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The map label for this gene is serS [H]

Identifier: 213157669

GI number: 213157669

Start: 3270747

End: 3272018

Strand: Reverse

Name: serS [H]

Synonym: AB57_3147

Alternate gene names: 213157669

Gene position: 3272018-3270747 (Counterclockwise)

Preceding gene: 213157670

Following gene: 213157668

Centisome position: 80.78

GC content: 42.06

Gene sequence:

>1272_bases
ATGATCGACCCTAAGTTACTCAGAAATAATATTGAAGTCGTTAATGCAGGTTTGGCAAAACGTGGTGTTCAGTTAGATGT
TCAAGAATGGGCATCTTTAGAGACTCGCCGTAAAGACTTGCAATCAAAAACTGAAAAGTTACAGGCAGAGCGAAATGCCG
GTGCTAAACAAGTGGGTCAGATTAAAAAATCCGGTGGTGATGCTTCTGAAATCATGGCACGTATGCAAGCCATTGGTGAT
GAAATTAAAGCTGCCGAAGTTGCTTTATCAGAGCTACAAAACGAGATTGAGCAAAAAGCGCTTAGCATTCCTAACTTGCC
GGACGAATCTGTACCAGCTGGTAAAGATGAAAATGATAACGTTGAAATCTCAAAATGGGGTACACCTCGTCAGTTCGATT
TTGAAATCAAAGATCATACTGATTTAGGTGAGTGGATGGGCGGACTGGAGTTTGAAACTGCCACTAAACTCACAGGCTCA
CGTTTTAGTGTGTTGAAGGGACCTTTAGCGCGTCTACAACGTGCTTTAACTCAGTTCATGCTCGATACCCATACTTTAAA
GAATGGTTATACCGAAGCGTATGTGCCTTATCTGGTAAATGCTGATTCATTACGTGGGACAGGTCAGTTACCAAAATTTG
AAGAAGATTTATTTAAACTTCAAGGCGAAAAAGAATACTACCTCATCCCTACAGCAGAAGTTCCAGTCACTAACTTTGTC
CGTGATGAAATTATTGATGCAGACCGTTTACCATTAAAATATGCGGCTCATACACCATGTTTCCGTAGTGAAGCGGGTTC
TTATGGTCGTGATACACGTGGTTTAATTCGTCAGCACCAATTTGATAAAGTTGAAATGGTGCAAATCGTTAAGCCTGAAA
CATCTATGCAGGCACTTGAAGAGCTTACTGCACATGCTGAGGGCATTTTACAGGCGCTTGGTTTGCCTTACCGCAAAATT
TTGCTCTGTGGTGGTGATATGGGCTTCGGTGCGACTAAAACTTATGATTTAGAAGTTTGGGTTCCAAGTCAAAATACTTA
CCGTGAAATTTCAAGCTGCTCTAATATGGGTGATTTCCAGGCACGTCGTATGAAAGCACGCTACCGTATGGATCAGAAGA
AGACCGAATTGGTGCACACTCTAAATGGTTCAGGCCTTGCTGTAGGGCGTACTTTACTTGCAGTGATGGAAAACTACCAA
CGCGAAGACGGTTCAATTGAGATTCCAGAAGTATTACGCCCATATATGGGTGGTGCAACGTTTATTGATTAA

Upstream 100 bases:

>100_bases
AGAATTGTGTGAAAGCTATTCGTTATGAAGATGATCACTATATTTTTTAGTGTTAAGGGCTTACACTATAGCCAGTTTTT
TACCCATATTATGATTGATT

Downstream 100 bases:

>100_bases
GCTTTGCATCTAAATTGTGCACGGTTTTTGCTTAAACATAGTCAGATGATTGATGTAGAGGTTTAAGGTGGATATTTTTC
CAATCTCTTTGAAGTTGCAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MIDPKLLRNNIEVVNAGLAKRGVQLDVQEWASLETRRKDLQSKTEKLQAERNAGAKQVGQIKKSGGDASEIMARMQAIGD
EIKAAEVALSELQNEIEQKALSIPNLPDESVPAGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGS
RFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
RDEIIDADRLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPETSMQALEELTAHAEGILQALGLPYRKI
LLCGGDMGFGATKTYDLEVWVPSQNTYREISSCSNMGDFQARRMKARYRMDQKKTELVHTLNGSGLAVGRTLLAVMENYQ
REDGSIEIPEVLRPYMGGATFID

