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The map label for this gene is hemN [H]

Identifier: 213157825

GI number: 213157825

Start: 3410572

End: 3411963

Strand: Reverse

Name: hemN [H]

Synonym: AB57_3309

Alternate gene names: 213157825

Gene position: 3411963-3410572 (Counterclockwise)

Preceding gene: 213157826

Following gene: 213157824

Centisome position: 84.24

GC content: 32.4

Gene sequence:

>1392_bases
ATGGATATTGTTTCAATTAAAAATTTCATCCAAAAAAATAAAGTAAGACATTTATCAAATAAAGTTCTACATACCCATCC
CTCACCTAAAATGTGGAAAACGGATTTAAAGGAAGAAGAAAATAATTACTTTTTATTAAATACAGATGCTCAATATAAGT
CTATAAATTTATATTTAGGCATTCCATATTGTATTCCTACTGATCCACCTCATTGTGGATTTTGTCTTTTCCCAACACAA
GACTATAAAGGTAAGCGGGAAATGGACTTTTATCTGGATTTTTTAAGTAGGGAAGCCCACTTATATAAAGAATTTTATCA
AGGAGCTAAGCTTGAAAGTTTGTATGTAGGAGGAGGTACACCTAATTTACTTCAGCCTAATGATTATATGAAACTGACTA
AGGTTGTATCTTCTCTTTTTCCCGATGCTGGTATATCTAGCCCTATAGAAATGACATTAGAAGGTATCCCTCAACTTTTT
AATGAAGATAAAATAAGAGCAATTAAAGATGCAGGTTTTAACCGTGTCAGTATGGGAGTACAACAGGTTAATGATGAGTT
AATCGCTACAAGCGGTCGAAAACAAACGAGAAAGCAGGTTTTTGATGCAATTGAATTGTTCCATAAGTATTCTTTATCTT
GTAACGTCGATTTGATCTATGGCTGGCCAAATCAAACGGTTGAGGCAATGCTAAGAGACTTGGAAAGTATTGTTCAATCA
GGAATAAAACATATTACTCACTATGAGCTTAATATTGCTGGTCGTTCTGACTTTGCGACAAAACAAAAGCAAAATACGCC
CTCTATTGAGAAGAAAATTGAAATGTATAACATTGCTAAACAGTTCTTAATAAGCAAAGGCTATAAACAAAAAACAGTAT
ATGATTGGGAAAAAGAAGATAATAACCAATTAATTTCAGAGAAATATTTATATGAAGATAACCTTAGAGACTGCTTAGAT
GCCAATGGGCAAAGTAAAATGACCACAATGAGTGGGCTGGGTTATGCAGCCGTTAATATGAGACTGCAACCTAACTCATC
AAGCATTAAATCTGTTTCAGCAATGAATCATCGAAACCTAACTGAATACTACAATGCAATATCTTTAAATAAACTTCCTG
TTGAACGTATGTTTGTTCATGATACTGAAGATGTAAAGTTAATTTGGATATTTCAAGCATTACAAGAGATGAAAATTAAC
ACCAAAAAGTACGAGAAAATTTTTAATAGTGATATTAAACTCGATTATAAGCCTATTTGGGATGCATTAGTCGAAGAAGG
TTGGGTAGAGCATAATGATGAATATATTAAACTTATTAATGAAGGTGAGTTTTATACTCCACTTATTCAGGCATTATTAA
GTCAACCTAGAATAAAATCTTTGCAACAGTAG

Upstream 100 bases:

>100_bases
AAAATAAAATTCTAATGTTTGGAAGAATTAAATTAATTGCGTAATTTGTTATATTTAAATACAATATATTTATTGATATA
TAATGACAAATATAGTGACT

Downstream 100 bases:

>100_bases
AAAATAAATGTCAATTCATAAAGAGCTGCATATTTTAAAAACAGATGACCATGGCGAGTTTGCTTTATGGGAAGTTGCTA
AAAGCGAGAATACCCTGATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDIVSIKNFIQKNKVRHLSNKVLHTHPSPKMWKTDLKEEENNYFLLNTDAQYKSINLYLGIPYCIPTDPPHCGFCLFPTQ
DYKGKREMDFYLDFLSREAHLYKEFYQGAKLESLYVGGGTPNLLQPNDYMKLTKVVSSLFPDAGISSPIEMTLEGIPQLF
NEDKIRAIKDAGFNRVSMGVQQVNDELIATSGRKQTRKQVFDAIELFHKYSLSCNVDLIYGWPNQTVEAMLRDLESIVQS
GIKHITHYELNIAGRSDFATKQKQNTPSIEKKIEMYNIAKQFLISKGYKQKTVYDWEKEDNNQLISEKYLYEDNLRDCLD
ANGQSKMTTMSGLGYAAVNMRLQPNSSSIKSVSAMNHRNLTEYYNAISLNKLPVERMFVHDTEDVKLIWIFQALQEMKIN
TKKYEKIFNSDIKLDYKPIWDALVEEGWVEHNDEYIKLINEGEFYTPLIQALLSQPRIKSLQQ

Sequences:

>Translated_463_residues
MDIVSIKNFIQKNKVRHLSNKVLHTHPSPKMWKTDLKEEENNYFLLNTDAQYKSINLYLGIPYCIPTDPPHCGFCLFPTQ
DYKGKREMDFYLDFLSREAHLYKEFYQGAKLESLYVGGGTPNLLQPNDYMKLTKVVSSLFPDAGISSPIEMTLEGIPQLF
NEDKIRAIKDAGFNRVSMGVQQVNDELIATSGRKQTRKQVFDAIELFHKYSLSCNVDLIYGWPNQTVEAMLRDLESIVQS
GIKHITHYELNIAGRSDFATKQKQNTPSIEKKIEMYNIAKQFLISKGYKQKTVYDWEKEDNNQLISEKYLYEDNLRDCLD
ANGQSKMTTMSGLGYAAVNMRLQPNSSSIKSVSAMNHRNLTEYYNAISLNKLPVERMFVHDTEDVKLIWIFQALQEMKIN
TKKYEKIFNSDIKLDYKPIWDALVEEGWVEHNDEYIKLINEGEFYTPLIQALLSQPRIKSLQQ
>Mature_463_residues
MDIVSIKNFIQKNKVRHLSNKVLHTHPSPKMWKTDLKEEENNYFLLNTDAQYKSINLYLGIPYCIPTDPPHCGFCLFPTQ
DYKGKREMDFYLDFLSREAHLYKEFYQGAKLESLYVGGGTPNLLQPNDYMKLTKVVSSLFPDAGISSPIEMTLEGIPQLF
NEDKIRAIKDAGFNRVSMGVQQVNDELIATSGRKQTRKQVFDAIELFHKYSLSCNVDLIYGWPNQTVEAMLRDLESIVQS
GIKHITHYELNIAGRSDFATKQKQNTPSIEKKIEMYNIAKQFLISKGYKQKTVYDWEKEDNNQLISEKYLYEDNLRDCLD
ANGQSKMTTMSGLGYAAVNMRLQPNSSSIKSVSAMNHRNLTEYYNAISLNKLPVERMFVHDTEDVKLIWIFQALQEMKIN
TKKYEKIFNSDIKLDYKPIWDALVEEGWVEHNDEYIKLINEGEFYTPLIQALLSQPRIKSLQQ

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=264, Percent_Identity=25.7575757575758, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789325, Length=237, Percent_Identity=27.8481012658228, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87082341, Length=419, Percent_Identity=24.1050119331742, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53697; Mature: 53697

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVSIKNFIQKNKVRHLSNKVLHTHPSPKMWKTDLKEEENNYFLLNTDAQYKSINLYLG
CCCHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHCCCCCCEEEEECCCCEEEEEEEEE
IPYCIPTDPPHCGFCLFPTQDYKGKREMDFYLDFLSREAHLYKEFYQGAKLESLYVGGGT
CCEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PNLLQPNDYMKLTKVVSSLFPDAGISSPIEMTLEGIPQLFNEDKIRAIKDAGFNRVSMGV
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
QQVNDELIATSGRKQTRKQVFDAIELFHKYSLSCNVDLIYGWPNQTVEAMLRDLESIVQS
HHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
GIKHITHYELNIAGRSDFATKQKQNTPSIEKKIEMYNIAKQFLISKGYKQKTVYDWEKED
HHHHHEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCC
NNQLISEKYLYEDNLRDCLDANGQSKMTTMSGLGYAAVNMRLQPNSSSIKSVSAMNHRNL
CCCHHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCH
TEYYNAISLNKLPVERMFVHDTEDVKLIWIFQALQEMKINTKKYEKIFNSDIKLDYKPIW
HHHHHHHCCCCCCHHHHEEECCCCEEEEHHHHHHHHHHCCHHHHHHHHCCCCEECCHHHH
DALVEEGWVEHNDEYIKLINEGEFYTPLIQALLSQPRIKSLQQ
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MDIVSIKNFIQKNKVRHLSNKVLHTHPSPKMWKTDLKEEENNYFLLNTDAQYKSINLYLG
CCCHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHCCCCCCEEEEECCCCEEEEEEEEE
IPYCIPTDPPHCGFCLFPTQDYKGKREMDFYLDFLSREAHLYKEFYQGAKLESLYVGGGT
CCEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PNLLQPNDYMKLTKVVSSLFPDAGISSPIEMTLEGIPQLFNEDKIRAIKDAGFNRVSMGV
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
QQVNDELIATSGRKQTRKQVFDAIELFHKYSLSCNVDLIYGWPNQTVEAMLRDLESIVQS
HHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
GIKHITHYELNIAGRSDFATKQKQNTPSIEKKIEMYNIAKQFLISKGYKQKTVYDWEKED
HHHHHEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCC
NNQLISEKYLYEDNLRDCLDANGQSKMTTMSGLGYAAVNMRLQPNSSSIKSVSAMNHRNL
CCCHHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCH
TEYYNAISLNKLPVERMFVHDTEDVKLIWIFQALQEMKINTKKYEKIFNSDIKLDYKPIW
HHHHHHHCCCCCCHHHHEEECCCCEEEEHHHHHHHHHHCCHHHHHHHHCCCCEECCHHHH
DALVEEGWVEHNDEYIKLINEGEFYTPLIQALLSQPRIKSLQQ
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]