQVM
EHVRTLRDRFTKATVKDVEQWPTEHKISGKAHFIDAKTIEVNGKRYQSKSFILAVGSTPNYDQSWKQELGDRLITTDQIF
ELNTLPKSIAIIGSGVIALEIAQAMHRLDVETTIFARSKRIGIFTSPKLQQLAQEELSKELNFLFETLPHEVKSTSDGVI
LNYKIDEKEESIQTEYVLSATGRSSLLDTLKLENIDKSFKDIKLLPVNAKTKQLDDYPIFIAGDAYTSTPLQHEAAHEGK
KVVYNCLNYPQVNAVKTLTPLGIVFSHPEMAIVGQSYKQLKDNGVDFVTGEASYERQGRAIVLGKNKGAIEVYIERESQK
LLGAELFTEATEHMAHLLSWIIGEKLTLNDILEKPFYHPTLEEGLRTALKHARRQLK

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=478, Percent_Identity=25.1046025104602, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=23.8611713665944, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI22035672, Length=294, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI148277065, Length=281, Percent_Identity=22.0640569395018, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI33519430, Length=281, Percent_Identity=22.0640569395018, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI33519428, Length=281, Percent_Identity=22.0640569395018, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI33519426, Length=281, Percent_Identity=22.0640569395018, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI148277071, Length=284, Percent_Identity=21.830985915493, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082354, Length=476, Percent_Identity=25, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=23.3115468409586, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=22.7906976744186, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=25, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=366, Percent_Identity=25.9562841530055, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71983419, Length=366, Percent_Identity=25.9562841530055, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=25.3112033195021, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6325240, Length=313, Percent_Identity=22.0447284345048, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=25.8620689655172, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24640549, Length=313, Percent_Identity=29.073482428115, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24640553, Length=313, Percent_Identity=29.073482428115, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=26.3598326359833, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17737741, Length=335, Percent_Identity=26.2686567164179, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 51119; Mature: 51119

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLIIIGAGTAGISAYKEAVKYTNNLLIINDGPWDTTCARVGCMPSKVLISTANRMHDI
CEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHH
QNAQEVGLSASADINTDQVMEHVRTLRDRFTKATVKDVEQWPTEHKISGKAHFIDAKTIE
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
VNGKRYQSKSFILAVGSTPNYDQSWKQELGDRLITTDQIFELNTLPKSIAIIGSGVIALE
ECCCEECCCEEEEEECCCCCCCHHHHHHHCCCEECHHHEEEECCCCHHHHHHCCCHHHHH
IAQAMHRLDVETTIFARSKRIGIFTSPKLQQLAQEELSKELNFLFETLPHEVKSTSDGVI
HHHHHHHCCCHHEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEE
LNYKIDEKEESIQTEYVLSATGRSSLLDTLKLENIDKSFKDIKLLPVNAKTKQLDDYPIF
EEEEECCHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEE
IAGDAYTSTPLQHEAAHEGKKVVYNCLNYPQVNAVKTLTPLGIVFSHPEMAIVGQSYKQL
EECCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHHHCCCCEEECCCCEEEECCHHHHH
KDNGVDFVTGEASYERQGRAIVLGKNKGAIEVYIERESQKLLGAELFTEATEHMAHLLSW
HHCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
IIGEKLTLNDILEKPFYHPTLEEGLRTALKHARRQLK
HHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFDLIIIGAGTAGISAYKEAVKYTNNLLIINDGPWDTTCARVGCMPSKVLISTANRMHDI
CEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHH
QNAQEVGLSASADINTDQVMEHVRTLRDRFTKATVKDVEQWPTEHKISGKAHFIDAKTIE
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
VNGKRYQSKSFILAVGSTPNYDQSWKQELGDRLITTDQIFELNTLPKSIAIIGSGVIALE
ECCCEECCCEEEEEECCCCCCCHHHHHHHCCCEECHHHEEEECCCCHHHHHHCCCHHHHH
IAQAMHRLDVETTIFARSKRIGIFTSPKLQQLAQEELSKELNFLFETLPHEVKSTSDGVI
HHHHHHHCCCHHEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEE
LNYKIDEKEESIQTEYVLSATGRSSLLDTLKLENIDKSFKDIKLLPVNAKTKQLDDYPIF
EEEEECCHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEE
IAGDAYTSTPLQHEAAHEGKKVVYNCLNYPQVNAVKTLTPLGIVFSHPEMAIVGQSYKQL
EECCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHHHCCCCEEECCCCEEEECCHHHHH
KDNGVDFVTGEASYERQGRAIVLGKNKGAIEVYIERESQKLLGAELFTEATEHMAHLLSW
HHCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
IIGEKLTLNDILEKPFYHPTLEEGLRTALKHARRQLK
HHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]