Sequences:

>Translated_423_residues
MIDPKLLRNNIEVVNAGLAKRGVQLDVQEWASLETRRKDLQSKTEKLQAERNAGAKQVGQIKKSGGDASEIMARMQAIGD
EIKAAEVALSELQNEIEQKALSIPNLPDESVPAGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGS
RFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
RDEIIDADRLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPETSMQALEELTAHAEGILQALGLPYRKI
LLCGGDMGFGATKTYDLEVWVPSQNTYREISSCSNMGDFQARRMKARYRMDQKKTELVHTLNGSGLAVGRTLLAVMENYQ
REDGSIEIPEVLRPYMGGATFID
>Mature_423_residues
MIDPKLLRNNIEVVNAGLAKRGVQLDVQEWASLETRRKDLQSKTEKLQAERNAGAKQVGQIKKSGGDASEIMARMQAIGD
EIKAAEVALSELQNEIEQKALSIPNLPDESVPAGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGS
RFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
RDEIIDADRLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPETSMQALEELTAHAEGILQALGLPYRKI
LLCGGDMGFGATKTYDLEVWVPSQNTYREISSCSNMGDFQARRMKARYRMDQKKTELVHTLNGSGLAVGRTLLAVMENYQ
REDGSIEIPEVLRPYMGGATFID

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=454, Percent_Identity=34.5814977973568, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI8923421, Length=405, Percent_Identity=29.1358024691358, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI225579074, Length=391, Percent_Identity=28.6445012787724, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=66.6666666666667, Blast_Score=589, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=32.183908045977, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=364, Percent_Identity=29.9450549450549, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320226, Length=438, Percent_Identity=30.1369863013699, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=422, Percent_Identity=31.2796208530806, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24581334, Length=456, Percent_Identity=32.2368421052632, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17737985, Length=339, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47398; Mature: 47398

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPKLLRNNIEVVNAGLAKRGVQLDVQEWASLETRRKDLQSKTEKLQAERNAGAKQVGQ
CCCHHHHHCCHHHHCCHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IKKSGGDASEIMARMQAIGDEIKAAEVALSELQNEIEQKALSIPNLPDESVPAGKDENDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGSRFSVLKGPLARLQRALTQFM
EEEEECCCCCEEEEEECCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
HHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHH
RDEIIDADRLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPETSMQALE
HHHHCCCCCCCEEHHCCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHEECCCHHHHHHH
ELTAHAEGILQALGLPYRKILLCGGDMGFGATKTYDLEVWVPSQNTYREISSCSNMGDFQ
HHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCHHH
ARRMKARYRMDQKKTELVHTLNGSGLAVGRTLLAVMENYQREDGSIEIPEVLRPYMGGAT
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCC
FID
CCC
>Mature Secondary Structure
MIDPKLLRNNIEVVNAGLAKRGVQLDVQEWASLETRRKDLQSKTEKLQAERNAGAKQVGQ
CCCHHHHHCCHHHHCCHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IKKSGGDASEIMARMQAIGDEIKAAEVALSELQNEIEQKALSIPNLPDESVPAGKDENDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGSRFSVLKGPLARLQRALTQFM
EEEEECCCCCEEEEEECCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
HHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHH
RDEIIDADRLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPETSMQALE
HHHHCCCCCCCEEHHCCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHEECCCHHHHHHH
ELTAHAEGILQALGLPYRKILLCGGDMGFGATKTYDLEVWVPSQNTYREISSCSNMGDFQ
HHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCHHH
ARRMKARYRMDQKKTELVHTLNGSGLAVGRTLLAVMENYQREDGSIEIPEVLRPYMGGAT
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCC
FID
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA