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The map label for this gene is folC [H]

Identifier: 213157881

GI number: 213157881

Start: 3476503

End: 3477789

Strand: Reverse

Name: folC [H]

Synonym: AB57_3371

Alternate gene names: 213157881

Gene position: 3477789-3476503 (Counterclockwise)

Preceding gene: 213157882

Following gene: 213157880

Centisome position: 85.86

GC content: 40.79

Gene sequence:

>1287_bases
TTGAAACAACAAGCTCCACTTTCAACAGACTCTTTAGATACATGGCTCAATTATTGGAGCCATGTTCACGTTACAGGGAT
CGATCTTGGTCTGGAACGTGTTATTCCCGTAGCAGAAAAATTAGGCGTGACTAAACCTAACGCCAAAGTTTTTACCGTTG
CTGGAACAAACGGGAAAGGTTCAACCACAACAACGCTTGCGTCTATATTAAAAGCACAAGGGTATAAAGTTGGGTTGTAT
CAATCACCGCATATCTATCGTTTTAACGAGCGAGTCAAATTAGGTGGAGTTGAAGTTGATGACCAAAGCCTGATTGATGC
TTTTGTACAAGTTGATCAGGCTCGTCGCGAGTGTGATTTAAGCCTATCTTTTTTTGAAGCAACCACTTTGGCTGCTTTTG
TTATTTTTAAACAGCAACAATGCGATGTATGGGTTCTTGAAGTCGGTTTAGGTGGGCGTCTTGATGTTGTCAACGTCATT
GACCCTGATATCGCCGTGATTACCAATATTGGTCTTGACCATACAGATTGGTTAGGCGATACCATCGAAAAAATTGCTTT
TGAAAAAGCAGGTATTATCCGACCTCATATTCCTGTCATTTTTGCAGGTGAGCAATCTTTGCCTCAAGCGATTCAAGATA
AGGCAAATAGCTCACAAGCCACGCTATACGCGATTAATAGAGATTATTTTTATAAACTCGCCGATGATGGAAAACATTGG
TATTTTGCAAGTGAAGGAACCACTTTAAGGTTGCCGCTTGGTACACTTGCAATCGAGAATATTGCAGGAGCAGTTGCGGC
CGTATTAAATAGCGGACTTGAAATCTCGCAACTAGCGCTAGAGGAGGGCATTACAAATGCCCGCTTGGCTGGACGCTTCG
AAGTGCGTCAAGTTAATGGAAAAACCATTATTTTTGATGCCGGACACAATCCTCATGGTGTTGAATTTTTGTTAAAGCAA
TTGCGAAATTTCTTAGAATACAATAAACAGTACACAGAAGTTGTCGCAGTATTTTCAATGCTGGCAGATAAAGATATAAA
ATCAGTAGTCGATTTGTTGAAACCTACTGTTTTACATTGGAAAATTGCTGAGTTGAATGTGCCGCGTGCTGCACCGATTC
AGCAATTGAATGACGCCCTGCAAGGCCAGACAATACAACAATTTGGCAATATCAAAGAGGCTTTTAAATCAGCGCTTGAG
CAAACAAATAACAATCAGCTGATTTTAGCCTGTGGTTCGTTTCATACTTTAGAAGCGATTTGGGAGTATTTGGAAGAATG
TCAATGA

Upstream 100 bases:

>100_bases
CAGAATATCTGCTTGATCATGGTGTGGTCGATCAGATTGTTCATCGTCATGCTTTACGTGATACTGTATCTCGTCTTGTA
TCAAAATTGATGAACTTACC

Downstream 100 bases:

>100_bases
ATAACAAACAACGCTGGATGGGTGGCGTTGTTTTATTAGGTGGTGGTGTTTTATTGGCAGCATTACTTCTAAAAGGAAAT
GAAGAAATAAAACAGGTAGA

Product: folylpolyglutamate synthetase/dihydrofolate synthase

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKQQAPLSTDSLDTWLNYWSHVHVTGIDLGLERVIPVAEKLGVTKPNAKVFTVAGTNGKGSTTTTLASILKAQGYKVGLY
QSPHIYRFNERVKLGGVEVDDQSLIDAFVQVDQARRECDLSLSFFEATTLAAFVIFKQQQCDVWVLEVGLGGRLDVVNVI
DPDIAVITNIGLDHTDWLGDTIEKIAFEKAGIIRPHIPVIFAGEQSLPQAIQDKANSSQATLYAINRDYFYKLADDGKHW
YFASEGTTLRLPLGTLAIENIAGAVAAVLNSGLEISQLALEEGITNARLAGRFEVRQVNGKTIIFDAGHNPHGVEFLLKQ
LRNFLEYNKQYTEVVAVFSMLADKDIKSVVDLLKPTVLHWKIAELNVPRAAPIQQLNDALQGQTIQQFGNIKEAFKSALE
QTNNNQLILACGSFHTLEAIWEYLEECQ

Sequences:

