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The map label for this gene is folP [H]

Identifier: 213157618

GI number: 213157618

Start: 3202867

End: 3203718

Strand: Reverse

Name: folP [H]

Synonym: AB57_3095

Alternate gene names: 213157618

Gene position: 3203718-3202867 (Counterclockwise)

Preceding gene: 213157619

Following gene: 213157617

Centisome position: 79.09

GC content: 41.43

Gene sequence:

>852_bases
ATGCAGTTAATATCTTTACCAAAGCAGATTTTACAGTGTGGACAGCTTCAATTAGATTTATCTCAGCCCCATGTTATGGG
TATCTTAAATGTCACTCCTGATTCTTTCAGTGATGGTGGTAAACATAACCAATTAGACCAAGCGGTTGATCATGCACTTA
GTATGATTGAGCAAGGCGCGACTATTATTGATATTGGGGGGGAATCTACCCGACCTGGTGCTTCAGAAGTTGTAGTAGAA
GAAGAAGTGCGTCGTGTGGTACCTGTGGTCGAGGCTTTATCTTACCATAACGTTATTTTGTCGATCGACACAAGTCAGCC
AGAAGTTATTCGCGCAGCAAAAGCAGCAGGGGCACATATCTGGAATGATGTCCGTGCCTTAACACGTCCCAATGCTTTAA
AAACTGCCGTAGAATTAGATATACCTGTAGTAATTATGCATATGCGCGGTGAACCAACGACAATGAATCAGTTGGATCAG
TACACTGATGTAACACTCGATGTGATGCAAGAGTTGCAACAGCGTATTGATGAGGCTTTGGCTGCTGGGGTAAAAAAGCA
CAATATTATTGTTGATCCTGGATTTGGCTTTGCGAAAAATGCCCAGCAAAATTTAAAACTATTAAAAGAATTTTGGAAAC
TTAATGAACTTGGTTATCCAATTTTATCCGGGCTTTCTCGTAAACGTTTCATAGGTGAAGCTTTACAAGGTGTTCCTGCA
GATCAACGTGCTGTGGGAAGTGTAACTGGGCATTTGCTTAGTATTCAGCAGGGAGCATCCATTGTAAGAGCGCATGATGT
AAAGGAAATGCATGAAGCAATTTTAGTTTGGAAAGCTATGCAGCAAGCCTAA

Upstream 100 bases:

>100_bases
CTTTTTTATTTGTCTTAACTTTGGATAAAGCTGAAAAGAAATCGACAGCATGTAAAGCTTACTTGCTAAAATAGCCGCTG
ATTTTGAACCGGAGCTTTTT

Downstream 100 bases:

>100_bases
ATAATGACGTTGTAAAATTGGACTTGCTCAGTGCTCATTAAAATAGAGTGGATGAGTGAGTCGGGTAAATATCTCGTGAT
TTTTACGAAAATATGTTATA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MQLISLPKQILQCGQLQLDLSQPHVMGILNVTPDSFSDGGKHNQLDQAVDHALSMIEQGATIIDIGGESTRPGASEVVVE
EEVRRVVPVVEALSYHNVILSIDTSQPEVIRAAKAAGAHIWNDVRALTRPNALKTAVELDIPVVIMHMRGEPTTMNQLDQ
YTDVTLDVMQELQQRIDEALAAGVKKHNIIVDPGFGFAKNAQQNLKLLKEFWKLNELGYPILSGLSRKRFIGEALQGVPA
DQRAVGSVTGHLLSIQQGASIVRAHDVKEMHEAILVWKAMQQA

Sequences:

>Translated_283_residues
MQLISLPKQILQCGQLQLDLSQPHVMGILNVTPDSFSDGGKHNQLDQAVDHALSMIEQGATIIDIGGESTRPGASEVVVE
EEVRRVVPVVEALSYHNVILSIDTSQPEVIRAAKAAGAHIWNDVRALTRPNALKTAVELDIPVVIMHMRGEPTTMNQLDQ
YTDVTLDVMQELQQRIDEALAAGVKKHNIIVDPGFGFAKNAQQNLKLLKEFWKLNELGYPILSGLSRKRFIGEALQGVPA
DQRAVGSVTGHLLSIQQGASIVRAHDVKEMHEAILVWKAMQQA
>Mature_283_residues
MQLISLPKQILQCGQLQLDLSQPHVMGILNVTPDSFSDGGKHNQLDQAVDHALSMIEQGATIIDIGGESTRPGASEVVVE
EEVRRVVPVVEALSYHNVILSIDTSQPEVIRAAKAAGAHIWNDVRALTRPNALKTAVELDIPVVIMHMRGEPTTMNQLDQ
YTDVTLDVMQELQQRIDEALAAGVKKHNIIVDPGFGFAKNAQQNLKLLKEFWKLNELGYPILSGLSRKRFIGEALQGVPA
DQRAVGSVTGHLLSIQQGASIVRAHDVKEMHEAILVWKAMQQA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=51.685393258427, Blast_Score=270, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6324073, Length=329, Percent_Identity=32.2188449848024, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31030; Mature: 31030

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLISLPKQILQCGQLQLDLSQPHVMGILNVTPDSFSDGGKHNQLDQAVDHALSMIEQGA
CCHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
TIIDIGGESTRPGASEVVVEEEVRRVVPVVEALSYHNVILSIDTSQPEVIRAAKAAGAHI
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHH
WNDVRALTRPNALKTAVELDIPVVIMHMRGEPTTMNQLDQYTDVTLDVMQELQQRIDEAL
HHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGVKKHNIIVDPGFGFAKNAQQNLKLLKEFWKLNELGYPILSGLSRKRFIGEALQGVPA
HCCHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCC
DQRAVGSVTGHLLSIQQGASIVRAHDVKEMHEAILVWKAMQQA
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLISLPKQILQCGQLQLDLSQPHVMGILNVTPDSFSDGGKHNQLDQAVDHALSMIEQGA
CCHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
TIIDIGGESTRPGASEVVVEEEVRRVVPVVEALSYHNVILSIDTSQPEVIRAAKAAGAHI
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHH
WNDVRALTRPNALKTAVELDIPVVIMHMRGEPTTMNQLDQYTDVTLDVMQELQQRIDEAL
HHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGVKKHNIIVDPGFGFAKNAQQNLKLLKEFWKLNELGYPILSGLSRKRFIGEALQGVPA
HCCHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCC
DQRAVGSVTGHLLSIQQGASIVRAHDVKEMHEAILVWKAMQQA
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]