>Translated_428_residues
MKQQAPLSTDSLDTWLNYWSHVHVTGIDLGLERVIPVAEKLGVTKPNAKVFTVAGTNGKGSTTTTLASILKAQGYKVGLY
QSPHIYRFNERVKLGGVEVDDQSLIDAFVQVDQARRECDLSLSFFEATTLAAFVIFKQQQCDVWVLEVGLGGRLDVVNVI
DPDIAVITNIGLDHTDWLGDTIEKIAFEKAGIIRPHIPVIFAGEQSLPQAIQDKANSSQATLYAINRDYFYKLADDGKHW
YFASEGTTLRLPLGTLAIENIAGAVAAVLNSGLEISQLALEEGITNARLAGRFEVRQVNGKTIIFDAGHNPHGVEFLLKQ
LRNFLEYNKQYTEVVAVFSMLADKDIKSVVDLLKPTVLHWKIAELNVPRAAPIQQLNDALQGQTIQQFGNIKEAFKSALE
QTNNNQLILACGSFHTLEAIWEYLEECQ
>Mature_428_residues
MKQQAPLSTDSLDTWLNYWSHVHVTGIDLGLERVIPVAEKLGVTKPNAKVFTVAGTNGKGSTTTTLASILKAQGYKVGLY
QSPHIYRFNERVKLGGVEVDDQSLIDAFVQVDQARRECDLSLSFFEATTLAAFVIFKQQQCDVWVLEVGLGGRLDVVNVI
DPDIAVITNIGLDHTDWLGDTIEKIAFEKAGIIRPHIPVIFAGEQSLPQAIQDKANSSQATLYAINRDYFYKLADDGKHW
YFASEGTTLRLPLGTLAIENIAGAVAAVLNSGLEISQLALEEGITNARLAGRFEVRQVNGKTIIFDAGHNPHGVEFLLKQ
LRNFLEYNKQYTEVVAVFSMLADKDIKSVVDLLKPTVLHWKIAELNVPRAAPIQQLNDALQGQTIQQFGNIKEAFKSALE
QTNNNQLILACGSFHTLEAIWEYLEECQ

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=342, Percent_Identity=27.1929824561404, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI66932984, Length=342, Percent_Identity=27.1929824561404, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1788654, Length=424, Percent_Identity=42.9245283018868, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17553148, Length=412, Percent_Identity=26.6990291262136, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17553150, Length=412, Percent_Identity=26.6990291262136, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71984923, Length=412, Percent_Identity=26.6990291262136, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323760, Length=331, Percent_Identity=29.607250755287, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324815, Length=192, Percent_Identity=34.8958333333333, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24641571, Length=191, Percent_Identity=36.6492146596859, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24581568, Length=173, Percent_Identity=31.7919075144509, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 47366; Mature: 47366

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01011 FOLYLPOLYGLU_SYNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQAPLSTDSLDTWLNYWSHVHVTGIDLGLERVIPVAEKLGVTKPNAKVFTVAGTNGKG
CCCCCCCCCCHHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
STTTTLASILKAQGYKVGLYQSPHIYRFNERVKLGGVEVDDQSLIDAFVQVDQARRECDL
CHHHHHHHHHHHCCCEEEEECCCCEEEECCEEEECCEEECHHHHHHHHHHHHHHHHHCCC
SLSFFEATTLAAFVIFKQQQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD
EEHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCHHHHH
TIEKIAFEKAGIIRPHIPVIFAGEQSLPQAIQDKANSSQATLYAINRDYFYKLADDGKHW
HHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCEE
YFASEGTTLRLPLGTLAIENIAGAVAAVLNSGLEISQLALEEGITNARLAGRFEVRQVNG
EEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCEEEEEEECC
KTIIFDAGHNPHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVDLLKPTVLHW
CEEEEECCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHEEE
KIAELNVPRAAPIQQLNDALQGQTIQQFGNIKEAFKSALEQTNNNQLILACGSFHTLEAI
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
WEYLEECQ
HHHHHHCC
>Mature Secondary Structure
MKQQAPLSTDSLDTWLNYWSHVHVTGIDLGLERVIPVAEKLGVTKPNAKVFTVAGTNGKG
CCCCCCCCCCHHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
STTTTLASILKAQGYKVGLYQSPHIYRFNERVKLGGVEVDDQSLIDAFVQVDQARRECDL
CHHHHHHHHHHHCCCEEEEECCCCEEEECCEEEECCEEECHHHHHHHHHHHHHHHHHCCC
SLSFFEATTLAAFVIFKQQQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD
EEHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCHHHHH
TIEKIAFEKAGIIRPHIPVIFAGEQSLPQAIQDKANSSQATLYAINRDYFYKLADDGKHW
HHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCEE
YFASEGTTLRLPLGTLAIENIAGAVAAVLNSGLEISQLALEEGITNARLAGRFEVRQVNG
EEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCEEEEEEECC
KTIIFDAGHNPHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVDLLKPTVLHW
CEEEEECCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHEEE
KIAELNVPRAAPIQQLNDALQGQTIQQFGNIKEAFKSALEQTNNNQLILACGSFHTLEAI
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
WEYLEECQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]